| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Demi C Galindo, William A Banks, Elizabeth M Rhe. The impact of acute rosiglitazone on insulin pharmacokinetics at the blood-brain barrier. Endocrinology, diabetes & metabolism. vol 3. issue 3. 2020-09-28. PMID:32704569. |
cns insulin levels are decreased and insulin receptor signalling is dampened in alzheimer's disease (ad). |
2020-09-28 |
2023-08-13 |
Not clear |
| Rajeev Taliyan, Sarathlal K Chandran, Violina Kakot. Therapeutic Approaches to Alzheimer's Type of Dementia: A Focus on FGF21 Mediated Neuroprotection. Current pharmaceutical design. vol 25. issue 23. 2020-04-16. PMID:31333086. |
with the identification of insulin and insulin receptors in some parts of the brain, it has become evident that certain metabolic conditions associated with insulin dysfunction like type 2 diabetes mellitus (t2dm), dyslipidemia, obesity etc., are also known to contribute to neurodegeneration mainly alzheimer's disease (ad). |
2020-04-16 |
2023-08-13 |
Not clear |
| Hilaree N Frazier, Adam O Ghoweri, Katie L Anderson, Ruei-Lung Lin, Nada M Porter, Olivier Thibaul. Broadening the definition of brain insulin resistance in aging and Alzheimer's disease. Experimental neurology. vol 313. 2020-02-24. PMID:30576640. |
following these discoveries, evidence of decreased brain insulin receptor number and function was reported in both clinical samples and animal models of aging and alzheimer's disease, setting the stage for the hypothesis that neuronal insulin resistance may underlie memory loss in these conditions. |
2020-02-24 |
2023-08-13 |
Not clear |
| Andre F Batista, Leticia Forny-Germano, Julia R Clarke, Natalia M Lyra E Silva, Jordano Brito-Moreira, Susan E Boehnke, Andrew Winterborn, Brian C Coe, Ann Lablans, Juliana F Vital, Suelen A Marques, Ana Mb Martinez, Matthias Gralle, Christian Holscher, William L Klein, Jean-Christophe Houzel, Sergio T Ferreira, Douglas P Munoz, Fernanda G De Felic. The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease. The Journal of pathology. vol 245. issue 1. 2019-10-17. PMID:29435980. |
the diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of alzheimer's disease. |
2019-10-17 |
2023-08-13 |
mouse |
| Fernanda Crunfli, Caio Henrique Mazucanti, Ruan Carlos Macêdo de Moraes, Andressa Pereira Costa, Alice Cristina Rodrigues, Cristoforo Scavone, Andréa da Silva Torrã. NO-Dependent Akt Inactivation by S-Nitrosylation as a Possible Mechanism of STZ-Induced Neuronal Insulin Resistance. Journal of Alzheimer's disease : JAD. vol 65. issue 4. 2019-08-26. PMID:30149447. |
sporadic alzheimer's disease (sad) is associated with energy metabolism deficiency and impairment of insulin receptor (ir) signaling in the brain. |
2019-08-26 |
2023-08-13 |
rat |
| Ari Robinson, Irit Lubitz, Dana Atrakchi-Baranes, Avital Licht-Murava, Pavel Katsel, Derek Leroith, Sigal Liraz-Zaltsman, Vahram Haroutunian, Michal Schnaider Beer. Combination of Insulin with a GLP1 Agonist Is Associated with Better Memory and Normal Expression of Insulin Receptor Pathway Genes in a Mouse Model of Alzheimer's Disease. Journal of molecular neuroscience : MN. vol 67. issue 4. 2019-05-29. PMID:30635783. |
combination of insulin with a glp1 agonist is associated with better memory and normal expression of insulin receptor pathway genes in a mouse model of alzheimer's disease. |
2019-05-29 |
2023-08-13 |
mouse |
| P Katsel, P Roussos, M S Beeri, M A Gama-Sosa, S Gandy, S Khan, V Haroutunia. Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer's disease and normalized by treatment with anti-diabetic agents. PloS one. vol 13. issue 11. 2019-04-11. PMID:30383799. |
parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by alzheimer's disease and normalized by treatment with anti-diabetic agents. |
2019-04-11 |
2023-08-13 |
Not clear |
| Chelsea M Griffith, Tore Eid, Gregory M Rose, Peter R Patryl. Evidence for altered insulin receptor signaling in Alzheimer's disease. Neuropharmacology. vol 136. issue Pt B. 2019-01-17. PMID:29353052. |
evidence for altered insulin receptor signaling in alzheimer's disease. |
2019-01-17 |
2023-08-13 |
mouse |
| Giovanna Scapin, Venkata P Dandey, Zhening Zhang, Winifred Prosise, Alan Hruza, Theresa Kelly, Todd Mayhood, Corey Strickland, Clinton S Potter, Bridget Carraghe. Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature. vol 556. issue 7699. 2018-08-17. PMID:29512653. |
insulin receptor dysfunction has been associated with many diseases, including diabetes, cancer and alzheimer's disease. |
2018-08-17 |
2023-08-13 |
Not clear |
| João Paulo Almeida Dos Santos, Adriana Vizuete, Fernanda Hansen, Regina Biasibetti, Carlos-Alberto Gonçalve. Early and Persistent O-GlcNAc Protein Modification in the Streptozotocin Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 61. issue 1. 2018-07-13. PMID:29154269. |
brain protein o-glcnacylation is diminished in alzheimer's disease (ad), and ogt targets include proteins of the insulin-signaling pathway (e.g., insulin receptor susbtrate-1, irs-1). |
2018-07-13 |
2023-08-13 |
rat |
| N Rajasekar, Chandishwar Nath, Kashif Hanif, Rakesh Shukl. Intranasal Insulin Administration Ameliorates Streptozotocin (ICV)-Induced Insulin Receptor Dysfunction, Neuroinflammation, Amyloidogenesis, and Memory Impairment in Rats. Molecular neurobiology. vol 54. issue 8. 2018-07-09. PMID:27730514. |
alzheimer's disease (ad) is associated with reduced insulin level and impairment of insulin receptor (ir) signaling in the brain, which correlates to amyloid pathology, neuroinflammation, and synaptic neurotoxicity. |
2018-07-09 |
2023-08-13 |
rat |
| A Knezovic, A Loncar, J Homolak, U Smailovic, J Osmanovic Barilar, L Ganoci, N Bozina, P Riederer, Melita Salkovic-Petrisi. Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease? Journal of neural transmission (Vienna, Austria : 1996). vol 124. issue 6. 2018-03-20. PMID:28470423. |
rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic alzheimer's disease? |
2018-03-20 |
2023-08-13 |
rat |
| Shingo Ito, Michel Ménard, Trevor Atkinson, Leslie Brown, James Whitfield, Balu Chakravarth. Relative expression of the p75 neurotrophin receptor, tyrosine receptor kinase A, and insulin receptor in SH-SY5Y neuroblastoma cells and hippocampi from Alzheimer's disease patients. Neurochemistry international. vol 101. 2018-01-12. PMID:27693452. |
relative expression of the p75 neurotrophin receptor, tyrosine receptor kinase a, and insulin receptor in sh-sy5y neuroblastoma cells and hippocampi from alzheimer's disease patients. |
2018-01-12 |
2023-08-13 |
human |
| Mirna Ezzat Sorial, Nesrine Salah El Dine El Saye. Protective effect of valproic acid in streptozotocin-induced sporadic Alzheimer's disease mouse model: possible involvement of the cholinergic system. Naunyn-Schmiedeberg's archives of pharmacology. vol 390. issue 6. 2017-11-08. PMID:28188358. |
in recent studies, insulin receptor desensitization and disturbances in the downstream effects of insulin receptor signaling were observed in the brains of alzheimer's patients. |
2017-11-08 |
2023-08-13 |
mouse |
| Silke Herzer, Sascha Meldner, Klara Rehder, Hermann-Josef Gröne, Viola Nordströ. Lipid microdomain modification sustains neuronal viability in models of Alzheimer's disease. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27639375. |
decreased neuronal insulin receptor (ir) signaling in alzheimer's disease is suggested to contribute to synaptic loss and neurodegeneration. |
2017-10-25 |
2023-08-13 |
mouse |
| Jerzy Leszek, Elzbieta Trypka, Vadim V Tarasov, Ghulam Md Ashraf, Gjumrakch Alie. Type 3 Diabetes Mellitus: A Novel Implication of Alzheimers Disease. Current topics in medicinal chemistry. vol 17. issue 12. 2017-07-05. PMID:28049395. |
the brain of patients with alzheimer disease (ad) showed the evidence of reduced expression of insulin and neuronal insulin receptors, as compared with those of age-matched controls. |
2017-07-05 |
2023-08-13 |
Not clear |
| J Osmanovic Barilar, A Knezovic, E Grünblatt, P Riederer, M Salkovic-Petrisi. Nine-month follow-up of the insulin receptor signalling cascade in the brain of streptozotocin rat model of sporadic Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 4. 2015-12-16. PMID:25503661. |
nine-month follow-up of the insulin receptor signalling cascade in the brain of streptozotocin rat model of sporadic alzheimer's disease. |
2015-12-16 |
2023-08-13 |
rat |
| J Osmanovic Barilar, A Knezovic, E Grünblatt, P Riederer, M Salkovic-Petrisi. Nine-month follow-up of the insulin receptor signalling cascade in the brain of streptozotocin rat model of sporadic Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 4. 2015-12-16. PMID:25503661. |
sporadic alzheimer disease (sad) is associated with impairment of insulin receptor (ir) signalling in the brain. |
2015-12-16 |
2023-08-13 |
rat |
| Katrin Morgen, Lutz Frölic. The metabolism hypothesis of Alzheimer's disease: from the concept of central insulin resistance and associated consequences to insulin therapy. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 4. 2015-12-16. PMID:25673434. |
insulin and insulin receptors are widely distributed in the brain and are impaired in the post-mortem alzheimer brain. |
2015-12-16 |
2023-08-13 |
Not clear |
| Wei Wang, Liang Yang, Liming Tan, Xiaomei Wu, Bo Jiang, Xiangmin She. Arg972 insulin receptor substrate-1 polymorphism and risk and severity of Alzheimer's disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 21. issue 7. 2015-01-05. PMID:24589556. |
arg972 insulin receptor substrate-1 polymorphism and risk and severity of alzheimer's disease. |
2015-01-05 |
2023-08-12 |
Not clear |