| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhong-Hao Zhang, Qiu-Yan Wu, Rui Zheng, Chen Chen, Yao Chen, Qiong Liu, Peter R Hoffmann, Jia-Zuan Ni, Guo-Li Son. Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 9. 2017-08-18. PMID:28137967. |
tau pathology was recently identified as a key driver of disease progression and an attractive therapeutic target in alzheimer's disease (ad). |
2017-08-18 |
2023-08-13 |
mouse |
| Hiroki Fujii, Tetsuya Takahashi, Tomoya Mukai, Shigeru Tanaka, Naohisa Hosomi, Hirofumi Maruyama, Norio Sakai, Masayasu Matsumot. Modifications of tau protein after cerebral ischemia and reperfusion in rats are similar to those occurring in Alzheimer's disease - Hyperphosphorylation and cleavage of 4- and 3-repeat tau. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 37. issue 7. 2017-08-14. PMID:27629097. |
modifications of tau protein after cerebral ischemia and reperfusion in rats are similar to those occurring in alzheimer's disease - hyperphosphorylation and cleavage of 4- and 3-repeat tau. |
2017-08-14 |
2023-08-13 |
rat |
| Courtney T Jollymore-Hughes, Ian R Pottie, Earl Martin, Terrone L Rosenberry, Sultan Darves. Development of acetophenone ligands as potential neuroimaging agents for cholinesterases. Bioorganic & medicinal chemistry. vol 24. issue 21. 2017-08-14. PMID:27637382. |
association of cholinesterase with β-amyloid plaques and tau neurofibrillary tangles in alzheimer's disease offers an opportunity to detect disease pathology during life. |
2017-08-14 |
2023-08-13 |
Not clear |
| Clément Danis, Clément Despres, Luiza M Bessa, Idir Malki, Hamida Merzougui, Isabelle Huvent, Haoling Qi, Guy Lippens, François-Xavier Cantrelle, Robert Schneider, Xavier Hanoulle, Caroline Smet-Nocca, Isabelle Landrie. Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins. Journal of visualized experiments : JoVE. issue 118. 2017-08-14. PMID:28060278. |
aggregates of the neuronal tau protein are found inside neurons of alzheimer's disease patients. |
2017-08-14 |
2023-08-13 |
Not clear |
| Athinoula L Petrou, Athina Terzidak. A meta-analysis and review examining a possible role for oxidative stress and singlet oxygen in diverse diseases. The Biochemical journal. vol 474. issue 16. 2017-08-14. PMID:28768713. |
of proteinaceous diseases that are related to the β-amyloid protein (alzheimer's), to tau protein (alzheimer's, pick's), to α-synuclein (parkinson's), prion, amylin (type ii diabetes), and to α-crystallin (cataract). |
2017-08-14 |
2023-08-13 |
Not clear |
| Ana B Caballero, Laia Terol-Ordaz, Alba Espargaró, Guillem Vázquez, Ernesto Nicolás, Raimon Sabaté, Patrick Game. Histidine-Rich Oligopeptides To Lessen Copper-Mediated Amyloid-β Toxicity. Chemistry (Weinheim an der Bergstrasse, Germany). vol 22. issue 21. 2017-08-11. PMID:27071336. |
brain copper imbalance plays an important role in amyloid-β aggregation, tau hyperphosphorylation, and neurotoxicity observed in alzheimer's disease (ad). |
2017-08-11 |
2023-08-13 |
Not clear |
| Anne-Sophie Cornec, Ludovica Monti, Jane Kovalevich, Vishruti Makani, Michael J James, Krishna G Vijayendran, Killian Oukoloff, Yuemang Yao, Virginia M-Y Lee, John Q Trojanowski, Amos B Smith, Kurt R Brunden, Carlo Ballator. Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases. Journal of medicinal chemistry. vol 60. issue 12. 2017-08-11. PMID:28530811. |
alzheimer's disease (ad) is a complex, multifactorial disease in which different neuropathological mechanisms are likely involved, including those associated with pathological tau and aβ species as well as neuroinflammation. |
2017-08-11 |
2023-08-13 |
Not clear |
| Jing L Guo, Sneha Narasimhan, Lakshmi Changolkar, Zhuohao He, Anna Stieber, Bin Zhang, Ronald J Gathagan, Michiyo Iba, Jennifer D McBride, John Q Trojanowski, Virginia M Y Le. Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice. The Journal of experimental medicine. vol 213. issue 12. 2017-08-08. PMID:27810929. |
unique pathological tau conformers from alzheimer's brains transmit tau pathology in nontransgenic mice. |
2017-08-08 |
2023-08-13 |
mouse |
| Jing L Guo, Sneha Narasimhan, Lakshmi Changolkar, Zhuohao He, Anna Stieber, Bin Zhang, Ronald J Gathagan, Michiyo Iba, Jennifer D McBride, John Q Trojanowski, Virginia M Y Le. Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice. The Journal of experimental medicine. vol 213. issue 12. 2017-08-08. PMID:27810929. |
filamentous tau aggregates are hallmark lesions in numerous neurodegenerative diseases, including alzheimer's disease (ad). |
2017-08-08 |
2023-08-13 |
mouse |
| Chloe K Nobuhara, Sarah L DeVos, Caitlin Commins, Susanne Wegmann, Benjamin D Moore, Allyson D Roe, Isabel Costantino, Matthew P Frosch, Rose Pitstick, George A Carlson, Christoph Hock, Roger M Nitsch, Fabio Montrasio, Jan Grimm, Anne E Cheung, Anthone W Dunah, Marion Wittmann, Thierry Bussiere, Paul H Weinreb, Bradley T Hyman, Shuko Taked. Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro. The American journal of pathology. vol 187. issue 6. 2017-08-08. PMID:28408124. |
the clinical progression of alzheimer disease (ad) is associated with the accumulation of tau neurofibrillary tangles, which may spread throughout the cortex by interneuronal tau transfer. |
2017-08-08 |
2023-08-13 |
mouse |
| Benjamin Combs, Nicholas M Kanaa. Exposure of the Amino Terminus of Tau Is a Pathological Event in Multiple Tauopathies. The American journal of pathology. vol 187. issue 6. 2017-08-08. PMID:28413156. |
conformational display of pad is an early marker of pathological tau in alzheimer disease (ad), but its role in other tauopathies has yet to be firmly established. |
2017-08-08 |
2023-08-13 |
human |
| Hans Zempel, Frank J A Dennissen, Yatender Kumar, Julia Luedtke, Jacek Biernat, Eva-Maria Mandelkow, Eckhard Mandelko. Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture. The Journal of biological chemistry. vol 292. issue 29. 2017-08-08. PMID:28536263. |
subcellular mislocalization of the microtubule-associated protein tau is a hallmark of alzheimer disease (ad) and other tauopathies. |
2017-08-08 |
2023-08-13 |
human |
| Nobuyuki Okamura, Ryuichi Harada, Katsutoshi Furukawa, Shozo Furumoto, Tetsuro Tago, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kud. Advances in the development of tau PET radiotracers and their clinical applications. Ageing research reviews. vol 30. 2017-08-07. PMID:26802556. |
recent clinical studies using these tracers have demonstrated significant tracer retention in sites susceptible to tau deposition in alzheimer's disease, as well as correlations with the disease severity and cognitive impairment in cases with dementia. |
2017-08-07 |
2023-08-13 |
human |
| Reham Atteya, Mohamed E Ashour, Elsayed E Ibrahim, Mohamed A Farag, Sherif F El-Khamis. Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin. Mechanisms of ageing and development. vol 161. issue Pt A. 2017-08-07. PMID:27282658. |
we identify the dyrk1a kinase inhibitor harmine, which phosphorylates tau that is deregulated in alzheimer's disease, as a potentiator of cell death induced by non-toxic doses of doxorubicin. |
2017-08-07 |
2023-08-13 |
Not clear |
| Vicent Bonet-Costa, Laura Corrales-Diaz Pomatto, Kelvin J A Davie. The Proteasome and Oxidative Stress in Alzheimer's Disease. Antioxidants & redox signaling. vol 25. issue 16. 2017-08-07. PMID:27392670. |
a major hallmark of alzheimer's disease pathology is the accumulation of amyloid-β (aβ) aggregates (an early marker of alzheimer's disease), and neurofibrillary tangles, comprising the hyper-phosphorylated microtubule-associated protein tau. |
2017-08-07 |
2023-08-13 |
Not clear |
| Vicent Bonet-Costa, Laura Corrales-Diaz Pomatto, Kelvin J A Davie. The Proteasome and Oxidative Stress in Alzheimer's Disease. Antioxidants & redox signaling. vol 25. issue 16. 2017-08-07. PMID:27392670. |
recent studies have indicated that both protein oxidation and excessive phosphorylation may limit proteasomal processing of aβ and tau in alzheimer's disease. |
2017-08-07 |
2023-08-13 |
Not clear |
| Pu Wang, Zhan-You Wan. Metal ions influx is a double edged sword for the pathogenesis of Alzheimer's disease. Ageing research reviews. vol 35. 2017-08-07. PMID:27829171. |
alzheimer's disease (ad) is a common form of dementia in aged people, which is defined by two pathological characteristics: β-amyloid protein (aβ) deposition and tau hyperphosphorylation. |
2017-08-07 |
2023-08-13 |
Not clear |
| Yvette C Wong, Dimitri Krain. α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies. Nature medicine. vol 23. issue 2. 2017-08-07. PMID:28170377. |
furthermore, α-synuclein contributes to the fibrilization of amyloid-b and tau, two key proteins in alzheimer's disease, which suggests a central role for α-synuclein toxicity in neurodegeneration. |
2017-08-07 |
2023-08-13 |
Not clear |
| Lilia Rodriguez, Nguyen-Vi Mohamed, Alexandre Desjardins, Roger Lippé, Edward A Fon, Nicole Lecler. Rab7A regulates tau secretion. Journal of neurochemistry. vol 141. issue 4. 2017-08-07. PMID:28222213. |
the axonal microtubule-associated protein tau, involved in alzheimer's disease (ad), can be found in the extracellular space where it could be taken up by neurons, an event that is believed to contribute to the propagation of tau pathology in the brain. |
2017-08-07 |
2023-08-13 |
human |
| Erik A Williams, Declan McGuone, Matthew P Frosch, Bradley T Hyman, Nora Laver, Anat Stemmer-Rachamimo. Absence of Alzheimer Disease Neuropathologic Changes in Eyes of Subjects With Alzheimer Disease. Journal of neuropathology and experimental neurology. vol 76. issue 5. 2017-08-07. PMID:28379416. |
alzheimer disease (ad) is the most common cause of dementia in the elderly, and is characterized by extracellular deposition of β-amyloid and intracellular accumulation of hyperphosphorylated tau protein in the brain. |
2017-08-07 |
2023-08-13 |
human |