| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F G Graef. New perspective on the pathophysiology of panic: merging serotonin and opioids in the periaqueductal gray. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 45. issue 4. 2013-07-03. PMID:22437485. |
experimental results obtained in rats performing one-way escape in the elevated t-maze, an animal model of panic, indicate that the inhibitory action of serotonin on defense is connected with activation of endogenous opioids in the periaqueductal gray. |
2013-07-03 |
2023-08-12 |
human |
| Daniela Baptista, Ricardo Luiz Nunes-de-Souza, Azair Canto-de-Souz. Activation of 5-HT(2C) receptors in the dorsal periaqueductal gray increases antinociception in mice exposed to the elevated plus-maze. Behavioural brain research. vol 235. issue 1. 2013-01-23. PMID:22800924. |
activation of 5-ht(2c) receptors in the dorsal periaqueductal gray increases antinociception in mice exposed to the elevated plus-maze. |
2013-01-23 |
2023-08-12 |
mouse |
| Daniela Baptista, Ricardo Luiz Nunes-de-Souza, Azair Canto-de-Souz. Activation of 5-HT(2C) receptors in the dorsal periaqueductal gray increases antinociception in mice exposed to the elevated plus-maze. Behavioural brain research. vol 235. issue 1. 2013-01-23. PMID:22800924. |
several findings have pointed to the role of the dorsal periaqueductal gray (dpag) serotonin 5-ht(1a) and 5-ht(2a-c) receptor subtypes in the modulation of defensive behavior in animals exposed to the elevated plus-maze (epm). |
2013-01-23 |
2023-08-12 |
mouse |
| E A Audi, J C de Aguiar, F G Graef. Mediation by serotonin of the antiaversive effect of zimelidine and propranolol injected into the dorsal midbrain central grey. Journal of psychopharmacology (Oxford, England). vol 2. issue 1. 2012-10-02. PMID:22159666. |
mediation by serotonin of the antiaversive effect of zimelidine and propranolol injected into the dorsal midbrain central grey. |
2012-10-02 |
2023-08-12 |
rat |
| E A Audi, J C de Aguiar, F G Graef. Mediation by serotonin of the antiaversive effect of zimelidine and propranolol injected into the dorsal midbrain central grey. Journal of psychopharmacology (Oxford, England). vol 2. issue 1. 2012-10-02. PMID:22159666. |
previously reported results indicate that serotonin (5-ht) inhibits the neural sub strate of aversion in the dorsal midbrain central grey (dcg) of the rat. |
2012-10-02 |
2023-08-12 |
rat |
| Priscilla Y Hwang, Kyle D Allen, Mohammed F Shamji, Liufang Jing, Brian A Mata, Mostafa A Gabr, Janet L Huebner, Virginia B Kraus, William J Richardson, Lori A Setto. Changes in midbrain pain receptor expression, gait and behavioral sensitivity in a rat model of radiculopathy. The open orthopaedics journal. vol 6. 2012-09-11. PMID:22962568. |
findings for pain receptors in the midbrain of np-treated rats included an increased expression of 5ht(2b) at 1, but not 4 weeks; increased expression of µ-or and mglur5 at 1 and 4 weeks (periaqueductal gray region only); and no changes in expression of mglur4 at any point in this study. |
2012-09-11 |
2023-08-12 |
rat |
| Camila M Roncon, Carla Biesdorf, Rosangela G Santana, Hélio Zangrossi, Frederico G Graeff, Elisabeth A Aud. The panicolytic-like effect of fluoxetine in the elevated T-maze is mediated by serotonin-induced activation of endogenous opioids in the dorsal periaqueductal grey. Journal of psychopharmacology (Oxford, England). vol 26. issue 4. 2012-08-17. PMID:22279131. |
serotonin (5-ht), opioids and the dorsal periaqueductal grey (dpag) have been implicated in the pathophysiology of panic disorder. |
2012-08-17 |
2023-08-12 |
rat |
| Vanessa Nunes-de-Souza, Ricardo Nunes-de-Souza, Robert John Rodgers, Azair Canto-de-Souz. Blockade of 5-HT(2) receptors in the periaqueductal grey matter (PAG) abolishes the anxiolytic-like effect of 5-HT(1A) receptor antagonism in the median raphe nucleus in mice. Behavioural brain research. vol 225. issue 2. 2012-01-24. PMID:21839779. |
blockade of 5-ht(2) receptors in the periaqueductal grey matter (pag) abolishes the anxiolytic-like effect of 5-ht(1a) receptor antagonism in the median raphe nucleus in mice. |
2012-01-24 |
2023-08-12 |
mouse |
| Vanessa Nunes-de-Souza, Ricardo Nunes-de-Souza, Robert John Rodgers, Azair Canto-de-Souz. Blockade of 5-HT(2) receptors in the periaqueductal grey matter (PAG) abolishes the anxiolytic-like effect of 5-HT(1A) receptor antagonism in the median raphe nucleus in mice. Behavioural brain research. vol 225. issue 2. 2012-01-24. PMID:21839779. |
in this context, it is known that blockade of 5-ht(1a) somatodendritic autoreceptors in the midbrain raphe nuclei increases the firing rate of these neurons, disinhibiting 5-ht release in postsynaptic target areas such as amygdala, hippocampus and periaqueductal grey matter (pag). |
2012-01-24 |
2023-08-12 |
mouse |
| Janaina M Zanoveli, Roger L H Pobbe, Valquiria C de Bortoli, Milene C Carvalho, Marcus L Brandão, Helio Zangross. Facilitation of 5-HT1A-mediated neurotransmission in dorsal periaqueductal grey matter accounts for the panicolytic-like effect of chronic fluoxetine. The international journal of neuropsychopharmacology. vol 13. issue 8. 2011-12-19. PMID:19941697. |
chronic administration of antidepressants such as fluoxetine and imipramine increases the responsiveness of 5-ht(1a) receptors in dorsal periaqueductal grey matter (dpag), a midbrain area consistently implicated in the pathogenesis of panic disorder. |
2011-12-19 |
2023-08-12 |
rat |
| Vânia Ramos Sela, Carla Biesdorf, Diego Henrique Ramos, Hélio Zangrossi, Frederico Guilherme Graeff, Elisabeth Aparecida Aud. Serotonin-1A receptors in the dorsal periaqueductal gray matter mediate the panicolytic-like effect of pindolol and paroxetine combination in the elevated T-maze. Neuroscience letters. vol 495. issue 1. 2011-09-13. PMID:21421022. |
since reported evidence has implicated the 5-ht(1a) receptors of the dorsal periaqueductal gray matter (dpag) in the panicolytic effect of antidepressants, rats treated with pindolol (5.0mg/kg, i.p.) |
2011-09-13 |
2023-08-12 |
rat |
| Jantarima Charoenphandhu, Jarinthorn Teerapornpuntakit, Amporn Nuntapornsak, Nateetip Krishnamra, Narattaphol Charoenphandh. Anxiety-like behaviors and expression of SERT and TPH in the dorsal raphé of estrogen- and fluoxetine-treated ovariectomized rats. Pharmacology, biochemistry, and behavior. vol 98. issue 4. 2011-08-24. PMID:21382399. |
furthermore, e2 and e2+flx similarly upregulated the mrna expression of serotonin reuptake transporter (sert) and tryptophan hydroxylase-2 in the dorsal raphé of ovx rats, while having no effect on sert expression in the frontal cortex, hippocampus, septum, amygdala and periaqueductal gray. |
2011-08-24 |
2023-08-12 |
rat |
| Frederico G Graef. [Serotonin, periaqueductal gray matter and panic disorder]. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). vol 25 Suppl 2. 2011-08-15. PMID:14978586. |
[serotonin, periaqueductal gray matter and panic disorder]. |
2011-08-15 |
2023-08-12 |
human |
| Frederico G Graef. [Serotonin, periaqueductal gray matter and panic disorder]. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). vol 25 Suppl 2. 2011-08-15. PMID:14978586. |
this article reviews experimental evidence and theoretical constructs that implicate serotonin (5-ht) modulation of defensive behavior within the midbrain periaqueductal gray matter(pag) in panic disorder. |
2011-08-15 |
2023-08-12 |
human |
| Joseph J Normandin, Anne Z Murph. Serotonergic lesions of the periaqueductal gray, a primary source of serotonin to the nucleus paragigantocellularis, facilitate sexual behavior in male rats. Pharmacology, biochemistry, and behavior. vol 98. issue 3. 2011-07-28. PMID:21296106. |
serotonergic lesions of the periaqueductal gray, a primary source of serotonin to the nucleus paragigantocellularis, facilitate sexual behavior in male rats. |
2011-07-28 |
2023-08-12 |
rat |
| Joseph J Normandin, Anne Z Murph. Serotonergic lesions of the periaqueductal gray, a primary source of serotonin to the nucleus paragigantocellularis, facilitate sexual behavior in male rats. Pharmacology, biochemistry, and behavior. vol 98. issue 3. 2011-07-28. PMID:21296106. |
the ventrolateral periaqueductal gray (vlpag) provides serotonin to this region, thus providing an anatomical and neurochemical basis for serotonergic regulation of the npgi. |
2011-07-28 |
2023-08-12 |
rat |
| Roger L H Pobbe, Helio Zangrossi, D Caroline Blanchard, Robert J Blanchar. Involvement of dorsal raphe nucleus and dorsal periaqueductal gray 5-HT receptors in the modulation of mouse defensive behaviors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 4. 2011-06-15. PMID:20570114. |
involvement of dorsal raphe nucleus and dorsal periaqueductal gray 5-ht receptors in the modulation of mouse defensive behaviors. |
2011-06-15 |
2023-08-12 |
mouse |
| Plínio Cabrera Casarotto, Valquiria Camin de Bortoli, Fernando Morgan de Aguiar Corrêa, Leonardo Barbosa Moraes Resstel, Hélio Zangross. Panicolytic-like effect of BDNF in the rat dorsal periaqueductal grey matter: the role of 5-HT and GABA. The international journal of neuropsychopharmacology. vol 13. issue 5. 2011-01-25. PMID:20047714. |
panicolytic-like effect of bdnf in the rat dorsal periaqueductal grey matter: the role of 5-ht and gaba. |
2011-01-25 |
2023-08-12 |
rat |
| Wenyu Fu, Erwan Le Maître, Veronique Fabre, Jean-Francois Bernard, Zhi-Qing David Xu, Tomas Hökfel. Chemical neuroanatomy of the dorsal raphe nucleus and adjacent structures of the mouse brain. The Journal of comparative neurology. vol 518. issue 17. 2010-10-08. PMID:20589909. |
here we studied, with histochemical techniques, the relation between serotonin, some other small-molecule transmitters, and a number of neuropeptides in the dorsal raphe nucleus (drn) and the adjacent ventral periaqueductal gray (vpag) of mouse, an important question being to establish possible differences from rat. |
2010-10-08 |
2023-08-12 |
mouse |
| Hideo Suzuki, S Duke Han, Louis R Luca. Chronic passive exposure to aggression decreases D2 and 5-HT 1B receptor densities. Physiology & behavior. vol 99. issue 5. 2010-06-09. PMID:20114057. |
however, receptor binding autoradiography identified lower densities of dopamine d(2) receptors in the cortical-accumbal regions (shell of the nucleus accumbens and cingulate and motor cortices) and lower 5-ht(1b) receptor densities in the tegmental regions (ventral tegmental area, substantia nigra pars compacta, and periaqueductal gray) among observers exposed to aggression, compared to controls. |
2010-06-09 |
2023-08-12 |
rat |