| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Zhang, Jiaying Lu, Min Wang, Chuantao Zuo, Jiehui Jian. Influence of Gender on Tau Precipitation in Alzheimer's Disease According to ATN Research Framework. Phenomics (Cham, Switzerland). vol 3. issue 6. 2024-01-15. PMID:38223687. |
tau proteins accumulation and their spreading pattern were affected by gender in cognitive impairment patients, especially in the progression of alzheimer's disease (ad). |
2024-01-15 |
2024-01-17 |
Not clear |
| Chen Hai-Chao, Cao Jia-Xin, Zhang Yi-Shu, Ma Yue-Zhang, Zhang Lu, Su Xiao-Mei, Gao Li-Ping, Jing Yu- Hon. High salt diet exacerbates cognitive deficits and neurovascular abnormalities in APP/PS1 mice and induces AD-like changes in wild-type mice. The Journal of nutritional biochemistry. 2024-01-13. PMID:38218348. |
although clinical data do not clearly indicate the relationship between hsd and the prevalence of alzheimer's disease (ad), animal experiments have shown that hsd can cause hyperphosphorylation of tau protein and cognition impairment. |
2024-01-13 |
2024-01-16 |
mouse |
| Wei Ma, Kui Lu, Hua-Min Liang, Jin-Yuan Zhan. Synapsin 1 Ameliorates Cognitive Impairment and Neuroinflammation in Rats with Alzheimer's Disease: An Experimental and Bioinformatics Study. Current Alzheimer research. 2024-01-12. PMID:38213171. |
alzheimer's disease (ad) is a persistent neuropathological injury that manifests via neuronal/synaptic death, age spot development, tau hyperphosphorylation, neuroinflammation, and apoptosis. |
2024-01-12 |
2024-01-14 |
rat |
| Mridula Bhalla, C Justin Le. Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state. Molecular brain. vol 17. issue 1. 2024-01-12. PMID:38216963. |
alzheimer's disease (ad) is characterized by the loss of memory due to aggregation of misphosphorylated tau and amyloid beta (aβ) plaques in the brain, elevated release of inhibitory neurotransmitter gamma-aminobutyric acid (gaba) and reactive oxygen species from astrocytes, and subsequent neurodegeneration. |
2024-01-12 |
2024-01-15 |
mouse |
| Florence Haut, Elentina K Argyrousi, Ottavio Aranci. Re-Arranging the Puzzle between the Amyloid-Beta and Tau Pathology: An APP-Centric Approach. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203429. |
after several years of research in the field of alzheimer's disease (ad), it is still unclear how amyloid-beta (aβ) and tau, two key hallmarks of the disease, mediate the neuropathogenic events that lead to ad. |
2024-01-11 |
2024-01-13 |
Not clear |
| Augusto J Mendes, Federica Ribaldi, Aurelien Lathuiliere, Nicholas J Ashton, Shorena Janelidze, Henrik Zetterberg, Max Scheffler, Frédéric Assal, Valentina Garibotto, Kaj Blennow, Oskar Hansson, Giovanni B Frison. Head-to-head study of diagnostic accuracy of plasma and cerebrospinal fluid p-tau217 versus p-tau181 and p-tau231 in a memory clinic cohort. Journal of neurology. 2024-01-10. PMID:38195896. |
phosphorylated tau (p-tau) 217 has recently received attention because it seems more reliable than other p-tau variants for identifying alzheimer's disease (ad) pathology. |
2024-01-10 |
2024-01-13 |
Not clear |
| Geoffrey Canet, Emma Rocaboy, Francis Laliberté, Emmanuelle Boscher, Isabelle Guisle, Sofia Diego-Diaz, Parissa Fereydouni-Forouzandeh, Robert A Whittington, Sébastien S Hébert, Vincent Pernet, Emmanuel Plane. Temperature-induced Artifacts in Tau Phosphorylation: Implications for Reliable Alzheimer's Disease Research. Experimental neurobiology. vol 32. issue 6. 2024-01-10. PMID:38196137. |
temperature-induced artifacts in tau phosphorylation: implications for reliable alzheimer's disease research. |
2024-01-10 |
2024-01-13 |
mouse |
| Geoffrey Canet, Emma Rocaboy, Francis Laliberté, Emmanuelle Boscher, Isabelle Guisle, Sofia Diego-Diaz, Parissa Fereydouni-Forouzandeh, Robert A Whittington, Sébastien S Hébert, Vincent Pernet, Emmanuel Plane. Temperature-induced Artifacts in Tau Phosphorylation: Implications for Reliable Alzheimer's Disease Research. Experimental neurobiology. vol 32. issue 6. 2024-01-10. PMID:38196137. |
in preclinical research on alzheimer's disease and related tauopathies, tau phosphorylation analysis is routinely employed in both cellular and animal models. |
2024-01-10 |
2024-01-13 |
mouse |
| Bram L van der Gaag, Natasja A C Deshayes, John J P Breve, John G J M Bol, Allert J Jonker, Jeroen J M Hoozemans, Jean-Philippe Courade, Wilma D J van de Ber. Distinct tau and alpha-synuclein molecular signatures in Alzheimer's disease with and without Lewy bodies and Parkinson's disease with dementia. Acta neuropathologica. vol 147. issue 1. 2024-01-10. PMID:38198008. |
distinct tau and alpha-synuclein molecular signatures in alzheimer's disease with and without lewy bodies and parkinson's disease with dementia. |
2024-01-10 |
2024-01-13 |
human |
| Tyler R Bell, Carol E Franz, Lisa T Eyler, Christine Fennema-Notestine, Olivia K Puckett, Stephen M Dorros, Matthew S Panizzon, Rahul C Pearce, Donald J Hagler, Michael J Lyons, Asad Beck, Jeremy A Elman, William S Kreme. Probable chronic pain, brain structure, and Alzheimer's plasma biomarkers in older men. The journal of pain. 2024-01-10. PMID:38199594. |
in this study, we provide one of the first assessments in humans, examining the associations of probable chronic pain with hippocampal volume, integrity of the locus coeruleus (lc)-an upstream site of tau deposition-and alzheimer's disease (ad)-related plasma biomarkers. |
2024-01-10 |
2024-01-13 |
mouse |
| Qiang Qiang, Loren Skudder-Hill, Tomoko Toyota, Zhe Huang, Wenshi Wei, Hiroaki Adach. CSF 14-3-3 zeta(ζ) isoform is associated with tau pathology and cognitive decline in Alzheimer's disease. Journal of the neurological sciences. vol 457. 2024-01-09. PMID:38194803. |
csf 14-3-3 zeta(ζ) isoform is associated with tau pathology and cognitive decline in alzheimer's disease. |
2024-01-09 |
2024-01-13 |
human |
| Qiang Qiang, Loren Skudder-Hill, Tomoko Toyota, Zhe Huang, Wenshi Wei, Hiroaki Adach. CSF 14-3-3 zeta(ζ) isoform is associated with tau pathology and cognitive decline in Alzheimer's disease. Journal of the neurological sciences. vol 457. 2024-01-09. PMID:38194803. |
previous studies demonstrated that 14-3-3ζ is deposited in the neurofibrillary tangles of alzheimer's disease (ad) brains, and that 14-3-3ζ interacts with tau from the purified neurofibrillary tangles of ad brain extract. |
2024-01-09 |
2024-01-13 |
human |
| Qiang Qiang, Loren Skudder-Hill, Tomoko Toyota, Zhe Huang, Wenshi Wei, Hiroaki Adach. CSF 14-3-3 zeta(ζ) isoform is associated with tau pathology and cognitive decline in Alzheimer's disease. Journal of the neurological sciences. vol 457. 2024-01-09. PMID:38194803. |
the present study examined the cerebrospinal fluid (csf) 14-3-3ζ levels of 719 participants from the alzheimer's disease neuroimaging initiative (adni), including cognitively normal (cn) participants, patients with mild cognitive impairment (mci) and patients with ad dementia, and aimed to identify whether csf 14-3-3ζ is associated with tau pathology. |
2024-01-09 |
2024-01-13 |
human |
| Lannah S Abasi, Nesreen Elathram, Manasi Movva, Amar Deep, Kevin D Corbett, Galia T Debelouchin. Phosphorylation regulates tau's phase separation behavior and interactions with chromatin. bioRxiv : the preprint server for biology. 2024-01-08. PMID:38187700. |
tau is a microtubule-associated protein often found in neurofibrillary tangles (nfts) in the brains of patients with alzheimer's disease (ad). |
2024-01-08 |
2024-01-10 |
Not clear |
| Kevin P Kotredes, Ravi S Pandey, Scott Persohn, Kierra Elderidge, Charles P Burton, Ethan W Miner, Kathryn A Haynes, Diogo Francisco S Santos, Sean-Paul Williams, Nicholas Heaton, Cynthia M Ingraham, Christopher Lloyd, Dylan Garceau, Rita O'Rourke, Sarah Herrick, Claudia Rangel-Barajas, Surendra Maharjan, Nian Wang, Michael Sasner, Bruce T Lamb, Paul R Territo, Stacey J Sukoff Rizzo, Gregory W Carter, Gareth R Howell, Adrian L Obla. Characterizing Molecular and Synaptic Signatures in mouse models of Late-Onset Alzheimer's Disease Independent of Amyloid and Tau Pathology. bioRxiv : the preprint server for biology. 2024-01-08. PMID:38187716. |
characterizing molecular and synaptic signatures in mouse models of late-onset alzheimer's disease independent of amyloid and tau pathology. |
2024-01-08 |
2024-01-10 |
mouse |
| Samantha C Burnham, Leonardo Iaccarino, Michael J Pontecorvo, Adam S Fleisher, Ming Lu, Emily C Collins, Michael D Devou. A review of the flortaucipir literature for positron emission tomography imaging of tau neurofibrillary tangles. Brain communications. vol 6. issue 1. 2024-01-08. PMID:38187878. |
alzheimer's disease is defined by the presence of β-amyloid plaques and neurofibrillary tau tangles potentially preceding clinical symptoms by many years. |
2024-01-08 |
2024-01-10 |
Not clear |
| Lydia Jiang, Jessica Robin, Nathanael Shing, Negar Mazloum-Farzaghi, Natalia Ladyka-Wojcik, Niroja Balakumar, Nicole D Anderson, Jennifer D Ryan, Morgan D Barense, Rosanna K Olse. Impaired perceptual discrimination of complex objects in older adults at risk for dementia. Hippocampus. 2024-01-08. PMID:38189156. |
tau pathology accumulates in the perirhinal cortex (prc) of the medial temporal lobe (mtl) during the earliest stages of the alzheimer's disease (ad), appearing decades before clinical diagnosis. |
2024-01-08 |
2024-01-10 |
Not clear |
| Ping Wang, Audrey Lynn, Kristy Miskimen, Yeunjoo E Song, Thomas Wisniewski, Mark Cohen, Brian S Appleby, Jiri G Safar, Jonathan L Haine. Genome-wide association studies identify novel loci in rapidly progressive Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-01-07. PMID:38184787. |
recent data suggest that distinct prion-like amyloid beta and tau strains are associated with rapidly progressive alzheimer's disease (rpad). |
2024-01-07 |
2024-01-09 |
Not clear |
| Juan Lantero-Rodriguez, Laia Montoliu-Gaya, Andrea L Benedet, Agathe Vrillon, Julien Dumurgier, Emmanuel Cognat, Wagner S Brum, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Bruno Becker, Gunnar Brinkmalm, Anniina Snellman, Hanna Huber, Hlin Kvartsberg, Nicholas J Ashton, Henrik Zetterberg, Claire Paquet, Pedro Rosa-Neto, Kaj Blenno. CSF p-tau205: a biomarker of tau pathology in Alzheimer's disease. Acta neuropathologica. vol 147. issue 1. 2024-01-06. PMID:38184490. |
csf p-tau205: a biomarker of tau pathology in alzheimer's disease. |
2024-01-06 |
2024-01-09 |
human |
| Juan Lantero-Rodriguez, Laia Montoliu-Gaya, Andrea L Benedet, Agathe Vrillon, Julien Dumurgier, Emmanuel Cognat, Wagner S Brum, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Bruno Becker, Gunnar Brinkmalm, Anniina Snellman, Hanna Huber, Hlin Kvartsberg, Nicholas J Ashton, Henrik Zetterberg, Claire Paquet, Pedro Rosa-Neto, Kaj Blenno. CSF p-tau205: a biomarker of tau pathology in Alzheimer's disease. Acta neuropathologica. vol 147. issue 1. 2024-01-06. PMID:38184490. |
post-mortem staging of alzheimer's disease (ad) neurofibrillary pathology is commonly performed by immunohistochemistry using at8 antibody for phosphorylated tau (p-tau) at positions 202/205. |
2024-01-06 |
2024-01-09 |
human |