| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Wang, Liang Yang, Liming Tan, Xiaomei Wu, Bo Jiang, Xiangmin She. Arg972 insulin receptor substrate-1 polymorphism and risk and severity of Alzheimer's disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 21. issue 7. 2015-01-05. PMID:24589556. |
we explored the association between the arg972 insulin receptor substrate-1 (irs1) polymorphism and the risk and severity of alzheimer's disease (ad). |
2015-01-05 |
2023-08-12 |
Not clear |
| Ignacio Pedrós, Dmitry Petrov, Michael Allgaier, Francesc Sureda, Emma Barroso, Carlos Beas-Zarate, Carme Auladell, Mercè Pallàs, Manuel Vázquez-Carrera, Gemma Casadesús, Jaume Folch, Antoni Camin. Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease. Biochimica et biophysica acta. vol 1842. issue 9. 2014-09-25. PMID:24887203. |
the present study had focused on the behavioral phenotype and gene expression profile of molecules related to insulin receptor signaling in the hippocampus of 3 and 6 month-old appswe/ps1de9 (app/ps1) transgenic mouse model of alzheimer's disease (ad). |
2014-09-25 |
2023-08-13 |
mouse |
| Caitriona M Long-Smith, Sean Manning, Paula L McClean, Meghan F Coakley, Domhnall J O'Halloran, Christian Holscher, Cora O'Neil. The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease. Neuromolecular medicine. vol 15. issue 1. 2013-08-29. PMID:23011726. |
the diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of alzheimer's disease. |
2013-08-29 |
2023-08-12 |
mouse |
| Caitriona M Long-Smith, Sean Manning, Paula L McClean, Meghan F Coakley, Domhnall J O'Halloran, Christian Holscher, Cora O'Neil. The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease. Neuromolecular medicine. vol 15. issue 1. 2013-08-29. PMID:23011726. |
alzheimer's disease (ad) has been shown to involve desensitised insulin receptor (ir) signalling. |
2013-08-29 |
2023-08-12 |
mouse |
| Oliver Stöhr, Katharina Schilbach, Lorna Moll, Moritz M Hettich, Susanna Freude, F Thomas Wunderlich, Marianne Ernst, Johanna Zemva, Jens C Brüning, Wilhelm Krone, Michael Udelhoven, Markus Schuber. Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease. Age (Dordrecht, Netherlands). vol 35. issue 1. 2013-06-18. PMID:22057897. |
insulin receptor signaling mediates app processing and β-amyloid accumulation without altering survival in a transgenic mouse model of alzheimer's disease. |
2013-06-18 |
2023-08-12 |
mouse |
| Oliver Stöhr, Katharina Schilbach, Lorna Moll, Moritz M Hettich, Susanna Freude, F Thomas Wunderlich, Marianne Ernst, Johanna Zemva, Jens C Brüning, Wilhelm Krone, Michael Udelhoven, Markus Schuber. Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease. Age (Dordrecht, Netherlands). vol 35. issue 1. 2013-06-18. PMID:22057897. |
in brains from patients with alzheimer's disease (ad), expression of insulin receptor (ir), insulin-like growth factor-1 receptor (igf-1r), and insulin receptor substrate proteins is downregulated. |
2013-06-18 |
2023-08-12 |
mouse |
| Igor A Pomytki. H2O2 Signalling Pathway: A Possible Bridge between Insulin Receptor and Mitochondria. Current neuropharmacology. vol 10. issue 4. 2013-06-05. PMID:23730255. |
in this view, the accumulation of dysfunctional mitochondria during chronological ageing and alzheimer's disease (ad) is a risk factor that may contribute to the development of dysfunctional cerebral insulin receptor signalling and insulin resistance. |
2013-06-05 |
2023-08-12 |
Not clear |
| Helgi B Schiöth, Suzanne Craft, Samantha J Brooks, William H Frey, Christian Benedic. Brain insulin signaling and Alzheimer's disease: current evidence and future directions. Molecular neurobiology. vol 46. issue 1. 2013-01-31. PMID:22205300. |
since alzheimer's disease (ad) is linked to cns insulin resistance, decreased expression of insulin and insulin receptor genes and attenuated permeation of blood-borne insulin across the blood-brain barrier, impaired brain insulin signaling could partially account for the cognitive deficits associated with this disease. |
2013-01-31 |
2023-08-12 |
Not clear |
| Helgi B Schiöth, William H Frey, Samantha J Brooks, Christian Benedic. Insulin to treat Alzheimer's disease: just follow your nose? Expert review of clinical pharmacology. vol 5. issue 1. 2012-09-04. PMID:22142155. |
alzheimer's disease (ad) is linked to cns insulin resistance, decreased expression of insulin and insulin receptor genes, and lower cerebrospinal insulin levels. |
2012-09-04 |
2023-08-12 |
Not clear |
| Lap Ho, Shrishailam Yemul, Lindsay Knable, Pavel Katsel, Rudy Zhao, Vahram Haroutunian, Giulio Maria Pasinett. Insulin receptor expression and activity in the brains of nondiabetic sporadic Alzheimer's disease cases. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22666619. |
insulin receptor expression and activity in the brains of nondiabetic sporadic alzheimer's disease cases. |
2012-08-23 |
2023-08-12 |
Not clear |
| Masato Maesako, Kengo Uemura, Akira Kuzuya, Kazuki Sasaki, Megumi Asada, Kiwamu Watanabe, Koichi Ando, Masakazu Kubota, Haruhiko Akiyama, Ryosuke Takahashi, Takeshi Kihara, Shun Shimohama, Ayae Kinoshit. Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling. Journal of neurochemistry. vol 121. issue 6. 2012-08-14. PMID:22443192. |
we have recently reported that presenilin 1 (ps1), a causative gene of familial alzheimer disease (ad), down-regulates the expression level of insulin receptor (ir) as well as its signaling through a γ-secretase-independent pathway. |
2012-08-14 |
2023-08-12 |
mouse |
| Emilie Faivre, Alison Hamilton, Christian Hölsche. Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice. European journal of pharmacology. vol 674. issue 2-3. 2012-05-03. PMID:22115896. |
insulin receptor desensitisation has been found in alzheimer brains, which may be the underlying link. |
2012-05-03 |
2023-08-12 |
mouse |
| Xin Liu, Yi-na Zhang, Zong-yan Teng, Li-hong Jian. [Abnormal expression of insulin receptor induced by Aβ(1-42) in rat hippocampus neuron]. Zhonghua yi xue za zhi. vol 90. issue 41. 2011-09-15. PMID:21211393. |
to detect the expression change of insulin receptor under the induction of aβ(1-42) in rat hippocampus neuron and thus from the receptor level explore the disorder of central nervous insulin signaling and molecular mechanism of alzheimer's disease. |
2011-09-15 |
2023-08-12 |
rat |
| Graeme P William. The role of oestrogen in the pathogenesis of obesity, type 2 diabetes, breast cancer and prostate disease. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). vol 19. issue 4. 2011-02-16. PMID:20535861. |
this review, in collaboration with hundreds of evidence-based clinical researchers, correlates the significant interactions these hormones exert upon the upregulation of p450 aromatase, oestrogen, leptin and insulin receptor function; the normal status quo of their binding globulins; and how adduct formation alters dna sequencing to ultimately produce an array of metabolic conditions ranging from menopausal symptoms and obesity to alzheimer's disease and breast and prostate cancer. |
2011-02-16 |
2023-08-12 |
Not clear |
| Aileen M Moloney, Rebecca J Griffin, Suzanne Timmons, Rosemary O'Connor, Rivka Ravid, Cora O'Neil. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiology of aging. vol 31. issue 2. 2010-03-15. PMID:18479783. |
defects in igf-1 receptor, insulin receptor and irs-1/2 in alzheimer's disease indicate possible resistance to igf-1 and insulin signalling. |
2010-03-15 |
2023-08-12 |
Not clear |
| Rodrigo A Fuentealba, Qiang Liu, Takahisa Kanekiyo, Juan Zhang, Guojun B. Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway. The Journal of biological chemistry. vol 284. issue 49. 2009-12-22. PMID:19815552. |
these results demonstrate that lrp1 mediates anti-apoptotic function in neurons by regulating insulin receptor and the akt survival pathway and suggest that restoring lrp1 expression in alzheimer disease brain might be beneficial to inhibiting neurodegeneration. |
2009-12-22 |
2023-08-12 |
mouse |
| S Freude, K Schilbach, M Schuber. The role of IGF-1 receptor and insulin receptor signaling for the pathogenesis of Alzheimer's disease: from model organisms to human disease. Current Alzheimer research. vol 6. issue 3. 2009-08-19. PMID:19519303. |
the role of igf-1 receptor and insulin receptor signaling for the pathogenesis of alzheimer's disease: from model organisms to human disease. |
2009-08-19 |
2023-08-12 |
human |
| Zinaida I Storozheva, Andrey T Proshin, Vladimir V Sherstnev, Tatiana P Storozhevykh, Yana E Senilova, Nadezhda A Persiyantseva, Vsevolod G Pinelis, Natalia A Semenova, Elena I Zakharova, Igor A Pomytki. Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia. BMC pharmacology. vol 8. 2008-08-08. PMID:18215309. |
accumulated evidence suggests that insulin resistance and impairments in cerebral insulin receptor signaling may contribute to age-related cognitive deficits and alzheimer's disease. |
2008-08-08 |
2023-08-12 |
Not clear |
| Paola Castri, Luisa Iacovelli, Antonio De Blasi, Franco Giubilei, Arianna Moretti, Francesca Tari Capone, Ferdinando Nicoletti, Francesco Orz. Reduced insulin-induced phosphatidylinositol-3-kinase activation in peripheral blood mononuclear leucocytes from patients with Alzheimer's disease. The European journal of neuroscience. vol 26. issue 9. 2008-03-14. PMID:17986027. |
the epidemiological finding of an increased risk of dementia in patients with diabetes mellitus has raised the hypothesis that a dysfunction of the insulin receptors plays a role in the pathogenesis of alzheimer's disease (ad). |
2008-03-14 |
2023-08-12 |
human |
| M Moosavi, N Naghdi, N Maghsoudi, S Zahedi As. Insulin protects against stress-induced impairments in water maze performance. Behavioural brain research. vol 176. issue 2. 2007-03-02. PMID:17116337. |
a direct role of hippocampal insulin receptor signaling in improving cognitive functions, including learning and memory, and the association of insulin receptor deterioration with brain degenerative dementia (e.g., alzheimer's disease) have attracted increasing interest. |
2007-03-02 |
2023-08-12 |
Not clear |