| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katie Larson Ode, Christine L Chan, Andrea Granados, Amir Moheet, Antoinette Moran, Amanda L Brenna. Cystic fibrosis related diabetes: Medical management. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. vol 18 Suppl 2. 2020-12-10. PMID:31679720. |
cftr potentiator and corrector therapy has yet to demonstrate an effect on the rate of cfrd, but may improve insulin secretion. |
2020-12-10 |
2023-08-13 |
Not clear |
| Dawood Khan, Ryan Kelsey, Rashmi R Maheshwari, Virginia M Stone, Annie Hasib, Fiona N Manderson Koivula, Aoife Watson, Stephen Harkin, Nigel Irwin, James A Shaw, Neville H McClenaghan, Viktória Venglovecz, Attila Ébert, Malin Flodström-Tullberg, Michael G White, Catriona Kell. Short-term CFTR inhibition reduces islet area in C57BL/6 mice. Scientific reports. vol 9. issue 1. 2020-11-06. PMID:31375720. |
temporary cftr inhibition had little long-term impact on glucose-stimulated, or glp-1 potentiated insulin secretion. |
2020-11-06 |
2023-08-13 |
mouse |
| Dawood Khan, Ryan Kelsey, Rashmi R Maheshwari, Virginia M Stone, Annie Hasib, Fiona N Manderson Koivula, Aoife Watson, Stephen Harkin, Nigel Irwin, James A Shaw, Neville H McClenaghan, Viktória Venglovecz, Attila Ébert, Malin Flodström-Tullberg, Michael G White, Catriona Kell. Short-term CFTR inhibition reduces islet area in C57BL/6 mice. Scientific reports. vol 9. issue 1. 2020-11-06. PMID:31375720. |
cftr inhibition has a rapid impact on islet area and insulin concentrations. |
2020-11-06 |
2023-08-13 |
mouse |
| Andrew W Norris, Katie Larson Ode, Lina Merjaneh, Srinath Sanda, Yaling Yi, Xingshen Sun, John F Engelhardt, Rebecca L Hul. Survival in a bad neighborhood: pancreatic islets in cystic fibrosis. The Journal of endocrinology. 2020-08-01. PMID:30759072. |
second, controversy exists in the literature regarding the presence/importance of β-cell intrinsic functions of cftr and its direct role in modulating insulin release. |
2020-08-01 |
2023-08-13 |
human |
| Andrew W Norris, Katie Larson Ode, Lina Merjaneh, Srinath Sanda, Yaling Yi, Xingshen Sun, John F Engelhardt, Rebecca L Hul. Survival in a bad neighborhood: pancreatic islets in cystic fibrosis. The Journal of endocrinology. 2020-08-01. PMID:30759072. |
third, loss of the cf transmembrane conductance regulator (cftr) from pancreatic ductal epithelium, the predominant site of its synthesis, results in paracrine effects that impair insulin release. |
2020-08-01 |
2023-08-13 |
human |
| Theodore G Lio. The Clinical Biology of Cystic Fibrosis Transmembrane Regulator Protein: Its Role and Function in Extrapulmonary Disease. Chest. vol 155. issue 3. 2019-12-20. PMID:30359614. |
cftr dysfunction in older individuals may have novel effects on glucose metabolism, control of insulin release, regulation of circadian rhythm, and cancer cell pathophysiology. |
2019-12-20 |
2023-08-13 |
human |
| Kyu Shik Mun, Kavisha Arora, Yunjie Huang, Fanmuyi Yang, Sunitha Yarlagadda, Yashaswini Ramananda, Maisam Abu-El-Haija, Joseph J Palermo, Balamurugan N Appakalai, Jaimie D Nathan, Anjaparavanda P Nare. Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders. Nature communications. vol 10. issue 1. 2019-12-12. PMID:31311920. |
here we show that defective cftr function in pdecs directly reduced insulin secretion in islet cells significantly. |
2019-12-12 |
2023-08-13 |
human |
| Kayani Kayani, Raihan Mohammed, Hasan Mohiaddi. Cystic Fibrosis-Related Diabetes. Frontiers in endocrinology. vol 9. 2019-11-20. PMID:29515516. |
we begin by reviewing our understanding of the pathogenesis of cfrd, as emerging evidence shows the cystic fibrosis transmembrane conductance regulator (cftr) also has important roles in the release of insulin and glucagon and in the protection of β cells from oxidative stress. |
2019-11-20 |
2023-08-13 |
Not clear |
| Anna Edlund, Mohammad Barghouth, Michael Huhn, Mia Abels, Jonathan Esguerra, Ines Mollet, Emma Svedin, Anna Wendt, Erik Renstrom, Enming Zhang, Nils Wierup, Bob J Scholte, Malin Flodström-Tullberg, Lena Eliasso. Defective exocytosis and processing of insulin in a cystic fibrosis mouse model. The Journal of endocrinology. 2019-11-20. PMID:30721137. |
cftr expression, beta cell mass, insulin granule distribution, hormone secretion and single cell capacitance changes were evaluated using islets (or beta cells) from f508del mice and age-matched wild-type mice aged 7-10 weeks. |
2019-11-20 |
2023-08-13 |
mouse |
| Andrew W Norri. Is Cystic Fibrosis-related Diabetes Reversible? New Data on CFTR Potentiation and Insulin Secretion. American journal of respiratory and critical care medicine. vol 199. issue 3. 2019-11-08. PMID:30192635. |
new data on cftr potentiation and insulin secretion. |
2019-11-08 |
2023-08-13 |
Not clear |
| Yoshinori Marunak. The Mechanistic Links between Insulin and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Cl International journal of molecular sciences. vol 18. issue 8. 2018-05-01. PMID:28805732. |
the mechanistic links between insulin and cystic fibrosis transmembrane conductance regulator (cftr) cl the cystic fibrosis transmembrane conductance regulator (cftr) cl |
2018-05-01 |
2023-08-13 |
Not clear |
| L Kessler, M Abél. [Pancreatic infringement exocrine and endocrine in cystic fibrosis]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. vol 23. issue 12S. 2018-01-16. PMID:28231890. |
the insulin secretion depending on the channel chlorine (cystic fibrosis transmembrane conductance regulator [cftr]) activity at the membrane surface of insulin cell is reduced prior to the occurrence of pancreatic histological lesions. |
2018-01-16 |
2023-08-13 |
Not clear |
| Reuven Tsabari, Hila Iron Elyashar, Malena Cohen Cymberknowh, Oded Breuer, Shoshana Armoni, Galit Livnat, Eitan Kerem, David Haim Zange. CFTR potentiator therapy ameliorates impaired insulin secretion in CF patients with a gating mutation. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. vol 15. issue 3. 2017-12-18. PMID:26547591. |
cftr potentiator therapy ameliorates impaired insulin secretion in cf patients with a gating mutation. |
2017-12-18 |
2023-08-13 |
Not clear |
| Xingshen Sun, Yaling Yi, Weiliang Xie, Bo Liang, Michael C Winter, Nan He, Xiaoming Liu, Meihui Luo, Yu Yang, Katie Larson Ode, Aliye Uc, Andrew W Norris, John F Engelhard. CFTR Influences Beta Cell Function and Insulin Secretion Through Non-Cell Autonomous Exocrine-Derived Factors. Endocrinology. vol 158. issue 10. 2017-10-13. PMID:28977592. |
cftr influences beta cell function and insulin secretion through non-cell autonomous exocrine-derived factors. |
2017-10-13 |
2023-08-13 |
human |
| Xingshen Sun, Yaling Yi, Weiliang Xie, Bo Liang, Michael C Winter, Nan He, Xiaoming Liu, Meihui Luo, Yu Yang, Katie Larson Ode, Aliye Uc, Andrew W Norris, John F Engelhard. CFTR Influences Beta Cell Function and Insulin Secretion Through Non-Cell Autonomous Exocrine-Derived Factors. Endocrinology. vol 158. issue 10. 2017-10-13. PMID:28977592. |
although β-cell dysfunction in cystic fibrosis (cf) leads to diabetes, the mechanism by which the cystic fibrosis transmembrane conductance regulator (cftr) channel influences islet insulin secretion remains debated. |
2017-10-13 |
2023-08-13 |
human |
| Xingshen Sun, Yaling Yi, Weiliang Xie, Bo Liang, Michael C Winter, Nan He, Xiaoming Liu, Meihui Luo, Yu Yang, Katie Larson Ode, Aliye Uc, Andrew W Norris, John F Engelhard. CFTR Influences Beta Cell Function and Insulin Secretion Through Non-Cell Autonomous Exocrine-Derived Factors. Endocrinology. vol 158. issue 10. 2017-10-13. PMID:28977592. |
we investigated the cftr-dependent islet-autonomous mechanisms affecting insulin secretion by using islets isolated from cftr knockout ferrets. |
2017-10-13 |
2023-08-13 |
human |
| Xingshen Sun, Yaling Yi, Weiliang Xie, Bo Liang, Michael C Winter, Nan He, Xiaoming Liu, Meihui Luo, Yu Yang, Katie Larson Ode, Aliye Uc, Andrew W Norris, John F Engelhard. CFTR Influences Beta Cell Function and Insulin Secretion Through Non-Cell Autonomous Exocrine-Derived Factors. Endocrinology. vol 158. issue 10. 2017-10-13. PMID:28977592. |
pharmacologic inhibition of cftr reduced gsis by wt ferret and human islets but similarly reduced insulin secretion and intracellular ca2+ in cftr knockout ferret islets, indicating that the mechanism of action is not through cftr. |
2017-10-13 |
2023-08-13 |
human |
| Fiona N Manderson Koivula, Neville H McClenaghan, Alan G S Harper, Catriona Kell. Islet-intrinsic effects of CFTR mutation. Diabetologia. vol 59. issue 7. 2017-08-28. PMID:27033560. |
in addition to the traditional view that cfrd is a consequence of fibrotic destruction of the pancreas as a whole, emerging evidence may implicate a role for cystic fibrosis transmembrane-conductance regulator (cftr) in the regulation of insulin secretion from the pancreatic islet. |
2017-08-28 |
2023-08-13 |
mouse |
| Fiona N Manderson Koivula, Neville H McClenaghan, Alan G S Harper, Catriona Kell. Islet-intrinsic effects of CFTR mutation. Diabetologia. vol 59. issue 7. 2017-08-28. PMID:27033560. |
recent experimental evidence suggests that functional cftr channels are required for insulin exocytosis and the regulation of membrane potential in the pancreatic beta cell, which may account for the impairments in insulin secretion observed in many cf patients. |
2017-08-28 |
2023-08-13 |
mouse |
| Fiona N Manderson Koivula, Neville H McClenaghan, Alan G S Harper, Catriona Kell. Islet-intrinsic effects of CFTR mutation. Diabetologia. vol 59. issue 7. 2017-08-28. PMID:27033560. |
however cfrd is the largest extra-pulmonary co-morbidity and rapidly accelerates lung decline • recent experimental evidence shows that functional cftr channels are required for normal patterns of first phase insulin secretion from the pancreatic beta cell • current clinical recommendations suggest that insulin is more effective than oral glucose-lowering drugs for the treatment of cfrd. |
2017-08-28 |
2023-08-13 |
mouse |