| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Raquel Barri. Management of endocrine disease: Cystic fibrosis-related diabetes: novel pathogenic insights opening new therapeutic avenues. European journal of endocrinology. vol 172. issue 4. 2015-04-24. PMID:25336504. |
consistently, recent evidence has confirmed that cftr is an important regulator of insulin secretion by islet β-cells. |
2015-04-24 |
2023-08-13 |
Not clear |
| Raquel Barri. Management of endocrine disease: Cystic fibrosis-related diabetes: novel pathogenic insights opening new therapeutic avenues. European journal of endocrinology. vol 172. issue 4. 2015-04-24. PMID:25336504. |
cftr modulators have recently shown in vitro capacity to enhance insulin secretion and thereby potential clinical utility in cfdr, including synergistic effects between corrector and potentiator drugs. |
2015-04-24 |
2023-08-13 |
Not clear |
| Melena D Bellin, Theresa Laguna, Janice Leschyshyn, Warren Regelmann, Jordan Dunitz, JoAnne Billings, Antoinette Mora. Insulin secretion improves in cystic fibrosis following ivacaftor correction of CFTR: a small pilot study. Pediatric diabetes. vol 14. issue 6. 2014-03-19. PMID:23952705. |
insulin secretion improves in cystic fibrosis following ivacaftor correction of cftr: a small pilot study. |
2014-03-19 |
2023-08-12 |
human |
| Melena D Bellin, Theresa Laguna, Janice Leschyshyn, Warren Regelmann, Jordan Dunitz, JoAnne Billings, Antoinette Mora. Insulin secretion improves in cystic fibrosis following ivacaftor correction of CFTR: a small pilot study. Pediatric diabetes. vol 14. issue 6. 2014-03-19. PMID:23952705. |
to determine whether the cystic fibrosis (cf) transmembrane conductance regulator (cftr) is involved in human insulin secretion by assessing the metabolic impact of the new cftr corrector-ivacaftor. |
2014-03-19 |
2023-08-12 |
human |
| Vincenzo Cardinale, Yunfang Wang, Guido Carpino, Cai-Bin Cui, Manuela Gatto, Massimo Rossi, Pasquale Bartolomeo Berloco, Alfredo Cantafora, Eliane Wauthier, Mark E Furth, Luca Inverardi, Juan Dominguez-Bendala, Camillo Ricordi, David Gerber, Eugenio Gaudio, Domenico Alvaro, Lola Rei. Multipotent stem/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets. Hepatology (Baltimore, Md.). vol 54. issue 6. 2012-02-07. PMID:21809358. |
they express endodermal transcription factors (e.g., sox9, sox17, foxa2, pdx1, hes1, ngn3, prox1) intranuclearly, stem/progenitor surface markers (epcam, ncam, cd133, cxcr4), and sometimes weakly adult liver, bile duct, and pancreatic genes (albumin, cystic fibrosis transmembrane conductance regulator [cftr], and insulin). |
2012-02-07 |
2023-08-12 |
mouse |
| Vincenzo Cardinale, Yunfang Wang, Guido Carpino, Cai-Bin Cui, Manuela Gatto, Massimo Rossi, Pasquale Bartolomeo Berloco, Alfredo Cantafora, Eliane Wauthier, Mark E Furth, Luca Inverardi, Juan Dominguez-Bendala, Camillo Ricordi, David Gerber, Eugenio Gaudio, Domenico Alvaro, Lola Rei. Multipotent stem/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets. Hepatology (Baltimore, Md.). vol 54. issue 6. 2012-02-07. PMID:21809358. |
transfer into distinct culture conditions, each comprised of a specific mix of hormones and matrix components, yields either cords of hepatocytes (express albumin, cyp3a4, and transferrin), branching ducts of cholangiocytes (expressing anion exchanger-2-ae2 and cftr), or regulatable c-peptide secreting neoislet-like clusters (expressing glucagon, insulin) and accompanied by changes in gene expression correlating with the adult fate. |
2012-02-07 |
2023-08-12 |
mouse |
| A E Damian. Review: Water channel proteins in the human placenta and fetal membranes. Placenta. vol 32 Suppl 2. 2011-06-07. PMID:21208655. |
insulin, hcg, camp and cftr have been found to be involved in the regulation of the molecular and functional expression of aqps. |
2011-06-07 |
2023-08-12 |
human |
| Tomoko Ueda-Nishimura, Naomi Niisato, Hiroaki Miyazaki, Yuji Naito, Norimasa Yoshida, Toshikazu Yoshikawa, Hoyoku Nishino, Yoshinori Marunak. Synergic action of insulin and genistein on Na+/K+/2Cl- cotransporter in renal epithelium. Biochemical and biophysical research communications. vol 332. issue 4. 2005-08-04. PMID:15925323. |
these observations suggest that: (1) insertion and endocytosis of nkcc are stimulated by insulin, (2) the insulin-induced stimulation of nkcc insertion into the basolateral membrane is offset by the stimulatory action on nkcc endocytosis from the basolateral membrane, (3) genistein stimulates insertion of both cftr cl(-) channel into the apical membrane and nkcc into the basolateral membrane, and (4) insulin and genistein synergically stimulated nkcc insertion into the basolateral membrane. |
2005-08-04 |
2023-08-12 |
Not clear |