| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kelsey M Moore, Wyatt L Oelberg, M Rose Glass, Matthew D Johnson, Laura E Been, Robert L Meise. Glutamate Afferents From the Medial Prefrontal Cortex Mediate Nucleus Accumbens Activation by Female Sexual Behavior. Frontiers in behavioral neuroscience. vol 13. 2020-10-01. PMID:31636548. |
as the mesocorticolimbic system is a primary neural circuit underlying sexual motivation, the goal of this study was to test the hypothesis that medial prefrontal cortex (mpfc) glutamate mediates sexual behavior activation of the nucleus accumbens. |
2020-10-01 |
2023-08-13 |
Not clear |
| Brooke Naylor, Negin Hesam-Shariati, James H McAuley, Simon Boag, Toby Newton-John, Caroline D Rae, Sylvia M Gusti. Reduced Glutamate in the Medial Prefrontal Cortex Is Associated With Emotional and Cognitive Dysregulation in People With Chronic Pain. Frontiers in neurology. vol 10. 2020-10-01. PMID:31849800. |
reduced glutamate in the medial prefrontal cortex is associated with emotional and cognitive dysregulation in people with chronic pain. |
2020-10-01 |
2023-08-13 |
human |
| Brooke Naylor, Negin Hesam-Shariati, James H McAuley, Simon Boag, Toby Newton-John, Caroline D Rae, Sylvia M Gusti. Reduced Glutamate in the Medial Prefrontal Cortex Is Associated With Emotional and Cognitive Dysregulation in People With Chronic Pain. Frontiers in neurology. vol 10. 2020-10-01. PMID:31849800. |
a decrease in glutamate in the medial prefrontal cortex (mpfc) has been extensively found in animal models of chronic pain. |
2020-10-01 |
2023-08-13 |
human |
| Xiao Liu, Jitao Li, Chunmei Guo, Hongli Wang, Yaxin Sun, Han Wang, Yun-Ai Su, Keqing Li, Tianmei S. Olanzapine Reverses MK-801-Induced Cognitive Deficits and Region-Specific Alterations of NMDA Receptor Subunits. Frontiers in behavioral neuroscience. vol 11. 2020-09-30. PMID:29375333. |
in this study, adopting repeated mk-801 treatment as an animal model of schizophrenia, we investigated whether antipsychotic drugs, olanzapine and haloperidol, can reverse mk-801-induced cognitive deficits and how the reversal processes recruited proteins involved in glutamate neurotransmission in rat medial prefrontal cortex (mpfc) and hippocampus. |
2020-09-30 |
2023-08-13 |
rat |
| Geehoon Chung, Sang Jeong Kim, Sun Kwang Ki. Metabotropic Glutamate Receptor 5 in the Medial Prefrontal Cortex as a Molecular Determinant of Pain and Ensuing Depression. Frontiers in molecular neuroscience. vol 11. 2020-09-29. PMID:30349459. |
metabotropic glutamate receptor 5 in the medial prefrontal cortex as a molecular determinant of pain and ensuing depression. |
2020-09-29 |
2023-08-13 |
Not clear |
| Brionna D Davis-Reyes, Veronica M Campbell, Michelle A Land, Holly L Chapman, Susan J Stafford, Noelle C Anastasi. Profile of cortical N-methyl-D-aspartate receptor subunit expression associates with inherent motor impulsivity in rats. Biochemical pharmacology. vol 168. 2020-07-13. PMID:31295463. |
glutamate neurotransmission through the n-methyl-d-aspartate receptors (nmdars) in the medial prefrontal cortex (mpfc), an important brain region in decision-making and goal-directed behaviors, plays a key role in motor impulsivity. |
2020-07-13 |
2023-08-13 |
rat |
| Yijuan Zou, Hui Zhang, Xi Chen, Wenliang Ji, Lanqun Mao, Hao Le. Age-dependent effects of (+)-MK801 treatment on glutamate release and metabolism in the rat medial prefrontal cortex. Neurochemistry international. vol 129. 2020-05-11. PMID:31299416. |
age-dependent effects of (+)-mk801 treatment on glutamate release and metabolism in the rat medial prefrontal cortex. |
2020-05-11 |
2023-08-13 |
rat |
| Yijuan Zou, Hui Zhang, Xi Chen, Wenliang Ji, Lanqun Mao, Hao Le. Age-dependent effects of (+)-MK801 treatment on glutamate release and metabolism in the rat medial prefrontal cortex. Neurochemistry international. vol 129. 2020-05-11. PMID:31299416. |
nmdar antagonist treatments in adolescent/young adult rodents are associated with augmented glutamate (glu) release and perturbed glu/glutamine (gln) metabolism in the medial prefrontal cortex (mpfc) resembling those found in first-episode schizophrenia. |
2020-05-11 |
2023-08-13 |
rat |
| Thu Ha Pham, Alain M Gardie. Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies. Pharmacology & therapeutics. vol 199. 2020-04-27. PMID:30851296. |
to date, the underlying mechanism involves glutamate release, then downstream activation of ampa receptors, which trigger mammalian target of rapamycin (mtor)-dependent structural plasticity via brain-derived neurotrophic factor (bdnf) and protein neo-synthesis in the medial prefrontal cortex (mpfc), a brain region strongly involved in ketamine therapeutic effects. |
2020-04-27 |
2023-08-13 |
Not clear |
| Chris Pickering, Johan Alsiö, Julia Morud, Mia Ericson, Trevor W Robbins, Bo Söderpal. Ethanol impairment of spontaneous alternation behaviour and associated changes in medial prefrontal glutamatergic gene expression precede putative markers of dependence. Pharmacology, biochemistry, and behavior. vol 132. 2019-11-20. PMID:25743187. |
in the medial prefrontal cortex, 2.5g/kg ethanol decreased mrna expression of brain-derived neurotrophic factor, nmda nr2a subunit, mglur8 receptor, homer1, the glutamate transporters slc1a1 and slc1a6 and srr. |
2019-11-20 |
2023-08-13 |
rat |
| Min-Jung Park, Bo Am Seo, Boyoung Lee, Hee-Sup Shin, Myoung-Goo Kan. Stress-induced changes in social dominance are scaled by AMPA-type glutamate receptor phosphorylation in the medial prefrontal cortex. Scientific reports. vol 8. issue 1. 2019-10-23. PMID:30301947. |
stress-induced changes in social dominance are scaled by ampa-type glutamate receptor phosphorylation in the medial prefrontal cortex. |
2019-10-23 |
2023-08-13 |
mouse |
| Min-Jung Park, Bo Am Seo, Boyoung Lee, Hee-Sup Shin, Myoung-Goo Kan. Stress-induced changes in social dominance are scaled by AMPA-type glutamate receptor phosphorylation in the medial prefrontal cortex. Scientific reports. vol 8. issue 1. 2019-10-23. PMID:30301947. |
it is known that social dominance is controlled by synaptic efficacy in the medial prefrontal cortex (mpfc) and that ampa-type glutamate receptor (ampa-r) is a key molecule for synaptic efficacy. |
2019-10-23 |
2023-08-13 |
mouse |
| Sayuri Ishiwata, Asami Umino, Toru Nishikaw. Involvement of neuronal and glial activities in control of the extracellular d-serine concentrations by the AMPA glutamate receptor in the mouse medial prefrontal cortex. Neurochemistry international. vol 119. 2019-09-30. PMID:28966065. |
involvement of neuronal and glial activities in control of the extracellular d-serine concentrations by the ampa glutamate receptor in the mouse medial prefrontal cortex. |
2019-09-30 |
2023-08-13 |
mouse |
| Lucia Caffino, Alessandro Piva, Giuseppe Giannotti, Marzia Di Chio, Francesca Mottarlini, Marco Venniro, David T Yew, Cristiano Chiamulera, Fabio Fumagall. Ketamine Self-Administration Reduces the Homeostasis of the Glutamate Synapse in the Rat Brain. Molecular neurobiology. vol 54. issue 9. 2019-05-08. PMID:27796754. |
our aim was to investigate the expression of crucial components of the glutamate synapse following chronic ketamine self-administration (s/a), focusing our attention on medial prefrontal cortex (mpfc) and hippocampus (hip), two brain regions involved in compulsive drug-seeking and drug-related cognitive disorders. |
2019-05-08 |
2023-08-13 |
human |
| Sarah N Isherwood, Trevor W Robbins, Jeffrey W Dalley, Anton Pekce. Bidirectional variation in glutamate efflux in the medial prefrontal cortex induced by selective positive and negative allosteric mGluR5 modulators. Journal of neurochemistry. vol 145. issue 2. 2019-04-26. PMID:29315577. |
bidirectional variation in glutamate efflux in the medial prefrontal cortex induced by selective positive and negative allosteric mglur5 modulators. |
2019-04-26 |
2023-08-13 |
rat |
| Roberta Monteiro Incrocci, Franciely Paliarin, Manoel Jorge Nobr. Prelimbic NMDA receptors stimulation mimics the attenuating effects of clozapine on the auditory electrophysiological rebound induced by ketamine withdrawal. Neurotoxicology. vol 69. 2019-03-15. PMID:30170016. |
pharmacologically, ket stimulates glutamate efflux in the medial prefrontal cortex, mainly in the prelimbic (prl) sub-region. |
2019-03-15 |
2023-08-13 |
rat |
| S-X Li, Y Han, L-Z Xu, K Yuan, R-X Zhang, C-Y Sun, D-F Xu, M Yuan, J-H Deng, S-Q Meng, X-J Gao, Q Wen, L-J Liu, W-L Zhu, Y-X Xue, M Zhao, J Shi, L L. Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects. Molecular psychiatry. vol 23. issue 3. 2019-03-12. PMID:28439098. |
in the present study, we found that chronic unpredictable stress (cus) induced extracellular glutamate accumulation, accompanied by an increase in the dapk1-nmdar interaction, the high expression of dapk1 and phosphorylated glun2b at ser1303, a decrease in phosphorylated dapk1 at ser308 and synaptic protein deficits in the rat medial prefrontal cortex (mpfc). |
2019-03-12 |
2023-08-13 |
rat |
| Suzanne T Witt, Natasha Morales Drissi, Sofie Tapper, Anna Wretman, Attila Szakács, Tove Hallböök, Anne-Marie Landtblom, Thomas Karlsson, Peter Lundberg, Maria Engströ. Evidence for cognitive resource imbalance in adolescents with narcolepsy. Brain imaging and behavior. vol 12. issue 2. 2019-03-04. PMID:28321606. |
all subjects also underwent mrs to measure gaba and glutamate concentrations in the medial prefrontal cortex. |
2019-03-04 |
2023-08-13 |
human |
| Hyeonwi Son, Ji Hyeong Baek, Bok Soon Go, Doo-Hyuk Jung, Sneha B Sontakke, Hye Jin Chung, Dong Hoon Lee, Gu Seob Roh, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Dong Kun Lee, Hyun Joon Ki. Glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex. Neuropharmacology. vol 143. 2019-02-25. PMID:30266598. |
glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex. |
2019-02-25 |
2023-08-13 |
mouse |
| Jan Kehr, Takashi Yoshitake, Fumio Ichinose, Shimako Yoshitake, Béla Kiss, István Gyertyán, Nika Adha. Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity. Psychopharmacology. vol 235. issue 5. 2019-02-20. PMID:29637288. |
effects of cariprazine on extracellular levels of glutamate, gaba, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity. |
2019-02-20 |
2023-08-13 |
rat |