| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hae Sol Moon, Ali Mahzarnia, Jacques Stout, Robert J Anderson, Madison Strain, Jessica T Tremblay, Zay Yar Han, Andrei Niculescu, Anna MacFarlane, Jasmine King, Allison Ashley-Koch, Darin Clark, Michael W Lutz, Alexandra Bade. Multivariate investigation of aging in mouse models expressing the Alzheimer's protective APOE2 allele: integrating cognitive metrics, brain imaging, and blood transcriptomics. Brain structure & function. 2023-12-13. PMID:38091051. |
apoe allelic variation is critical in brain aging and alzheimer's disease (ad). |
2023-12-13 |
2023-12-17 |
mouse |
| Braison Liemisa, Samantha F Newbury, Mariah J Novy, Jonathan A Pasato, Jose Morales-Corraliza, Katherine Y Peng, Paul M Mathew. Brain apolipoprotein E levels in mice challenged by a Western diet increase in an allele-dependent manner. Aging brain. vol 4. 2023-12-07. PMID:38058491. |
human apolipoprotein e (apoe) is the greatest determinant of genetic risk for memory deficits and alzheimer's disease (ad). |
2023-12-07 |
2023-12-10 |
mouse |
| Anna Rubinski, Anna Dewenter, Lukai Zheng, Nicolai Franzmeier, Henry Stephenson, Yuetiva Deming, Marco Duering, Benno Gesierich, Jannis Denecke, An-Vi Pham, Barbara Bendlin, Michael Ewer. Florbetapir PET-assessed demyelination is associated with faster tau accumulation in an APOE ε4-dependent manner. European journal of nuclear medicine and molecular imaging. 2023-12-04. PMID:38049659. |
the main objectives were to test whether (1) a decrease in myelin is associated with enhanced rate of fibrillar tau accumulation and cognitive decline in alzheimer's disease, and (2) whether apolipoprotein e (apoe) ε4 genotype is associated with worse myelin decrease and thus tau accumulation. |
2023-12-04 |
2023-12-10 |
Not clear |
| Julie Le Borgne, Philippe Amouyel, Ole Andreassen, Ruth Frikke-Schmidt, Mikko Hiltunen, Martin Ingelsson, Alfredo Ramirez, Giacomina Rossi, Agustin Ruiz, Pascual Sanchez-Juan, Rebecca Sims, Kristel Sleegers, Magda Tsolaki, Sven J van der Lee, Julie Williams, Jean-Charles Lambert, Céline Bellengue. Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-12-02. PMID:38041824. |
association of mgmt and bin1 genes with alzheimer's disease risk across sex and apoe ε4 status. |
2023-12-02 |
2023-12-10 |
Not clear |
| Matteo De Marco, Laura M Wright, Jose Manuel Valera Bermejo, Cameron E Ferguso. APOE ε4 positivity predicts centrality of episodic memory nodes in patients with mild cognitive impairment: A cohort-based, graph theory-informed study of cognitive networks. Neuropsychologia. 2023-12-01. PMID:38040087. |
as network neuroscience can capture the systemic impact of apoe variability at a neuroimaging level, this study investigated the network-based cognitive endophenotypes of ε4-carriers and non-carriers across the continuum between normal ageing and alzheimer's dementia (ad). |
2023-12-01 |
2023-12-10 |
Not clear |
| Yi Guan, Chia Hsin Cheng, Luis I Bellomo, Sriman Narain, Sherman J Bigornia, Mahdi O Garelnabi, Tammy Scott, José M Ordovás, Katherine L Tucker, Rafeeque Bhadelia, Bang-Bon Ko. APOE4 allele-specific associations between diet, multimodal biomarkers, and cognition among Puerto Rican adults in Massachusetts. Frontiers in aging neuroscience. vol 15. 2023-11-30. PMID:38035273. |
apolipoprotein e (apoe) is the strongest genetic risk factor for sporadic alzheimer's disease (ad), and the ε4 allele (apoe4) may interact with lifestyle factors that relate to brain structural changes, underlying the increased risk of ad. |
2023-11-30 |
2023-12-10 |
Not clear |
| Youssef Razouqi, Ihssane El Bouchikhi, Hassan El-Abid, Soukayna Baammi, Ayoub Nedbour, Ahmed Omar Touhami Ahami, Achraf El Allali, Laila Bouguenouc. Novel APOE Mutation in a Moroccan Subject Suffering from Alzheimer Disease: A Case Study and Exploration of Pathogenic Implication. Alzheimer disease and associated disorders. vol 37. issue 4. 2023-11-28. PMID:38015425. |
novel apoe mutation in a moroccan subject suffering from alzheimer disease: a case study and exploration of pathogenic implication. |
2023-11-28 |
2023-11-29 |
human |
| Emily Lewkowicz, Mari N Nakamura, Michael J Rynkiewicz, Olga Gursk. Molecular modeling of apoE in complexes with Alzheimer's amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. Cellular and molecular life sciences : CMLS. vol 80. issue 12. 2023-11-27. PMID:38010414. |
molecular modeling of apoe in complexes with alzheimer's amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. |
2023-11-27 |
2023-11-29 |
human |
| Emily Lewkowicz, Mari N Nakamura, Michael J Rynkiewicz, Olga Gursk. Molecular modeling of apoE in complexes with Alzheimer's amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. Cellular and molecular life sciences : CMLS. vol 80. issue 12. 2023-11-27. PMID:38010414. |
to understand how apoe interacts with alzheimer's amyloid-β (aβ) peptide in fibrillary deposits, the nmr structure of full-length human apoe was docked to four structures of patient-derived aβ |
2023-11-27 |
2023-11-29 |
human |
| Dongbing Lai, Michael Zhang, Rudong Li, Chi Zhang, Pengyue Zhang, Yunlong Liu, Sujuan Gao, Tatiana Forou. Identifying Genes Associated with Alzheimer's Disease Using Gene-Based Polygenic Risk Score. Journal of Alzheimer's disease : JAD. 2023-11-26. PMID:38007651. |
except apoe, alzheimer's disease (ad) associated genes identified in recent large-scale genome-wide association studies (gwas) had small effects and explained a small portion of heritability. |
2023-11-26 |
2023-11-28 |
Not clear |
| Yan-Bing Liu, Xue-Jie Wang, Lan Tan, Chen-Chen Tan, Wei X. PICALM Variation Moderates the Relationships of APOE ɛ4 with Alzheimer's Disease Cerebrospinal Biomarkers and Memory Function Among Non-Demented Population. Journal of Alzheimer's disease : JAD. 2023-11-26. PMID:38007652. |
picalm variation moderates the relationships of apoe ɛ4 with alzheimer's disease cerebrospinal biomarkers and memory function among non-demented population. |
2023-11-26 |
2023-11-28 |
Not clear |
| Yan-Bing Liu, Xue-Jie Wang, Lan Tan, Chen-Chen Tan, Wei X. PICALM Variation Moderates the Relationships of APOE ɛ4 with Alzheimer's Disease Cerebrospinal Biomarkers and Memory Function Among Non-Demented Population. Journal of Alzheimer's disease : JAD. 2023-11-26. PMID:38007652. |
apoe ɛ4 and picalm are established genes associated with risk of late-onset alzheimer's disease (ad). |
2023-11-26 |
2023-11-28 |
Not clear |
| Sheng-Min Wang, Dong Woo Kang, Yoo Hyun Um, Sunghwan Kim, Chang Uk Lee, Hyun Kook Li. Functional Connectivity Change Associated With Apolipoprotein E Allotypes Precedes Structural Connectivity and Neurodegeneration in Cognitive Normal Older Adults Without Cerebral Aβ Deposition. Psychiatry investigation. vol 20. issue 11. 2023-11-24. PMID:37997333. |
apolipoprotein e (apoe) gene is known to influence cerebral functional connectivity (fc) in alzheimer's disease continuum. |
2023-11-24 |
2023-11-29 |
Not clear |
| Alexandra Litvinchuk, Jung H Suh, Jing L Guo, Karin Lin, Sonnet S Davis, Nga Bien-Ly, Eric Tycksen, G Travis Tabor, Javier Remolina Serrano, Melissa Manis, Xin Bao, Choonghee Lee, Megan Bosch, Enmanuel J Perez, Carla M Yuede, Anil G Cashikar, Jason D Ulrich, Gilbert Di Paolo, David M Holtzma. Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist. Neuron. 2023-11-23. PMID:37995685. |
apolipoprotein e (apoe) is a strong genetic risk factor for late-onset alzheimer's disease (load). |
2023-11-23 |
2023-11-29 |
mouse |
| Do-Hoon Kim, Minyoung Oh, Jae Seung Ki. Prediction of Conversion from Mild Cognitive Impairment to Alzheimer's Disease Using Amyloid PET and Brain MR Imaging Data: A 48-Month Follow-Up Analysis of the Alzheimer's Disease Neuroimaging Initiative Cohort. Diagnostics (Basel, Switzerland). vol 13. issue 21. 2023-11-14. PMID:37958271. |
age, mini-mental state examination (mmse), cognitive subscale of the alzheimer's disease assessment scale (adas-cog), apolipoprotein e (apoe), standardized uptake value ratio (suvr), av45_bass, mr_bai, and shape feature were significantly different between converters and non-converters. |
2023-11-14 |
2023-11-20 |
Not clear |
| Qiang Chen, Luis Aguirre, Huanhuan Zhao, Felix Borrego, Itziar de Rojas, Lingyan Su, Pan P Li, Bao Zhang, Erzsebet Kokovay, James D Lechleiter, Harald H Göring, Philip L De Jager, Joel E Kleinman, Thomas M Hyde, Agustín Ruiz, Daniel R Weinberger, Sudha Seshadri, Liang M. Identification of a specific APOE transcript and functional elements associated with Alzheimer's disease. medRxiv : the preprint server for health sciences. 2023-11-14. PMID:37961425. |
identification of a specific apoe transcript and functional elements associated with alzheimer's disease. |
2023-11-14 |
2023-11-20 |
Not clear |
| Qiang Chen, Luis Aguirre, Huanhuan Zhao, Felix Borrego, Itziar de Rojas, Lingyan Su, Pan P Li, Bao Zhang, Erzsebet Kokovay, James D Lechleiter, Harald H Göring, Philip L De Jager, Joel E Kleinman, Thomas M Hyde, Agustín Ruiz, Daniel R Weinberger, Sudha Seshadri, Liang M. Identification of a specific APOE transcript and functional elements associated with Alzheimer's disease. medRxiv : the preprint server for health sciences. 2023-11-14. PMID:37961425. |
the apoe gene is the strongest genetic risk factor for late-onset alzheimer's disease (load). |
2023-11-14 |
2023-11-20 |
Not clear |
| Kevin Kirchner, Linda Garvert, Luise Kühn, Sarah Bonk, Hans Jörgen Grabe, Sandra Van der Auwer. Detrimental Effects of ApoE ε4 on Blood-Brain Barrier Integrity and Their Potential Implications on the Pathogenesis of Alzheimer's Disease. Cells. vol 12. issue 21. 2023-11-10. PMID:37947590. |
detrimental effects of apoe ε4 on blood-brain barrier integrity and their potential implications on the pathogenesis of alzheimer's disease. |
2023-11-10 |
2023-11-20 |
Not clear |
| Cassandra Morrison, Mahsa Dadar, Farooq Kamal, D Louis Collin. Differences in AD-related pathology profiles across APOE groups. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023-11-07. PMID:37935216. |
the apolipoprotein (apoe) ɛ4 allele is a risk factor for alzheimer's disease (ad), while the ɛ2 allele is thought to be protective against ad. |
2023-11-07 |
2023-11-20 |
human |
| Cassandra Morrison, Mahsa Dadar, Farooq Kamal, D Louis Collin. Differences in AD-related pathology profiles across APOE groups. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023-11-07. PMID:37935216. |
alzheimer's disease neuroimaging participants were divided into one of four apoe allele profiles (e4= ɛ4ɛ4 or ɛ3 ɛ4; e2= ɛ2ɛ2 or ɛ2ɛ3; e3= ɛ3ɛ3; or e24= ɛ2ɛ4). |
2023-11-07 |
2023-11-20 |
human |