| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter J Vollbrecht, Kathryn M Nesbitt, Victoria M Addis, Keenan M Boulnemour, Daniel A Micheli, Kendall B Smith, Darleen A Sandoval, Robert T Kennedy, Carrie R Ferrari. Differential Regulation of Nucleus Accumbens Glutamate and GABA in Obesity-Prone and Obesity-Resistant Rats. Journal of neurochemistry. 2022-11-06. PMID:36336816. |
differential regulation of nucleus accumbens glutamate and gaba in obesity-prone and obesity-resistant rats. |
2022-11-06 |
2023-08-14 |
rat |
| Daozhong Jin, Hong Chen, Shao-Rui Chen, Hui-Lin Pa. α2δ-1 Protein drives opioid-induced conditioned reward and synaptic NMDA receptor hyperactivity in the nucleus accumbens. Journal of neurochemistry. 2022-10-12. PMID:36222452. |
glutamate nmda receptors (nmdars) in the nucleus accumbens (nac) are critically involved in drug dependence and reward. |
2022-10-12 |
2023-08-14 |
mouse |
| Shuo Li, Xiao-Qin Zhang, Chuan-Chuan Liu, Zhi-Yuan Wang, Guan-Yi Lu, Hao-Wei Shen, Ning Wu, Jin Li, Fei L. IRAS/Nischarin modulates morphine reward by glutamate receptor activation in the nucleus accumbens of mouse brain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076473. |
iras/nischarin modulates morphine reward by glutamate receptor activation in the nucleus accumbens of mouse brain. |
2022-09-09 |
2023-08-14 |
mouse |
| Carlos Morgan, Patricio Sáez-Briones, Rafael Barra, Andrea Reyes, Katherine Zepeda-Morales, Luis Constandil, Miguel Ríos, Paulina Ramírez, Héctor Burgos, Alejandro Hernánde. Prefrontal Cortical Control of Activity in Nucleus Accumbens Core Is Weakened by High-Fat Diet and Prevented by Co-Treatment with N-Acetylcysteine: Implications for the Development of Obesity. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077493. |
a loss of neuroplastic control on nucleus accumbens (nac) neuronal activity exerted by the medial prefrontal cortex (mpfc) through long-term depression (ltd) is involved in triggering drug-seeking behavior and relapse on several substances of abuse due to impaired glutamate homeostasis in tripartite synapses of the nucleus accumbens (nac) core. |
2022-09-09 |
2023-08-14 |
mouse |
| Julie E Finnell, Carrie R Ferrari. Intra-NAc insulin reduces the motivation for food and food intake without altering cue-triggered food-seeking. Physiology & behavior. 2022-06-26. PMID:35753434. |
furthermore, insulin receptor activation alters dopamine and glutamate transmission within mesolimbic regions that influence food-seeking and feeding including the nucleus accumbens (nac). |
2022-06-26 |
2023-08-14 |
rat |
| Viktor A Stratilov, Oleg V Vetrovoy, Ekaterina I Tyulkov. Prenatal Hypoxia Affects Nicotine Consumption and Withdrawal in Adult Rats via Impairment of the Glutamate System in the Brain. Molecular neurobiology. 2022-05-17. PMID:35581520. |
psh rats also demonstrated an increased level of phosphorylated darpp-32 protein (known as the relay for dopamine and glutamate signaling) at 34 threonine (pthr34darpp-32) in relation to its total amount in the nucleus accumbens of the striatum (nac). |
2022-05-17 |
2023-08-13 |
rat |
| Yan Li, Zhi Chen, Jianting Zhao, Heming Yu, Xiangyu Chen, Yong He, Yu Tian, Yue Wang, Chong Chen, Ke Cheng, Peng Xi. Neurotransmitter and Related Metabolic Profiling in the Nucleus Accumbens of Chronic Unpredictable Mild Stress-Induced Anhedonia-Like Rats. Frontiers in behavioral neuroscience. vol 16. 2022-05-16. PMID:35571281. |
anhedonia, as a core symptom, was closely associated with altered levels of 5-hydroxytryptamine (5-ht), dopamine (da), and diverse types of glutamate (glu) receptors in the nucleus accumbens (nac). |
2022-05-16 |
2023-08-13 |
rat |
| Alexander D Maitland, Carrie R Ferrari. Effect of rate of intravenous cocaine infusion on psychomotor sensitization and striatal AMPAR expression in female rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554015. |
furthermore, increases in cell-surface expression of ampa-type glutamate receptors within the nucleus accumbens (nac) are associated with psychomotor sensitization and enhanced cocaine-seeking, but potential effects of roi on nac glutamate plasticity had not been examined. |
2022-05-13 |
2023-08-13 |
rat |
| Chelsea Brown, Jackie Beltran, Elissa Fultz, Tori Tran, Brooke Barger, Nyssa Williams, Waylon Yen, Asher Park, Tod Kippin, Karen Szumlinsk. Investigating the Role of Corticostriatal Glutamate Signaling in Methamphetamine Reward and Reinforcement. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554032. |
while the majority of addiction research has implicated the dopamine system, the long-term neuroplasticity that maintains ma use disorder also involves drug-induced changes in glutamate signaling in reward regions of the brain like the nucleus accumbens (nac) and prefrontal cortex (pfc). |
2022-05-13 |
2023-08-13 |
Not clear |
| Shalini Dogra, P Jeffrey Con. Activation of group II metabotropic glutamate (mGlu2/3) receptors regulates excitatory synaptic plasticity in the nucleus accumbens: Implications for the treatment of schizophrenia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554561. |
activation of group ii metabotropic glutamate (mglu2/3) receptors regulates excitatory synaptic plasticity in the nucleus accumbens: implications for the treatment of schizophrenia. |
2022-05-13 |
2023-08-13 |
Not clear |
| Troy D Fort, Mary E Cai. The Role of Astroglial xCT in Mitigating Cue-Induced Amphetamine-Seeking. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555299. |
glutamate is maintained by a combination of astrocytic and neuronal transporters within the nucleus accumbens (acb) and disruptions in this homeostasis engender sud. |
2022-05-13 |
2023-08-13 |
rat |
| Katsuya Kami, Fumihiro Tajima, Emiko Senb. Brain Mechanisms of Exercise-Induced Hypoalgesia: To Find a Way Out from "Fear-Avoidance Belief". International journal of molecular sciences. vol 23. issue 5. 2022-03-10. PMID:35270027. |
we found that voluntary exercise (ve) activated glutamate (glu) neurons in the medial basal amyg projecting to the nucleus accumbens (nac) lateral shell, while it almost completely suppressed npp-induced activation of gaba neurons in the central nucleus of the amyg (cea). |
2022-03-10 |
2023-08-13 |
mouse |
| Rusty W Nall, Lauren N Beloate, Michael E Meyerink, Tiffany Penaloza, Jade Doolittle, Brett Froeliger, Peter W Kalivas, Constanza Garcia-Kelle. Assessing combined effects of varenicline and N-acetylcysteine on reducing nicotine seeking in rats. Addiction biology. vol 27. issue 2. 2022-03-01. PMID:35229943. |
animal models reveal that glutamate dysregulation in the nucleus accumbens is associated with nicotine relapse. |
2022-03-01 |
2023-08-13 |
rat |
| Hong-Ju Yang, Briana J Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L Gardner, Zheng-Xiong X. Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-29. PMID:35091501. |
in this study, we systemically evaluated the effects of multiple glutamate transporter (glt) inhibitors on extracellular glutamate and dopamine (da) in the nucleus accumbens (nac), intravenous cocaine self-administration, intracranial brain-stimulation reward, and reinstatement of cocaine seeking in male and female rats. |
2022-01-29 |
2023-08-13 |
rat |
| Pan Zhang, Olivia C Perez, Bruce R Southey, Jonathan V Sweedler, Amynah A Pradhan, Sandra L Rodriguez-Za. Alternative Splicing Mechanisms Underlying Opioid-Induced Hyperalgesia. Genes. vol 12. issue 10. 2021-12-03. PMID:34680965. |
splicing of genes in the gonadotropin-releasing hormone receptor pathway was detected in the nucleus accumbens while splicing in the vascular endothelial growth factor, endogenous cannabinoid signaling, circadian clock system, and metabotropic glutamate receptor pathways was detected in the trigeminal ganglia. |
2021-12-03 |
2023-08-13 |
mouse |
| Etna J E Engeli, Niklaus Zoelch, Andreas Hock, Carlos Nordt, Lea M Hulka, Matthias Kirschner, Milan Scheidegger, Fabrizio Esposito, Markus R Baumgartner, Anke Henning, Erich Seifritz, Boris B Quednow, Marcus Herdene. Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction. Molecular psychiatry. vol 26. issue 9. 2021-11-15. PMID:32601455. |
impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction. |
2021-11-15 |
2023-08-13 |
human |
| Etna J E Engeli, Niklaus Zoelch, Andreas Hock, Carlos Nordt, Lea M Hulka, Matthias Kirschner, Milan Scheidegger, Fabrizio Esposito, Markus R Baumgartner, Anke Henning, Erich Seifritz, Boris B Quednow, Marcus Herdene. Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction. Molecular psychiatry. vol 26. issue 9. 2021-11-15. PMID:32601455. |
animal models suggest a disrupted glutamate homeostasis in the nucleus accumbens to underlie addiction-like behavior. |
2021-11-15 |
2023-08-13 |
human |
| Etna J E Engeli, Niklaus Zoelch, Andreas Hock, Carlos Nordt, Lea M Hulka, Matthias Kirschner, Milan Scheidegger, Fabrizio Esposito, Markus R Baumgartner, Anke Henning, Erich Seifritz, Boris B Quednow, Marcus Herdene. Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction. Molecular psychiatry. vol 26. issue 9. 2021-11-15. PMID:32601455. |
here, we applied a tailored proton magnetic resonance spectroscopy protocol that allows glutamate quantification within the human nucleus accumbens. |
2021-11-15 |
2023-08-13 |
human |
| Etna J E Engeli, Niklaus Zoelch, Andreas Hock, Carlos Nordt, Lea M Hulka, Matthias Kirschner, Milan Scheidegger, Fabrizio Esposito, Markus R Baumgartner, Anke Henning, Erich Seifritz, Boris B Quednow, Marcus Herdene. Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction. Molecular psychiatry. vol 26. issue 9. 2021-11-15. PMID:32601455. |
we found significantly reduced basal glutamate concentrations in the nucleus accumbens in cocaine-addicted (n = 26) compared with healthy individuals (n = 30), and increased glutamate levels during cue-induced craving in cocaine-addicted individuals compared with baseline. |
2021-11-15 |
2023-08-13 |
human |
| Masahito Nangaku, Kouhei Yoshino, Yasunori Oda, Makoto Kimura, Hiroshi Kimura, Yuki Hirose, Yukihiko Shirayama, Masaomi Iy. Astroglial glutamate transporter 1 and glutamine synthetase of the nucleus accumbens are involved in the antidepressant-like effects of allopregnanolone in learned helplessness rats. Behavioural brain research. vol 401. 2021-11-15. PMID:33359844. |
astroglial glutamate transporter 1 and glutamine synthetase of the nucleus accumbens are involved in the antidepressant-like effects of allopregnanolone in learned helplessness rats. |
2021-11-15 |
2023-08-13 |
rat |