| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Priya Sandhu, Mansur Mohammad Naeem, Chunyu Lu, Premkumari Kumarathasan, James Gomes, Ajoy Basa. Ser Bioorganic & medicinal chemistry letters. vol 27. issue 3. 2017-07-04. PMID:27989667. |
ser proteolytic truncation of microtubule associated human (h) tau protein by caspase-3 at the carboxy (c) terminus has been linked to the pathogenesis of alzheimer's disease (ad). |
2017-07-04 |
2023-08-13 |
human |
| Marius Chiasseu, Jorge L Cueva Vargas, Laurie Destroismaisons, Christine Vande Velde, Nicole Leclerc, Adriana Di Pol. Tau Accumulation, Altered Phosphorylation, and Missorting Promote Neurodegeneration in Glaucoma. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 21. 2017-07-03. PMID:27225768. |
the axonal-enriched microtubule-associated protein tau is a key mediator of neurotoxicity in alzheimer's disease and other tauopathies. |
2017-07-03 |
2023-08-13 |
rat |
| Andrew W Hwang, Hanna Trzeciakiewicz, Dave Friedmann, Chao-Xing Yuan, Ronen Marmorstein, Virginia M Y Lee, Todd J Cohe. Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members. PloS one. vol 11. issue 12. 2017-07-03. PMID:28002468. |
lysine acetylation has emerged as a dominant post-translational modification (ptm) regulating tau proteins in alzheimer's disease (ad) and related tauopathies. |
2017-07-03 |
2023-08-13 |
human |
| Christina Dammers, Deniz Yolcu, Laura Kukuk, Dieter Willbold, Marcus Pickhardt, Eckhard Mandelkow, Anselm H C Horn, Heinrich Sticht, Marwa Nidal Malhis, Nadja Will, Judith Schuster, Susanne Aileen Funk. Selection and Characterization of Tau Binding ᴅ-Enantiomeric Peptides with Potential for Therapy of Alzheimer Disease. PloS one. vol 11. issue 12. 2017-07-03. PMID:28006031. |
selection and characterization of tau binding ᴅ-enantiomeric peptides with potential for therapy of alzheimer disease. |
2017-07-03 |
2023-08-13 |
Not clear |
| Christina Dammers, Deniz Yolcu, Laura Kukuk, Dieter Willbold, Marcus Pickhardt, Eckhard Mandelkow, Anselm H C Horn, Heinrich Sticht, Marwa Nidal Malhis, Nadja Will, Judith Schuster, Susanne Aileen Funk. Selection and Characterization of Tau Binding ᴅ-Enantiomeric Peptides with Potential for Therapy of Alzheimer Disease. PloS one. vol 11. issue 12. 2017-07-03. PMID:28006031. |
a variety of neurodegenerative disorders, including alzheimer disease (ad), are associated with neurofibrillary tangles composed of the tau protein, as well as toxic tau oligomers. |
2017-07-03 |
2023-08-13 |
Not clear |
| Zhong-Hao Zhang, Lei Wen, Qiu-Yan Wu, Chen Chen, Rui Zheng, Qiong Liu, Jia-Zuan Ni, Guo-Li Son. Long-Term Dietary Supplementation with Selenium-Enriched Yeast Improves Cognitive Impairment, Reverses Synaptic Deficits, and Mitigates Tau Pathology in a Triple Transgenic Mouse Model of Alzheimer's Disease. Journal of agricultural and food chemistry. vol 65. issue 24. 2017-07-03. PMID:28578584. |
long-term dietary supplementation with selenium-enriched yeast improves cognitive impairment, reverses synaptic deficits, and mitigates tau pathology in a triple transgenic mouse model of alzheimer's disease. |
2017-07-03 |
2023-08-13 |
mouse |
| Niklas Mattsson, Ulf Andreasson, Henrik Zetterberg, Kaj Blenno. Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease. JAMA neurology. vol 74. issue 5. 2017-06-30. PMID:28346578. |
existing cerebrospinal fluid (csf) or imaging (tau positron emission tomography) biomarkers for alzheimer disease (ad) are invasive or expensive. |
2017-06-30 |
2023-08-13 |
Not clear |
| V Cubinková, B Valachová, V Brezováková, R Szabó, I Zimová, Z Kostecká, S Jadha. Next generation tau models in Alzheimer's disease research - virus based gene delivery systems. Acta virologica. vol 61. issue 1. 2017-06-29. PMID:28105850. |
next generation tau models in alzheimer's disease research - virus based gene delivery systems. |
2017-06-29 |
2023-08-13 |
Not clear |
| Arne Ittner, Sook Wern Chua, Josefine Bertz, Alexander Volkerling, Julia van der Hoven, Amadeus Gladbach, Magdalena Przybyla, Mian Bi, Annika van Hummel, Claire H Stevens, Stefania Ippati, Lisa S Suh, Alexander Macmillan, Greg Sutherland, Jillian J Kril, Ana P G Silva, Joel P Mackay, Anne Poljak, Fabien Delerue, Yazi D Ke, Lars M Ittne. Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice. Science (New York, N.Y.). vol 354. issue 6314. 2017-06-28. PMID:27856911. |
site-specific phosphorylation of tau inhibits amyloid-β toxicity in alzheimer's mice. |
2017-06-28 |
2023-08-13 |
mouse |
| Arne Ittner, Sook Wern Chua, Josefine Bertz, Alexander Volkerling, Julia van der Hoven, Amadeus Gladbach, Magdalena Przybyla, Mian Bi, Annika van Hummel, Claire H Stevens, Stefania Ippati, Lisa S Suh, Alexander Macmillan, Greg Sutherland, Jillian J Kril, Ana P G Silva, Joel P Mackay, Anne Poljak, Fabien Delerue, Yazi D Ke, Lars M Ittne. Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice. Science (New York, N.Y.). vol 354. issue 6314. 2017-06-28. PMID:27856911. |
amyloid-β (aβ) toxicity in alzheimer's disease (ad) is considered to be mediated by phosphorylated tau protein. |
2017-06-28 |
2023-08-13 |
mouse |
| Armin Zlomuzica, Dorothea Dere, Sonja Binder, Maria Angelica De Souza Silva, Joseph P Huston, Ekrem Der. Neuronal histamine and cognitive symptoms in Alzheimer's disease. Neuropharmacology. vol 106. 2017-06-27. PMID:26025658. |
alzheimer's disease is a neurodegenerative disorder characterized by extracellular amyloid plaque deposits, mainly composed of amyloid-beta peptide and intracellular neurofibrillary tangles consisting of aggregated hyperphosphorylated tau protein. |
2017-06-27 |
2023-08-13 |
Not clear |
| Marzena Ułamek-Kozioł, Ryszard Pluta, Anna Bogucka-Kocka, Sławomir Januszewski, Janusz Kocki, Stanisław J Czuczwa. Brain ischemia with Alzheimer phenotype dysregulates Alzheimer's disease-related proteins. Pharmacological reports : PR. vol 68. issue 3. 2017-06-27. PMID:26940197. |
generation and deposition of β-amyloid peptide and tau protein pathology are essential factors involved in alzheimer's disease development as well as in postischemic brain dementia. |
2017-06-27 |
2023-08-13 |
Not clear |
| Mengjie Xu, Yan Dong, Shutong Wan, Tingxu Yan, Jingdi Cao, Lidan Wu, Kaishun Bi, Ying Ji. Schisantherin B ameliorates Aβ Physiology & behavior. vol 167. 2017-06-27. PMID:27660034. |
schisantherin b ameliorates aβ accumulation of amyloid beta (aβ) peptide and hyperphosphorylated tau protein has been proposed to play roles in neural destruction which induce alzheimer's disease (ad) progresses, glutamate transporter type 1 (glt-1) and glycogen synthase kinase3β (gsk3β) may be the pathological links between aβ and tau pathology. |
2017-06-27 |
2023-08-13 |
mouse |
| Steffen Kutter, Timo Eichner, Alexandra M Deaconescu, Dorothee Ker. Regulation of Microtubule Assembly by Tau and not by Pin1. Journal of molecular biology. vol 428. issue 9 Pt A. 2017-06-26. PMID:26996940. |
pin1 binding and catalysis of phosphorylated tau at the at180 epitope, which was implicated in alzheimer's disease, has been reported to be crucial for restoring tau's ability to promote mt polymerization in vitro and in vivo [1]. |
2017-06-26 |
2023-08-13 |
Not clear |
| Steffen Kutter, Timo Eichner, Alexandra M Deaconescu, Dorothee Ker. Regulation of Microtubule Assembly by Tau and not by Pin1. Journal of molecular biology. vol 428. issue 9 Pt A. 2017-06-26. PMID:26996940. |
surprisingly, we discover that pin1 does not promote phosphorylated tau-induced mt formation in vitro, refuting the commonly accepted model in which pin1 binding and catalysis on the a180 epitope restores the function of the alzheimer's associated phosphorylated tau in tubulin assembly [1, 2]. |
2017-06-26 |
2023-08-13 |
Not clear |
| Timo Eichner, Steffen Kutter, Wladimir Labeikovsky, Vanessa Buosi, Dorothee Ker. Molecular Mechanism of Pin1-Tau Recognition and Catalysis. Journal of molecular biology. vol 428. issue 9 Pt A. 2017-06-26. PMID:26996941. |
extensive phosphorylation of the microtubule binding protein tau has been implicated in neurodegeneration and alzheimer's disease. |
2017-06-26 |
2023-08-13 |
human |
| Timo Eichner, Steffen Kutter, Wladimir Labeikovsky, Vanessa Buosi, Dorothee Ker. Molecular Mechanism of Pin1-Tau Recognition and Catalysis. Journal of molecular biology. vol 428. issue 9 Pt A. 2017-06-26. PMID:26996941. |
using nmr, isothermal calorimetry (itc), and small angle x-ray scattering (saxs), we dissect binding and catalysis on multiple phosphorylated tau with particular emphasis toward the alzheimer's associated at180 tau epitope containing phosphorylated thr231 and ser235. |
2017-06-26 |
2023-08-13 |
human |
| Timo Eichner, Steffen Kutter, Wladimir Labeikovsky, Vanessa Buosi, Dorothee Ker. Molecular Mechanism of Pin1-Tau Recognition and Catalysis. Journal of molecular biology. vol 428. issue 9 Pt A. 2017-06-26. PMID:26996941. |
our mechanistic results on site-specific binding and catalysis together with the lack of an increase of dephosphorylation rates by pp2a counter a series of previously published models for the role of pin1 catalysis of tau in alzheimer's disease. |
2017-06-26 |
2023-08-13 |
human |
| Pengcheng Han, Geidy Serrano, Thomas G Beach, Richard J Caselli, Junxiang Yin, Ningning Zhuang, Jiong Sh. A Quantitative Analysis of Brain Soluble Tau and the Tau Secretion Factor. Journal of neuropathology and experimental neurology. vol 76. issue 1. 2017-06-23. PMID:28069930. |
neurofibrillary tangles (nfts) represent products of insoluble tau protein in the brains of patients with alzheimer disease (ad). |
2017-06-23 |
2023-08-13 |
human |
| Sara Garcia-Ratés, Paul Morrill, Henry Tu, Gwenael Pottiez, Antoine-Scott Badin, Cristina Tormo-Garcia, Catherine Heffner, Clive W Coen, Susan A Greenfiel. (I) Pharmacological profiling of a novel modulator of the α7 nicotinic receptor: Blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains. Neuropharmacology. vol 105. 2017-06-21. PMID:26867503. |
the primary cause of alzheimer's disease is unlikely to be the much studied markers amyloid beta or tau. |
2017-06-21 |
2023-08-13 |
Not clear |