| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elke Mayumi Furuya-da-Cunha, Rimenez Rodrigues de Souza, Azair Canto-de-Souz. Rat exposure in mice with neuropathic pain induces fear and antinociception that is not reversed by 5-HT2C receptor activation in the dorsal periaqueductal gray. Behavioural brain research. vol 307. 2017-11-28. PMID:27059332. |
previous studies have demonstrated that serotonin 5-ht2c receptors in the dorsal periaqueductal gray (dpag) mediate both anxiety and antinociception in mice submitted to the elevated plus maze. |
2017-11-28 |
2023-08-13 |
mouse |
| Frederico G Graef. Translational approach to the pathophysiology of panic disorder: Focus on serotonin and endogenous opioids. Neuroscience and biobehavioral reviews. vol 76. issue Pt A. 2017-10-30. PMID:28073587. |
experimental results obtained in rat models of panic indicate that serotonin interacts synergistically with endogenous opioids in the dorsal periaqueductal gray through 5-ht1a and μ-opioid receptors to inhibit proximal defense and, supposedly, panic attacks. |
2017-10-30 |
2023-08-13 |
human |
| Diána G Balázsfi, Dóra Zelena, Lívia Farkas, Kornél Demeter, István Barna, Csaba Cserép, Virág T Takács, Gábor Nyíri, Flóra Gölöncsér, Beáta Sperlágh, Tamás F Freund, József Halle. Median raphe region stimulation alone generates remote, but not recent fear memory traces. PloS one. vol 12. issue 7. 2017-09-26. PMID:28708877. |
the optogenetic stimulation patterns (50hz theta burst and 20hz) used in our tests elicited serotonin release in vitro and lead to activation primarily in the periaqueductal gray examined by c-fos immunohistochemistry. |
2017-09-26 |
2023-08-13 |
mouse |
| Danielle A Diniz, Júlia Alvarenga Petrocchi, Larissa Caldeira Navarro, Tâmara Cristina Souza, Marina G M Castor, Andrea C Perez, Igor D G Duarte, Thiago R L Romer. Serotonin induces peripheral mechanical antihyperalgesic effects in mice. European journal of pharmacology. vol 767. 2016-10-05. PMID:26460149. |
moreover, it has been shown that 5-ht released in the dorsal horn of the spinal cord by stimulation of the periaqueductal gray causes activation of inhibitory interneurons, resulting in inhibition of spinal neurons. |
2016-10-05 |
2023-08-13 |
mouse |
| A Spiacci, T de Oliveira Sergio, G S F da Silva, M L Glass, L C Schenberg, N Garcia-Cairasco, H Zangross. Serotonin in the dorsal periaqueductal gray inhibits panic-like defensive behaviors in rats exposed to acute hypoxia. Neuroscience. vol 307. 2016-07-06. PMID:26319117. |
serotonin in the dorsal periaqueductal gray inhibits panic-like defensive behaviors in rats exposed to acute hypoxia. |
2016-07-06 |
2023-08-13 |
rat |
| Toshiharu Tazawa, Yoshinori Kamiya, Ayako Kobayashi, Kensuke Saeki, Masahito Takiguchi, Yusuke Nakahashi, Hironobu Shinbori, Kengo Funakoshi, Takahisa Got. Spinal cord stimulation modulates supraspinal centers of the descending antinociceptive system in rats with unilateral spinal nerve injury. Molecular pain. vol 11. 2016-03-08. PMID:26104415. |
the nucleus raphe magnus (nrm) in the rostral ventromedial medulla is a major source of serotonin [5-hydroxytryptamine (5-ht)] to the das, but the role of the dorsal raphe nucleus (drn) in the ventral periaqueductal gray matter is still unclear. |
2016-03-08 |
2023-08-13 |
rat |
| Hélio Zangrossi, Frederico G Graef. Serotonin in anxiety and panic: contributions of the elevated T-maze. Neuroscience and biobehavioral reviews. vol 46 Pt 3. 2015-07-17. PMID:24657635. |
the evidence so far reported with the etm supports the above hypothesis and indicates that: (1) whereas 5-ht neurons located at the dorsal raphe nucleus are involved in the regulation of both inhibitory avoidance and escape, those of the median raphe nucleus are primarily implicated in the former task; (2) facilitation of 5-ht1a- and 5-ht2a-mediated neurotransmission in the dorsal periaqueductal gray (dpag) is likely to mediate the panicolytic drug action; (3) stimulation of 5-ht2c receptors in the basolateral amygdala increases anxiety and is implicated in the anxiogenesis caused by short-term administration of antidepressant drugs, and (4) 5-ht1a and the μ-opioid receptors work together in the dpag to modulate escape or panic attacks. |
2015-07-17 |
2023-08-12 |
rat |
| Evan D Paul, Philip L Johnson, Anantha Shekhar, Christopher A Lowr. The Deakin/Graeff hypothesis: focus on serotonergic inhibition of panic. Neuroscience and biobehavioral reviews. vol 46 Pt 3. 2015-07-17. PMID:24661986. |
evidence supporting this panic inhibition system comes from the following observations: (1) serotonergic neurons located in the 'ventrolateral dorsal raphe nucleus' (drvl) as well as the ventrolateral periaqueductal gray (vlpag) inhibit dorsal periaqueductal gray-elicited panic-like responses; (2) chronic, but not acute, antidepressant treatment potentiates serotonin's panicolytic effect; (3) contextual fear activates a central nucleus of the amygdala-drvl/vlpag circuit implicated in mediating freezing and inhibiting panic-like escape behaviors; (4) drvl/vlpag serotonergic neurons are central chemoreceptors and modulate the behavioral and cardiorespiratory response to panicogenic agents such as sodium lactate and co2. |
2015-07-17 |
2023-08-12 |
Not clear |
| Newton S Canteras, Frederico G Graef. Executive and modulatory neural circuits of defensive reactions: implications for panic disorder. Neuroscience and biobehavioral reviews. vol 46 Pt 3. 2015-07-17. PMID:24709069. |
as for the drug treatment, animal models of panic indicate that the drugs currently used for treating panic disorder should work by enhancing 5-ht inhibition of neural systems that command proximal defense in both the dorsal periaqueductal gray and in the medial hypothalamus. |
2015-07-17 |
2023-08-13 |
Not clear |
| Cybele Garcia-Leal, Frederico Guilherme Graeff, Cristina Marta Del-Be. Experimental public speaking: contributions to the understanding of the serotonergic modulation of fear. Neuroscience and biobehavioral reviews. vol 46 Pt 3. 2015-07-17. PMID:25277282. |
these data are compatible with the deakin and graeff hypothesis that serotonin inhibits fear, as accessed by public speaking tasks, and that this inhibition is likely related to the actions of serotonin in the dorsal periaqueductal grey matter. |
2015-07-17 |
2023-08-13 |
human |
| Dietmar Hestermann, Yasin Temel, Arjan Blokland, Lee Wei Li. Acute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation. Behavioural brain research. vol 273. 2015-05-11. PMID:25043730. |
interestingly, the periaqueductal gray (pag), a midbrain structure which regulates anxiety behavior - has robust 5-ht fibers and reciprocal connections with the hypothalamic-pituitary-adrenal (hpa) axis. |
2015-05-11 |
2023-08-13 |
Not clear |
| Chuanming Wang, Wei Bi, Yanran Liang, Xiuna Jing, Songhua Xiao, Yannan Fang, Qiaoyun Shi, Enxiang Ta. Paroxetine engenders analgesic effects through inhibition of p38 phosphorylation in a rat migraine model. Neural regeneration research. vol 7. issue 13. 2015-02-27. PMID:25722689. |
following treatment, mechanical withdrawal thresholds were significantly higher, extracellular concentrations of 5-hydroxytryptamine in the periaqueductal grey matter and nucleus reticularis gigantocellularis were higher, and the expression of phosphorylated p38 in the trigeminal nucleus caudalis was lower. |
2015-02-27 |
2023-08-13 |
rat |
| Camila M Roncon, Carla Biesdorf, Norberto C Coimbra, Elisabeth A Audi, Hélio Zangrossi, Frederico G Graef. Cooperative regulation of anxiety and panic-related defensive behaviors in the rat periaqueductal grey matter by 5-HT1A and μ-receptors. Journal of psychopharmacology (Oxford, England). vol 27. issue 12. 2015-01-27. PMID:23598399. |
previous results with the elevated t-maze (etm) test indicate that the antipanic action of serotonin (5-ht) in the dorsal periaqueductal grey (dpag) depends on the activation endogenous opioid peptides. |
2015-01-27 |
2023-08-12 |
rat |
| Valquíria Camin de Bortoli, Paula Shimene de Melo Yamashita, Hélio Zangross. 5-HT1A and 5-HT2A receptor control of a panic-like defensive response in the rat dorsomedial hypothalamic nucleus. Journal of psychopharmacology (Oxford, England). vol 27. issue 12. 2015-01-27. PMID:23787365. |
in the dorsal periaqueductal gray matter (dpag), another key panic-associated area, serotonin, through the activation of 5-ht1a and 5-ht2a receptors, exerts an inhibitory role on escape expression. |
2015-01-27 |
2023-08-12 |
rat |
| C L Bethea, A Kim, A P Reddy, A Chin, S C Bethea, J L Camero. Hypothalamic KISS1 expression, gonadotrophin-releasing hormone and neurotransmitter innervation vary with stress and sensitivity in macaques. Journal of neuroendocrinology. vol 26. issue 5. 2014-12-08. PMID:24617839. |
upstream of kiss1, norepinephrine axons in the rostral arcuate nucleus and serotonin axons in the anterior hypothalamus and periaqueductal grey were measured by immunohistochemistry. |
2014-12-08 |
2023-08-12 |
monkey |
| Renato Leonardo de Freitas, Rithiele Cristina de Oliveira, Ricardo de Oliveira, Tatiana Paschoalin-Maurin, Fernando Morgan de Aguiar Corrêa, Norberto Cysne Coimbr. The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT₂A and 5-HT₂C serotonergic receptors in post-ictal antinociception. Synapse (New York, N.Y.). vol 68. issue 1. 2014-06-20. PMID:23913301. |
the periaqueductal gray matter (pag) consists in a brainstem structure rich in 5-hydroxytryptamine (5-ht) inputs related to the modulation of pain. |
2014-06-20 |
2023-08-12 |
Not clear |
| Frédérique Courtois, Serge Carrier, Kathleen Charvier, Pierre A Guertin, Nicolas Morel Journe. The control of male sexual responses. Current pharmaceutical design. vol 19. issue 24. 2014-01-27. PMID:23360268. |
brain modulation of these reflexes will be discussed through neurophysiological evidence involving structures such as the medial preoptic area of hypothalamus (mpoa), the paraventricular nucleus (pvn), the periaqueductal gray (pag), and the nucleus para-gigantocellularis (npgi), and through neuropharmacological evidence involving neurotransmitters such as serotonin (5-ht), dopamine and oxytocin. |
2014-01-27 |
2023-08-12 |
human |
| Hyo-Jin Jeong, Karen Lam, Vanessa A Mitchell, Christopher W Vaugha. Serotonergic modulation of neuronal activity in rat midbrain periaqueductal gray. Journal of neurophysiology. vol 109. issue 11. 2013-12-16. PMID:23515792. |
serotonin (5-ht) modulates pain and anxiety from within the midbrain periaqueductal gray (pag). |
2013-12-16 |
2023-08-12 |
rat |
| Peng Li, Stephanie C Tjen-A-Loo. Mechanism of the inhibitory effect of electroacupuncture on experimental arrhythmias. Journal of acupuncture and meridian studies. vol 6. issue 2. 2013-10-18. PMID:23591002. |
these studies were mostly conducted in the department of physiology, shanghai medical university; recently the mechanism of acupuncture's effect on arrhythmias was analyzed in the school of medicine, university of california, irvine, which involves the following: (1)the inhibitory effect of ea on ventricular extrasystoles can be induced by hypothalamic defense area stimulation: a low-current and low-frequency stimulation of the median nerve underneath acupoints p 5 or deep peroneal nerve underneath s 36 can activate arcuate nucleus-ventral periaqueductal gray -nuclei raphe pathway and release endorphin, enkephaline, gamma-aminobutyric acid (gaba), 5-hydroxytryptamine (5-ht), etc., thus inhibiting the rostral ventrolateral medulla (rvlm), decreasing sympathetic outflow, and alleviating ventricular extrasystoles; (2) the bradycardia induced by stimulation of aortic depressor nerve can be blocked by stimulation of superficial radial nerve (underneath li 6-7) or superficial peroneal nerve (underneath g37-39): these stimulations activate the rvlm release opioids and gaba to inhibit nucleus tractus solitarius and vagal nuclei, and block vagal bradycardia. |
2013-10-18 |
2023-08-12 |
Not clear |
| F G Graef. New perspective on the pathophysiology of panic: merging serotonin and opioids in the periaqueductal gray. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 45. issue 4. 2013-07-03. PMID:22437485. |
new perspective on the pathophysiology of panic: merging serotonin and opioids in the periaqueductal gray. |
2013-07-03 |
2023-08-12 |
human |