| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dawn Belt Davis, Jeremy A Lavine, Joshua I Suhonen, Kimberly A Krautkramer, Mary E Rabaglia, Jamie M Sperger, Luis A Fernandez, Brian S Yandell, Mark P Keller, I-Ming Wang, Eric E Schadt, Alan D Atti. FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation. Molecular endocrinology (Baltimore, Md.). vol 24. issue 9. 2010-12-22. PMID:20660304. |
in the f2 leptin(ob/ob) population, increased expression of foxm1 and its target genes segregated with higher insulin and lower glucose levels. |
2010-12-22 |
2023-08-12 |
mouse |
| Ehab R El-Haroun, Dominique P Bureau, John P Can. A mechanistic model of nutritional control of protein synthesis in animal tissues. Journal of theoretical biology. vol 262. issue 2. 2010-01-27. PMID:19808042. |
dietary effects are due to concentrations of amino acids and insulin in circulation that affect activities of two key translational regulators, eukaryotic initiation factor 2 (f2) and eukaryotic initiation factor 4e binding protein 1 (bp). |
2010-01-27 |
2023-08-12 |
Not clear |
| Yoshihiko Ito, Kazuo Obara, Rikuko Ikeda, Megumi Ishii, Yoshiyuki Tanabe, Tomohisa Ishikawa, Koichi Nakayam. Passive stretching produces Akt- and MAPK-dependent augmentations of GLUT4 translocation and glucose uptake in skeletal muscles of mice. Pflugers Archiv : European journal of physiology. vol 451. issue 6. 2009-07-30. PMID:16244881. |
passive stretching mainly induced glut4 translocation from an intracellular membrane-rich fraction (pf5) to a plasma membrane-rich fraction (f2) and accelerated glucose uptake in hindlimb muscles; whereas electrical stimulation, which mimics physical exercise in vivo, and insulin, each induced glut4 translocation from an intracellular membrane-rich fraction (pf5) to a fraction rich in plasma membrane (f2), and to one rich in transverse tubules (pf3), along with subsequent glucose uptake. |
2009-07-30 |
2023-08-12 |
mouse |
| Rodrigo Ferreira de Moura, Carla Ribeiro, Juliana Aparecida de Oliveira, Eliane Stevanato, Maria Alice Rostom de Mell. Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols. The British journal of nutrition. vol 101. issue 8. 2009-07-08. PMID:19007450. |
in the fructose groups f2 and f3 glucose tolerance and insulin sensitivity were lower, while triacylglycerolaemia was higher than the respective controls c2 and c3 (p < 0.05). |
2009-07-08 |
2023-08-12 |
human |
| A M M Sadeghi, M R Avadi, Sh Ejtemaimehr, Sh Abashzadeh, A Partoazar, F Dorkoosh, M Faghihi, M Rafiee-Tehrani, H E Junginge. Development of a Gas Empowered Drug Delivery system for peptide delivery in the small intestine. Journal of controlled release : official journal of the Controlled Release Society. vol 134. issue 1. 2009-04-10. PMID:19014985. |
the administrations of insulin using the formulation f1 resulted in a low fr value of 0.2%+/-0.1%, while the formulations f2 and f3 resulted in a much higher fr values of 0.6+/-0.2% and 1.1%+/-0.4%, respectively. |
2009-04-10 |
2023-08-12 |
Not clear |
| Donatella Gniuli, Alessandra Calcagno, Maria Emiliana Caristo, Alessandra Mancuso, Veronica Macchi, Geltrude Mingrone, Roberto Vetto. Effects of high-fat diet exposure during fetal life on type 2 diabetes development in the progeny. Journal of lipid research. vol 49. issue 9. 2008-10-06. PMID:18493032. |
the aim of our study was to verify: 1) whether a high-fat (hf) diet in young adult mice induces alterations in beta-cell mass, proliferation, neogenesis, and apoptosis, as well as insulin sensitivity and secretion; 2) whether these alterations may be reversible after hf diet suspension; 3) the effects in a first (f1) and second generation (f2) of mice without direct exposure to a hf diet after birth. |
2008-10-06 |
2023-08-12 |
mouse |
| Alessandra R Pinheiro, Isadora D M Salvucci, Marcia B Aguila, Carlos A Mandarim-de-Lacerd. Protein restriction during gestation and/or lactation causes adverse transgenerational effects on biometry and glucose metabolism in F1 and F2 progenies of rats. Clinical science (London, England : 1979). vol 114. issue 5. 2008-02-21. PMID:17927565. |
in conclusion, low protein during gestation improves bm, fat mass and growth rate in f1 rats, but has adverse effects on glucose and leptin metabolism, resulting in insulin resistance in adult f1 and f2 offspring. |
2008-02-21 |
2023-08-12 |
rat |
| Alessandra R Pinheiro, Isadora D M Salvucci, Marcia B Aguila, Carlos A Mandarim-de-Lacerd. Protein restriction during gestation and/or lactation causes adverse transgenerational effects on biometry and glucose metabolism in F1 and F2 progenies of rats. Clinical science (London, England : 1979). vol 114. issue 5. 2008-02-21. PMID:17927565. |
low protein during lactation has adverse effects on glucose, insulin and leptin metabolism, resulting in insulin resistance in adult f2 offspring. |
2008-02-21 |
2023-08-12 |
rat |
| T W Lau, Y W Chan, C P Lau, C M Chan, C B S Lau, K P Fung, P C Leung, Y Y H. Investigation of the effects of Chinese medicine on fibroblast viability: implications in wound healing. Phytotherapy research : PTR. vol 21. issue 10. 2008-01-31. PMID:17583899. |
interestingly, f1 and f2 enhanced the viability of primary cultured fibroblasts from the diabetic patient even in the face of insulin resistance. |
2008-01-31 |
2023-08-12 |
Not clear |
| H M Hammon, O Bellmann, J Voigt, F Schneider, C Küh. Glucose-dependent insulin response and milk production in heifers within a segregating resource family population. Journal of dairy science. vol 90. issue 7. 2007-11-27. PMID:17582108. |
an experiment was initiated to evaluate the glucose-dependent insulin response in relation to milk production in f2 crossbred cattle with respect to secretion type (holstein) and accretion type (charolais). |
2007-11-27 |
2023-08-12 |
cattle |
| H M Hammon, O Bellmann, J Voigt, F Schneider, C Küh. Glucose-dependent insulin response and milk production in heifers within a segregating resource family population. Journal of dairy science. vol 90. issue 7. 2007-11-27. PMID:17582108. |
in 52 dairy heifers of 5 f2 half-sib families, glucose-dependent insulin responses were investigated during first lactation to test the hypothesis that the different genetic disposition for milk production within the f2 population would affect the insulin response to glucose. |
2007-11-27 |
2023-08-12 |
cattle |
| H M Hammon, O Bellmann, J Voigt, F Schneider, C Küh. Glucose-dependent insulin response and milk production in heifers within a segregating resource family population. Journal of dairy science. vol 90. issue 7. 2007-11-27. PMID:17582108. |
in conclusion, milk production as well as the glucose-dependent insulin response of f2 charolais x german holstein crossbred dairy heifers differed between half-sib families, with both parameters displaying an inverse relation to each other. |
2007-11-27 |
2023-08-12 |
cattle |
| Manikkavasagar Thamotharan, Meena Garg, Shilpa Oak, Lisa M Rogers, Gerald Pan, Frank Sangiorgi, Paul W N Lee, Sherin U Devaska. Transgenerational inheritance of the insulin-resistant phenotype in embryo-transferred intrauterine growth-restricted adult female rat offspring. American journal of physiology. Endocrinology and metabolism. vol 292. issue 5. 2007-07-19. PMID:17213472. |
we conclude that transgenerational presence of aberrant glucose/insulin metabolism and skeletal muscle insulin signaling of the adult f2 iugr female offspring is independent of the immediate intrauterine environment, supporting nutritionally induced heritable mechanisms contributing to the epidemic of type 2 diabetes mellitus. |
2007-07-19 |
2023-08-12 |
rat |
| Zhiguang Su, Yuhua Li, Jessica C James, Alan H Matsumoto, Gregory A Helm, Aldons J Lusis, Weibin Sh. Genetic linkage of hyperglycemia, body weight and serum amyloid-P in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice. Human molecular genetics. vol 15. issue 10. 2006-10-03. PMID:16595606. |
fasting plasma levels of glucose, insulin and serum amyloid-p (sap) and body weight in 234 female f2 mice were measured after being fed the western diet for 12 weeks. |
2006-10-03 |
2023-08-12 |
mouse |
| Susanne M Clee, Brian S Yandell, Kathryn M Schueler, Mary E Rabaglia, Oliver C Richards, Summer M Raines, Edward A Kabara, Daniel M Klass, Eric T-K Mui, Donald S Stapleton, Mark P Gray-Keller, Matthew B Young, Jonathan P Stoehr, Hong Lan, Igor Boronenkov, Philipp W Raess, Matthew T Flowers, Alan D Atti. Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus. Nature genetics. vol 38. issue 6. 2006-08-30. PMID:16682971. |
we previously mapped the type 2 diabetes mellitus-2 locus (t2dm2), which affects fasting insulin levels, to distal chromosome 19 in a leptin-deficient obese f2 intercross derived from c57bl/6 (b6) and btbr t+ tf/j (btbr) mice. |
2006-08-30 |
2023-08-12 |
mouse |
| Atul M Doke, Ajit Sadan. Detection of glucose and related analytes by biosensors: a fractal analysis. Journal of receptor and signal transduction research. vol 26. issue 1-2. 2006-05-09. PMID:16595338. |
for example, for the binding of plasma insulin, as the fractal dimension value increases by a factor of 2.47 from d(f1)=0.6827 to d(f2)=1.6852, the binding rate coefficient increases by a factor of 4.92 from k(1)=1.0232 to k(2)=5.0388. |
2006-05-09 |
2023-08-12 |
Not clear |
| E Zambrano, P M Martínez-Samayoa, C J Bautista, M Deás, L Guillén, G L Rodríguez-González, C Guzmán, F Larrea, P W Nathaniels. Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactation. The Journal of physiology. vol 566. issue Pt 1. 2005-09-16. PMID:15860532. |
we determined whether when f0 female rats are exposed to protein restriction during pregnancy and/or lactation their f1 female pups deliver f2 offspring with in vivo evidence of altered glucose and insulin metabolism. |
2005-09-16 |
2023-08-12 |
rat |
| E Zambrano, P M Martínez-Samayoa, C J Bautista, M Deás, L Guillén, G L Rodríguez-González, C Guzmán, F Larrea, P W Nathaniels. Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactation. The Journal of physiology. vol 566. issue Pt 1. 2005-09-16. PMID:15860532. |
male f2 cr offspring showed evidence of insulin resistance. |
2005-09-16 |
2023-08-12 |
rat |
| E Zambrano, P M Martínez-Samayoa, C J Bautista, M Deás, L Guillén, G L Rodríguez-González, C Guzmán, F Larrea, P W Nathaniels. Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactation. The Journal of physiology. vol 566. issue Pt 1. 2005-09-16. PMID:15860532. |
in contrast rc f2 females showed evidence of insulin resistance. |
2005-09-16 |
2023-08-12 |
rat |
| E Zambrano, P M Martínez-Samayoa, C J Bautista, M Deás, L Guillén, G L Rodríguez-González, C Guzmán, F Larrea, P W Nathaniels. Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactation. The Journal of physiology. vol 566. issue Pt 1. 2005-09-16. PMID:15860532. |
sex differences were also observed in f2 offspring in resting glucose and insulin and insulin: glucose ratios. |
2005-09-16 |
2023-08-12 |
rat |