| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akihiko Wada, Hiroki Yokoo, Toshihiko Yanagita, Hideyuki Kobayash. New twist on neuronal insulin receptor signaling in health, disease, and therapeutics. Journal of pharmacological sciences. vol 99. issue 2. 2006-05-03. PMID:16210778. |
defective insulin receptor signalings are associated with the dementia in normal aging and patients with age-related neurodegenerative diseases (e.g., alzheimer's disease); the cognitive impairment can be reversed with systemic administration of insulin in the euglycemic condition. |
2006-05-03 |
2023-08-12 |
Not clear |
| Melita Salkovic-Petrisic, Florian Tribl, Manuela Schmidt, Siegfried Hoyer, Peter Riedere. Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway. Journal of neurochemistry. vol 96. issue 4. 2006-04-06. PMID:16412093. |
the insulin-resistant brain state is related to late-onset sporadic alzheimer's disease, and alterations in the insulin receptor (ir) and its downstream phosphatidylinositol-3 kinase signalling pathway have been found in human brain. |
2006-04-06 |
2023-08-12 |
human |
| Lixia Zhao, Bruce Teter, Takashi Morihara, Giselle P Lim, Surendra S Ambegaokar, Oliver J Ubeda, Sally A Frautschy, Greg M Col. Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 49. 2005-07-07. PMID:15590928. |
insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for alzheimer's disease intervention. |
2005-07-07 |
2023-08-12 |
mouse |
| N Henneberg, S Hoye. Desensitization of the neuronal insulin receptor: a new approach in the etiopathogenesis of late-onset sporadic dementia of the Alzheimer type (SDAT)? Archives of gerontology and geriatrics. vol 21. issue 1. 2005-03-14. PMID:15374226. |
desensitization of the neuronal insulin receptor: a new approach in the etiopathogenesis of late-onset sporadic dementia of the alzheimer type (sdat)? |
2005-03-14 |
2023-08-12 |
Not clear |
| N Henneberg, S Hoye. Desensitization of the neuronal insulin receptor: a new approach in the etiopathogenesis of late-onset sporadic dementia of the Alzheimer type (SDAT)? Archives of gerontology and geriatrics. vol 21. issue 1. 2005-03-14. PMID:15374226. |
this led us to hypothesize that the abnormal reduction in glucose utilization found in alzheimer brains is preceded by a desensitization of cerebral insulin receptors which might be due to enhanced levels of stress factors such as cortisol and catecholamines. |
2005-03-14 |
2023-08-12 |
Not clear |
| Wei-Qin Zhao, Hui Chen, Michael J Quon, Daniel L Alko. Insulin and the insulin receptor in experimental models of learning and memory. European journal of pharmacology. vol 490. issue 1-3. 2004-11-03. PMID:15094074. |
furthermore, deterioration of insulin receptor signaling appears to be associated with aging-related brain degeneration such as the alzheimer's dementia and cognitive impairment in aged subjects suffering type 2 diabetes mellitus. |
2004-11-03 |
2023-08-12 |
human |
| Siegfried Hoye. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. European journal of pharmacology. vol 490. issue 1-3. 2004-11-03. PMID:15094078. |
glucose metabolism and insulin receptor signal transduction in alzheimer disease. |
2004-11-03 |
2023-08-12 |
Not clear |
| Siegfried Hoye. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. European journal of pharmacology. vol 490. issue 1-3. 2004-11-03. PMID:15094078. |
in early-onset familial alzheimer disease, the inhibition of neuronal insulin receptor function may be due to competitive binding of amyloid beta (abeta) to the insulin receptor. |
2004-11-03 |
2023-08-12 |
Not clear |
| Siegfried Hoye. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. European journal of pharmacology. vol 490. issue 1-3. 2004-11-03. PMID:15094078. |
in late-onset sporadic alzheimer disease, the neuronal insulin receptor may be desensitized by inhibition of receptor function at different sites by noradrenaline and/or cortisol, the levels of which both increase with increasing age. |
2004-11-03 |
2023-08-12 |
Not clear |
| Siegfried Hoye. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. European journal of pharmacology. vol 490. issue 1-3. 2004-11-03. PMID:15094078. |
as far as the metabolism of amyloid precursor protein (app) in late-onset sporadic alzheimer disease is concerned, neuronal insulin receptor dysfunction may result in the intracellular accumulation of abeta and in subsequent cellular damage. |
2004-11-03 |
2023-08-12 |
Not clear |
| Siegfried Hoye. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. European journal of pharmacology. vol 490. issue 1-3. 2004-11-03. PMID:15094078. |
in this context, the desensitization of the neuronal insulin receptor in late-onset sporadic alzheimer disease is different from that occurring in normal aging and early-onset familial alzheimer disease. |
2004-11-03 |
2023-08-12 |
Not clear |
| Ling Xie, Erik Helmerhorst, Kevin Taddei, Brian Plewright, Wilhelm Van Bronswijk, Ralph Martin. Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 10. 2002-05-29. PMID:12006603. |
alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor. |
2002-05-29 |
2023-08-12 |
Not clear |
| S Hoyer, S K Lee, T Löffler, R Schlieb. Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease? Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193160. |
it has been hypothesized that a central even in the early pathogenesis of sporadic alzheimer disease (sad) is the dysfunction of the neuronal insulin receptor signal transduction. |
2001-02-08 |
2023-08-12 |
Not clear |
| L Frölich, D Blum-Degen, P Riederer, S Hoye. A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease. Annals of the New York Academy of Sciences. vol 893. 2000-02-25. PMID:10672251. |
a disturbance in the neuronal insulin receptor signal transduction in sporadic alzheimer's disease. |
2000-02-25 |
2023-08-12 |
human |
| H Lannert, S Hoye. Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats. Behavioral neuroscience. vol 112. issue 5. 1999-01-26. PMID:9829797. |
drastic abnormalities have been demonstrated to occur in cerebral glucose and energy metabolism in sporadic alzheimer's disease, pointing to a primary disturbance in neuronal insulin and insulin receptor signal transduction and contributing to the causation of dementia. |
1999-01-26 |
2023-08-12 |
rat |
| S Hoye. Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis. Journal of neural transmission (Vienna, Austria : 1996). vol 105. issue 4-5. 1998-10-30. PMID:9720971. |
this hypothesis is based on the findings of frölich and coworkers (this volume) who clearly demonstrate a perturbation of the neuronal insulin/ insulin receptor signal transduction pathway which is considered to be the pathobiochemical basis for the drastic reduction in glucose/energy metabolism in alzheimer brain. |
1998-10-30 |
2023-08-12 |
Not clear |
| L Frölich, D Blum-Degen, H G Bernstein, S Engelsberger, J Humrich, S Laufer, D Muschner, A Thalheimer, A Türk, S Hoyer, R Zöchling, K W Boissl, K Jellinger, P Riedere. Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 105. issue 4-5. 1998-10-30. PMID:9720972. |
brain insulin and insulin receptors in aging and sporadic alzheimer's disease. |
1998-10-30 |
2023-08-12 |
human |
| L Frölich, D Blum-Degen, H G Bernstein, S Engelsberger, J Humrich, S Laufer, D Muschner, A Thalheimer, A Türk, S Hoyer, R Zöchling, K W Boissl, K Jellinger, P Riedere. Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 105. issue 4-5. 1998-10-30. PMID:9720972. |
to detect changes in the functional activity of the brain insulin neuromodulatory system of sdat patients, we determined the concentrations of insulin and c-peptide as well as insulin receptor binding and igf-i receptor binding in several regions of postmortem brain cortex during aging and alzheimer's disease. |
1998-10-30 |
2023-08-12 |
human |
| D Blum-Degen, L Frölich, S Hoyer, P Riedere. Altered regulation of brain glucose metabolism as a cause of neurodegenerative disorders? Journal of neural transmission. Supplementum. vol 46. 1996-12-10. PMID:8821049. |
it will be the aim of our study to demonstrate whether there exist any changes in the content of insulin, its receptor and/or in the functionality of the insulin receptor and its signal transduction in neurodegenerative disorders as alzheimer's and parkinson's disease. |
1996-12-10 |
2023-08-12 |
Not clear |
| R Duelli, H Schröck, W Kuschinsky, S Hoye. Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 12. issue 8. 1995-06-14. PMID:7747600. |
the present data are in accordance with the hypothesis that an impairment in the control of neuronal glucose metabolism at the insulin receptor site may exist in sporadic dementia of alzheimer type (dat), and can be studied by the icv stz animal model. |
1995-06-14 |
2023-08-12 |
rat |