| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enrico Premi, Juergen Dukart, Irene Mattioli, Ilenia Libri, Marta Pengo, Yasmine Gadola, Maria Cotelli, Rosa Manenti, Giuliano Binetti, Stefano Gazzina, Antonella Alberici, Mauro Magoni, Giacomo Koch, Roberto Gasparotti, Alessandro Padovani, Barbara Borron. Unravelling neurotransmitters impairment in primary progressive aphasias. Human brain mapping. 2023-01-17. PMID:36649260. |
as compared to hc, voxel-based brain changes in ppa were significantly associated with spatial distribution of serotonin, dopamine, and glutamatergic pathways (p < .05, false discovery rate corrected-corrected). |
2023-01-17 |
2023-08-14 |
Not clear |
| Chenglin Li, Kaiji Ni, Meiru Qi, Jie Li, Kexin Yang, Yanli Lu. The anterior cingulate cortex contributes to the analgesic rather than the anxiolytic effects of duloxetine in chronic pain-induced anxiety. Frontiers in neuroscience. vol 16. 2022-12-12. PMID:36507338. |
furthermore, we used fiber photometry to discover decreased glutamatergic excitability and enhanced serotonin concentration in acc after intraperitoneal injection of duloxetine. |
2022-12-12 |
2023-08-14 |
mouse |
| Elena Martín-González, Manuela Olmedo-Córdoba, Pilar Flores, Margarita Moreno-Montoy. Differential neurobiological markers in phenotype-stratified rats modeling high or low vulnerability to compulsive behavior: A narrative review. Current neuropharmacology. 2022-11-22. PMID:36411566. |
specifically, we reviewed preclinical studies on sip, that have assessed the effects of serotonergic, dopaminergic, and glutamatergic drugs; leading to the description of the neurobiological markers, such as the key role of the serotonin 5-ht2a receptor and glutamatergic signaling in a phenotype vulnerable to compulsivity as high drinker hd rats selected by sip. |
2022-11-22 |
2023-08-14 |
rat |
| Daisuke Ib. Role of interaction of mGlu2 and 5-HT Pharmacology, biochemistry, and behavior. 2022-10-16. PMID:36244526. |
role of interaction of mglu2 and 5-ht the serotonergic and glutamatergic neurotransmitter systems have been implicated in the pathophysiology of schizophrenia, and increasing evidence shows that they interact functionally. |
2022-10-16 |
2023-08-14 |
Not clear |
| Alice Taddeucci, Guendalina Olivero, Alessandra Roggeri, Claudio Milanese, Francesco Paolo Di Giorgio, Massimo Grilli, Mario Marchi, Beatrice Garrone, Anna Pittalug. Presynaptic 5-HT Cells. vol 11. issue 19. 2022-10-14. PMID:36230998. |
presynaptic 5-ht the glutamatergic nerve endings of a rat prefrontal cortex (pfc) possess presynaptic 5-ht |
2022-10-14 |
2023-08-14 |
rat |
| Wen-Qiang Ge, Ou-Yang Zhan-Mu, Chao Chen, Hong Zhang, Xiao-Yu Wang, Xin Liu, Li Li, Yu-Ye Lan, Chen-Nan Li, Jia-Can Sun, Run-Lin Shi, Zi-Yue Dou, Hui-Lin Pan, Hong-Ping Li, Xiang-Hong Jing, Man L. Electroacupuncture reduces chronic itch Frontiers in pharmacology. vol 13. 2022-09-22. PMID:36133809. |
in contrast, knockout of cb1 receptors on glutamatergic neurons in the vlpag blocked the antipruritic effects of ea and the inhibitory effect of ea on the 5-ht concentration in the medulla oblongata. |
2022-09-22 |
2023-08-14 |
mouse |
| Wen-Qiang Ge, Ou-Yang Zhan-Mu, Chao Chen, Hong Zhang, Xiao-Yu Wang, Xin Liu, Li Li, Yu-Ye Lan, Chen-Nan Li, Jia-Can Sun, Run-Lin Shi, Zi-Yue Dou, Hui-Lin Pan, Hong-Ping Li, Xiang-Hong Jing, Man L. Electroacupuncture reduces chronic itch Frontiers in pharmacology. vol 13. 2022-09-22. PMID:36133809. |
our findings suggest that ea treatment reduces chronic itch by activation of cb1 receptors on glutamatergic neurons and inhibition of cb1 receptors on gabaergic neurons in the vlpag, thereby inhibiting the 5-ht release from the medulla oblongata to grpr-expressing neurons in the spinal cord. |
2022-09-22 |
2023-08-14 |
mouse |
| Lasse Brandt, Shuyan Liu, Christine Heim, Andreas Hein. The effects of social isolation stress and discrimination on mental health. Translational psychiatry. vol 12. issue 1. 2022-09-21. PMID:36130935. |
animal models indicate that social separation stress, particularly in early life, activates the hypothalamic-pituitary-adrenal axis and interacts with monoaminergic, glutamatergic, and gabaergic neurotransmitter systems, inducing long-lasting reductions in serotonin turnover and alterations in dopamine receptor sensitivity. |
2022-09-21 |
2023-08-14 |
human |
| Elena López-Terrones, Pau Celada, Maurizio S Riga, Francesc Artiga. Preferential In Vivo Inhibitory Action of Serotonin in Rat Infralimbic versus Prelimbic Cortex: Relevance for Antidepressant Treatments. Cerebral cortex (New York, N.Y. : 1991). vol 32. issue 14. 2022-07-18. PMID:35848862. |
the modulation of glutamatergic neurotransmission in il [but not in the adjacent prelimbic (prl) cortex] evokes antidepressant-like or depressive-like behaviors, associated with changes in serotonin (5-ht) function, highlighting the relevance of glutamate/serotonin interactions in il for emotional control. |
2022-07-18 |
2023-08-14 |
human |
| Elena López-Terrones, Pau Celada, Maurizio S Riga, Francesc Artiga. Preferential In Vivo Inhibitory Action of Serotonin in Rat Infralimbic versus Prelimbic Cortex: Relevance for Antidepressant Treatments. Cerebral cortex (New York, N.Y. : 1991). vol 32. issue 14. 2022-07-18. PMID:35848862. |
the remarkable inhibitory action of 5-ht in il suggests that 5-ht-enhancing drugs may exert their antidepressant action by normalizing a glutamatergic hyperactivity in the vacc of mdd patients. |
2022-07-18 |
2023-08-14 |
human |
| R Kh Lyukmanov, A A Rimkevichus, E V Gnedovskaya, N A Suponev. [Pharmacotherapy in post-stroke rehabilitation]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 122. issue 6. 2022-06-27. PMID:35758946. |
the article presents data on the conditions of use and efficacy of botulinum toxin preparations, oral muscle relaxants, selective serotonin reuptake inhibitors, acetylcholinesterase inhibitors and a glutamatergic transmission modulator in post-stroke neurorehabilitation, and provides recommendations for their rational and safe use. |
2022-06-27 |
2023-08-14 |
Not clear |
| Takuma Nishijo, Etsuko Suzuki, Toshihiko Momiyam. Serotonin 5-HT The Journal of physiology. 2022-05-22. PMID:35598305. |
serotonin 5-ht we performed a patch-clamp study to investigate serotonin (5-ht)-induced modulation of glutamatergic transmission onto cholinergic neurones in the rat basal forebrain (bf) slices. |
2022-05-22 |
2023-08-13 |
rat |
| Tijana Bojić, Milan Sencanski, Vladimir Perovic, Jelena Milicevic, Sanja Glisi. In Silico Screening of Natural Compounds for Candidates 5HT6 Receptor Antagonists against Alzheimer's Disease. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35565976. |
one of the targets that attract the most attention for the potential therapy of ad is the serotonin 5ht6 receptor, which is the receptor situated exclusively in cns on glutamatergic and gabaergic neurons. |
2022-05-14 |
2023-08-13 |
Not clear |
| Shazia Dawood, Samina Bano, Abdulla Abu-Bakr Badaw. Inflammation and serotonin deficiency in major depressive disorder: Molecular docking of antidepressant and antiinflammatory drugs to tryptophan and indoleamine 2,3-dioxygenases. Bioscience reports. 2022-05-04. PMID:35506370. |
the rapidly acting antidepressant ketamine does not dock to either enzyme, but may act by inhibiting kynurenine monooxygenase thereby antagonising glutamatergic activation to normalise serotonin function. |
2022-05-04 |
2023-08-13 |
Not clear |
| Shazia Dawood, Samina Bano, Abdulla Abu-Bakr Badaw. Inflammation and serotonin deficiency in major depressive disorder: Molecular docking of antidepressant and antiinflammatory drugs to tryptophan and indoleamine 2,3-dioxygenases. Bioscience reports. 2022-05-04. PMID:35506370. |
tdo inhibition remains the major common property of antidepressants and tdo induction the most likely mechanism of defective serotonin synthesis in mdd. tdo inhibition and increased free trp availability by salicylate may underpin the antidepressant effect of aspirin and distinguish it from other nonsteroidal antiinflammatory drugs. the controversial findings with ido in mdd patients with an inflammatory state can be explained by ido induction being overridden by changes in subsequent kp enzymes influencing glutamatergic function. |
2022-05-04 |
2023-08-13 |
Not clear |
| Luis Alameda, Giulia Trotta, Harriet Quigley, Victoria Rodriguez, Romayne Gadelrab, Daniella Dwir, Emma Dempster, Chloe C Y Wong, Marta Di Fort. Can epigenetics shine a light on the biological pathways underlying major mental disorders? Psychological medicine. 2022-02-23. PMID:35193719. |
particularly, human research exploring dna methylation has provided new and promising insights into the role of biological pathways implicated in the aetio-pathogenesis of psychiatric conditions, including: monoaminergic (serotonin and dopamine), gabaergic, glutamatergic, neurogenesis, inflammatory and immune response and oxidative stress. |
2022-02-23 |
2023-08-13 |
human |
| Amin Charousaei, Mohammad Nasehi, Vahab Babapour, Salar Vaseghi, Mohammad-Reza Zarrindas. The effect of 5-HT Behavioural brain research. vol 397. 2021-11-15. PMID:32991927. |
the effect of 5-ht increasing evidence shows the close relationship between hippocampal glutamatergic and serotonergic systems through the modulation of behavioral responses. |
2021-11-15 |
2023-08-13 |
Not clear |
| Min Tae M Park, Peter Jeon, Ali R Khan, Kara Dempster, M Mallar Chakravarty, Jason P Lerch, Michael MacKinley, Jean Théberge, Lena Palaniyappa. Hippocampal neuroanatomy in first episode psychosis: A putative role for glutamate and serotonin receptors. Progress in neuro-psychopharmacology & biological psychiatry. vol 110. 2021-11-01. PMID:33691200. |
disrupted serotonergic and glutamatergic signaling interact and contribute to the pathophysiology of schizophrenia, which is particularly relevant for the hippocampus where diverse expression of serotonin receptors is noted. |
2021-11-01 |
2023-08-13 |
human |
| B Spurny, T Vanicek, R Seiger, M B Reed, M Klöbl, V Ritter, J Unterholzner, G M Godbersen, L R Silberbauer, D Pacher, S Klug, M E Konadu, G Gryglewski, S Trattnig, W Bogner, R Lanzenberge. Effects of SSRI treatment on GABA and glutamate levels in an associative relearning paradigm. NeuroImage. vol 232. 2021-10-14. PMID:33657450. |
treatment with selective serotonin reuptake inhibitors (ssris) does not solely affect the serotonergic system but shows downstream effects on gaba- and glutamatergic neurotransmission, potentially helping to restore cognitive function via neuroplastic effects. |
2021-10-14 |
2023-08-13 |
human |
| Rie Tohge, Satoshi Kaneko, Satoshi Morise, Mitsuaki Oki, Norihiro Takenouchi, Aya Murakami, Masataka Nakamura, Hirofumi Kusaka, Yusuke Yakushij. Zonisamide attenuates the severity of levodopa-induced dyskinesia via modulation of the striatal serotonergic system in a rat model of Parkinson's disease. Neuropharmacology. vol 198. 2021-10-14. PMID:34474045. |
serotonin type 1a receptor (5ht1a) is primarily expressed on glutamatergic nerve terminals, and 5ht1b is expressed on gabaergic medium spiny neurons (msns). |
2021-10-14 |
2023-08-13 |
rat |