| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrés Norambuena, Horst Wallrabe, Rui Cao, Dora Bigler Wang, Antonia Silva, Zdenek Svindrych, Ammasi Periasamy, Song Hu, Rudolph E Tanzi, Doo Yeon Kim, George S Bloo. A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-β oligomers. The EMBO journal. vol 37. issue 22. 2019-10-01. PMID:30348864. |
amyloid-β oligomers, which are precursors of amyloid plaques in alzheimer's disease brain and stimulate mtorc1 protein kinase activity at the plasma membrane but not at lysosomes, block this nutrient-induced mitochondrial activity (nima) by a mechanism dependent on tau, which forms neurofibrillary tangles in alzheimer's disease brain. |
2019-10-01 |
2023-08-13 |
Not clear |
| Kenjiro On. Alzheimer's disease as oligomeropathy. Neurochemistry international. vol 119. 2019-09-30. PMID:28821400. |
alzheimer's disease (ad) is the most common age-related neurodegenerative disorder and is characterized by pathological aggregates of amyloid β-protein (aβ) and tau protein. |
2019-09-30 |
2023-08-13 |
mouse |
| Panagiotis Alexopoulos, Jennifer Roesler, Lukas Werle, Nathalie Thierjung, Iliana Lentzari, Marion Ortner, Timo Grimmer, Nikolaos Laskaris, Antonios Politis, Philippos Gourzis, Alexander Kurz, Robert Perneczk. Fluid biomarker agreement and interrelation in dementia due to Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 2. 2019-09-30. PMID:29143217. |
the cerebrospinal fluid (csf) levels of β-amyloid 42, total tau, and phosphorylated tau 181 are supposed to be all continuously abnormal in dementia due to alzheimer's disease (ad), being the most advanced disease stage. |
2019-09-30 |
2023-08-13 |
Not clear |
| Martina Radli, Stefan G D Rüdige. Dancing with the Diva: Hsp90-Client Interactions. Journal of molecular biology. vol 430. issue 18 Pt B. 2019-09-30. PMID:29782836. |
structural studies show interaction modes of hsp90 with the intrinsically disordered alzheimer's disease-causing protein tau, the kinase cdk4 in a partially unfolded state and the folded ligand-binding domain of a steroid receptor. |
2019-09-30 |
2023-08-13 |
Not clear |
| Annachiara Gandini, Manuela Bartolini, Daniele Tedesco, Loreto Martinez-Gonzalez, Carlos Roca, Nuria E Campillo, Josefa Zaldivar-Diez, Concepción Perez, Giampaolo Zuccheri, Andrea Miti, Alessandra Feoli, Sabrina Castellano, Sabrina Petralla, Barbara Monti, Martina Rossi, Fabio Moda, Giuseppe Legname, Ana Martinez, Maria Laura Bolognes. Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors. Journal of medicinal chemistry. vol 61. issue 17. 2019-09-30. PMID:30078314. |
several findings propose the altered tau protein network as an important target for alzheimer's disease (ad). |
2019-09-30 |
2023-08-13 |
Not clear |
| Anna Czarna, Jinhua Wang, Diana Zelencova, Yao Liu, Xianming Deng, Hwan Geun Choi, Tinghu Zhang, Wenjun Zhou, Jae Won Chang, Hanne Kildalsen, Ole Morten Seternes, Nathanael S Gray, Richard A Engh, Ulli Rothweile. Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors. Journal of medicinal chemistry. vol 61. issue 17. 2019-09-30. PMID:30095246. |
these inhibitors effectively block the tau phosphorylation that is a hallmark of alzheimer's disease. |
2019-09-30 |
2023-08-13 |
Not clear |
| David J Koss, Marina Dubini, Heather Buchanan, Claire Hull, Bettina Plat. Distinctive temporal profiles of detergent-soluble and -insoluble tau and Aβ species in human Alzheimer's disease. Brain research. vol 1699. 2019-09-30. PMID:30102892. |
distinctive temporal profiles of detergent-soluble and -insoluble tau and aβ species in human alzheimer's disease. |
2019-09-30 |
2023-08-13 |
human |
| David J Koss, Marina Dubini, Heather Buchanan, Claire Hull, Bettina Plat. Distinctive temporal profiles of detergent-soluble and -insoluble tau and Aβ species in human Alzheimer's disease. Brain research. vol 1699. 2019-09-30. PMID:30102892. |
alzheimer's disease (ad) pathology relevant proteins tau and beta-amyloid (aβ) exist as an array of post-translationally modified and conformationally altered species with varying abundance, solubility and toxicity. |
2019-09-30 |
2023-08-13 |
human |
| Koen Demaegd, Joost Schymkowitz, Frederic Roussea. Transcellular Spreading of Tau in Tauopathies. Chembiochem : a European journal of chemical biology. vol 19. issue 23. 2019-09-30. PMID:30133080. |
tau, a microtubule-associated protein playing a key role in a group of neurodegenerative diseases such as alzheimer's disease, spreads throughout the brain, inducing pathology. |
2019-09-30 |
2023-08-13 |
Not clear |
| Suzanne E Schindler, Julia D Gray, Brian A Gordon, Chengjie Xiong, Richard Batrla-Utermann, Marian Quan, Simone Wahl, Tammie L S Benzinger, David M Holtzman, John C Morris, Anne M Faga. Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 11. 2019-09-27. PMID:29501462. |
levels of amyloid β peptide 42 (aβ42), total tau, and phosphorylated tau-181 are well-established cerebrospinal fluid (csf) biomarkers of alzheimer's disease, but variability in manual plate-based assays has limited their use. |
2019-09-27 |
2023-08-13 |
Not clear |
| Sarah K Kaufman, Kelly Del Tredici, Talitha L Thomas, Heiko Braak, Marc I Diamon. Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer's disease and PART. Acta neuropathologica. vol 136. issue 1. 2019-09-27. PMID:29752551. |
tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in alzheimer's disease and part. |
2019-09-27 |
2023-08-13 |
human |
| Sarah K Kaufman, Kelly Del Tredici, Talitha L Thomas, Heiko Braak, Marc I Diamon. Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer's disease and PART. Acta neuropathologica. vol 136. issue 1. 2019-09-27. PMID:29752551. |
alzheimer's disease (ad) is characterized by accumulation of tau neurofibrillary tangles (nfts) and, according to the prion model, transcellular propagation of pathological "seeds" may underlie its progression. |
2019-09-27 |
2023-08-13 |
human |
| Maitrayee Sardar Sinha, Anna Ansell-Schultz, Livia Civitelli, Camilla Hildesjö, Max Larsson, Lars Lannfelt, Martin Ingelsson, Martin Hallbec. Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers. Acta neuropathologica. vol 136. issue 1. 2019-09-27. PMID:29934873. |
the gradual deterioration of cognitive functions in alzheimer's disease is paralleled by a hierarchical progression of amyloid-beta and tau brain pathology. |
2019-09-27 |
2023-08-13 |
Not clear |
| Nicholas J Ashton, Mark Ide, Michael Schöll, Kaj Blennow, Simon Lovestone, Abdul Hye, Henrik Zetterber. No association of salivary total tau concentration with Alzheimer's disease. Neurobiology of aging. vol 70. 2019-09-27. PMID:30007161. |
no association of salivary total tau concentration with alzheimer's disease. |
2019-09-27 |
2023-08-13 |
human |
| Dong Liu, Hanbing Lu, Elliot Stein, Zhujuan Zhou, Yihong Yang, Mark P Mattso. Brain regional synchronous activity predicts tauopathy in 3×TgAD mice. Neurobiology of aging. vol 70. 2019-09-27. PMID:30015035. |
alzheimer's disease (ad) is characterized by progressive cognitive impairment and by extensive neuronal loss associated with extracellular amyloid β-peptide (aβ) plaques and intraneuronal tau pathology in temporal and parietal lobes. |
2019-09-27 |
2023-08-13 |
mouse |
| Juan Antonio García-León, Alfredo Cabrera-Socorro, Kristel Eggermont, Ann Swijsen, Joke Terryn, Raheem Fazal, FatemehArefeh Nami, Laura Ordovás, Ana Quiles, Frederic Lluis, Lutgarde Serneels, Keimpe Wierda, Annerieke Sierksma, Mohamed Kreir, Francisco Pestana, Philip Van Damme, Bart De Strooper, Lieven Thorrez, Andreas Ebneth, Catherine M Verfailli. Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 10. 2019-09-27. PMID:30036493. |
tauopathies are neurodegenerative diseases characterized by tau protein-related pathology, including frontotemporal dementia and alzheimer's disease among others. |
2019-09-27 |
2023-08-13 |
human |
| Antonella Tramutola, Giulia Abate, Chiara Lanzillotta, Francesca Triani, Eugenio Barone, Federica Iavarone, Federica Vincenzoni, Massimo Castagnola, Mariagrazia Marziano, Maurizio Memo, Emirena Garrafa, D Allan Butterfield, Marzia Perluigi, Fabio Di Domenico, Daniela Ubert. Protein nitration profile of CD3 Free radical biology & medicine. vol 129. 2019-09-27. PMID:30321702. |
protein nitration profile of cd3 alzheimer's disease (ad) is a progressive form of dementia characterized by increased production of amyloid-β plaques and hyperphosphorylated tau protein, mitochondrial dysfunction, elevated oxidative stress, reduced protein clearance, among other. |
2019-09-27 |
2023-08-13 |
Not clear |
| Klaus Fließbach, Cornelia McCormick, Barbara Kaulen, Anja Schneide. [Anti-tau therapies-what can be expected?] Der Nervenarzt. vol 90. issue 9. 2019-09-25. PMID:31332452. |
alzheimer's disease is histopathologically characterized by aggregation of two proteins, namely amyloid-beta peptide and tau protein. |
2019-09-25 |
2023-08-13 |
Not clear |
| Yakeel T Quiroz, Reisa A Sperling, Daniel J Norton, Ana Baena, Joseph F Arboleda-Velasquez, Danielle Cosio, Aaron Schultz, Molly Lapoint, Edmarie Guzman-Velez, John B Miller, Leo A Kim, Kewei Chen, Pierre N Tariot, Francisco Lopera, Eric M Reiman, Keith A Johnso. Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease. JAMA neurology. vol 75. issue 5. 2019-09-24. PMID:29435558. |
association between amyloid and tau accumulation in young adults with autosomal dominant alzheimer disease. |
2019-09-24 |
2023-08-13 |
Not clear |
| Eric McDade, Randall J Batema. Tau Positron Emission Tomography in Autosomal Dominant Alzheimer Disease: Small Windows, Big Picture. JAMA neurology. vol 75. issue 5. 2019-09-24. PMID:29435570. |
tau positron emission tomography in autosomal dominant alzheimer disease: small windows, big picture. |
2019-09-24 |
2023-08-13 |
Not clear |