| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Vrettou, Liying Yan, Kent W Nilsson, Åsa Wallén-Mackenzie, Ingrid Nylander, Erika Comasc. DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34321562. |
the present study aimed to investigate whether dna methylation of the vesicular glutamate transporters (vglut)1-3 is related to previously observed vglut1-3 transcriptional differences in the ventral tegmental area (vta), nucleus accumbens (acb), dorsal striatum (dstr) and medial prefrontal cortex (mpfc) of adult rats exposed to els, modelled by maternal separation, and voluntary ethanol consumption. |
2021-11-08 |
2023-08-13 |
rat |
| C N Logan, G Rojas, C S Wilkinson, A K Polo Escorcia, C M Reichel, J Peris, L A Knacksted. Systemic oxytocin increases glutamate efflux in the nucleus accumbens core of cocaine-experienced male and female rats but only increases dopamine efflux in males. Behavioural brain research. vol 417. 2021-11-08. PMID:34551348. |
these data are the first to find that systemic oxytocin increases nucleus accumbens glutamate after cocaine experience, providing a mechanism of action by which oxytocin attenuates the reinstatement of cocaine seeking in both male and female rats. |
2021-11-08 |
2023-08-13 |
rat |
| Ai T M Nguyen, Tran V B Quach, Peddanna Kotha, Szu-Yu Chien, Iona J MacDonald, Hsien-Yuan Lane, Cheng-Hao Tu, Jaung-Geng Lin, Yi-Hung Che. Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34211013. |
this experimental study compared the effects of electroacupuncture (ea) at acupoints li4 and li11 with those of another potentially beneficial intervention, gabapentin (gbp), alone or in combination, on reinstatement of cocaine-induced conditioned place preference (cpp) and levels of Δfosb and glutamate receptor subunit 2 (glur2) expression in the nucleus accumbens (nac). |
2021-11-03 |
2023-08-13 |
Not clear |
| Erik J Garcia, Mary E Cai. Isolation housing elevates amphetamine seeking independent of nucleus accumbens glutamate receptor adaptations. The European journal of neuroscience. vol 54. issue 7. 2021-11-01. PMID:34481424. |
isolation housing elevates amphetamine seeking independent of nucleus accumbens glutamate receptor adaptations. |
2021-11-01 |
2023-08-13 |
rat |
| Erik J Garcia, Mary E Cai. Isolation housing elevates amphetamine seeking independent of nucleus accumbens glutamate receptor adaptations. The European journal of neuroscience. vol 54. issue 7. 2021-11-01. PMID:34481424. |
preclinical models have determined that glutamate receptor plasticity within the nucleus accumbens (nac) drives amplified cue-evoked drug seeking after prolonged abstinence (>40 days). |
2021-11-01 |
2023-08-13 |
rat |
| Tomaz Martini, Jürgen A Ripperger, Jimmy Stalin, Andrej Kores, Michael Stumpe, Urs Albrech. Deletion of the clock gene Period2 (Per2) in glial cells alters mood-related behavior in mice. Scientific reports. vol 11. issue 1. 2021-10-27. PMID:34112905. |
this is paralleled by an increase of the gaba transporter 2 (gat2/slc6a13) and dopamine receptor d3 (drd3) mrna, and a reduction of glutamate levels in the nucleus accumbens (nac). |
2021-10-27 |
2023-08-13 |
mouse |
| Karen K Szumlinski, Daria L Thompson, Rachel M Renton, Alexis W Ary, Kevin D Lomina. Enduring dysregulation of nucleus accumbens catecholamine and glutamate transmission by developmental exposure to phenylpropanolamine. Brain research. vol 1748. 2021-10-25. PMID:32896521. |
enduring dysregulation of nucleus accumbens catecholamine and glutamate transmission by developmental exposure to phenylpropanolamine. |
2021-10-25 |
2023-08-13 |
mouse |
| Steven R Laviolett. Molecular and neuronal mechanisms underlying the effects of adolescent nicotine exposure on anxiety and mood disorders. Neuropharmacology. vol 184. 2021-10-22. PMID:33245960. |
nicotine can potently regulate the transmission of various neurochemicals, including dopamine (da), γ-amino-butyric acid (gaba) and glutamate, within various mesocorticolimbic structures, such as the ventral tegmental area (vta), nucleus accumbens (nac) and prefrontal cortex (pfc), all of which show pathologies in these disorders. |
2021-10-22 |
2023-08-13 |
Not clear |
| Y Sar. Potential therapeutic role of glutamate transporter 1 for the treatment of alcohol dependence. OA alcohol. vol 1. issue 1. 2021-10-21. PMID:24409344. |
alcohol-seeking behaviour is promoted by increased glutamate transmission in key regions of the mesocorticolimbic reward circuit, including the nucleus accumbens and prefrontal cortex. |
2021-10-21 |
2023-08-12 |
human |
| Alejandra M Pacchioni, Peter W Kaliva. The Role of AMPAR Trafficking Mediated by Neuronal Pentraxins in Cocaine-induced Neuroadaptations. Molecular and cellular pharmacology. vol 1. issue 2. 2021-10-20. PMID:20336176. |
glutamate ampa receptors (ampar) in the nucleus accumbens have an important role in cocaine-induced neuroadaptations. |
2021-10-20 |
2023-08-12 |
mouse |
| Xiaotao Xu, Kaixuan Wu, Xiaqing Ma, Wenying Wang, Haiyan Wang, Min Huang, Limin Luo, Chen Su, Tifei Yuan, Haibo Shi, Ji Han, Aizhong Wang, Tao X. mGluR5-Mediated eCB Signaling in the Nucleus Accumbens Controls Vulnerability to Depressive-Like Behaviors and Pain After Chronic Social Defeat Stress. Molecular neurobiology. vol 58. issue 10. 2021-10-08. PMID:34227060. |
we hypothesized that metabotropic glutamate receptor 5 (mglur5) expressed in the nucleus accumbens (nac) normalizes the depressive-like behaviors and pain following csds. |
2021-10-08 |
2023-08-13 |
mouse |
| Claudia Rangel-Barajas, Israel Coronel, Yanping Zhang, Maribel Hernández, Stephen L Boehm I. Low-level developmental lead exposure does not predispose to adult alcohol self-administration, but does increase the risk of relapsing to alcohol seeking in mice: Contrasting role of GLT1 and xCT brain expression. Neuropharmacology. vol 181. 2021-09-23. PMID:33010299. |
because pb exposure is associated with increased glutamatergic tone, we also studied the effects on the expression of synaptic and non-synaptic glutamate transporters in brain regions associated with drug addiction such as the nucleus accumbens (nac), dorsomedial striatum (dms), dorsolateral striatum (dls), and medial prefrontal cortex (mpfc). |
2021-09-23 |
2023-08-13 |
mouse |
| William C Griffin, Harold L Haun, Vorani S Ramachandra, Lori A Knackstedt, Patrick J Mulholland, Howard C Becke. Effects of ceftriaxone on ethanol drinking and GLT-1 expression in ethanol dependence and relapse drinking. Alcohol (Fayetteville, N.Y.). vol 92. 2021-09-23. PMID:33465464. |
previous reports from our laboratory show that cie increases extracellular glutamate in the nucleus accumbens (nac) and that manipulating accumbal glutamate concentrations will alter ethanol drinking, indicating that glutamate homeostasis plays a crucial role in ethanol drinking in this model. |
2021-09-23 |
2023-08-13 |
mouse |
| Lori A Knackstedt, Lizhen Wu, Jeffrey Rothstein, Svetlana Vidensky, John Gordon, Mercy Ramanjulu, Paul Dunman, Benjamin Blass, Wayne Childers, Magid Abou-Gharbi. MC-100093, a Novel The Journal of pharmacology and experimental therapeutics. vol 378. issue 2. 2021-09-23. PMID:33986035. |
in rodents, the glutamate transporter-1 (glt-1) is downregulated in the nucleus accumbens after cocaine self-administration, and increasing the expression and function of glt-1 reduces the reinstatement of cocaine seeking. |
2021-09-23 |
2023-08-13 |
Not clear |
| Adam Hamed, Miron Bartosz Kurs. Social deprivation substantially changes multi-structural neurotransmitter signature of social interaction: Glutamate concentration in amygdala and VTA as a key factor in social encounter-induced 50-kHz ultrasonic vocalization. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 37. 2021-08-26. PMID:32651127. |
social encounter-induced 50-khz usvs were bound up with changes in glutamate in amygdala and vta, glycine in the amygdala, vta, hippocampus, nucleus accumbens and cpu, and dopamine metabolites in vta and cpu. |
2021-08-26 |
2023-08-13 |
rat |
| Sumin Sohn, Sunghyun Kim, Ju Hwan Yang, Eun Sang Cho. Linking of NMDA receptors and mGluR5 in the nucleus accumbens core to repeated cocaine-induced 50-kHz ultrasonic vocalization in rats. Addiction biology. 2021-08-25. PMID:34378829. |
this study demonstrated the linking of glutamate receptors in the nucleus accumbens (nac) to vocal expression of 50-khz usv calls after repeated cocaine administration in freely moving rats. |
2021-08-25 |
2023-08-13 |
rat |
| Javier Novoa, Carlos J Rivero, Enrique U Pérez-Cardona, Jaime A Freire-Arvelo, Juan Zegers, Héctor E Yarur, Iván G Santiago-Marerro, José L Agosto-Rivera, Jorge L González-Pérez, Katia Gysling, Annabell C Segarr. Social isolation of adolescent male rats increases anxiety and K The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:34097788. |
this study investigated the effects of social isolation after weaning on anxiety, body weight and locomotion, and on extracellular dopamine (da) and glutamate (glu) in the nucleus accumbens (nac) and their modulation by corticotropin releasing factor receptor 1. |
2021-08-20 |
2023-08-13 |
rat |
| Luis H Llano López, Pablo Melonari, Marisa Olguin, Miriam Débora Fraile, Adriana I Landa, Pascual A Gargiul. Effects of atenolol injected into the nucleus accumbens septi in rats in the elevated plus-maze test. Journal of basic and clinical physiology and pharmacology. vol 31. issue 6. 2021-08-13. PMID:32598313. |
background in previous studies, we have observed that glutamate antagonists injected within the nucleus accumbens septi (nas) induced an anxiolytic-like effect in the elevated plus maze (epm) test in rats. |
2021-08-13 |
2023-08-13 |
rat |
| Carol A Dannenhoffer, David F Werner, Elena I Varlinskaya, Linda P Spea. Adolescent intermittent ethanol exposure does not alter responsiveness to ifenprodil or expression of vesicular GABA and glutamate transporters. Developmental psychobiology. vol 63. issue 5. 2021-08-12. PMID:33511630. |
experiment 3 assessed protein expression of vesicular transporters of gaba (vgat) and glutamate (vglut2) within the prelimbic cortex and nucleus accumbens in adolescents versus adults and in aie adults versus controls. |
2021-08-12 |
2023-08-13 |
rat |
| Hui Shen, Kai Chen, Rosa Anna M Marino, Ross A McDevitt, Zheng-Xiong X. Deletion of VGLUT2 in midbrain dopamine neurons attenuates dopamine and glutamate responses to methamphetamine in mice. Pharmacology, biochemistry, and behavior. vol 202. 2021-08-10. PMID:33444596. |
to test this hypothesis, we used cre-loxp techniques to selectively delete vglut2 from midbrain da neurons, and then examined nucleus accumbens (nac) da and glutamate responses to meth using in vivo brain microdialysis between da-vglut2-ko mice and their vglut2-het littermates. |
2021-08-10 |
2023-08-13 |
mouse |