| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Toda, S Hayashi, W L Fu, Y Nagasak. Serotonin antagonism in isolated canine cerebral arteries. Japanese journal of pharmacology. issue 1. 1976-07-06. PMID:1263357. |
it may be concluded that an alpha-adrenergic mechanism is not involved in the genesis of serotonin-induced contractions and that serotonin acts directly on serotonergic receptors in canine cerebral arteries. |
1976-07-06 |
2023-08-11 |
Not clear |
| H Tamir, M M Rappor. Is the serotonin binding protein (SBP) a soluble storage form for serotonin? Research communications in chemical pathology and pharmacology. vol 13. issue 2. 1976-06-02. PMID:1257610. |
the binding of serotonin to a soluble, high affinity binding protein (sbp) present in synaptosomes and assoicated with serotonergic tracts, has now been studied for the effect of drugs and, in particular, drugs interacting with contractile proteins. |
1976-06-02 |
2023-08-11 |
Not clear |
| L M Yunger, J A Harve. Behavioral effects of L-5-hydroxytryptophan after destruction of ascending serotonergic pathways in the rat: the role of catecholaminergic neurons. The Journal of pharmacology and experimental therapeutics. vol 196. issue 2. 1976-05-10. PMID:1255478. |
it was concluded that l-5-htp can be decarboxylated to 5-ht in serotonergic and catecholaminergic neurons and that the behavioral effects of l-5-htp in lesioned rats may be due to the formation of 5-ht in catecholaminergic neurons where it may act as a "false-transmitter." |
1976-05-10 |
2023-08-11 |
rat |
| E K Orenberg, S R Vandenberg, J D Barchas, M M Herma. Neurochemical studies in a mouse teratoma with neuroepithelial differentiation. Presence of cyclic AMP, serotonin and enzymes of the serotonergic, adrenergic and cholinergic systems. Brain research. vol 101. issue 2. 1976-03-20. PMID:1140. |
presence of cyclic amp, serotonin and enzymes of the serotonergic, adrenergic and cholinergic systems. |
1976-03-20 |
2023-08-11 |
mouse |
| L E Hicks, J D Maser, G G Gallup, P H Edso. Possible serotonergic mediation of tonic immobility: effects of morphine and serotonin blockade. Psychopharmacologia. vol 42. issue 1. 1975-11-06. PMID:125432. |
possible serotonergic mediation of tonic immobility: effects of morphine and serotonin blockade. |
1975-11-06 |
2023-08-11 |
Not clear |
| J A Harvey, A J Schlosberg, L M Yunge. Behavioral correlates of serotonin depletion. Federation proceedings. vol 34. issue 9. 1975-11-05. PMID:125207. |
depletion of telencephalic serotonin (5-ht) content by medical forebrain bundle lesions, which interrupt the ascending serotonergic pathways or by dl-p-chlorophenylalanine produces an increased sensitivity to pain as measured by the flinch-jump, stabilimetric, or hot-plate methods. |
1975-11-05 |
2023-08-11 |
rat |
| J A Harvey, A J Schlosberg, L M Yunge. Behavioral correlates of serotonin depletion. Federation proceedings. vol 34. issue 9. 1975-11-05. PMID:125207. |
all three of these telencephalic areas are innervated by the ascending serotonergic pathways, and cells in these areas show inhibition of firing following the iontophoretic application of 5-ht. |
1975-11-05 |
2023-08-11 |
rat |
| J A Harvey, A J Schlosberg, L M Yunge. Behavioral correlates of serotonin depletion. Federation proceedings. vol 34. issue 9. 1975-11-05. PMID:125207. |
a review of a variety of behavioral effects of 5-ht depletion including an enhanced response to lysergic acid diethylamide and amphetamine suggests that the ascending serotonergic system may have a general role in the inhibition of arousal, rather than a specific role with respect to various categories of behavior. |
1975-11-05 |
2023-08-11 |
rat |
| M H Aprison, J N Hingtgen, W J McBrid. Serotonergic and cholinergic mechanisms during disruption of approach and avoidance behavior. Federation proceedings. vol 34. issue 9. 1975-11-05. PMID:1080120. |
our hypothesis to explain these two apparent opposite biochemical states which result in similar behavioral disruptions is that in both cases more 5-ht is released within certain key serotonergic synapses mediating this behavior. |
1975-11-05 |
2023-08-11 |
rat |
| M H Aprison, J N Hingtgen, W J McBrid. Serotonergic and cholinergic mechanisms during disruption of approach and avoidance behavior. Federation proceedings. vol 34. issue 9. 1975-11-05. PMID:1080120. |
tnot only are the levels of 5-ht significantly higher in preparations of nerve endings isolated from the telencephalon and diencephalon of pigeons given injections of d,l-5-htp, but in vitro studies also show that low concentrations of l-5-htp significantly increased the release of radioactive 5-ht from serotonergic nerve endings. |
1975-11-05 |
2023-08-11 |
rat |
| D W Gallager, G K Aghajania. Effects of chlorimipramine and lysergic acid diethylamide on efflux of precursor-formed 3-H-serotonin: correlations with serotonergic impulse flow. The Journal of pharmacology and experimental therapeutics. vol 193. issue 3. 1975-11-01. PMID:168347. |
the effects of d-lysergic acid diethylamide (lsd) and chlorimipramine (cimi) on the firing rate of serotonergic (5-ht) neurons and on the in vivo efflux of 5-ht were investigated in parallel. |
1975-11-01 |
2023-08-11 |
Not clear |
| D W Gallager, G K Aghajania. Effects of chlorimipramine and lysergic acid diethylamide on efflux of precursor-formed 3-H-serotonin: correlations with serotonergic impulse flow. The Journal of pharmacology and experimental therapeutics. vol 193. issue 3. 1975-11-01. PMID:168347. |
impulse flow in serotonergic neurons was monitored by single unit recording from raphe (5-ht) neurons. |
1975-11-01 |
2023-08-11 |
Not clear |
| N Tod. Analysis of the effect of 5-hydroxykynurenamine,, a serotonin metabolite, on isolated cerebral arteries, aortas and atria. The Journal of pharmacology and experimental therapeutics. vol 193. issue 2. 1975-10-10. PMID:1142096. |
it appears that 5-hk produces vascular contractions via serotonergic receptors, inhibits specifically the contractile response of arteries and aortas to serotonin and causes a tachycardia in rabbit atria by liberating catecholamines from adrenergic nerves. |
1975-10-10 |
2023-08-11 |
human |
| R G Schaub, K M Meyer. Evidence for a small functional pool of serotonin in neurohumoral transmission. Research communications in chemical pathology and pharmacology. vol 10. issue 1. 1975-07-07. PMID:235778. |
decreasing central nervous system (cns) concentrations of serotonin (5-ht) via para-chlorophenylalanine (pcpa) will profoundly increase the severity of the disease although the basic defect does not involve serotonergic neurons. |
1975-07-07 |
2023-08-11 |
Not clear |
| R G Schaub, K M Meyer. Evidence for a small functional pool of serotonin in neurohumoral transmission. Research communications in chemical pathology and pharmacology. vol 10. issue 1. 1975-07-07. PMID:235778. |
the results suggest that serotonin may be synthesized in excess of neuronal transmitter needs and that the estimation of whole brain turnover rates and concentrations of 5-ht may not yield a true measure of serotonergic neuronal activity. |
1975-07-07 |
2023-08-11 |
Not clear |
| J A Harvey, S E McMaster, L M Yunge. P-Chloramphetamine: Selective neurotoxic action in brain. Science (New York, N.Y.). vol 187. issue 4179. 1975-06-02. PMID:47181. |
these results confirm previous suggestions that the long-term reduction in serotonin content of brain, tryptophan-5-hydroxylase activity, and uptake of serotonin after injection of p-chloroamphetamine is due to a neurotoxic effect of the drug or some metabolite on serotonergic cell bodies. |
1975-06-02 |
2023-08-11 |
rat |
| H J Haigler, G K Aghajania. Peripheral serotonin antagonists: failure to antagonize serotonin in brain areas receiving a prominent serotonergic input. Journal of neural transmission. vol 35. issue 4. 1975-03-14. PMID:4373531. |
peripheral serotonin antagonists: failure to antagonize serotonin in brain areas receiving a prominent serotonergic input. |
1975-03-14 |
2023-08-11 |
Not clear |
| J E Goldman, J H Schwart. Cellular specificity of serotonin storage and axonal transport in identified neurones of Aplysia californica. The Journal of physiology. vol 242. issue 1. 1975-02-27. PMID:4548090. |
both serotonergic and cholinergic neurones converted [(3)h]5htp to [(3)h]5-hydroxytryptamine ([(3)h]5ht).3. |
1975-02-27 |
2023-08-11 |
aplysia |
| J E Goldman, J H Schwart. Cellular specificity of serotonin storage and axonal transport in identified neurones of Aplysia californica. The Journal of physiology. vol 242. issue 1. 1975-02-27. PMID:4548090. |
in serotonergic cells, 5ht was present primarily in particulate form; the transmitter readily moved from cell bodies into nerves by selective transport. |
1975-02-27 |
2023-08-11 |
aplysia |
| J E Goldman, J H Schwart. Cellular specificity of serotonin storage and axonal transport in identified neurones of Aplysia californica. The Journal of physiology. vol 242. issue 1. 1975-02-27. PMID:4548090. |
serotonergic neurones possess specific mechanisms for the storage and axonal transport of 5ht which are absent in cholinergic cells. |
1975-02-27 |
2023-08-11 |
aplysia |