| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Ariga, W D Jarvis, R K Y. Role of sphingolipid-mediated cell death in neurodegenerative diseases. Journal of lipid research. vol 39. issue 1. 1998-03-26. PMID:9469581. |
inappropriate initiation of apoptosis has been proposed to underlie the progressive neuronal attrition associated with various neurodegenerative diseases such as alzheimer's disease (ad), parkinson's disease (pd), amyotrophic lateral sclerosis (als), and other neurological disorders that are characterized by the gradual loss of specific populations of neurons. |
1998-03-26 |
2023-08-12 |
Not clear |
| F Yang, X Sun, W Beech, B Teter, S Wu, J Sigel, H V Vinters, S A Frautschy, G M Col. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. The American journal of pathology. vol 152. issue 2. 1998-03-06. PMID:9466564. |
antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in alzheimer's disease. |
1998-03-06 |
2023-08-12 |
human |
| M P Mattson, Q Guo, K Furukawa, W A Pederse. Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease. Journal of neurochemistry. vol 70. issue 1. 1998-02-02. PMID:9422341. |
presenilins, the endoplasmic reticulum, and neuronal apoptosis in alzheimer's disease. |
1998-02-02 |
2023-08-12 |
mouse |
| S M de la Monte, Y K Sohn, J R Wand. Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease. Journal of the neurological sciences. vol 152. issue 1. 1998-01-02. PMID:9395128. |
correlates of p53- and fas (cd95)-mediated apoptosis in alzheimer's disease. |
1998-01-02 |
2023-08-12 |
Not clear |
| S M de la Monte, Y K Sohn, J R Wand. Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease. Journal of the neurological sciences. vol 152. issue 1. 1998-01-02. PMID:9395128. |
apoptosis may be an important mechanism of cell loss in alzheimer's disease (ad). |
1998-01-02 |
2023-08-12 |
Not clear |
| P Vito, T Ghayur, L D'Adami. Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage. The Journal of biological chemistry. vol 272. issue 45. 1997-12-12. PMID:9353287. |
reduction of ps2 protein levels by antisense rna protects from apoptosis, whereas overexpression of an alzheimer's ps2 mutant increases cell death induced by several stimuli. |
1997-12-12 |
2023-08-12 |
Not clear |
| G A MacGibbon, P A Lawlor, M Walton, E Sirimanne, R L Faull, B Synek, E Mee, B Connor, M Draguno. Expression of Fos, Jun, and Krox family proteins in Alzheimer's disease. Experimental neurology. vol 147. issue 2. 1997-11-21. PMID:9344557. |
there is growing evidence supporting a role for apoptosis and/or pcd in alzheimer's disease (ad), based on dna fragmentation studies and recent findings of increased levels of inducible transcription factors (itfs) such as c-jun in ad brains. |
1997-11-21 |
2023-08-12 |
human |
| S Janicki, M J Monteir. Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I). The Journal of cell biology. vol 139. issue 2. 1997-11-20. PMID:9334350. |
increased apoptosis arising from increased expression of the alzheimer's disease-associated presenilin-2 mutation (n141i). |
1997-11-20 |
2023-08-12 |
mouse |
| U Thatte, S Dahanuka. Apoptosis: clinical relevance and pharmacological manipulation. Drugs. vol 54. issue 4. 1997-11-13. PMID:9339959. |
aids and neurodegenerative disorders like alzheimer's or parkinson's disease represent the most widely studied group of disorders where an excess of apoptosis has been implicated. |
1997-11-13 |
2023-08-12 |
Not clear |
| M Yaar, B A Gilchres. Human melanocytes as a model system for studies of Alzheimer disease. Archives of dermatology. vol 133. issue 10. 1997-11-10. PMID:9382568. |
nerve growth factor, which has been reported to attenuate the loss of cholinergic neurons in alzheimer disease, protects melanocytes from apoptosis induced by beta-amyloid. |
1997-11-10 |
2023-08-12 |
human |
| H Adle-Biassette, L Wingertsmann, F J Authier, H Kondo, F Poron, C Héry, J Bell, M Tardieu, R Gherardi, F Gra. [Neuronal apoptosis in the central and peripheral nervous system in HIV infection]. Archives d'anatomie et de cytologie pathologiques. vol 45. issue 2-3. 1997-11-07. PMID:9382614. |
we demonstrated neuronal apoptosis in all aids cases and in the alzheimer's cases. |
1997-11-07 |
2023-08-12 |
human |
| U Giambarella, T Yamatsuji, T Okamoto, T Matsui, T Ikezu, Y Murayama, M A Levine, A Katz, N Gautam, I Nishimot. G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP. The EMBO journal. vol 16. issue 16. 1997-10-17. PMID:9305632. |
g protein betagamma complex-mediated apoptosis by familial alzheimer's disease mutant of app. |
1997-10-17 |
2023-08-12 |
Not clear |
| J Li, M Xu, H Zhou, J Ma, H Potte. Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell. vol 90. issue 5. 1997-10-16. PMID:9298903. |
we discuss a pathogenic pathway for familial alzheimer's disease in which defective presenilin function causes chromosome missegregation during mitosis, resulting in apoptosis and/or trisomy 21 mosaicism. |
1997-10-16 |
2023-08-12 |
Not clear |
| K Sugaya, M Reeves, M McKinne. Topographic associations between DNA fragmentation and Alzheimer's disease neuropathology in the hippocampus. Neurochemistry international. vol 31. issue 2. 1997-09-02. PMID:9220460. |
to identify whether the process of apoptosis bears a topographic relationship to selected aspects of alzheimer's disease (ad) pathology, we used an in situ nick translation method (tunel) to map dna fragmentation in hippocampal sections immunostained for abnormally phosphorylated tau, which exists in the neurofibrillary tangles (nfts) and in the dystrophic neurites associated with senile plaques. |
1997-09-02 |
2023-08-12 |
human |
| S Vyas, F Javoy-Agid, M T Herrero, O Strada, F Boissiere, U Hibner, Y Agi. Expression of Bcl-2 in adult human brain regions with special reference to neurodegenerative disorders. Journal of neurochemistry. vol 69. issue 1. 1997-07-24. PMID:9202314. |
in patients with alzheimer's and parkinson's diseases, quantification of bcl-2 mrna in the nucleus basalis of meynert and substantia nigra, respectively, showed that the expression was unaltered compared with controls, raising the possibility that the expression of other components of apoptosis is modulated. |
1997-07-24 |
2023-08-12 |
mouse |
| L Zhang, B Zhao, D T Yew, J W Kusiak, G S Rot. Processing of Alzheimer's amyloid precursor protein during H2O2-induced apoptosis in human neuronal cells. Biochemical and biophysical research communications. vol 235. issue 3. 1997-07-24. PMID:9207249. |
processing of alzheimer's amyloid precursor protein during h2o2-induced apoptosis in human neuronal cells. |
1997-07-24 |
2023-08-12 |
human |
| L Zhang, B Zhao, D T Yew, J W Kusiak, G S Rot. Processing of Alzheimer's amyloid precursor protein during H2O2-induced apoptosis in human neuronal cells. Biochemical and biophysical research communications. vol 235. issue 3. 1997-07-24. PMID:9207249. |
the processing of alzheimer's amyloid precursor protein was studied by western blotting during h2o2 induced apoptosis in cultures of human neuroblastoma cells. |
1997-07-24 |
2023-08-12 |
human |
| L Zhang, B Zhao, D T Yew, J W Kusiak, G S Rot. Processing of Alzheimer's amyloid precursor protein during H2O2-induced apoptosis in human neuronal cells. Biochemical and biophysical research communications. vol 235. issue 3. 1997-07-24. PMID:9207249. |
the results suggest a possible vicious cycle involving h2o2, a beta and apoptosis which may contribute to the neuronal death mechanism in alzheimer's disease. |
1997-07-24 |
2023-08-12 |
human |
| I Kruman, A J Bruce-Keller, D Bredesen, G Waeg, M P Mattso. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 13. 1997-07-17. PMID:9185546. |
oxidative stress is believed to play important roles in neuronal cell death associated with many different neurodegenerative conditions (e.g., alzheimer's disease, parkinson's disease, and cerebral ischemia), and it is believed also that apoptosis is an important mode of cell death in these disorders. |
1997-07-17 |
2023-08-12 |
rat |
| E Lacanà, J K Ganjei, P Vito, L D'Adami. Dissociation of apoptosis and activation of IL-1beta-converting enzyme/Ced-3 proteases by ALG-2 and the truncated Alzheimer's gene ALG-3. Journal of immunology (Baltimore, Md. : 1950). vol 158. issue 11. 1997-06-19. PMID:9164928. |
dissociation of apoptosis and activation of il-1beta-converting enzyme/ced-3 proteases by alg-2 and the truncated alzheimer's gene alg-3. |
1997-06-19 |
2023-08-12 |
mouse |