| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z Nagy, M M Esiri, A D Smit. The cell division cycle and the pathophysiology of Alzheimer's disease. Neuroscience. vol 87. issue 4. 1998-12-30. PMID:9759963. |
evidence is growing of a role of apoptosis in neurodegenerative disorders including alzheimer's disease. |
1998-12-30 |
2023-08-12 |
human |
| S Bursztajn, R DeSouza, D L McPhie, S A Berman, J Shioi, N K Robakis, R L Nev. Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 23. 1998-12-18. PMID:9822738. |
overexpression in neurons of human presenilin-1 or a presenilin-1 familial alzheimer disease mutant does not enhance apoptosis. |
1998-12-18 |
2023-08-12 |
human |
| S Bursztajn, R DeSouza, D L McPhie, S A Berman, J Shioi, N K Robakis, R L Nev. Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 23. 1998-12-18. PMID:9822738. |
programmed cell death, or apoptosis, has been implicated in alzheimer's disease (ad). |
1998-12-18 |
2023-08-12 |
human |
| G Perry, A Nunomura, P Lucassen, H Lassmann, M A Smit. Apoptosis and Alzheimer's disease. Science (New York, N.Y.). vol 282. issue 5392. 1998-12-01. PMID:9867630. |
apoptosis and alzheimer's disease. |
1998-12-01 |
2023-08-12 |
Not clear |
| Z Zhang, H Hartmann, V M Do, D Abramowski, C Sturchler-Pierrat, M Staufenbiel, B Sommer, M van de Wetering, H Clevers, P Saftig, B De Strooper, X He, B A Yankne. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature. vol 395. issue 6703. 1998-11-04. PMID:9790190. |
thus, mutations in presenilin-1 may increase neuronal apoptosis by altering the stability of beta-catenin, predisposing individuals to early-onset alzheimer's disease. |
1998-11-04 |
2023-08-12 |
mouse |
| I Farkas, L Baranyi, Z S Liposits, T Yamamoto, H Okad. Complement C5a anaphylatoxin fragment causes apoptosis in TGW neuroblastoma cells. Neuroscience. vol 86. issue 3. 1998-10-29. PMID:9692726. |
our data suggest that neurons expressing neuronal c5a receptor are more vulnerable to the apoptosis associated with the neuronal c5a receptor and the possibility that abnormal activation of c5a receptor and c5a anaphylatoxin fragments might be involved in the pathogenesis of alzheimer's disease. |
1998-10-29 |
2023-08-12 |
human |
| J Hiraoka, K Asano, H Sano, K Fujisawa, M Ohno, G Takemura, S Minatoguchi, H Ohashi, T Fujiwara, H Fujiwar. [Participation of apoptosis in renal amyloidosis]. Nihon Jinzo Gakkai shi. vol 40. issue 4. 1998-09-15. PMID:9654911. |
recently, it was reported that apoptosis plays an important role in the pathogenesis of type-2 diabetes mellitus and alzheimer's disease of which amyloid deposition is seen in the tissue. |
1998-09-15 |
2023-08-12 |
human |
| M Barinag. Is apoptosis key in Alzheimer's disease? Science (New York, N.Y.). vol 281. issue 5381. 1998-09-09. PMID:9735049. |
is apoptosis key in alzheimer's disease? |
1998-09-09 |
2023-08-12 |
Not clear |
| Q Guo, W Fu, J Xie, H Luo, S F Sells, J W Geddes, V Bondada, V M Rangnekar, M P Mattso. Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease. Nature medicine. vol 4. issue 8. 1998-08-25. PMID:9701251. |
in alzheimer disease (ad), neurons may die by apoptosis, and amyloid beta-protein (a beta) may play a role in this. |
1998-08-25 |
2023-08-12 |
Not clear |
| M P Lambert, A K Barlow, B A Chromy, C Edwards, R Freed, M Liosatos, T E Morgan, I Rozovsky, B Trommer, K L Viola, P Wals, C Zhang, C E Finch, G A Krafft, W L Klei. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 11. 1998-06-22. PMID:9600986. |
germ-line knockout of fyn, a protein tyrosine kinase linked to apoptosis and elevated in alzheimer's disease, also was neuroprotective. |
1998-06-22 |
2023-08-12 |
Not clear |
| C W Cotma. Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease. Neurobiology of aging. vol 19. issue 1 Suppl. 1998-06-12. PMID:9562464. |
apoptosis decision cascades and neuronal degeneration in alzheimer's disease. |
1998-06-12 |
2023-08-12 |
Not clear |
| I Nishimot. A new paradigm for neurotoxicity by FAD mutants of betaAPP: a signaling abnormality. Neurobiology of aging. vol 19. issue 1 Suppl. 1998-06-12. PMID:9562465. |
cellular expression of those familial alzheimer's disease-associated mutants causes neuronal cells to undergo apoptotic death; and procedures inhibiting the signal of normal betaapp block the mutant-induced apoptosis. |
1998-06-12 |
2023-08-12 |
Not clear |
| M Dragunow, G A MacGibbon, P Lawlor, N Butterworth, B Connor, C Henderson, M Walton, A Woodgate, P Hughes, R L Faul. Apoptosis, neurotrophic factors and neurodegeneration. Reviews in the neurosciences. vol 8. issue 3-4. 1998-06-05. PMID:9548234. |
in this review we describe the evidence implicating apoptosis in neurodegenerative diseases with a particular emphasis on alzheimer's disease. |
1998-06-05 |
2023-08-12 |
human |
| C Stadelmann, W Brück, C Bancher, K Jellinger, H Lassman. Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis. Journal of neuropathology and experimental neurology. vol 57. issue 5. 1998-06-04. PMID:9596416. |
alzheimer disease: dna fragmentation indicates increased neuronal vulnerability, but not apoptosis. |
1998-06-04 |
2023-08-12 |
human |
| S I Savitz, D M Rosenbau. Apoptosis in neurological disease. Neurosurgery. vol 42. issue 3. 1998-05-15. PMID:9526991. |
further investigations into neuronal apoptosis should focus on all of the criteria that the original investigators outlined 25 years ago, to clarify whether apoptosis and/or another form of cell death mediates neuronal degeneration in physiological settings and in neurological diseases such as alzheimer's disease, parkinson's disease, epilepsy, and ischemia/stroke. |
1998-05-15 |
2023-08-12 |
Not clear |
| S M de la Monte, Y K Sohn, N Ganju, J R Wand. P53- and CD95-associated apoptosis in neurodegenerative diseases. Laboratory investigation; a journal of technical methods and pathology. vol 78. issue 4. 1998-05-07. PMID:9564885. |
p53 or cd95 gene up-regulation precedes apoptosis in many cell types, and a potential role for these molecules in apoptosis of neurons and glial cells has already been demonstrated in alzheimer's disease (ad). |
1998-05-07 |
2023-08-12 |
Not clear |
| S M de la Monte, Y K Sohn, N Ganju, J R Wand. P53- and CD95-associated apoptosis in neurodegenerative diseases. Laboratory investigation; a journal of technical methods and pathology. vol 78. issue 4. 1998-05-07. PMID:9564885. |
to determine whether apoptosis in other neurodegenerative diseases is mediated by similar mechanisms, p53 and cd95 expression were examined in postmortem central nervous system tissues from patients with diffuse lewy body disease (dlbd), pick's disease (pkd), progressive supranuclear palsy (psp), multiple system atrophy (msa), parkinson's disease (pd), amyotrophic lateral sclerosis (als), and down's syndrome plus alzheimer's disease (dn+ad). |
1998-05-07 |
2023-08-12 |
Not clear |
| Y Kitamura, S Shimohama, W Kamoshima, T Ota, Y Matsuoka, Y Nomura, M A Smith, G Perry, P J Whitehouse, T Taniguch. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Brain research. vol 780. issue 2. 1998-05-04. PMID:9507158. |
alteration of proteins regulating apoptosis, bcl-2, bcl-x, bax, bak, bad, ich-1 and cpp32, in alzheimer's disease. |
1998-05-04 |
2023-08-12 |
Not clear |
| Y Kitamura, S Shimohama, W Kamoshima, T Ota, Y Matsuoka, Y Nomura, M A Smith, G Perry, P J Whitehouse, T Taniguch. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Brain research. vol 780. issue 2. 1998-05-04. PMID:9507158. |
recently, apoptosis has been implicated in the selective neuronal loss of alzheimer's disease (ad). |
1998-05-04 |
2023-08-12 |
Not clear |
| B Draczynska-Lusiak, Y M Chen, A Y Su. Oxidized lipoproteins activate NF-kappaB binding activity and apoptosis in PC12 cells. Neuroreport. vol 9. issue 3. 1998-04-29. PMID:9512401. |
results indicated that oxidized lipoproteins may serve as an oxidative mediator and may activate apoptosis through a nuclear signalling pathway contributing to the pathology in alzheimer's disease. |
1998-04-29 |
2023-08-12 |
Not clear |