| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D R Shasa, J F Odhiambo, N M Long, N Tuersunjiang, P W Nathanielsz, S P For. Multigenerational impact of maternal overnutrition/obesity in the sheep on the neonatal leptin surge in granddaughters. International journal of obesity (2005). vol 39. issue 4. 2016-01-26. PMID:25354845. |
this study evaluated the multigenerational impact of ob on insulin:glucose dynamics of mature female f1 offspring fed only to requirements throughout gestation and on their lambs (f2 generation). |
2016-01-26 |
2023-08-13 |
Not clear |
| Wen-yuan Ding, Lin Liu, Zhi-hao Wang, Meng-xiong Tang, Yun Ti, Lu Han, Lei Zhang, Yun Zhang, Ming Zhong, Wei Zhan. FP-receptor gene silencing ameliorates myocardial fibrosis and protects from diabetic cardiomyopathy. Journal of molecular medicine (Berlin, Germany). vol 92. issue 6. 2015-01-09. PMID:24500109. |
prostaglandin f2(α)-f-prostanoid (pgf2(α)-fp) receptor is closely related to insulin resistance, which plays a causal role in the pathogenesis of diabetic cardiomyopathy (dcm). |
2015-01-09 |
2023-08-12 |
human |
| Harish Vashist. Flexibility in the insulin receptor ectodomain enables docking of insulin in crystallographic conformation observed in a hormone-bound microreceptor. Membranes. vol 4. issue 4. 2014-10-14. PMID:25309993. |
however, insulin-bound structures of truncated ir suggest that crystallographic conformation of insulin cannot be accommodated in the full ir ectodomain due to steric overlap of insulin with the first two type iii fibronectin domains (f1 and f2), which are contributed to the insulin binding-pocket by the second subunit in the ir homodimer. |
2014-10-14 |
2023-08-13 |
Not clear |
| Harish Vashist. Flexibility in the insulin receptor ectodomain enables docking of insulin in crystallographic conformation observed in a hormone-bound microreceptor. Membranes. vol 4. issue 4. 2014-10-14. PMID:25309993. |
in this work, we present an all-atom structural model of complex of insulin and the ir ectodomain, where no structural overlap of insulin with the receptor domains (f1 and f2) is observed. |
2014-10-14 |
2023-08-13 |
Not clear |
| Gengqi Li, Huailong Chang, Wei Xia, Zhenxing Mao, Yuanyuan Li, Shunqing X. F0 maternal BPA exposure induced glucose intolerance of F2 generation through DNA methylation change in Gck. Toxicology letters. vol 228. issue 3. 2014-09-12. PMID:24793715. |
f2 generation was found to exhibited glucose intolerance and insulin resistance in ipgtt and ipitt, as well as the downregulation of glucokinase (gck) gene in liver. |
2014-09-12 |
2023-08-13 |
Not clear |
| Nadya Merchant, Syed T Rahman, Mushtaq Ahmad, Janice M Parrott, Julie Johnson, Keith C Ferdinand, Bobby V Kha. Changes in biomarkers and 24 hours blood pressure in hypertensive African Americans with the metabolic syndrome: comparison of amlodipine/olmesartan versus hydrochlorothiazide/losartan. Journal of the American Society of Hypertension : JASH. vol 7. issue 5. 2014-05-12. PMID:23835112. |
after 14 weeks of therapy, treatment with a/o had a significant effect on reducing the production of reactive oxygen series, plasminogen activator inhibitor-1, f2 isoprostane, myeloperoxidase, and homeostasis model assessment for insulin resistance while l/h treatment only significantly lowered levels of plasminogen activator inhibitor-1 and homeostasis model assessment for insulin resistance. |
2014-05-12 |
2023-08-12 |
human |
| C Schreiver, U Jacoby, B Watzer, A Thomas, D Haffner, D-C Fische. Glycaemic variability in paediatric patients with type 1 diabetes on continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDI): a cross-sectional cohort study. Clinical endocrinology. vol 79. issue 5. 2014-05-08. PMID:23134485. |
this cross-sectional observational cohort study was designed to investigate i) whether glycaemic variability in paediatric patients with type 1 diabetes is lower in those using an insulin pump (csii) compared with those using multiple daily insulin injections (mdi) and ii) whether urinary f2 -isoprostanes and/or urinary prostaglandin f2 excretion as surrogate marker of oxidative stress and cyclooxygenase activity are associated with glycaemic variability. |
2014-05-08 |
2023-08-12 |
Not clear |
| Jun-ichi Sut. QTL mapping of genes controlling plasma insulin and leptin concentrations: metabolic effect of obesity QTLs identified in an F2 intercross between C57BL/6J and DDD.Cg-A(y) inbred mice. The Journal of veterinary medical science. vol 75. issue 7. 2014-02-28. PMID:23439608. |
qtl mapping of genes controlling plasma insulin and leptin concentrations: metabolic effect of obesity qtls identified in an f2 intercross between c57bl/6j and ddd.cg-a(y) inbred mice. |
2014-02-28 |
2023-08-12 |
mouse |
| Jun-ichi Sut. QTL mapping of genes controlling plasma insulin and leptin concentrations: metabolic effect of obesity QTLs identified in an F2 intercross between C57BL/6J and DDD.Cg-A(y) inbred mice. The Journal of veterinary medical science. vol 75. issue 7. 2014-02-28. PMID:23439608. |
although insulin and leptin concentrations and pc1 were not normally distributed in combined f2 mice, results of single qtl scans by parametric and non-parametric methods were very similar. |
2014-02-28 |
2023-08-12 |
mouse |
| Meena Garg, Manikkavasagar Thamotharan, Yun Dai, Paul W N Lee, Sherin U Devaska. Embryo-transfer of the F2 postnatal calorie restricted female rat offspring into a control intra-uterine environment normalizes the metabolic phenotype. Metabolism: clinical and experimental. vol 62. issue 3. 2013-07-01. PMID:23021963. |
despite the absence of gestational hyperglycemia in the f1 pngr female, naturally born second generation (f2) pngr female adult offspring reportedly exhibit obesity, hyperglycemia with insulin resistance. |
2013-07-01 |
2023-08-12 |
rat |
| Melanie Tran, Linda A Gallo, Andrew J Jefferies, Karen M Moritz, Mary E Wlode. Transgenerational metabolic outcomes associated with uteroplacental insufficiency. The Journal of endocrinology. vol 217. issue 1. 2013-05-06. PMID:23420315. |
we determined whether impaired glucose tolerance, reduced insulin secretion, and pancreatic deficits are evident in second-generation (f2) male and female offspring from growth-restricted mothers, in a rat model of uteroplacental insufficiency. |
2013-05-06 |
2023-08-12 |
rat |
| Melanie Tran, Linda A Gallo, Andrew J Jefferies, Karen M Moritz, Mary E Wlode. Transgenerational metabolic outcomes associated with uteroplacental insufficiency. The Journal of endocrinology. vol 217. issue 1. 2013-05-06. PMID:23420315. |
f2 glucose tolerance, insulin secretion, and sensitivity were assessed at 6 and 12 months and pancreatic morphology was quantified at all study ages. |
2013-05-06 |
2023-08-12 |
rat |
| Melanie Tran, Linda A Gallo, Andrew J Jefferies, Karen M Moritz, Mary E Wlode. Transgenerational metabolic outcomes associated with uteroplacental insufficiency. The Journal of endocrinology. vol 217. issue 1. 2013-05-06. PMID:23420315. |
at 6 months, f2 restricted male offspring exhibited blunted first-phase insulin response (-35%), which was associated with reduced pancreatic β-cell mass (-29%). |
2013-05-06 |
2023-08-12 |
rat |
| Melanie Tran, Linda A Gallo, Andrew J Jefferies, Karen M Moritz, Mary E Wlode. Transgenerational metabolic outcomes associated with uteroplacental insufficiency. The Journal of endocrinology. vol 217. issue 1. 2013-05-06. PMID:23420315. |
by contrast, f2 restricted females had increased β-cell mass despite reduced first-phase insulin response (-38%). |
2013-05-06 |
2023-08-12 |
rat |
| Melanie Tran, Linda A Gallo, Andrew J Jefferies, Karen M Moritz, Mary E Wlode. Transgenerational metabolic outcomes associated with uteroplacental insufficiency. The Journal of endocrinology. vol 217. issue 1. 2013-05-06. PMID:23420315. |
regardless of maternal birth weight, f2 control and restricted males had reduced homeostatic model assessment of insulin resistance and elevated plasma triglyceride concentrations at 6 months and reduced whole-body insulin sensitivity at 6 and 12 months compared with females. |
2013-05-06 |
2023-08-12 |
rat |
| Melanie Tran, Linda A Gallo, Andrew J Jefferies, Karen M Moritz, Mary E Wlode. Transgenerational metabolic outcomes associated with uteroplacental insufficiency. The Journal of endocrinology. vol 217. issue 1. 2013-05-06. PMID:23420315. |
we report that low maternal birth weight is associated with reduced first-phase insulin response and gender-specific differences in pancreatic morphology in the f2. |
2013-05-06 |
2023-08-12 |
rat |
| F Depreter, A Burniat, D Blocklet, S Lacroix, M Cnop, F Fery, N Van Aelst, G Pilcer, M Deleers, S Goldman, K Amigh. Comparative pharmacoscintigraphic and pharmacokinetic evaluation of two new formulations of inhaled insulin in type 1 diabetic patients. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. vol 80. issue 1. 2012-07-02. PMID:21983605. |
the formulations were either microparticles of insulin without excipients (f1) or lipid-coated insulin microparticles (f2). |
2012-07-02 |
2023-08-12 |
Not clear |
| F Depreter, A Burniat, D Blocklet, S Lacroix, M Cnop, F Fery, N Van Aelst, G Pilcer, M Deleers, S Goldman, K Amigh. Comparative pharmacoscintigraphic and pharmacokinetic evaluation of two new formulations of inhaled insulin in type 1 diabetic patients. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. vol 80. issue 1. 2012-07-02. PMID:21983605. |
bioavailability was evaluated by quantifying serum insulin levels over a period of 6 h. lung deposition was found to be 50 ± 9% and 24 ± 8% for the f1 and f2 formulations, respectively. |
2012-07-02 |
2023-08-12 |
Not clear |
| F Depreter, A Burniat, D Blocklet, S Lacroix, M Cnop, F Fery, N Van Aelst, G Pilcer, M Deleers, S Goldman, K Amigh. Comparative pharmacoscintigraphic and pharmacokinetic evaluation of two new formulations of inhaled insulin in type 1 diabetic patients. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. vol 80. issue 1. 2012-07-02. PMID:21983605. |
the two formulations showed interesting pharmacokinetic profiles (t(max) of 26 and 16 min for f1 and f2, respectively) that mimic the physiological insulin secretion pattern. |
2012-07-02 |
2023-08-12 |
Not clear |
| Daniel C Benyshek, Carol S Johnston, John F Martin, William D Ros. Insulin sensitivity is normalized in the third generation (F3) offspring of developmentally programmed insulin resistant (F2) rats fed an energy-restricted diet. Nutrition & metabolism. vol 5. 2011-07-14. PMID:18928547. |
insulin sensitivity is normalized in the third generation (f3) offspring of developmentally programmed insulin resistant (f2) rats fed an energy-restricted diet. |
2011-07-14 |
2023-08-12 |
rat |