| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Augustine Chemparathy, Yann Le Guen, Sunny Chen, Eun-Gyung Lee, Lesley Leong, John E Gorzynski, Tanner D Jensen, Alexis Ferrasse, Guangxue Xu, Hong Xiang, Michael E Belloy, Nandita Kasireddy, Andrés Peña-Tauber, Kennedy Williams, Ilaria Stewart, Lia Talozzi, Thomas S Wingo, James J Lah, Suman Jayadev, Chadwick M Hales, Elaine Peskind, Daniel D Child, Sigrun Roeber, C Dirk Keene, Le Cong, Euan A Ashley, Chang-En Yu, Michael D Greiciu. APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's disease pathology. Neuron. 2024-02-01. PMID:38301647. |
apoe loss-of-function variants: compatible with longevity and associated with resistance to alzheimer's disease pathology. |
2024-02-01 |
2024-02-04 |
Not clear |
| Augustine Chemparathy, Yann Le Guen, Sunny Chen, Eun-Gyung Lee, Lesley Leong, John E Gorzynski, Tanner D Jensen, Alexis Ferrasse, Guangxue Xu, Hong Xiang, Michael E Belloy, Nandita Kasireddy, Andrés Peña-Tauber, Kennedy Williams, Ilaria Stewart, Lia Talozzi, Thomas S Wingo, James J Lah, Suman Jayadev, Chadwick M Hales, Elaine Peskind, Daniel D Child, Sigrun Roeber, C Dirk Keene, Le Cong, Euan A Ashley, Chang-En Yu, Michael D Greiciu. APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's disease pathology. Neuron. 2024-02-01. PMID:38301647. |
the ε4 allele of apolipoprotein e (apoe) is the strongest genetic risk factor for sporadic alzheimer's disease (ad). |
2024-02-01 |
2024-02-04 |
Not clear |
| Veronika Matuskova, Katerina Veverova, Dylan J Jester, Vaclav Matoska, Zahinoor Ismail, Katerina Sheardova, Hana Horakova, Jiri Cerman, Jan Laczó, Ross Andel, Jakub Hort, Martin Vyhnale. Mild behavioral impairment in early Alzheimer's disease and its association with APOE and BDNF risk genetic polymorphisms. Alzheimer's research & therapy. vol 16. issue 1. 2024-01-26. PMID:38279143. |
mild behavioral impairment in early alzheimer's disease and its association with apoe and bdnf risk genetic polymorphisms. |
2024-01-26 |
2024-01-29 |
human |
| Michael R Strickland, Michael J Rau, Brock Summers, Katherine Basore, John Wulf, Hong Jiang, Yun Chen, Jason D Ulrich, Gwendalyn J Randolph, Rui Zhang, James A J Fitzpatrick, Anil G Cashikar, David M Holtzma. Apolipoprotein E secreted by astrocytes forms antiparallel dimers in discoidal lipoproteins. Neuron. 2024-01-24. PMID:38266643. |
the apolipoprotein e gene (apoe) is of great interest due to its role as a risk factor for late-onset alzheimer's disease. |
2024-01-24 |
2024-01-27 |
Not clear |
| Lucas Trevizani Rasmussen, Roger Willian de Labio, Mônica Pezenatto Dos Santos, Bruno Mari Fredi, Eduardo Federighi Baisi Chagas, Elizabeth Suchi Chen, Gustavo Turecki, Marília de Arruda Cardoso Smith, Spencer Luiz Marques Payã. Changes in Expression of Key Genes in Alzheimer's Disease: A Specific Brain Tissue Change. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024-01-24. PMID:38267766. |
in the present study, the expression of ten genes (app, ps1 and ps2, apoe, apba2, lrp1, grin2b, insr, gjb1, and ide) involved in the main pathways related to alzheimer's disease were analyzed in auditory cortices and cerebellum from 29 ad patients and 29 healthy older adult. |
2024-01-24 |
2024-01-27 |
Not clear |
| Valborg Gudmundsdottir, Elisabet Frick, Valur Emilsson, Thorarinn Jonmundsson, Anna Steindorsdottir, Erik C B Johnson, Raquel Puerta, Eric Dammer, Anantharaman Shantaraman, Amanda Cano, Merce Boada, Sergi Valero, Pablo Garcia-Gonzalez, Elias Gudmundsson, Alexander Gudjonsson, Rebecca Pitts, Xiazi Qiu, Nancy Finkel, Joseph Loureiro, Anthony Orth, Nicholas Seyfried, Allan Levey, Agustín Ruiz, Thor Aspelund, Lori Jennings, Lenore Launer, Vilmundur Gudnaso. Serum proteomics reveals APOE dependent and independent protein signatures in Alzheimer's disease. Research square. 2024-01-23. PMID:38260284. |
serum proteomics reveals apoe dependent and independent protein signatures in alzheimer's disease. |
2024-01-23 |
2024-01-25 |
Not clear |
| Cassandra Morrison, Michael D Oliver, Virginia Berry, Farooq Kamal, Mahsa Dada. The influence of APOE status on rate of cognitive decline. GeroScience. 2024-01-22. PMID:38253819. |
apolipoprotein (apoe) ɛ4 positivity and subjective cognitive decline (scd) both increase risk of alzheimer's disease (ad) development. |
2024-01-22 |
2024-01-25 |
Not clear |
| Melanie T Odenkirk, Xueyun Zheng, Jennifer E Kyle, Kelly G Stratton, Carrie D Nicora, Kent J Bloodsworth, Catriona A Mclean, Colin L Masters, Matthew E Monroe, James D Doecke, Richard D Smith, Kristin E Burnum-Johnson, Blaine R Roberts, Erin S Bake. Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer's Disease Across Distinct Brain Regions. Journal of proteome research. 2024-01-18. PMID:38236019. |
deciphering apoe genotype-driven proteomic and lipidomic alterations in alzheimer's disease across distinct brain regions. |
2024-01-18 |
2024-01-20 |
Not clear |
| L I Thompson, M Cummings, S Emrani, D J Libon, A Ang, C Karjadi, R Au, C Li. Digital Clock Drawing as an Alzheimer's Disease Susceptibility Biomarker: Associations with Genetic Risk Score and APOE in Older Adults. The journal of prevention of Alzheimer's disease. vol 11. issue 1. 2024-01-17. PMID:38230720. |
digital clock drawing as an alzheimer's disease susceptibility biomarker: associations with genetic risk score and apoe in older adults. |
2024-01-17 |
2024-01-19 |
Not clear |
| S M Pruntel, B C van Munster, J J de Vries, A Vissink, A Visse. Oral Health as a Risk Factor for Alzheimer Disease. The journal of prevention of Alzheimer's disease. vol 11. issue 1. 2024-01-17. PMID:38230738. |
4 theories could be distinguished that describe the possible links between oral health and the development or onset of alzheimer's disease; 1) role of pathogens, 2) role of inflammatory mediators, 3) role of apoe alleles and 4) role of aβ peptide. |
2024-01-17 |
2024-01-19 |
Not clear |
| Francisco C Almeida, Kalicharan Patra, Andreas Giannisis, Anezka Niesnerova, Renu Nandakumar, Ewa Ellis, Tiago Gil Oliveira, Henrietta M Nielse. APOE genotype dictates lipidomic signatures in primary human hepatocytes. Journal of lipid research. 2024-01-12. PMID:38216055. |
apolipoprotein e (apoe) genetic variants are most notably known for their divergent impact on the risk of developing alzheimer's disease. |
2024-01-12 |
2024-01-15 |
human |
| Meenakshisundaram Balasubramaniam, Jagadeesh Narasimhappagari, Ling Liu, Akshatha Ganne, Srinivas Ayyadevara, Ramani Atluri, Haarika Ayyadevara, Guy Caldwell, Robert J Shmookler Reis, Steven W Barger, W Sue T Griffi. Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer's disease by targeted small molecules. Communications biology. vol 7. issue 1. 2024-01-08. PMID:38191671. |
homozygosity for the ε4 allele of apoe increases the odds of developing alzheimer's by 12 to 15 times relative to the most common ε3;ε3 genotype, and its association with higher plaque loads comports with evidence that apoeε4 compromises autophagy. |
2024-01-08 |
2024-01-10 |
mouse |
| Jessica Blumenfeld, Oscar Yip, Min Joo Kim, Yadong Huan. Cell type-specific roles of APOE4 in Alzheimer disease. Nature reviews. Neuroscience. 2024-01-08. PMID:38191720. |
the ɛ4 allele of the apolipoprotein e gene (apoe), which translates to the apoe4 isoform, is the strongest genetic risk factor for late-onset alzheimer disease (ad). |
2024-01-08 |
2024-01-10 |
Not clear |
| Lisa Waterink, Larissa A Masselink, Sven J van der Lee, Leonie N C Visser, Solange Cleutjens, Jetske van der Schaar, Argonde C van Harten, Philip Scheltens, Sietske A M Sikkes, Wiesje M van der Flier, Marissa D Zwa. Interest in genetic susceptibility testing and disclosure of AD dementia risk in cognitively normal adults: a survey study. Alzheimer's research & therapy. vol 16. issue 1. 2024-01-03. PMID:38167083. |
apolipoprotein-e (apoe) genetic testing for alzheimer's disease is becoming more important as clinical trials are increasingly targeting individuals carrying apoe-ε4 alleles. |
2024-01-03 |
2024-01-06 |
Not clear |
| Daichi Shigemizu, Koya Fukunaga, Akiko Yamakawa, Mutsumi Suganuma, Kosuke Fujita, Tetsuaki Kimura, Ken Watanabe, Taisei Mushiroda, Takashi Sakurai, Shumpei Niida, Kouichi Ozak. The HLA-DRB1*09:01-DQB1*03:03 haplotype is associated with the risk for late-onset Alzheimer's disease in APOE [Formula: see text]4-negative Japanese adults. npj aging. vol 10. issue 1. 2024-01-03. PMID:38167405. |
the hla-drb1*09:01-dqb1*03:03 haplotype is associated with the risk for late-onset alzheimer's disease in apoe [formula: see text]4-negative japanese adults. |
2024-01-03 |
2024-01-06 |
human |
| Sergio Branciamore, Grigoriy Gogoshin, Andrei S Rodin, Amanda J Myer. The Human Brainome: changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with APOE E4 to alter risk for late onset Alzheimer's disease. Research square. 2024-01-03. PMID:38168398. |
the human brainome: changes in expression of vgf, specc1l, hla-dra and ranbp3l act with apoe e4 to alter risk for late onset alzheimer's disease. |
2024-01-03 |
2024-01-06 |
human |
| Ghazaleh Eskandari-Sedighi, Mathew Blurton-Jone. Microglial APOE4: more is less and less is more. Molecular neurodegeneration. vol 18. issue 1. 2023-12-20. PMID:38115077. |
apolipoprotein e (apoe) is the single greatest genetic risk factor for late onset alzheimer's disease (ad). |
2023-12-20 |
2023-12-23 |
Not clear |
| Mingyue He, Zhan Liu, Tenghong Lian, Peng Guo, Wenjing Zhang, Yue Huang, Yanan Zhang, Gaifen Liu, Weijiao Zhang, Jinghui Li, Huiying Guan, Weijia Zhang, Dongmei Luo, Jing Qi, Hao Yue, Xiaomin Wang, Wei Zhan. Role of nerve growth factor on cognitive impairment in patients with Alzheimer's disease carrying apolipoprotein E ε4. CNS neuroscience & therapeutics. 2023-12-19. PMID:38112032. |
to investigate the roles of neurotrophic factors on cognition in patients with alzheimer's disease (ad) carrying apolipoprotein e (apoe) ε4. |
2023-12-19 |
2023-12-21 |
Not clear |
| Darshak Gadara, Vratislav Berka, Zdenek Spaci. High-Throughput Microbore LC-MS Lipidomics to Investigate APOE Phenotypes. Analytical chemistry. 2023-12-19. PMID:38113351. |
as a proof of concept, μlc-ms/ms analysis of alzheimer's disease patient-derived ipsc cerebral organoid reveals differential lipid metabolism depending on apoe phenotype (e3/3 vs e4/4). |
2023-12-19 |
2023-12-23 |
Not clear |
| Jeffrey S Wefel, Snehal Deshmukh, Paul D Brown, David R Grosshans, Erik P Sulman, Jane H Cerhan, Minesh P Mehta, Deepak Khuntia, Wenyin Shi, Mark V Mishra, John H Suh, Nadia N Laack, Yuhchyau Chen, Amarinthia Amy Curtis, Joanna M Laba, Ahmed Elsayed, Anu Thakrar, Stephanie L Pugh, Deborah W Brune. Impact of Apolipoprotein E (APOE) Genotype on Neurocognitive Function (NCF) in Patients with Brain Metastasis (BM): An Analysis of NRG Oncology's RTOG 0614. International journal of radiation oncology, biology, physics. 2023-12-15. PMID:38101486. |
the e4 allele of the apolipoprotein e (apoe) gene is associated with increased risk of alzheimer's disease, and ncf decline associated with a variety of neurologic diseases and insults. |
2023-12-15 |
2023-12-18 |
Not clear |