| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rita B Messing, Loy D Lytl. Serotonin-containing neurons: their possible role in pain and analgesia. Pain. vol 4. issue 1. 1978-01-27. PMID:22060. |
this evidence, based on studies employing pharmacological, surgical, electrophysiological, and dietary manipulations of central nervous system serotonergic neurotransmission, suggests that increases in the activity of brain and spinal cord serotonin neurons are associated with analgesia and enhanced antinociceptive drug potency, whereas decreases in the activities of these neurons correlate with hyperalgesia and diminished analgesic drug potency. |
1978-01-27 |
2023-08-11 |
Not clear |
| J H Growdo. Postural changes, tremor, and myoclonus in the rat immediately following injections of p-chloromaphetamine. Neurology. vol 27. issue 11. 1978-01-27. PMID:563003. |
pretreatment with drugs that interfere with the uptake of p-chloroamphetamine into terminals of serotonergic neurons (fluoxetine), depress brain serotonin levels (p-chlorophenylalanine), or block serotonin receptors (methiothepin or methergoline) suppressed this syndrome, whereas drugs that antagonize the effects of dopamine, norepinephrine, and acetylcholine did not. |
1978-01-27 |
2023-08-11 |
rat |
| A Michanek, B J Meyerso. A comparative study of different amphetamines on copulatory behavior and stereotype activity in the female rat. Psychopharmacology. vol 53. issue 2. 1977-10-20. PMID:408843. |
lordosis response in the female rat has been shown to be inhibited by increased central nervous serotonergic (5-ht) as well as dopaminergic (da) activity. |
1977-10-20 |
2023-08-11 |
rat |
| V M Pickel, T H Joh, D J Rei. A serotonergic innervation of noradrenergic neurons in nucleus locus coeruleus: demonstration by immunocytochemical localization of the transmitter specific enzymes tyrosine and tryptophan hydroxylase. Brain research. vol 131. issue 2. 1977-10-14. PMID:19125. |
immunocytochemical localization of the neurotransmitter synthesizing enzymes, tyrosine and tryptophan hydroxylase, was used to determine whether the noradrenergic neurons in the nucleus locus coeruleus of the rat are innervated by serotonergic (5-ht) neurons. |
1977-10-14 |
2023-08-11 |
rat |
| M L Cohen, K S Wile. Neuronal uptake inhibitors, nisoxetine and fluoxetine on rat vascular contractions. European journal of pharmacology. vol 44. issue 3. 1977-10-14. PMID:891602. |
furthermore, these data provide indirect evidence against a functionally important serotonergic uptake process in rat blood vessels and suggest that neuronal uptake of serotonin does not exert a major role in terminating the vascular action of this biogenic amine. |
1977-10-14 |
2023-08-11 |
rat |
| J K Wan. Antinociceptive effect of intrathecally administered serotonin. Anesthesiology. vol 47. issue 3. 1977-09-29. PMID:578085. |
it is assumed that serotonin molecules penetrate the spinal cord tissue and activate the antinociceptive serotonergic pathyways. |
1977-09-29 |
2023-08-11 |
Not clear |
| M Palkovits, J M Saavedra, D M Jacoboqitz, J S Kizer, L Záborszky, M J Brownstei. Serotonergic innervation of the forebrain: effect of lesions on serotonin and tryptophan hydroxylase levels. Brain research. vol 130. issue 1. 1977-09-22. PMID:884514. |
serotonergic innervation of the forebrain: effect of lesions on serotonin and tryptophan hydroxylase levels. |
1977-09-22 |
2023-08-11 |
Not clear |
| A J Mandell, S Knap. Regulation of serotonin biosynthesis in brain: role of the high affinity uptake of tryptophan into serotonergic neurons. Federation proceedings. vol 36. issue 8. 1977-08-25. PMID:872948. |
regulation of serotonin biosynthesis in brain: role of the high affinity uptake of tryptophan into serotonergic neurons. |
1977-08-25 |
2023-08-11 |
Not clear |
| S M Stah. The human platelet. A diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders. Archives of general psychiatry. vol 34. issue 5. 1977-06-30. PMID:140632. |
comparison of the properties of blood platelets and serotonergic synaptosomes suggests that the human platelet can serve as an appropriate model for the transport, metabolism, and release of serotonin (5-ht) by cns serotonergic neurons. |
1977-06-30 |
2023-08-11 |
human |
| B L Jacobs, S M Simon, D D Ruimy, M E Trulso. A quantitative rotational model for studying serotonergic function in the rat. Brain research. vol 124. issue 2. 1977-05-20. PMID:139194. |
these data indicate that the turning response of rats with unilateral destruction of brain serotonin nerve terminals provides a sensitive tool for quantifiably studying changes in serotonergic function. |
1977-05-20 |
2023-08-11 |
rat |
| J Blasig, R Papeschi, C Gramsch, A Her. Central serotonergic mechanisms and development of morphine dependence. Drug and alcohol dependence. vol 1. issue 3. 1977-04-25. PMID:138583. |
since chronic reduction of 5-ht level during the whole time of morphine exposure changed withdrawal symptomatology in nearly the same way as did a decrease in 5-ht level during the time of withdrawal only, it is suggested that serotonergic mechanisms are not linked to the basic processes underlying dependence development but that they are only involved in the nervous pathways mediating the expression of some withdrawal signs. |
1977-04-25 |
2023-08-11 |
rat |
| S S Mosko, D Haubrich, B L Jacob. Serotonergic afferents to the dorsal raphe nucleus: evdience from HRP and synaptosomal uptake studies. Brain research. vol 119. issue 2. 1977-02-26. PMID:830388. |
a serotonergic innervation of the dorsal raphe was also demonstrated by the presence of high affinity uptake of [3h]5-ht (km=0.17 mum) into synaptosomal suspensions of the dorsal raphe nucleus. |
1977-02-26 |
2023-08-11 |
rat |
| S S Mosko, D Haubrich, B L Jacob. Serotonergic afferents to the dorsal raphe nucleus: evdience from HRP and synaptosomal uptake studies. Brain research. vol 119. issue 2. 1977-02-26. PMID:830388. |
synaptosomal uptake of [3h]5-ht was blocked by selective destruction of serotonergic axon terminals induced by the intraventricular injection of 200 mug of 5,7-dihydroxytryptamine following desipramine hcl pretreatment, but not by destruction of catecholaminergic axon terminals induced by intraventricularly injected 6-hydroxydopamine (2 x 250 mug). |
1977-02-26 |
2023-08-11 |
rat |
| R A Green, J D Barchas, G R Elliott, J S Carman, R J Wyat. The tryptolines: effect of intraventricular administration on spontaneous motor activity of rats. Pharmacology, biochemistry, and behavior. vol 5. issue 4. 1977-02-26. PMID:1005486. |
since both the tryptolines and tryptamines have been shown to be inhibitors of 5-hydroxytryptamine uptake, it may be possible that these compounds are acting indirectly throught an effect on the serotonergic system. |
1977-02-26 |
2023-08-11 |
rat |
| D W Gallager, G K Aghajania. Effect of antipsychotic drugs on the firing of dorsal raphe cells. I. Role of adrenergic system. European journal of pharmacology. vol 39. issue 2. 1977-01-03. PMID:10173. |
the activity of serotonergic (5ht) neurons in the dorsal raphe nucleus was inhibited by the i.v. |
1977-01-03 |
2023-08-11 |
Not clear |
| D W Gallager, G K Aghajania. Effect of antipsychotic drugs on the firing of dorsal raphe cells. II. Reversal by picrotoxin. European journal of pharmacology. vol 39. issue 2. 1977-01-03. PMID:10174. |
as reported in the preceding study, the ability of certain antipsychotic and adrenolytic agents to inhibit the spontaneous firing of serotonergic 5ht neurons in the dorsal raphe nucleus appeared to be related to adrenergic blocking efficacy. |
1977-01-03 |
2023-08-11 |
Not clear |
| J H Schwartz, J E Goldman, R T Ambron, D J Goldber. Axonal transport of vesicles carrying (3H)serotonin in the metacerebral neuron of Aplysia californica. Cold Spring Harbor symposia on quantitative biology. vol 40. 1976-09-25. PMID:59657. |
because the serotonergic vesicle appears to be more stable to isolation than the cholinergic vesicle and because serotonin, like other transmitter molecules with primary amino groups, can be fixed into tissue with aldehyde fixatives, we were able to show that serotonergic vesicles, originating from the cell body, are transported in both branches of the axon by fast axonal transport. |
1976-09-25 |
2023-08-11 |
aplysia |
| M E Trulso. Biological bases for the integration of appetitive and consummatory grooming behaviors in the cat: a review. Pharmacology, biochemistry, and behavior. vol 4. issue 3. 1976-08-23. PMID:1084531. |
systemic administration of 5-hydroxytryptophan or monoamine oxidase inhibition plus tryptophan administration abolishes the abnormal grooming behavior in each group of cats, and microinjections of 5-hydroxytryptophan or serotonin into the superior colliculi has the same effect, indicating that the change in a serotonergic system is a critical aspect of the abnormal behavior in cats with lesions and that a serotonergic system may also be involved in the genesis of the abnormal grooming behavior in thyroidectomized cats. |
1976-08-23 |
2023-08-11 |
cat |
| T Magnusson, A Carlsson, G H Fisher, D Chang, K Folker. Effect of synthetic substance P on monoaminergic mechanisms in brain. Journal of neural transmission. vol 38. issue 2. 1976-08-02. PMID:5576. |
a similar stimulation of noradrenaline and 5-hydroxytryptamine indicate a similar transmitter role for noradrenergic and serotonergic neurons. |
1976-08-02 |
2023-08-11 |
Not clear |
| G K Aghajanian, H J Hailgle. Hallucinogenic indoleamines: Preferential action upon presynaptic serotonin receptors. Psychopharmacology communications. vol 1. issue 6. 1976-07-06. PMID:1063421. |
the results support the hypothesis that low doses of indoleamine halluciogens act preferentially upon presynaptic serotonin receptors to inhibit raphe neurons, thus releasing postsynaptic neurons from a tonic inhibitory serotonergic influence. |
1976-07-06 |
2023-08-11 |
rat |