| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samuel A Molina, Hannah K Moriarty, Daniel T Infield, Barry R Imhoff, Rachel J Vance, Agnes H Kim, Jason M Hansen, William R Hunt, Michael Koval, Nael A McCart. Insulin signaling via the PI3-kinase/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner. American journal of physiology. Lung cellular and molecular physiology. vol 312. issue 5. 2017-07-31. PMID:28213469. |
insulin stimulation of akt1 and akt2 signaling in cf airway cells was diminished compared with that observed in airway cells expressing wild-type cftr. |
2017-07-31 |
2023-08-13 |
human |
| Luisa Montanini, Francesca Cirillo, Arianna Smerieri, Giovanna Pisi, Ida Giardino, Maria d'Apolito, Cinzia Spaggiari, Sergio Bernasconi, Sergio Amarri, Maria Elisabeth Stree. HMGB1 Is Increased by CFTR Loss of Function, Is Lowered by Insulin, and Increases In Vivo at Onset of CFRD. The Journal of clinical endocrinology and metabolism. vol 101. issue 3. 2016-08-15. PMID:26760176. |
hmgb1 is increased by cftr loss of function, is lowered by insulin, and increases in vivo at onset of cfrd. |
2016-08-15 |
2023-08-13 |
Not clear |
| Thierry Ntimbane, Geneviève Mailhot, Schohraya Spahis, Remi Rabasa-Lhoret, Marie-Laure Kleme, Danielle Melloul, Emmanuelle Brochiero, Yves Berthiaume, Emile Lev. CFTR silencing in pancreatic β-cells reveals a functional impact on glucose-stimulated insulin secretion and oxidative stress response. American journal of physiology. Endocrinology and metabolism. vol 310. issue 3. 2016-06-14. PMID:26625901. |
cftr silencing in pancreatic β-cells reveals a functional impact on glucose-stimulated insulin secretion and oxidative stress response. |
2016-06-14 |
2023-08-13 |
human |
| Thierry Ntimbane, Geneviève Mailhot, Schohraya Spahis, Remi Rabasa-Lhoret, Marie-Laure Kleme, Danielle Melloul, Emmanuelle Brochiero, Yves Berthiaume, Emile Lev. CFTR silencing in pancreatic β-cells reveals a functional impact on glucose-stimulated insulin secretion and oxidative stress response. American journal of physiology. Endocrinology and metabolism. vol 310. issue 3. 2016-06-14. PMID:26625901. |
the main objective of this study was to shed light on the role of the cystic fibrosis transmembrane conductance regulator (cftr) in combination with oxs in insulin secretion from pancreatic β-cells. |
2016-06-14 |
2023-08-13 |
human |
| Thierry Ntimbane, Geneviève Mailhot, Schohraya Spahis, Remi Rabasa-Lhoret, Marie-Laure Kleme, Danielle Melloul, Emmanuelle Brochiero, Yves Berthiaume, Emile Lev. CFTR silencing in pancreatic β-cells reveals a functional impact on glucose-stimulated insulin secretion and oxidative stress response. American journal of physiology. Endocrinology and metabolism. vol 310. issue 3. 2016-06-14. PMID:26625901. |
cftr silencing was accomplished in min6 cells by stable expression of small hairpin rnas (shrna), and glucose-induced insulin secretion was evaluated in the presence and absence of the valuable prooxidant system iron/ascorbate (fe/asc; 0.075/0.75 mm) along with or without the antioxidant trolox (1 mm). |
2016-06-14 |
2023-08-13 |
human |
| Thierry Ntimbane, Geneviève Mailhot, Schohraya Spahis, Remi Rabasa-Lhoret, Marie-Laure Kleme, Danielle Melloul, Emmanuelle Brochiero, Yves Berthiaume, Emile Lev. CFTR silencing in pancreatic β-cells reveals a functional impact on glucose-stimulated insulin secretion and oxidative stress response. American journal of physiology. Endocrinology and metabolism. vol 310. issue 3. 2016-06-14. PMID:26625901. |
our findings indicate that cftr deficiency in combination with oxs may contribute to endocrine cell dysfunction and insulin secretion, which at least in part may explain the development of cfrd. |
2016-06-14 |
2023-08-13 |
human |
| Ghislaine Fontés, Julien Ghislain, Isma Benterki, Bader Zarrouki, Dominique Trudel, Yves Berthiaume, Vincent Poitou. The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice. Diabetes. vol 64. issue 12. 2016-03-15. PMID:26283735. |
we conclude that the Δf508 cftr mutation does not lead to an intrinsic β-cell secretory defect but is associated with insulin resistance and a β-cell mass deficit in aging mutants. |
2016-03-15 |
2023-08-13 |
mouse |
| Shmuel Mualle. CFTR does it again: control of insulin secretion. Science China. Life sciences. vol 57. issue 10. 2015-12-15. PMID:25216710. |
cftr does it again: control of insulin secretion. |
2015-12-15 |
2023-08-13 |
Not clear |
| Jing Hui Guo, Hui Chen, Ye Chun Ruan, Xue Lian Zhang, Xiao Hu Zhang, Kin Lam Fok, Lai Ling Tsang, Mei Kuen Yu, Wen Qing Huang, Xiao Sun, Yiu Wa Chung, Xiaohua Jiang, Yoshiro Sohma, Hsiao Chang Cha. Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR. Nature communications. vol 5. 2015-12-14. PMID:25025956. |
glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by cftr. |
2015-12-14 |
2023-08-13 |
mouse |
| Jing Hui Guo, Hui Chen, Ye Chun Ruan, Xue Lian Zhang, Xiao Hu Zhang, Kin Lam Fok, Lai Ling Tsang, Mei Kuen Yu, Wen Qing Huang, Xiao Sun, Yiu Wa Chung, Xiaohua Jiang, Yoshiro Sohma, Hsiao Chang Cha. Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR. Nature communications. vol 5. 2015-12-14. PMID:25025956. |
up to 50% adult patients with cystic fibrosis (cf), a disease caused by mutations in the gene encoding the cf transmembrane conductance regulator (cftr), develop cf-related diabetes (cfrd) with most patients exhibiting insulin insufficiency. |
2015-12-14 |
2023-08-13 |
mouse |
| Jing Hui Guo, Hui Chen, Ye Chun Ruan, Xue Lian Zhang, Xiao Hu Zhang, Kin Lam Fok, Lai Ling Tsang, Mei Kuen Yu, Wen Qing Huang, Xiao Sun, Yiu Wa Chung, Xiaohua Jiang, Yoshiro Sohma, Hsiao Chang Cha. Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR. Nature communications. vol 5. 2015-12-14. PMID:25025956. |
here we show that cftr is a regulator of glucose-dependent electrical acitivities and insulin secretion in β-cells. |
2015-12-14 |
2023-08-13 |
mouse |
| Jing Hui Guo, Hui Chen, Ye Chun Ruan, Xue Lian Zhang, Xiao Hu Zhang, Kin Lam Fok, Lai Ling Tsang, Mei Kuen Yu, Wen Qing Huang, Xiao Sun, Yiu Wa Chung, Xiaohua Jiang, Yoshiro Sohma, Hsiao Chang Cha. Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR. Nature communications. vol 5. 2015-12-14. PMID:25025956. |
we demonstrate that glucose elicited whole-cell currents, membrane depolarization, electrical bursts or action potentials, ca(2+) oscillations and insulin secretion are abolished or reduced by inhibitors or knockdown of cftr in primary mouse β-cells or rinm5f β-cell line, or significantly attenuated in cftr mutant (df508) mice compared with wild-type mice. |
2015-12-14 |
2023-08-13 |
mouse |
| Jing Hui Guo, Hui Chen, Ye Chun Ruan, Xue Lian Zhang, Xiao Hu Zhang, Kin Lam Fok, Lai Ling Tsang, Mei Kuen Yu, Wen Qing Huang, Xiao Sun, Yiu Wa Chung, Xiaohua Jiang, Yoshiro Sohma, Hsiao Chang Cha. Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR. Nature communications. vol 5. 2015-12-14. PMID:25025956. |
our results reveal a role of cftr in glucose-induced electrical activities and insulin secretion in β-cells, shed light on the pathogenesis of cfrd and possibly other idiopathic diabetes, and present a potential treatment strategy. |
2015-12-14 |
2023-08-13 |
mouse |
| Hongxin Sun, Naomi Niisato, Toshio Inui, Yoshinori Marunak. Insulin is involved in transcriptional regulation of NKCC and the CFTR Cl(-) channel through PI3K activation and ERK inactivation in renal epithelial cells. The journal of physiological sciences : JPS. vol 64. issue 6. 2015-06-25. PMID:25239597. |
insulin is involved in transcriptional regulation of nkcc and the cftr cl(-) channel through pi3k activation and erk inactivation in renal epithelial cells. |
2015-06-25 |
2023-08-13 |
Not clear |
| Hongxin Sun, Naomi Niisato, Toshio Inui, Yoshinori Marunak. Insulin is involved in transcriptional regulation of NKCC and the CFTR Cl(-) channel through PI3K activation and ERK inactivation in renal epithelial cells. The journal of physiological sciences : JPS. vol 64. issue 6. 2015-06-25. PMID:25239597. |
interestingly, insulin treatment remarkably enhanced the forskolin-stimulated cl(-) secretion associated with an increase in apical cl(-) conductance by upregulating mrna expression of both cftr and nkcc, although insulin treatment alone had no effect on the basal cl(-) secretion or apical cl(-) conductance without forskolin application. |
2015-06-25 |
2023-08-13 |
Not clear |
| Hongxin Sun, Naomi Niisato, Toshio Inui, Yoshinori Marunak. Insulin is involved in transcriptional regulation of NKCC and the CFTR Cl(-) channel through PI3K activation and ERK inactivation in renal epithelial cells. The journal of physiological sciences : JPS. vol 64. issue 6. 2015-06-25. PMID:25239597. |
ly294002 (a pi3k inhibitor) reduced the cl(-) secretion by suppressing mrna expression of nkcc, whereas insulin still had a stimulatory action on mrna expression of cftr even in the presence of ly294002. |
2015-06-25 |
2023-08-13 |
Not clear |
| Hongxin Sun, Naomi Niisato, Toshio Inui, Yoshinori Marunak. Insulin is involved in transcriptional regulation of NKCC and the CFTR Cl(-) channel through PI3K activation and ERK inactivation in renal epithelial cells. The journal of physiological sciences : JPS. vol 64. issue 6. 2015-06-25. PMID:25239597. |
on the other hand, we found that a mek inhibitor (pd98059) further enhanced the insulin-stimulated cftr mrna expression and the cl(-) secretion in forskolin-stimulated a6 cells and that insulin induced slight, transient activation of erk followed by significant inactivation of erk. |
2015-06-25 |
2023-08-13 |
Not clear |
| Hongxin Sun, Naomi Niisato, Toshio Inui, Yoshinori Marunak. Insulin is involved in transcriptional regulation of NKCC and the CFTR Cl(-) channel through PI3K activation and ERK inactivation in renal epithelial cells. The journal of physiological sciences : JPS. vol 64. issue 6. 2015-06-25. PMID:25239597. |
these observations suggest that: (1) insulin respectively upregulates mrna expression of nkcc and cftr through activation of pi3k and inactivation of erk; (2) insulin signals on mrna expression of nkcc and cftr are not enough to stimulate transepithelial cl(-) secretion, but enhance the stimulatory action of camp on transepithelial cl(-) secretion. |
2015-06-25 |
2023-08-13 |
Not clear |
| Anna Edlund, Jonathan L S Esguerra, Anna Wendt, Malin Flodström-Tullberg, Lena Eliasso. CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells. BMC medicine. vol 12. 2015-06-18. PMID:24885604. |
cftr and anoctamin 1 (ano1) contribute to camp amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells. |
2015-06-18 |
2023-08-13 |
human |
| Anna Edlund, Jonathan L S Esguerra, Anna Wendt, Malin Flodström-Tullberg, Lena Eliasso. CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells. BMC medicine. vol 12. 2015-06-18. PMID:24885604. |
although patients with cf often have disturbances in glucose metabolism including impaired insulin release, no previous studies have tested the hypothesis that cftr has a biological function in pancreatic beta-cells. |
2015-06-18 |
2023-08-13 |
human |