| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji Cheng, Brian J North, Tao Zhang, Xiangpeng Dai, Kaixiong Tao, Jianping Guo, Wenyi We. The emerging roles of protein homeostasis-governing pathways in Alzheimer's disease. Aging cell. vol 17. issue 5. 2019-09-12. PMID:29992725. |
while both aβ plaques and tau aggregates could in turn enhance the dysfunction of these proteostatic pathways, eventually leading to apoptotic or necrotic neuronal death and pathogenesis of alzheimer's disease. |
2019-09-12 |
2023-08-13 |
mouse |
| Azhar Hussain, Elsa S Tabrez, Adil Muhammad, Jagannadha Rao Peel. The Mechanisms of Dietary Phytoestrogen as a Potential Treatment and Prevention Agent against Alzheimer's Disease. Critical reviews in eukaryotic gene expression. vol 28. issue 4. 2019-09-12. PMID:30311580. |
this paper aims to contribute to the collective understanding of phytoestrogen's role in the treatment and prevention of alzheimer's disease by describing its various mechanisms, including its ability to decrease amyloid beta peptide production, promote calcium outflow and acetylcholine release, and reduce tau protein phosphorylation. |
2019-09-12 |
2023-08-13 |
Not clear |
| Fabrizio Biundo, Dolores Del Prete, Hong Zhang, Ottavio Arancio, Luciano D'Adami. A role for tau in learning, memory and synaptic plasticity. Scientific reports. vol 8. issue 1. 2019-09-09. PMID:29453339. |
tau plays a pivotal role in the pathogenesis of neurodegenerative disorders: mutations in the gene encoding for tau (mapt) are linked to fronto-temporal dementia (ftd) and hyper-phosphorylated aggregates of tau forming neurofibrillary tangles (nfts) that constitute a pathological hallmark of alzheimer disease (ad) and ftd. |
2019-09-09 |
2023-08-13 |
Not clear |
| Ulf Andreasson, Julia Kuhlmann, Josef Pannee, Robert M Umek, Erik Stoops, Hugo Vanderstichele, Anja Matzen, Manu Vandijck, Martine Dauwe, Andreas Leinenbach, Sandra Rutz, Erik Portelius, Ingrid Zegers, Henrik Zetterberg, Kaj Blenno. Commutability of the certified reference materials for the standardization of β-amyloid 1-42 assay in human cerebrospinal fluid: lessons for tau and β-amyloid 1-40 measurements. Clinical chemistry and laboratory medicine. vol 56. issue 12. 2019-09-09. PMID:29949507. |
the core alzheimer's disease cerebrospinal fluid (csf) biomarkers total tau (t-tau), phosphorylated tau (p-tau), β-amyloid 1-42 (aβ42) and β-amyloid 1-40 (aβ40) are increasing in importance and are now part of the research criteria for the diagnosis of the disease. |
2019-09-09 |
2023-08-13 |
human |
| M K Schultz, R Gentzel, M Usenovic, C Gretzula, C Ware, S Parmentier-Batteur, J B Schachter, H A Zariwal. Pharmacogenetic neuronal stimulation increases human tau pathology and trans-synaptic spread of tau to distal brain regions in mice. Neurobiology of disease. vol 118. 2019-09-09. PMID:30049665. |
in alzheimer's disease (ad), tau pathology has a spatiotemporally distinct pattern of progressive spread along anatomically connected neural pathways. |
2019-09-09 |
2023-08-13 |
mouse |
| Umesh Gangishetti, J Christina Howell, Richard J Perrin, Natalia Louneva, Kelly D Watts, Alexander Kollhoff, Murray Grossman, David A Wolk, Leslie M Shaw, John C Morris, John Q Trojanowski, Anne M Fagan, Steven E Arnold, William T H. Non-beta-amyloid/tau cerebrospinal fluid markers inform staging and progression in Alzheimer's disease. Alzheimer's research & therapy. vol 10. issue 1. 2019-09-09. PMID:30253800. |
alzheimer's disease (ad) is a complex neurodegenerative disorder characterized by neuropathologic changes involving beta-amyloid (aβ), tau, neuronal loss, and other associated biological events. |
2019-09-09 |
2023-08-13 |
Not clear |
| Qing-E Zhang, Sihai Ling, Peng Li, Saina Zhang, Chee H Ng, Gabor S Ungvari, Liang-Jen Wang, Sheng-Yu Lee, Gang Wang, Yu-Tao Xian. The association between urinary Alzheimer-associated neuronal thread protein and cognitive impairment in late-life depression: a controlled pilot study. International journal of biological sciences. vol 14. issue 11. 2019-09-09. PMID:30263001. |
accumulation of tau protein is associated with both alzheimer's disease (ad) and late-life depression (lld). |
2019-09-09 |
2023-08-13 |
human |
| Tina Ukmar-Godec, Saskia Hutten, Matthew P Grieshop, Nasrollah Rezaei-Ghaleh, Maria-Sol Cima-Omori, Jacek Biernat, Eckhard Mandelkow, Johannes Söding, Dorothee Dormann, Markus Zweckstette. Lysine/RNA-interactions drive and regulate biomolecular condensation. Nature communications. vol 10. issue 1. 2019-09-09. PMID:31266957. |
consistent with the ability of lysine to drive phase separation, lysine-rich variants of the alzheimer's disease-linked protein tau undergo coacervation with rna in vitro and bind to stress granules in cells. |
2019-09-09 |
2023-08-13 |
human |
| Melanie Das, Sumihiro Maeda, Bozhong Hu, Gui-Qiu Yu, Weikun Guo, Isabel Lopez, Xinxing Yu, Chao Tai, Xin Wang, Lennart Muck. Neuronal levels and sequence of tau modulate the power of brain rhythms. Neurobiology of disease. vol 117. 2019-09-06. PMID:29859869. |
the a152t-variant of human tau (htau-a152t) increases the risk of alzheimer's disease (ad) and several other tauopathies. |
2019-09-06 |
2023-08-13 |
mouse |
| Chelsea T Tiernan, Stephen D Ginsberg, Bin He, Sarah M Ward, Angela L Guillozet-Bongaarts, Nicholas M Kanaan, Elliott J Mufson, Scott E Count. Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's disease. Neurobiology of disease. vol 117. 2019-09-06. PMID:29859871. |
cholinergic basal forebrain neurons of the nucleus basalis of meynert (nbm) regulate attentional and memory function and are exquisitely prone to tau pathology and neurofibrillary tangle (nft) formation during the progression of alzheimer's disease (ad). |
2019-09-06 |
2023-08-13 |
Not clear |
| Bikash Choudhary, Eckhard Mandelkow, Eva-Maria Mandelkow, Ghulam Jeelani Pi. Glutamatergic nervous system degeneration in a C. elegans Tau Neurobiology of disease. vol 117. 2019-09-06. PMID:29894752. |
a recently identified tau variant, p.a152t, has been reported as a risk factor for frontotemporal dementia-related disorders and alzheimer disease. |
2019-09-06 |
2023-08-13 |
caenorhabditis_elegans |
| Peter Parbo, Rola Ismail, Michael Sommerauer, Morten G Stokholm, Allan K Hansen, Kim V Hansen, Ali Amidi, Jeppe L Schaldemose, Hanne Gottrup, Hans Brændgaard, Simon F Eskildsen, Per Borghammer, Rainer Hinz, Joel Aanerud, David J Brook. Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study. Neurobiology of disease. vol 117. 2019-09-06. PMID:29902557. |
does inflammation precede tau aggregation in early alzheimer's disease? |
2019-09-06 |
2023-08-13 |
Not clear |
| Peter Parbo, Rola Ismail, Michael Sommerauer, Morten G Stokholm, Allan K Hansen, Kim V Hansen, Ali Amidi, Jeppe L Schaldemose, Hanne Gottrup, Hans Brændgaard, Simon F Eskildsen, Per Borghammer, Rainer Hinz, Joel Aanerud, David J Brook. Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study. Neurobiology of disease. vol 117. 2019-09-06. PMID:29902557. |
our aim was to assess with positron emission tomography (pet) the temporal and spatial inter-relationships between levels of cortical microglial activation and the aggregated amyloid-β and tau load in mild cognitive impairment (mci) and early alzheimer's disease (ad). |
2019-09-06 |
2023-08-13 |
Not clear |
| Alexander K Foote, Lydia H Manger, Michael R Holden, Martin Margittai, Randall H Goldsmit. Time-resolved multirotational dynamics of single solution-phase tau proteins reveals details of conformational variation. Physical chemistry chemical physics : PCCP. vol 21. issue 4. 2019-09-05. PMID:30632561. |
single molecules of tau, an idp associated with alzheimer's disease, are trapped in solution using a microfluidic device, and a time-resolved fluorescence anisotropy decay is recorded for each molecule. |
2019-09-05 |
2023-08-13 |
Not clear |
| Heidi Martini-Stoica, Allysa L Cole, Daniel B Swartzlander, Fading Chen, Ying-Wooi Wan, Lakshya Bajaj, David A Bader, Virginia M Y Lee, John Q Trojanowski, Zhandong Liu, Marco Sardiello, Hui Zhen. TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. The Journal of experimental medicine. vol 215. issue 9. 2019-09-04. PMID:30108137. |
the progression of tau pathology in alzheimer's disease follows a stereotyped pattern, and recent evidence suggests a role of synaptic connections in this process. |
2019-09-04 |
2023-08-13 |
mouse |
| Heidi Martini-Stoica, Allysa L Cole, Daniel B Swartzlander, Fading Chen, Ying-Wooi Wan, Lakshya Bajaj, David A Bader, Virginia M Y Lee, John Q Trojanowski, Zhandong Liu, Marco Sardiello, Hui Zhen. TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. The Journal of experimental medicine. vol 215. issue 9. 2019-09-04. PMID:30108137. |
our study suggests that astrocytic tfeb plays a functional role in modulating extracellular tau and the propagation of neuronal tau pathology in tauopathies such as alzheimer's disease. |
2019-09-04 |
2023-08-13 |
mouse |
| Milan Stoiljkovic, Craig Kelley, Tamas L Horvath, Mihály Hajó. Neurophysiological signals as predictive translational biomarkers for Alzheimer's disease treatment: effects of donepezil on neuronal network oscillations in TgF344-AD rats. Alzheimer's research & therapy. vol 10. issue 1. 2019-08-30. PMID:30301466. |
translational research in alzheimer's disease (ad) pathology provides evidence that accumulation of amyloid-β and hyperphosphorylated tau, neuropathological hallmarks of ad, is associated with complex disturbances in synaptic and neuronal function leading to oscillatory abnormalities in the neuronal networks that support memory and cognition. |
2019-08-30 |
2023-08-13 |
rat |
| Petr Novak, Reinhold Schmidt, Eva Kontsekova, Branislav Kovacech, Tomas Smolek, Stanislav Katina, Lubica Fialova, Michal Prcina, Vojtech Parrak, Peter Dal-Bianco, Martin Brunner, Wolfgang Staffen, Michael Rainer, Matej Ondrus, Stefan Ropele, Miroslav Smisek, Roman Sivak, Norbert Zilka, Bengt Winblad, Michal Nova. FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer's disease. Alzheimer's research & therapy. vol 10. issue 1. 2019-08-30. PMID:30355322. |
fundamant: an interventional 72-week phase 1 follow-up study of aadvac1, an active immunotherapy against tau protein pathology in alzheimer's disease. |
2019-08-30 |
2023-08-13 |
Not clear |
| Petr Novak, Reinhold Schmidt, Eva Kontsekova, Branislav Kovacech, Tomas Smolek, Stanislav Katina, Lubica Fialova, Michal Prcina, Vojtech Parrak, Peter Dal-Bianco, Martin Brunner, Wolfgang Staffen, Michael Rainer, Matej Ondrus, Stefan Ropele, Miroslav Smisek, Roman Sivak, Norbert Zilka, Bengt Winblad, Michal Nova. FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer's disease. Alzheimer's research & therapy. vol 10. issue 1. 2019-08-30. PMID:30355322. |
neurofibrillary pathology composed of tau protein is closely correlated with severity and phenotype of cognitive impairment in patients with alzheimer's disease and non-alzheimer's tauopathies. |
2019-08-30 |
2023-08-13 |
Not clear |
| Petr Novak, Reinhold Schmidt, Eva Kontsekova, Branislav Kovacech, Tomas Smolek, Stanislav Katina, Lubica Fialova, Michal Prcina, Vojtech Parrak, Peter Dal-Bianco, Martin Brunner, Wolfgang Staffen, Michael Rainer, Matej Ondrus, Stefan Ropele, Miroslav Smisek, Roman Sivak, Norbert Zilka, Bengt Winblad, Michal Nova. FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer's disease. Alzheimer's research & therapy. vol 10. issue 1. 2019-08-30. PMID:30355322. |
targeting pathological tau proteins via immunotherapy is a promising strategy for disease-modifying treatment of alzheimer's disease. |
2019-08-30 |
2023-08-13 |
Not clear |