| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad Haddadi, Mehrnaz Haghi, Niloofar Rezaei, Zahra Kiani, Taha Akkülah, Arzu Celi. APOE and Alzheimer's disease: Pathologic clues from transgenic Drosophila melanogaster. Archives of gerontology and geriatrics. vol 123. 2024-03-27. PMID:38537387. |
apoe and alzheimer's disease: pathologic clues from transgenic drosophila melanogaster. |
2024-03-27 |
2024-03-30 |
human |
| Masashi Fujita, Zongmei Gao, Lu Zeng, Cristin McCabe, Charles C White, Bernard Ng, Gilad Sahar Green, Orit Rozenblatt-Rosen, Devan Phillips, Liat Amir-Zilberstein, Hyo Lee, Richard V Pearse, Atlas Khan, Badri N Vardarajan, Krzysztof Kiryluk, Chun Jimmie Ye, Hans-Ulrich Klein, Gao Wang, Aviv Regev, Naomi Habib, Julie A Schneider, Yanling Wang, Tracy Young-Pearse, Sara Mostafavi, David A Bennett, Vilas Menon, Philip L De Jage. Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain. Nature genetics. 2024-03-22. PMID:38514782. |
a new variant influences apoe expression only in microglia and is associated with greater cerebral amyloid angiopathy but not alzheimer's disease pathology, after adjusting for apoeε4, providing mechanistic insights into both pathologies. |
2024-03-22 |
2024-03-24 |
Not clear |
| Rosemary J Jackson, Megan S Keiser, Jonah C Meltzer, Dustin P Fykstra, Steven E Dierksmeier, Soroush Hajizadeh, Johannes Kreuzer, Robert Morris, Alexandra Melloni, Tsuneo Nakajima, Luis Tecedor, Paul T Ranum, Ellie Carrell, YongHong Chen, Maryam A Nishtar, David M Holtzman, Wilhelm Haas, Beverly L Davidson, Bradley T Hyma. APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease. Molecular therapy : the journal of the American Society of Gene Therapy. 2024-03-20. PMID:38504517. |
epidemiological studies show that individuals who carry the relatively uncommon apoe ε2 allele rarely develop alzheimer disease, and if they do they have a later age of onset, milder clinical course, and less severe neuropathological findings. |
2024-03-20 |
2024-03-23 |
mouse |
| Rosemary J Jackson, Megan S Keiser, Jonah C Meltzer, Dustin P Fykstra, Steven E Dierksmeier, Soroush Hajizadeh, Johannes Kreuzer, Robert Morris, Alexandra Melloni, Tsuneo Nakajima, Luis Tecedor, Paul T Ranum, Ellie Carrell, YongHong Chen, Maryam A Nishtar, David M Holtzman, Wilhelm Haas, Beverly L Davidson, Bradley T Hyma. APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease. Molecular therapy : the journal of the American Society of Gene Therapy. 2024-03-20. PMID:38504517. |
the contrast is especially stark when compared with the major genetic risk factor for alzheimer disease, apoe ε4, which has an age of onset several decades earlier, a more aggressive clinical course and more severe neuropathological findings, especially in terms of the amount of amyloid deposition. |
2024-03-20 |
2024-03-23 |
mouse |
| Verena Heise, Alison Offer, William Whiteley, Clare E Mackay, Jane M Armitage, Sarah Paris. A comprehensive analysis of APOE genotype effects on human brain structure in the UK Biobank. Translational psychiatry. vol 14. issue 1. 2024-03-13. PMID:38472178. |
alzheimer's disease (ad) risk is increased in carriers of the apolipoprotein e (apoe) ε4 allele and decreased in ε2 allele carriers compared with the ε3ε3 genotype. |
2024-03-13 |
2024-03-15 |
human |
| Patrycja Dzianok, Ewa Kubli. PEARL-Neuro Database: EEG, fMRI, health and lifestyle data of middle-aged people at risk of dementia. Scientific data. vol 11. issue 1. 2024-03-07. PMID:38453963. |
here we describe a database that includes genetic data on apolipoprotein e (apoe) and phosphatidylinositol binding clathrin assembly protein (picalm) genes, both of which are known to increase the risk of late-onset alzheimer's disease, paired with psychometric (memory, intelligence, mood, personality, stress coping strategies), basic demographic and health data on a cohort of 192 healthy middle-aged (50-63) individuals. |
2024-03-07 |
2024-03-10 |
human |
| Xianfeng Yu, Xia Zhou, Zhengbo He, Beiqi He, Ke Wan, Min Wei, Tengfei Guo, Ying Ha. Sleep and APOE-ε4 have a synergistic effect on plasma biomarkers and longitudinal cognitive decline in older adults. CNS neuroscience & therapeutics. vol 30. issue 2. 2024-02-29. PMID:38421124. |
sleep disorders are prevalent among patients with alzheimer's disease (ad), and the apoe ε4 genotype is a key genetic risk factor for sporadic ad. |
2024-02-29 |
2024-03-02 |
Not clear |
| Rebecca Panitch, Nathan Sahelijo, Junming Hu, Kwangsik Nho, David A Bennett, Kathryn L Lunetta, Rhoda Au, Thor D Stein, Lindsay A Farrer, Gyungah R Ju. APOE genotype-specific methylation patterns are linked to Alzheimer disease pathology and estrogen response. Translational psychiatry. vol 14. issue 1. 2024-02-29. PMID:38424036. |
apoe genotype-specific methylation patterns are linked to alzheimer disease pathology and estrogen response. |
2024-02-29 |
2024-03-03 |
Not clear |
| Rebecca Panitch, Nathan Sahelijo, Junming Hu, Kwangsik Nho, David A Bennett, Kathryn L Lunetta, Rhoda Au, Thor D Stein, Lindsay A Farrer, Gyungah R Ju. APOE genotype-specific methylation patterns are linked to Alzheimer disease pathology and estrogen response. Translational psychiatry. vol 14. issue 1. 2024-02-29. PMID:38424036. |
the joint effects of apoe genotype and dna methylation on alzheimer disease (ad) risk is relatively unknown. |
2024-02-29 |
2024-03-03 |
Not clear |
| Mariana Nepomuceno, Paloma Monllor, Maria Jose Cardells, Artemis Ftara, Maria Magallon, Francisco Dasí, Mari Carmen Badia, Jose Viña, Ana Llore. Redox-associated changes in healthy individuals at risk of Alzheimer's disease. A ten-year follow-up study. Free radical biology & medicine. 2024-02-28. PMID:38417685. |
carrying an allele 4 of the apolipoprotein e (apoe) is the best-established genetic risk factor to develop alzheimer's disease (ad). |
2024-02-28 |
2024-03-02 |
Not clear |
| B Jolly, V Scari. Letter to the Editor: Alzheimer's Disease-Associated APOE ε4 Frequencies in Indian Population Genomes May Suggest Implications in Lecanemab Treatment. The journal of prevention of Alzheimer's disease. vol 11. issue 2. 2024-02-20. PMID:38374759. |
letter to the editor: alzheimer's disease-associated apoe ε4 frequencies in indian population genomes may suggest implications in lecanemab treatment. |
2024-02-20 |
2024-02-22 |
Not clear |
| Chantal M Ferguson, Samuel Hildebrand, Bruno M D C Godinho, Julianna Buchwald, Dimas Echeverria, Andrew Coles, Anastasia Grigorenko, Lorenc Vangjeli, Jacquelyn Sousa, Nicholas McHugh, Matthew Hassler, Francesco Santarelli, Michael T Heneka, Evgeny Rogaev, Anastasia Khvorov. Silencing Apoe with divalent-siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-02-20. PMID:38375983. |
silencing apoe with divalent-sirnas improves amyloid burden and activates immune response pathways in alzheimer's disease. |
2024-02-20 |
2024-02-22 |
Not clear |
| Hyug-Gi Kim, Yunan Tian, Sue Min Jung, Soonchan Park, Hak Young Rhee, Chang-Woo Ryu, Geon-Ho Jahn. Predicting the apolipoprotein E ε4 allele carrier status based on gray matter volumes and cognitive function. Brain and behavior. vol 14. issue 1. 2024-02-20. PMID:38376028. |
apolipoprotein e (apoe) ε4 carriers have a higher risk of developing alzheimer's disease (ad) and show brain atrophy and cognitive decline even before diagnosis. |
2024-02-20 |
2024-02-22 |
Not clear |
| Claudia Tato-Fernández, Laura L Ekblad, Elina Pietilä, Virva Saunavaara, Semi Helin, Riitta Parkkola, Henrik Zetterberg, Kaj Blennow, Juha O Rinne, Anniina Snellma. Cognitively healthy APOE4/4 carriers show white matter impairment associated with serum NfL and amyloid-PET. Neurobiology of disease. 2024-02-16. PMID:38365046. |
except for aging, carrying the apoe ε4 allele (apoe4) is the most important risk factor for sporadic alzheimer's disease. |
2024-02-16 |
2024-02-19 |
human |
| Ananthan Ambikairajah, Mizanur Khondoker, Edward Morris, Ann-Marie G de Lange, Rasha N M Saleh, Anne Marie Minihane, Michael Hornberge. Investigating the synergistic effects of hormone replacement therapy, apolipoprotein E and age on brain health in the UK Biobank. Human brain mapping. vol 45. issue 2. 2024-02-10. PMID:38339898. |
yet, the role of sex-specific risk factors during midlife, including hormone replacement therapy (hrt) and their interaction with other major risk factors for alzheimer's disease, such as apolipoprotein e (apoe)-e4 genotype and age, on brain health remains unclear. |
2024-02-10 |
2024-02-12 |
human |
| Ian A Windham, Alex E Powers, Joey V Ragusa, E Diane Wallace, Maria Clara Zanellati, Victoria H Williams, Colby H Wagner, Kristen K White, Sarah Cohe. APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size. The Journal of cell biology. vol 223. issue 4. 2024-02-09. PMID:38334983. |
the e4 variant of apoe strongly predisposes individuals to late-onset alzheimer's disease. |
2024-02-09 |
2024-02-11 |
Not clear |
| Ana-Caroline Raulin, Sydney V Doss, Michael G Heckman, Emily C Craver, Zonghua Li, Tadafumi C Ikezu, Hiroaki Sekiya, Chia-Chen Liu, Yuka A Martens, Cassandra L Rosenberg, Lindsey A Kuchenbecker, Michael DeTure, R Ross Reichard, Aivi T Nguyen, Eleni Constantopoulos, Rachel A Larsen, Emmaline K Kounaves, Melissa E Murray, Dennis W Dickson, Ronald C Petersen, Guojun Bu, Takahisa Kanekiy. Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease. Acta neuropathologica communications. vol 12. issue 1. 2024-02-09. PMID:38336940. |
impact of apoe on amyloid and tau accumulation in argyrophilic grain disease and alzheimer's disease. |
2024-02-09 |
2024-02-12 |
Not clear |
| Lauren Edwards, Kelsey R Thomas, Alexandra J Weigand, Emily C Edmonds, Alexandra L Clark, Einat K Brenner, Sarah J Banks, Paul E Gilbert, Daniel A Nation, Lisa Delano-Wood, Mark W Bondi, Katherine J Bange. Pulse pressure and APOE ε4 dose interact to affect cerebral blood flow in older adults without dementia. Cerebral circulation - cognition and behavior. vol 6. 2024-02-08. PMID:38328026. |
144 older adults without dementia from the alzheimer's disease neuroimaging initiative underwent arterial spin labeling and t1-weighted mri, apoe genotyping, fluorodeoxyglucose positron emission tomography (fdg-pet), lumbar puncture, and blood pressure (bp) assessment. |
2024-02-08 |
2024-02-10 |
human |
| Gillian K Carling, Li Fan, Nessa R Foxe, Kendra Norman, Pearly Ye, Man Ying Wong, Daphne Zhu, Fangmin Yu, Jielin Xu, Allan Yarahmady, Hao Chen, Yige Huang, Sadaf Amin, Emmanouil Zacharioudakis, Xiaoying Chen, David M Holtzman, Sue-Ann Mok, Evripidis Gavathiotis, Subhash C Sinha, Feixiong Cheng, Wenjie Luo, Shiaoching Gong, Li Ga. Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model. bioRxiv : the preprint server for biology. 2024-02-08. PMID:38328219. |
the strongest risk factors for alzheimer's disease (ad) include the χ4 allele of apolipoprotein e (apoe), the |
2024-02-08 |
2024-02-10 |
Not clear |
| Guillermo Santos-Sánchez, Eduardo Ponce-España, Ana Isabel Álvarez-López, Justo Pedroche, María Del Carmen Millán-Linares, María-Soledad Fernández-Pachón, Patricia Judith Lardone, Ivan Cruz-Chamorro, Antonio Carrillo-Vic. A lupin protein hydrolysate protects the central nervous system from oxidative stress in WD-fed ApoE Molecular nutrition & food research. 2024-02-03. PMID:38308501. |
a lupin protein hydrolysate protects the central nervous system from oxidative stress in wd-fed apoe oxidative stress plays a crucial role in neurodegenerative diseases like parkinson's and alzheimer's. |
2024-02-03 |
2024-02-05 |
human |