| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisa Canepa, Silvia Fossat. Impact of Tau on Neurovascular Pathology in Alzheimer's Disease. Frontiers in neurology. vol 11. 2021-02-15. PMID:33488493. |
impact of tau on neurovascular pathology in alzheimer's disease. |
2021-02-15 |
2023-08-13 |
human |
| Hiroyuki Watanabe, Haruka Tatsumi, Sho Kaide, Yoichi Shimizu, Shimpei Iikuni, Masahiro On. Structure-Activity Relationships of Radioiodinated 6,5,6-Tricyclic Compounds for the Development of Tau Imaging Probes. ACS medicinal chemistry letters. vol 11. issue 2. 2021-02-13. PMID:32071677. |
tau aggregate, which is the main component of the neurofibrillary tangle, is an attractive imaging target for diagnosing and monitoring the progression of alzheimer's disease (ad). |
2021-02-13 |
2023-08-13 |
Not clear |
| Jean-Marc M Grandjean, Alexander Y Jiu, John W West, Atsushi Aoyagi, Daniel G Droege, Manuel Elepano, Makoto Hirasawa, Masakazu Hirouchi, Ryo Murakami, Joanne Lee, Koji Sasaki, Shimpei Hirano, Takao Ohyama, Benjamin C Tang, Roy J Vaz, Masahiro Inoue, Steven H Olson, Stanley B Prusiner, Jay Conrad, Nick A Para. Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity. ACS medicinal chemistry letters. vol 11. issue 2. 2021-02-13. PMID:32071678. |
tau prions feature in the brains of patients suffering from alzheimer's disease and other tauopathies. |
2021-02-13 |
2023-08-13 |
Not clear |
| Sarah L Morris, Ming-Ying Tsai, Sarah Aloe, Karin Bechberger, Svenja König, Gerardo Morfini, Scott T Brad. Defined Tau Phosphospecies Differentially Inhibit Fast Axonal Transport Through Activation of Two Independent Signaling Pathways. Frontiers in molecular neuroscience. vol 13. 2021-02-13. PMID:33568975. |
the at8 antibody recognizes a complex phosphoepitope site on tau that is detectable in a healthy brain but significantly increased in alzheimer's disease (ad) and other tauopathies. |
2021-02-13 |
2023-08-13 |
human |
| Anton Forsberg Morén, Andrea Varron. Timing is everything: tau imaging across stages of Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 9. 2021-02-12. PMID:32947616. |
timing is everything: tau imaging across stages of alzheimer's disease. |
2021-02-12 |
2023-08-13 |
Not clear |
| Shorena Janelidze, David Berron, Ruben Smith, Olof Strandberg, Nicholas K Proctor, Jeffrey L Dage, Erik Stomrud, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Oskar Hansso. Associations of Plasma Phospho-Tau217 Levels With Tau Positron Emission Tomography in Early Alzheimer Disease. JAMA neurology. vol 78. issue 2. 2021-02-12. PMID:33165506. |
associations of plasma phospho-tau217 levels with tau positron emission tomography in early alzheimer disease. |
2021-02-12 |
2023-08-13 |
Not clear |
| So Yamamoto, Tomoko Kayama, Moeko Noguchi-Shinohara, Tsuyoshi Hamaguchi, Masahito Yamada, Keiko Abe, Shoko Kobayash. Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway. NPJ science of food. vol 5. issue 1. 2021-02-12. PMID:33514742. |
rosmarinic acid (ra), a polyphenol found in lamiaceae herbs, is a candidate of preventive ingredients against alzheimer's disease (ad) as it potently suppresses the aggregation of amyloid β (aβ); however, the effect of ra on tau phosphorylation and cognitive dysfunction remains unclear. |
2021-02-12 |
2023-08-13 |
mouse |
| Karlen Gazarian, Luis Ramirez-Garcia, Luis Tapía Orozco, José Luna-Muñoz, Mar Pacheco-Herrer. Human Dental Pulp Stem Cells Display a Potential for Modeling Alzheimer Disease-Related Tau Modifications. Frontiers in neurology. vol 11. 2021-02-12. PMID:33569035. |
human dental pulp stem cells display a potential for modeling alzheimer disease-related tau modifications. |
2021-02-12 |
2023-08-13 |
human |
| Karlen Gazarian, Luis Ramirez-Garcia, Luis Tapía Orozco, José Luna-Muñoz, Mar Pacheco-Herrer. Human Dental Pulp Stem Cells Display a Potential for Modeling Alzheimer Disease-Related Tau Modifications. Frontiers in neurology. vol 11. 2021-02-12. PMID:33569035. |
the tau specificity of eight of these antibodies was confirmed by their affinity to neurofibrillary tangles (nfts) in alzheimer's disease (ad) postmortem brain samples. |
2021-02-12 |
2023-08-13 |
human |
| Qi Lu, Cheng Chen, Yuting Xiong, Guodong Li, Xiaofei Zhang, Yahui Zhang, Dongdong Wang, Zhichao Zhu, Xiuling Li, Guangyan Qing, Taolei Sun, Xinmiao Lian. High-Efficiency Phosphopeptide and Glycopeptide Simultaneous Enrichment by Hydrogen Bond-based Bifunctional Smart Polymer. Analytical chemistry. vol 92. issue 9. 2021-02-11. PMID:32233396. |
in particular, an interplay between phosphorylation and glycosylation regulates the hyperphosphorylation of protein tau, which is regarded as one of the pathologic features of alzheimer's disease (ad). |
2021-02-11 |
2023-08-13 |
Not clear |
| Simon M Bell, Matteo De Marco, Katy Barnes, Pamela J Shaw, Laura Ferraiuolo, Daniel J Blackburn, Heather Mortiboys, Annalena Venner. Deficits in Mitochondrial Spare Respiratory Capacity Contribute to the Neuropsychological Changes of Alzheimer's Disease. Journal of personalized medicine. vol 10. issue 2. 2021-02-11. PMID:32365522. |
alzheimer's disease (ad) is diagnosed using neuropsychological testing, supported by amyloid and tau biomarkers and neuroimaging abnormalities. |
2021-02-11 |
2023-08-13 |
human |
| Rui Xiong, Xiu-Ling Wang, Jian-Ming Wu, Yong Tang, Wen-Qiao Qiu, Xin Shen, Jin-Feng Teng, Rong Pan, Ya Zhao, Lu Yu, Jian Liu, Hai-Xia Chen, Da-Lian Qin, Chong-Lin Yu, An-Guo W. Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway. Journal of ethnopharmacology. vol 251. 2021-02-10. PMID:31917277. |
polyphenols isolated from lychee seed inhibit alzheimer's disease-associated tau through improving insulin resistance via the irs-1/pi3k/akt/gsk-3β pathway. |
2021-02-10 |
2023-08-13 |
rat |
| Rui Xiong, Xiu-Ling Wang, Jian-Ming Wu, Yong Tang, Wen-Qiao Qiu, Xin Shen, Jin-Feng Teng, Rong Pan, Ya Zhao, Lu Yu, Jian Liu, Hai-Xia Chen, Da-Lian Qin, Chong-Lin Yu, An-Guo W. Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway. Journal of ethnopharmacology. vol 251. 2021-02-10. PMID:31917277. |
our preliminary studies have proven that an active fraction derived from lychee seed (lsf) can significantly decrease the blood glucose level, inhibit amyloid-β (aβ) fibril formation and tau hyperphosphorylation, and improve the cognitive function and behavior of alzheimer's disease (ad) model rats. |
2021-02-10 |
2023-08-13 |
rat |
| Lidia Ciccone, Chenghui Shi, Davide di Lorenzo, Anne-Cécile Van Baelen, Nicolo Tonal. The Positive Side of the Alzheimer's Disease Amyloid Cross-Interactions: The Case of the Aβ 1-42 Peptide with Tau, TTR, CysC, and ApoA1. Molecules (Basel, Switzerland). vol 25. issue 10. 2021-02-10. PMID:32456156. |
the positive side of the alzheimer's disease amyloid cross-interactions: the case of the aβ 1-42 peptide with tau, ttr, cysc, and apoa1. |
2021-02-10 |
2023-08-13 |
Not clear |
| Lidia Ciccone, Chenghui Shi, Davide di Lorenzo, Anne-Cécile Van Baelen, Nicolo Tonal. The Positive Side of the Alzheimer's Disease Amyloid Cross-Interactions: The Case of the Aβ 1-42 Peptide with Tau, TTR, CysC, and ApoA1. Molecules (Basel, Switzerland). vol 25. issue 10. 2021-02-10. PMID:32456156. |
alzheimer's disease (ad) represents a progressive amyloidogenic disorder whose advancement is widely recognized to be connected to amyloid-β peptides and tau aggregation. |
2021-02-10 |
2023-08-13 |
Not clear |
| Dong-Yu Fan, Hao-Lun Sun, Pu-Yang Sun, Jie-Ming Jian, Wei-Wei Li, Ying-Ying Shen, Fan Zeng, Yan-Jiang Wang, Xian-Le B. The Correlations Between Plasma Fibrinogen With Amyloid-Beta and Tau Levels in Patients With Alzheimer's Disease. Frontiers in neuroscience. vol 14. 2021-02-10. PMID:33551734. |
the correlations between plasma fibrinogen with amyloid-beta and tau levels in patients with alzheimer's disease. |
2021-02-10 |
2023-08-13 |
Not clear |
| Kunie Ando, Sarah Houben, Mégane Homa, Marie-Ange de Fisenne, Marie-Claude Potier, Christophe Erneux, Jean-Pierre Brion, Karelle Lero. Alzheimer's Disease: Tau Pathology and Dysfunction of Endocytosis. Frontiers in molecular neuroscience. vol 13. 2021-02-10. PMID:33551742. |
alzheimer's disease: tau pathology and dysfunction of endocytosis. |
2021-02-10 |
2023-08-13 |
Not clear |
| Ana Claudia Amaral, Beatriz G Perez-Nievas, Michael Siao Tick Chong, Alicia Gonzalez-Martinez, Herminia Argente-Escrig, Sara Rubio-Guerra, Caitlin Commins, Serra Muftu, Bahareh Eftekharzadeh, Eloise Hudry, Zhanyun Fan, Prianca Ramanan, Shuko Takeda, Matthew P Frosch, Susanne Wegmann, Teresa Gomez-Isl. Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation. iScience. vol 24. issue 2. 2021-02-10. PMID:33554064. |
it has been suggested that aberrant activation of glycogen synthase kinase-3-beta (gsk-3β) can trigger abnormal tau hyperphosphorylation and aggregation, which ultimately leads to neuronal/synaptic damage and impaired cognition in alzheimer disease (ad). |
2021-02-10 |
2023-08-13 |
mouse |
| Julia van der Hoven, Annika van Hummel, Magdalena Przybyla, Prita R Asih, Mehul Gajwani, Astrid F Feiten, Yazi D Ke, Arne Ittner, Janet van Eersel, Lars M Ittne. Contribution of endogenous antibodies to learning deficits and astrocytosis in human P301S mutant tau transgenic mice. Scientific reports. vol 10. issue 1. 2021-02-09. PMID:32796905. |
antibodies have been explored extensively as a potential therapeutic for alzheimer's disease, where amyloid-β (aβ) peptides and the tau protein deposit in patient brains. |
2021-02-09 |
2023-08-13 |
mouse |
| Kenji Tagai, Maiko Ono, Manabu Kubota, Soichiro Kitamura, Keisuke Takahata, Chie Seki, Yuhei Takado, Hitoshi Shinotoh, Yasunori Sano, Yasuharu Yamamoto, Kiwamu Matsuoka, Hiroyuki Takuwa, Masafumi Shimojo, Manami Takahashi, Kazunori Kawamura, Tatsuya Kikuchi, Maki Okada, Haruhiko Akiyama, Hisaomi Suzuki, Mitsumoto Onaya, Takahiro Takeda, Kimihito Arai, Nobutaka Arai, Nobuyuki Araki, Yuko Saito, John Q Trojanowski, Virginia M Y Lee, Sushil K Mishra, Yoshiki Yamaguchi, Yasuyuki Kimura, Masanori Ichise, Yutaka Tomita, Ming-Rong Zhang, Tetsuya Suhara, Masahiro Shigeta, Naruhiko Sahara, Makoto Higuchi, Hitoshi Shimad. High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and Non-Alzheimer's Disease Tauopathies. Neuron. vol 109. issue 1. 2021-02-09. PMID:33125873. |
high-contrast in vivo imaging of tau pathologies in alzheimer's and non-alzheimer's disease tauopathies. |
2021-02-09 |
2023-08-13 |
Not clear |