| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mirjana Carli, Eleonora Calcagno, Ester Mainini, Jorn Arnt, Roberto W Invernizz. Sertindole restores attentional performance and suppresses glutamate release induced by the NMDA receptor antagonist CPP. Psychopharmacology. vol 214. issue 3. 2011-07-14. PMID:21049266. |
blockade of n-methyl-d-aspartic acid (nmda) receptors in the rat medial prefrontal cortex (mpfc) impairs performance in the five-choice serial reaction time task (5-csrtt) and increases glutamate (glu) release. |
2011-07-14 |
2023-08-12 |
rat |
| Mirjana Carli, Eleonora Calcagno, Pierangela Mainolfi, Ester Mainini, Roberto W Invernizz. Effects of aripiprazole, olanzapine, and haloperidol in a model of cognitive deficit of schizophrenia in rats: relationship with glutamate release in the medial prefrontal cortex. Psychopharmacology. vol 214. issue 3. 2011-07-14. PMID:21052982. |
effects of aripiprazole, olanzapine, and haloperidol in a model of cognitive deficit of schizophrenia in rats: relationship with glutamate release in the medial prefrontal cortex. |
2011-07-14 |
2023-08-12 |
rat |
| Yasuya Nakato, Tomohiro Abekawa, Koki Ito, Takeshi Inoue, Tsukasa Koyam. Lamotrigine blocks apoptosis induced by repeated administration of high-dose methamphetamine in the medial prefrontal cortex of rats. Neuroscience letters. vol 490. issue 3. 2011-06-01. PMID:21093543. |
using the model, the effect of ltg (30 mg/kg) on methamphetamine (meth, 2.5 mg/kg)-induced increases in extracellular glutamate levels in the medial prefrontal cortex (mpfc) was examined in this study. |
2011-06-01 |
2023-08-12 |
rat |
| L Pozzi, M Baviera, G Sacchetti, E Calcagno, C Balducci, R W Invernizzi, M Carl. Attention deficit induced by blockade of N-methyl D-aspartate receptors in the prefrontal cortex is associated with enhanced glutamate release and cAMP response element binding protein phosphorylation: role of metabotropic glutamate receptors 2/3. Neuroscience. vol 176. 2011-06-01. PMID:21193020. |
infusion of 50 ng/side 3-(r)-2-carboxypiperazin-4-propyl-1-phosphonic acid ((r)-cpp), a competitive glutamate nmda receptor antagonist, into the medial prefrontal cortex (mpfc) of rats performing the five-choice serial reaction time (5-csrt) task, reduced accuracy of visual discrimination (measured by % correct responses) and enhanced impulsivity (measured by the number of premature responses) and compulsivity (measured by the number of perseverative responses). |
2011-06-01 |
2023-08-12 |
rat |
| L Pozzi, M Baviera, G Sacchetti, E Calcagno, C Balducci, R W Invernizzi, M Carl. Attention deficit induced by blockade of N-methyl D-aspartate receptors in the prefrontal cortex is associated with enhanced glutamate release and cAMP response element binding protein phosphorylation: role of metabotropic glutamate receptors 2/3. Neuroscience. vol 176. 2011-06-01. PMID:21193020. |
in parallel studies using microdialysis technique and western blot analysis we found that (r)-cpp (100 μm) infused in the medial prefrontal cortex increased glutamate efflux whereas injected in the medial prefrontal cortex at a dose causing impairments in attentional performance (50 ng/side) increased p-s(133)creb in the frontal cortex (fc), decreased it in the caudate-putamen (cpu) and was without effect in the nucleus accumbens (nac). |
2011-06-01 |
2023-08-12 |
rat |
| Keiko Ohoyama, Satoshi Yamamura, Tatsuya Hamaguchi, Masanori Nakagawa, Eishi Motomura, Takashi Shiroyama, Hisashi Tanii, Motohiro Okad. Effect of novel atypical antipsychotic, blonanserin, on extracellular neurotransmitter level in rat prefrontal cortex. European journal of pharmacology. vol 653. issue 1-3. 2011-05-02. PMID:21147094. |
to clarify the mechanisms of action of blonanserin, an atypical antipsychotic drug, we studied the effects of systemic administration of blonanserin and risperidone on extracellular levels of norepinephrine, dopamine, serotonin, gaba and glutamate in the medial prefrontal cortex using microdialysis, and neuronal firing in the ventral tegmental area, locus coeruleus, dorsal raphe nucleus and mediodorsal thalamic nucleus using radiotelemetry. |
2011-05-02 |
2023-08-12 |
rat |
| Tomohiro Abekawa, Koki Ito, Shin Nakagawa, Yasuya Nakato, Tsukasa Koyam. Effects of aripiprazole and haloperidol on progression to schizophrenia-like behavioural abnormalities and apoptosis in rodents. Schizophrenia research. vol 125. issue 1. 2011-04-26. PMID:20833512. |
this study examined the hypothesis that apz blocks enhanced glutamate release in the medial prefrontal cortex (mpfc) during psychotic episodes of schizophrenia, thereby preventing progression of the pathophysiology. |
2011-04-26 |
2023-08-12 |
Not clear |
| Kou Takahashi, Hiroyasu Murasawa, Kazumasa Yamaguchi, Misa Yamada, Akiko Nakatani, Masumi Yoshida, Takashi Iwai, Masatoshi Inagaki, Mitsuhiko Yamada, Akiyoshi Saito. Riluzole rapidly attenuates hyperemotional responses in olfactory bulbectomized rats, an animal model of depression. Behavioural brain research. vol 216. issue 1. 2011-02-18. PMID:20620171. |
in addition, we demonstrated that single riluzole treatment (10 mg/kg, po) significantly decreased extracellular glutamate levels in medial prefrontal cortex of obx rats by in vivo microdialysis. |
2011-02-18 |
2023-08-12 |
rat |
| Zhimin Li, Mona Boules, Katrina Williams, Andres Gordillo, Shuhua Li, Elliott Richelso. Similarities in the behavior and molecular deficits in the frontal cortex between the neurotensin receptor subtype 1 knockout mice and chronic phencyclidine-treated mice: relevance to schizophrenia. Neurobiology of disease. vol 40. issue 2. 2011-01-12. PMID:20659557. |
our results showed many similarities between untreated nts1(-/-) mice and wt mice chronically treated with pcp (as compared with untreated wt mice): 1) lower pcp-induced locomotor activity; 2) similar avolition-like behavior in forced-swim test and tail suspension test; 3) lower prefrontal glutamate levels; 4) less pcp-induced dopamine release in medial prefrontal cortex (mpfc); and 5) down-regulation of mrna and protein for da d(1), da d(2), and nmdar2a in mpfc. |
2011-01-12 |
2023-08-12 |
mouse |
| Dayan Knox, Shane A Perrine, Sophie A George, Matthew P Galloway, Israel Liberzo. Single prolonged stress decreases glutamate, glutamine, and creatine concentrations in the rat medial prefrontal cortex. Neuroscience letters. vol 480. issue 1. 2010-09-24. PMID:20546834. |
single prolonged stress decreases glutamate, glutamine, and creatine concentrations in the rat medial prefrontal cortex. |
2010-09-24 |
2023-08-12 |
rat |
| Dayan Knox, Shane A Perrine, Sophie A George, Matthew P Galloway, Israel Liberzo. Single prolonged stress decreases glutamate, glutamine, and creatine concentrations in the rat medial prefrontal cortex. Neuroscience letters. vol 480. issue 1. 2010-09-24. PMID:20546834. |
in order to address this, we used high-resolution magic angle spinning proton magnetic resonance spectroscopy (hr-mas (1)h mrs) ex vivo to assay levels of neurochemicals critical for energy metabolism (creatine and lactate), excitatory (glutamate and glutamine) and inhibitory (gamma amino butyric acid (gaba)) neurotransmission, and neuronal integrity (n-acetylaspartate (naa)) in the medial prefrontal cortex (mpfc), amygdala complex, and hippocampus of sps and control rats. |
2010-09-24 |
2023-08-12 |
rat |
| Xavier López-Gil, Francesc Artigas, Albert Adel. Unraveling monoamine receptors involved in the action of typical and atypical antipsychotics on glutamatergic and serotonergic transmission in prefrontal cortex. Current pharmaceutical design. vol 16. issue 5. 2010-06-25. PMID:19909228. |
in the present work, we used in vivo microdialysis to examine: first, the effects of mk-801, on the efflux of glutamate and serotonin (5-ht) in the medial prefrontal cortex (mpfc) of the rat; second, whether the mk-801-induced changes in the cortical efflux of both transmitters could be blocked by atypical (clozapine and olanzapine) and classical (haloperidol and chlorpromazine) antipsychotic drugs given intra-mpfc; and third, the role of local blockade of dopamine d(2)/d(3)/d(4), serotonin 5-ht(2a) and alpha(1)-adrenergic receptors as well as agonism at dopamine d(1)/d(5) and 5-ht(1a) receptors in the mpfc on the increased efflux of glutamate and 5-ht elicited by mk-801. |
2010-06-25 |
2023-08-12 |
rat |
| Derek Lupinsky, Luc Moquin, Alain Gratto. Interhemispheric regulation of the medial prefrontal cortical glutamate stress response in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 22. 2010-06-21. PMID:20519537. |
while stressors are known to increase medial prefrontal cortex (pfc) glutamate (glu) levels, the mechanism(s) subserving this response remain to be elucidated. |
2010-06-21 |
2023-08-12 |
rat |
| Bernadette M Cortese, Todd R Mitchell, Matthew P Galloway, Kristen E Prevost, Jidong Fang, Gregory J Moore, Thomas W Uhd. Region-specific alteration in brain glutamate: possible relationship to risk-taking behavior. Physiology & behavior. vol 99. issue 4. 2010-05-12. PMID:20006966. |
an inverse relationship between glutamate in the medial prefrontal cortex and risk taking in the epm and a positive association between the ratio of glutamate in the hippocampus to medial prefrontal cortex and risk taking was revealed. |
2010-05-12 |
2023-08-12 |
rat |
| Zhimin Li, Mona Boules, Katrina Williams, Joanna Peris, Elliott Richelso. The novel neurotensin analog NT69L blocks phencyclidine (PCP)-induced increases in locomotor activity and PCP-induced increases in monoamine and amino acids levels in the medial prefrontal cortex. Brain research. vol 1311. 2010-04-08. PMID:19948149. |
pcp injection significantly increased activity as well as the extracellular concentration of norepinephrine (ne), 5-ht, dopamine (da), and glutamate in the medial prefrontal cortex (mpfc). |
2010-04-08 |
2023-08-12 |
rat |
| Arne Mørk, Louise M Witten, Jørn Arn. Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved. Psychopharmacology. vol 206. issue 1. 2009-12-29. PMID:19506838. |
effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved. |
2009-12-29 |
2023-08-12 |
rat |
| Dilshani W N Dissanayake, Margarita Zachariou, Charles A Marsden, Robert Maso. Effects of phencyclidine on auditory gating in the rat hippocampus and the medial prefrontal cortex. Brain research. vol 1298. 2009-12-16. PMID:19699183. |
this study examined the effect of the glutamate receptor antagonist, phencyclidine (pcp) on auditory gating in the ca3 region and dentate gyrus (dg) of rat hippocampus and medial prefrontal cortex (mpfc). |
2009-12-16 |
2023-08-12 |
rat |
| Xiaohu Xie, Jeffery D Stekete. Effects of repeated exposure to cocaine on group II metabotropic glutamate receptor function in the rat medial prefrontal cortex: behavioral and neurochemical studies. Psychopharmacology. vol 203. issue 3. 2009-09-28. PMID:19005645. |
effects of repeated exposure to cocaine on group ii metabotropic glutamate receptor function in the rat medial prefrontal cortex: behavioral and neurochemical studies. |
2009-09-28 |
2023-08-12 |
rat |
| Xiaohu Xie, Jeffery D Stekete. Effects of repeated exposure to cocaine on group II metabotropic glutamate receptor function in the rat medial prefrontal cortex: behavioral and neurochemical studies. Psychopharmacology. vol 203. issue 3. 2009-09-28. PMID:19005645. |
enhanced excitatory output from the medial prefrontal cortex (mpfc), which can be modulated by group ii metabotropic glutamate receptors (mglur), is thought to play a key role in the development of sensitization to cocaine. |
2009-09-28 |
2023-08-12 |
rat |
| Gerard J Mare. Activation of adenosine(1) (A(1)) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats. Neuropharmacology. vol 56. issue 8. 2009-08-28. PMID:19324062. |
activation of adenosine a(1) heteroceptors, like mglu2 autoreceptors, decreases glutamate release in the medial prefrontal cortex (mpfc) and other limbic brain regions. |
2009-08-28 |
2023-08-12 |
rat |