| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mansour Haidar, Benjamin Schmid, Agustín Ruiz, Andreas Ebneth, Alfredo Cabrera-Socorr. Generation of three isogenic, gene-edited iPSC lines carrying the APOE-Christchurch mutation into the three common APOE variants: APOE2Ch, APOE3Ch and APOE4Ch. Stem cell research. vol 77. 2024-05-04. PMID:38703665. |
late-onset alzheimer's disease (ad) has become the paradigm of a non-mendelian complex neurodegenerative disease, for which a major genetic determinant is known, the apoe locus. |
2024-05-04 |
2024-05-07 |
Not clear |
| Conner Frank, Abigail Albertazzi, Claire Murph. The effect of the apolipoprotein E ε4 allele and olfactory function on odor identification networks. Brain and behavior. vol 14. issue 5. 2024-05-04. PMID:38702902. |
the combination of apolipoprotein e ε4 (apoe ε4) status, odor identification, and odor familiarity predicts conversion to mild cognitive impairment (mci) and alzheimer's disease (ad). |
2024-05-04 |
2024-05-06 |
Not clear |
| Lijuan Xu, Chao Ren, Chenxi Jing, Gang Wang, Hongchun Wei, Min Kong, Maowen B. Predicting amyloid-PET and clinical conversion in apolipoprotein E ε3/ε3 non-demented individuals with multidimensional factors. The European journal of neuroscience. 2024-05-03. PMID:38698692. |
the apolipoprotein e (apoe) ε4 is a well-established risk factor of amyloid-β (aβ) in alzheimer's disease (ad). |
2024-05-03 |
2024-05-05 |
Not clear |
| Zahra Shirzadi, Jasmeer Chhatwa. APOE Genotype and White Matter Hyperintensities in Sporadic Alzheimer Disease-Reply. JAMA neurology. 2024-04-29. PMID:38683603. |
apoe genotype and white matter hyperintensities in sporadic alzheimer disease-reply. |
2024-04-29 |
2024-05-02 |
Not clear |
| Saira Mirza, Tim Wilkinson, Mario Maselli. APOE Genotype and White Matter Hyperintensities in Sporadic Alzheimer Disease. JAMA neurology. 2024-04-29. PMID:38683620. |
apoe genotype and white matter hyperintensities in sporadic alzheimer disease. |
2024-04-29 |
2024-05-02 |
Not clear |
| Sachin P Patil, Bella R Kueh. Discovery of Small Molecule Glycolytic Stimulants for Enhanced ApoE Lipidation in Alzheimer's Disease Cell Model. Pharmaceuticals (Basel, Switzerland). vol 17. issue 4. 2024-04-27. PMID:38675451. |
discovery of small molecule glycolytic stimulants for enhanced apoe lipidation in alzheimer's disease cell model. |
2024-04-27 |
2024-04-29 |
human |
| Matthew W McMaster, Avisha Shah, John Kangarlu, Ryan Cheikhali, William H Frishman, Wilbert S Arono. The Impact of the Apolipoprotein E Genotype on Cardiovascular Disease and Cognitive Disorders. Cardiology in review. 2024-04-25. PMID:38661359. |
the impact of apoe on alzheimer's disease and a discussion of why it is possibly unrelated to ascvd prevention are included. |
2024-04-25 |
2024-04-28 |
Not clear |
| Lina Vandermeulen, Ivana Geric, Laura Fumagalli, Mohamed Kreir, Ashley Lu, Annelies Nonneman, Jessie Premereur, Leen Wolfs, Rafaela Policarpo, Nicola Fattorelli, An De Bondt, Ilse Van Den Wyngaert, Bob Asselbergh, Mark Fiers, Bart De Strooper, Constantin d'Ydewalle, Renzo Mancus. Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease. Molecular neurodegeneration. vol 19. issue 1. 2024-04-24. PMID:38654375. |
the discovery of genetic variants in genes predominately or exclusively expressed in myeloid cells, such as apolipoprotein e (apoe) and triggering receptor expressed on myeloid cells 2 (trem2), as the strongest risk factors for alzheimer's disease (ad) highlights the importance of microglial biology in the brain. |
2024-04-24 |
2024-04-26 |
human |
| Xueli Zhang, Zhuoting Zhu, Yu Huang, Xianwen Shang, Terence J O'Brien, Patrick Kwan, Jason Ha, Wei Wang, Shunming Liu, Xiayin Zhang, Katerina Kiburg, Yining Bao, Jing Wang, Honghua Yu, Mingguang He, Lei Zhan. Shared genetic aetiology of Alzheimer's disease and age-related macular degeneration by APOC1 and APOE genes. BMJ neurology open. vol 6. issue 1. 2024-04-22. PMID:38646507. |
shared genetic aetiology of alzheimer's disease and age-related macular degeneration by apoc1 and apoe genes. |
2024-04-22 |
2024-04-24 |
Not clear |
| Colleen Lacey, Theone Paterson, Jodie R Gawrylu. Impact of APOE-ε alleles on brain structure and cognitive function in healthy older adults: A VBM and DTI replication study. PloS one. vol 19. issue 4. 2024-04-18. PMID:38635499. |
the apolipoprotein e (apoe) gene has been established in the alzheimer's disease (ad) literature to impact brain structure and function and may also show congruent effects in healthy older adults, although findings in this population are much less consistent. |
2024-04-18 |
2024-04-21 |
Not clear |
| Dong Yan Zhang, Jian Wang, Gangtong Huang, Sara Langberg, Feng Ding, Nikolay V Dokholya. APOE regulates the transport of GM1. bioRxiv : the preprint server for biology. 2024-04-15. PMID:38617316. |
while the ε4 allele of apoe (apoe4) is associated with a significant genetic risk factor for late-onset alzheimer's disease (ad), no mechanistic understanding of its contribution to ad etiology has been established yet. |
2024-04-15 |
2024-04-17 |
Not clear |
| Haixu Ma, Zhuoyu Shi, Minjeong Kim, Bin Liu, Patrick J Smith, Yufeng Liu, Guorong W. Disentangling Sex-Dependent Effects of APOE on Diverse Trajectories of Cognitive Decline in Alzheimer's Disease. NeuroImage. 2024-04-13. PMID:38614371. |
disentangling sex-dependent effects of apoe on diverse trajectories of cognitive decline in alzheimer's disease. |
2024-04-13 |
2024-04-16 |
Not clear |
| Chiara Giuseppina Bonomi, Alessandro Martorana, Denise Fiorelli, Marzia Nuccetelli, Fabio Placidi, Nicola Biagio Mercuri, Caterina Mott. Constitutive NOS Production Is Modulated by Alzheimer's Disease Pathology Depending on APOE Genotype. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612537. |
constitutive nos production is modulated by alzheimer's disease pathology depending on apoe genotype. |
2024-04-13 |
2024-04-15 |
Not clear |
| Chiara Giuseppina Bonomi, Alessandro Martorana, Denise Fiorelli, Marzia Nuccetelli, Fabio Placidi, Nicola Biagio Mercuri, Caterina Mott. Constitutive NOS Production Is Modulated by Alzheimer's Disease Pathology Depending on APOE Genotype. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612537. |
we aimed to explore the relationship between amyloid pathology and no dynamics by comparing the cerebrospinal fluid (csf) levels of nnos and enos of 8 healthy controls (hc) and 27 patients with a clinical diagnosis of alzheimer's disease and isolated csf amyloid changes, stratified according to apoe ε genotype (apoe ε3 = 13, apoe ε4 = 14). |
2024-04-13 |
2024-04-15 |
Not clear |
| Natalia S Ogonowski, Luis M García-Marín, Amali S Fernando, Victor Flores-Ocampo, Miguel E Renterí. Impact of genetic predisposition to late-onset neurodegenerative diseases on early life outcomes and brain structure. Translational psychiatry. vol 14. issue 1. 2024-04-11. PMID:38605018. |
overall, our review found several studies focused on apoe haplotypes and alzheimer's risk, but a limited number of studies leveraging polygenic risk scores or focused on genetic susceptibility to other late-onset conditions. |
2024-04-11 |
2024-04-14 |
Not clear |
| Jordan N Williamson, Shirley A James, Sean P Mullen, Bradley P Sutton, Tracey Wszalek, Beni Mulyana, Peter Mukli, Andriy Yabluchanskiy, Yuan Yan. Sex differences in interacting genetic and functional connectivity biomarkers in Alzheimer's disease. GeroScience. 2024-04-10. PMID:38598069. |
the purpose of this study was to determine if the apoe genotype plays a role in the observed sex differences in hippocampal functional connectivity in alzheimer's disease. |
2024-04-10 |
2024-04-12 |
human |
| Sarah K Royse, Beth E Snitz, Ashley V Hill, Alexandria C Reese, Rebecca E Roush, M Ilyas Kamboh, Marnie Bertolet, Anum Saeed, Brian J Lopresti, Victor L Villemagne, Oscar L Lopez, Steven E Reis, James T Becker, Ann D Cohe. Apolipoprotein E and Alzheimer's disease pathology in African American older adults. Neurobiology of aging. vol 139. 2024-04-06. PMID:38582070. |
the apolipoprotein-e4 (apoe*4) and apolipoprotein-e2 (apoe*2) alleles are more common in african american versus non-hispanic white populations, but relationships of both alleles with alzheimer's disease (ad) pathology among african american individuals are unclear. |
2024-04-06 |
2024-04-10 |
human |
| Mason D Tate, Hande Karahan, Jungsu Ki. APOE loss of function: A genetic shield against Alzheimer's disease. Neuron. vol 112. issue 7. 2024-04-04. PMID:38574724. |
apoe loss of function: a genetic shield against alzheimer's disease. |
2024-04-04 |
2024-04-07 |
Not clear |
| Hannah E Ison, Mohammad Mowaswes, Ronen Durst, Thorsten Leucker, Joshua W Knowles, Emily E Brow. Is it time for a paradigm shift? Inclusion of APOE on genetic dyslipidemia panels. Journal of genetic counseling. 2024-03-29. PMID:38549201. |
despite these known associations, there is often hesitancy around ordering apoe genetic testing due to the association with alzheimer's disease. |
2024-03-29 |
2024-03-31 |
Not clear |
| Pin Wang, Wenxian Sun, Jin Gong, Xiaodong Han, Chang Xu, Yufei Chen, Yuting Yang, Heya Luan, Shaoqi Li, Ruina Li, Boye Wen, Sirong Lv, Runqi Chen, Jinxuan Guo, Cuibai We. Generation of human induced pluripotent stem cell line (XWHNi004-A) from a male with APOE gene mutation. Stem cell research. vol 77. 2024-03-29. PMID:38552354. |
genetic polymorphism of apolipoprotein e (apoe) confers differential susceptibility to alzheimer's disease (ad), and apoe ɛ4 variants is the most powerful risk factor for this disease. |
2024-03-29 |
2024-04-01 |
human |