| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiangxiang Zhu, Zilei Zhang, Xin Yang, Longkai Qi, Yinrui Guo, Xiaocui Tang, Yizhen Xie, Diling Che. Improvement of extraction from Hericium erinaceus on the gut-brain axis in AD-like mice. Brain research. 2022-08-07. PMID:35934088. |
in this study, results showed the extractions of hericium erinaceus can ameliorate the learning and memory abilities significantly, reduce the swelling of brain tissues, neuronal apoptosis, and down-regulate the expression of alzheimer's disease intracellular markers including tau and aβ1-42. |
2022-08-07 |
2023-08-14 |
mouse |
| Tania Arora, Vikash Prashar, Randeep Singh, Tushar Singh Barwal, Harish Changotra, Arti Sharma, Jyoti Parkas. Dysregulated miRNAs in Progression and Pathogenesis of Alzheimer's Disease. Molecular neurobiology. 2022-07-22. PMID:35867206. |
alzheimer's disease (ad) is a progressive degeneration of neurons due to the accumulation of amyloid-β peptide (aβ) and hyper-phosphorylation of tau protein in the neuronal milieu leading to increased oxidative stress and apoptosis. |
2022-07-22 |
2023-08-14 |
human |
| Vanesa Carmona Mata, Joshua Goldber. Morin and isoquercitrin protect against ischemic neuronal injury by modulating signaling pathways and stimulating mitochondrial biogenesis. Nutritional neuroscience. 2022-07-20. PMID:35857717. |
the search for the etiology of alzheimer's disease has revealed dysregulation of amyloid protein precursors, β-secretase, mitophagy, apoptosis, and tau protein genes after ischemic brain injury. |
2022-07-20 |
2023-08-14 |
Not clear |
| Lin Wang, Bi-Qiang Zhou, Ying-Hong Li, Qian-Qian Jiang, Wei-Hong Cong, Ke-Ji Chen, Xiao-Min Wen, Zheng-Zhi W. Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer's disease. Neural regeneration research. vol 18. issue 1. 2022-07-08. PMID:35799547. |
previous studies have shown that berberine has neuroprotective effects against alzheimer's disease, including antagonizing tau phosphorylation, and inhibiting acetylcholinesterase activity and neural cell apoptosis. |
2022-07-08 |
2023-08-14 |
mouse |
| Hai Duc Nguyen, Min-Sun Ki. The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships : The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships. Biological trace element research. 2022-07-07. PMID:35798913. |
the most commonly retrieved genes for each disease were different, but essential biological pathways such as oxidative stress, altered lipoprotein metabolism, fluid shear stress and atherosclerosis, apoptosis, the il-6 signaling pathway, and alzheimer's disease were highlighted. |
2022-07-07 |
2023-08-14 |
Not clear |
| In Soo Ryu, Dae Hoon Kim, Hyun-Jeong Cho, Jin-Hyeob Ry. The role of microRNA-485 in neurodegenerative diseases. Reviews in the neurosciences. 2022-07-06. PMID:35793556. |
neuropathological conditions such as the accumulation of misfolded proteins can cause neuroinflammation, apoptosis, and synaptic dysfunction in the brain, leading to the development of ndds including alzheimer's disease (ad) and parkinson's disease (pd). |
2022-07-06 |
2023-08-14 |
Not clear |
| Xiaoman Xu, Yi Zhan. Regulation of Oxidative Stress by Long Non-coding RNAs in Central Nervous System Disorders. Frontiers in molecular neuroscience. vol 15. 2022-07-05. PMID:35782387. |
central nervous system (cns) disorders, such as ischemic stroke, alzheimer's disease, parkinson's disease, spinal cord injury, glioma, and epilepsy, involve oxidative stress and neuronal apoptosis, often leading to long-term disability or death. |
2022-07-05 |
2023-08-14 |
Not clear |
| Mingzhu Chen, Yizi Zhu, Huajun Li, Yubo Zhang, Mei Ha. A Quantitative Proteomic Approach Explores the Possible Mechanisms by Which the Small Molecule Stemazole Promotes the Survival of Human Neural Stem Cells. Brain sciences. vol 12. issue 6. 2022-06-24. PMID:35741576. |
combined with a diseases database of alzheimer's disease (ad), caspase-2 (casp2), pka c-alpha (prkaca), fibronectin (fn1), large neutral amino acid transporter small subunit 1 (slc7a5), which are involved in cell proliferation and apoptosis, this was further validated by enzyme activity assay and molecular docking, and regarded as putative targets regulated by stemazole. |
2022-06-24 |
2023-08-14 |
human |
| Rehana Khatoon, Pooja Kaushik, Suhel Parve. Mitochondria-Related Apoptosis Regulation by Minocycline: A Study on a Transgenic ACS omega. vol 7. issue 23. 2022-06-20. PMID:35721948. |
mitochondria-related apoptosis regulation by minocycline: a study on a transgenic alzheimer's disease (ad) is a very complicated and multifactorial neurological disorder having limited therapeutic interventions illustrated by the impairment in memory and cognitive function. |
2022-06-20 |
2023-08-14 |
Not clear |
| Xiaohui Ma, Linlin Liu, Jing Men. Retraction notice to "MicroRNA-125b promotes neurons cell apoptosis and tau phosphorylation in Alzheimer's disease" [Neurosci. Lett. 661 (2017) 57-62]. Neuroscience letters. vol 783. 2022-06-12. PMID:35691149. |
retraction notice to "microrna-125b promotes neurons cell apoptosis and tau phosphorylation in alzheimer's disease" [neurosci. |
2022-06-12 |
2023-08-14 |
Not clear |
| Chunxia Huang, John Man Tak Chu, Yan Liu, Vivian Suk Wai Kwong, Raymond Chuen Chung Chang, Gordon Tin Chun Won. Sevoflurane Induces Neurotoxicity in the Animal Model with Alzheimer's Disease Neuropathology via Modulating Glutamate Transporter and Neuronal Apoptosis. International journal of molecular sciences. vol 23. issue 11. 2022-06-10. PMID:35682930. |
sevoflurane induces neurotoxicity in the animal model with alzheimer's disease neuropathology via modulating glutamate transporter and neuronal apoptosis. |
2022-06-10 |
2023-08-14 |
mouse |
| Riane Richard, Shaker Mous. Necroptosis in Alzheimer's disease: Potential therapeutic target. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 152. 2022-06-06. PMID:35665670. |
hyperglycemia activates the switch from apoptosis to necroptosis, and alzheimer's disease is considered "diabetes type 3.' |
2022-06-06 |
2023-08-14 |
Not clear |
| Hailun Jiang, Jianghong Liu, Shuilong Guo, Li Zeng, Zhongdi Cai, Junxia Zhang, Linlin Wang, Zhuorong Li, Rui Li. miR-23b-3p rescues cognition in Alzheimer's disease by reducing tau phosphorylation and apoptosis via GSK-3β signaling pathways. Molecular therapy. Nucleic acids. vol 28. 2022-05-20. PMID:35592504. |
mir-23b-3p rescues cognition in alzheimer's disease by reducing tau phosphorylation and apoptosis via gsk-3β signaling pathways. |
2022-05-20 |
2023-08-13 |
mouse |
| Jie-Ming Jian, Dong-Yu Fan, Ding-Yuan Tian, Yuan Cheng, Pu-Yang Sun, Cheng-Rong Tan, Gui-Hua Zeng, Chen-Yang He, Ye-Ran Wang, Jie Zhu, Xiu-Qing Yao, Yan-Jiang Wang, Yu-Hui Li. Naturally-Occurring Antibodies Against Bim are Decreased in Alzheimer's Disease and Attenuate AD-type Pathology in a Mouse Model. Neuroscience bulletin. 2022-05-15. PMID:35570231. |
increased neuronal apoptosis is an important pathological feature of alzheimer's disease (ad). |
2022-05-15 |
2023-08-13 |
mouse |
| Jenaro Lemus-de la Cruz, Cinthia I Landa-Moreno, Mitchell Trejo-Hurtado, Donovan J Peña-Montes, Rafael Salgado-Garciglia, Salvador Manzo-Avalos, Christian Cortés-Rojo, Rocío Montoya-Pérez, Alfredo Saavedra-Molin. Evaluation of the antioxidant effects of green synthesis silver nanoparticles on brain from rats with experimental diabetes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560655. |
with the course of the disease, there are various complications at the brain level, such as the development of alzheimer's, cognitive decline, alterations in neurotransmission, neuroinflammation, apoptosis, and necrosis, among others. |
2022-05-13 |
2023-08-13 |
rat |
| Grant Kawecki, Kelsie M King, Nicholas Cramer, David R Bevan, Anne M Brow. Simulations of Cross-Amyloid Aggregation of Amyloid-β and Islet Amyloid Polypeptide Fragments. Biophysical journal. 2022-05-11. PMID:35538665. |
the formation of aβ aggregates facilitates the progression of alzheimer's disease (ad), while iapp aggregates induce pancreatic β-cell apoptosis, leading to exacerbation of type 2 diabetes (t2d). |
2022-05-11 |
2023-08-13 |
Not clear |
| Kyonghwan Choe, Hyun Young Park, Muhammad Ikram, Hyeon Jin Lee, Tae Ju Park, Rahat Ullah, Myeong Ok Ki. Systematic Review of the Common Pathophysiological Mechanisms in COVID-19 and Neurodegeneration: The Role of Bioactive Compounds and Natural Antioxidants. Cells. vol 11. issue 8. 2022-04-23. PMID:35455977. |
several links connect covid-19 with alzheimer's disease (ad), such as elevated oxidative stress, uncontrolled release of the inflammatory cytokines, and mitochondrial apoptosis. |
2022-04-23 |
2023-08-13 |
Not clear |
| Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Mahdi Mohaqiq, Hamed Shoorei, Aria Baniahmad, Mohammad Taheri, Elena Jamal. Interplay Between Non-Coding RNAs and Programmed Cell Death Proteins. Frontiers in oncology. vol 12. 2022-04-11. PMID:35402235. |
consistent with the important roles of these proteins in the regulation of apoptosis, dysregulation of pdcds is associated with diverse disorders ranging from intervertebral disc degeneration, amyotrophic lateral sclerosis, immune thrombocytopenia, type 1 diabetes, congenital hypothyroidism, alzheimer's disease to different types of cancers. |
2022-04-11 |
2023-08-13 |
Not clear |
| Chia Chi Lee, Tzu Chen Wang, Hsin Yu Wang, Bin Hsu, Rong Jhen Shih, Neng Wen Lo, Chun Yuan Wan. Association Between HSPA5 Promoter Polymorphisms and a Reduced Risk of Normal Tension Glaucoma. Ophthalmic research. 2022-04-04. PMID:35378534. |
the potential similarities between alzheimer's disease and ntg in cellular apoptosis leading to neuro-degeneration have been shown in recent studies. |
2022-04-04 |
2023-08-13 |
Not clear |
| Hai Duc Nguyen, Min-Sun Ki. Exposure to a mixture of heavy metals induces cognitive impairment: genes and microRNAs involved. Toxicology. 2022-03-29. PMID:35346790. |
although prevalent genes obtained from investigated heavy metals of cognitive impairment were different, the "pi3k-akt signaling pathway", "pathways of neurodegeneration-multiple diseases", "apoptosis", "apoptosis-multiple species", "p53 signaling pathway", "nf-kappa b signaling pathway", and "alzheimer's disease pathway" were highlighted. |
2022-03-29 |
2023-08-13 |
Not clear |