| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Liu, Jingya Zhao, Guangxiu L. miR-106b inhibits tau phosphorylation at Tyr18 by targeting Fyn in a model of Alzheimer's disease. Biochemical and biophysical research communications. vol 478. issue 2. 2017-05-17. PMID:27520374. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by β-amyloid deposits and neurofibrillary tangles consisting of hyperphosphorylated tau protein. |
2017-05-17 |
2023-08-13 |
Not clear |
| Susan A Austin, Zvonimir S Katusi. Loss of Endothelial Nitric Oxide Synthase Promotes p25 Generation and Tau Phosphorylation in a Murine Model of Alzheimer's Disease. Circulation research. vol 119. issue 10. 2017-05-12. PMID:27601478. |
loss of endothelial nitric oxide synthase promotes p25 generation and tau phosphorylation in a murine model of alzheimer's disease. |
2017-05-12 |
2023-08-13 |
Not clear |
| Niklas Mattsson, Henrik Zetterberg, Shorena Janelidze, Philip S Insel, Ulf Andreasson, Erik Stomrud, Sebastian Palmqvist, David Baker, Cristina A Tan Hehir, Andreas Jeromin, David Hanlon, Linan Song, Leslie M Shaw, John Q Trojanowski, Michael W Weiner, Oskar Hansson, Kaj Blenno. Plasma tau in Alzheimer disease. Neurology. vol 87. issue 17. 2017-05-12. PMID:27694257. |
plasma tau in alzheimer disease. |
2017-05-12 |
2023-08-13 |
Not clear |
| Niklas Mattsson, Henrik Zetterberg, Shorena Janelidze, Philip S Insel, Ulf Andreasson, Erik Stomrud, Sebastian Palmqvist, David Baker, Cristina A Tan Hehir, Andreas Jeromin, David Hanlon, Linan Song, Leslie M Shaw, John Q Trojanowski, Michael W Weiner, Oskar Hansson, Kaj Blenno. Plasma tau in Alzheimer disease. Neurology. vol 87. issue 17. 2017-05-12. PMID:27694257. |
to test whether plasma tau is altered in alzheimer disease (ad) and whether it is related to changes in cognition, csf biomarkers of ad pathology (including β-amyloid [aβ] and tau), brain atrophy, and brain metabolism. |
2017-05-12 |
2023-08-13 |
Not clear |
| Shi-Jie Liu, Ping Zheng, David K Wright, Gabi Dezsi, Emma Braine, Thanh Nguyen, Niall M Corcoran, Leigh A Johnston, Christopher M Hovens, Jamie N Mayo, Matthew Hudson, Sandy R Shultz, Nigel C Jones, Terence J O'Brie. Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau. Brain : a journal of neurology. vol 139. issue Pt 7. 2017-05-10. PMID:27289302. |
downregulation of protein phosphatase 2a, a protein that causes the hyperphosphorylation of tau, is implicated in neurodegenerative diseases commonly associated with epilepsy, such as alzheimer's disease and traumatic brain injury. |
2017-05-10 |
2023-08-13 |
rat |
| Matthias Brendel, Anna Jaworska, Federico Probst, Felix Overhoff, Viktoria Korzhova, Simon Lindner, Janette Carlsen, Peter Bartenstein, Ryuichi Harada, Yukitsuka Kudo, Christian Haass, Fred Van Leuven, Nobuyuki Okamura, Jochen Herms, Axel Rominge. Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 57. issue 5. 2017-05-09. PMID:26912432. |
abnormal accumulation of tau aggregates in the brain is one of the hallmarks of alzheimer disease neuropathology. |
2017-05-09 |
2023-08-13 |
mouse |
| Sergey Shcherbinin, Adam J Schwarz, Abhinay Joshi, Michael Navitsky, Matthew Flitter, William R Shankle, Michael D Devous, Mark A Mintu. Kinetics of the Tau PET Tracer 18F-AV-1451 (T807) in Subjects with Normal Cognitive Function, Mild Cognitive Impairment, and Alzheimer Disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 57. issue 10. 2017-05-09. PMID:27151986. |
kinetics of the tau pet tracer 18f-av-1451 (t807) in subjects with normal cognitive function, mild cognitive impairment, and alzheimer disease. |
2017-05-09 |
2023-08-13 |
human |
| Eric D Hostetler, Abbas M Walji, Zhizhen Zeng, Patricia Miller, Idriss Bennacef, Cristian Salinas, Brett Connolly, Liza Gantert, Hyking Haley, Marie Holahan, Mona Purcell, Kerry Riffel, Talakad G Lohith, Paul Coleman, Aileen Soriano, Aimie Ogawa, Serena Xu, Xiaoping Zhang, Elizabeth Joshi, Joseph Della Rocca, David Hesk, David J Schenk, Jeffrey L Evelhoc. Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 57. issue 10. 2017-05-09. PMID:27230925. |
a pet tracer is desired to help guide the discovery and development of disease-modifying therapeutics for neurodegenerative diseases characterized by neurofibrillary tangles (nfts), the predominant tau pathology in alzheimer disease (ad). |
2017-05-09 |
2023-08-13 |
human |
| Abolfazl Jangholi, Mohammad Reza Ashrafi-Kooshk, Seyed Shahriar Arab, Gholamhossein Riazi, Farzad Mokhtari, Mansour Poorebrahim, Hamid Mahdiuni, Boris I Kurganov, Ali Akbar Moosavi-Movahedi, Reza Khodarahm. Appraisal of role of the polyanionic inducer length on amyloid formation by 412-residue 1N4R Tau protein: A comparative study. Archives of biochemistry and biophysics. vol 609. 2017-05-09. PMID:27638048. |
neurofibrillary tangles, mainly composed of fibrils formed by the microtubule-associated protein; tau, are a hallmark of a group of neurodegenerative diseases such as alzheimer's disease. |
2017-05-09 |
2023-08-13 |
Not clear |
| Marta Nesteruk, Tomasz Nesteruk, Maria Styczyńska, Monika Mandecka, Anna Barczak, Maria Barcikowsk. Combined use of biochemical and volumetric biomarkers to assess the risk of conversion of mild cognitive impairment to Alzheimer's disease. Folia neuropathologica. vol 54. issue 4. 2017-05-09. PMID:28139818. |
the aim of our study was to evaluate the usefulness of several biomarkers in predicting the conversion of mild cognitive impairment (mci) to alzheimer's disease (ad): β-amyloid and tau proteins in cerebrospinal fluid and the volumetric evaluation of brain structures including the hippocampus in magnetic resonance imaging (mri). |
2017-05-09 |
2023-08-13 |
Not clear |
| Adam J Schwarz, Peng Yu, Bradley B Miller, Sergey Shcherbinin, James Dickson, Michael Navitsky, Abhinay D Joshi, Michael D Devous, Mark S Mintu. Regional profiles of the candidate tau PET ligand 18F-AV-1451 recapitulate key features of Braak histopathological stages. Brain : a journal of neurology. vol 139. issue Pt 5. 2017-05-08. PMID:26936940. |
see thal and vandenberghe doi101093/brain/aww057 for a scientific commentary on this article: post-mortem braak staging of neurofibrillary tau tangle topographical distribution is one of the core neuropathological criteria for the diagnosis of alzheimer's disease. |
2017-05-08 |
2023-08-13 |
human |
| Adam J Schwarz, Peng Yu, Bradley B Miller, Sergey Shcherbinin, James Dickson, Michael Navitsky, Abhinay D Joshi, Michael D Devous, Mark S Mintu. Regional profiles of the candidate tau PET ligand 18F-AV-1451 recapitulate key features of Braak histopathological stages. Brain : a journal of neurology. vol 139. issue Pt 5. 2017-05-08. PMID:26936940. |
in vivo (18)f-av-1451 positron emission tomography images across the alzheimer's disease spectrum could be classified into patterns similar to those prescribed by braak neuropathological staging of tau pathology. |
2017-05-08 |
2023-08-13 |
human |
| Rik Ossenkoppele, Daniel R Schonhaut, Michael Schöll, Samuel N Lockhart, Nagehan Ayakta, Suzanne L Baker, James P O'Neil, Mustafa Janabi, Andreas Lazaris, Averill Cantwell, Jacob Vogel, Miguel Santos, Zachary A Miller, Brianne M Bettcher, Keith A Vossel, Joel H Kramer, Maria L Gorno-Tempini, Bruce L Miller, William J Jagust, Gil D Rabinovic. Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 5. 2017-05-08. PMID:26962052. |
tau pet patterns mirror clinical and neuroanatomical variability in alzheimer's disease. |
2017-05-08 |
2023-08-13 |
human |
| Rik Ossenkoppele, Daniel R Schonhaut, Michael Schöll, Samuel N Lockhart, Nagehan Ayakta, Suzanne L Baker, James P O'Neil, Mustafa Janabi, Andreas Lazaris, Averill Cantwell, Jacob Vogel, Miguel Santos, Zachary A Miller, Brianne M Bettcher, Keith A Vossel, Joel H Kramer, Maria L Gorno-Tempini, Bruce L Miller, William J Jagust, Gil D Rabinovic. Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 5. 2017-05-08. PMID:26962052. |
in this study, we tested the hypothesis that tau pathology is closely linked to symptomatology and patterns of glucose hypometabolism in alzheimer's disease, in contrast to the more diffuse distribution of amyloid-β pathology. |
2017-05-08 |
2023-08-13 |
human |
| Rik Ossenkoppele, Daniel R Schonhaut, Michael Schöll, Samuel N Lockhart, Nagehan Ayakta, Suzanne L Baker, James P O'Neil, Mustafa Janabi, Andreas Lazaris, Averill Cantwell, Jacob Vogel, Miguel Santos, Zachary A Miller, Brianne M Bettcher, Keith A Vossel, Joel H Kramer, Maria L Gorno-Tempini, Bruce L Miller, William J Jagust, Gil D Rabinovic. Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 5. 2017-05-08. PMID:26962052. |
we included 20 patients meeting criteria for probable alzheimer's disease dementia or mild cognitive impairment due to alzheimer's disease, presenting with a variety of clinical phenotypes, and 15 amyloid-β-negative cognitively normal individuals, who underwent (18)f-av1451 (tau), (11)c-pib (amyloid-β) and (18)f-fdg (glucose metabolism) positron emission tomography, apolipoprotein e (apoe) genotyping and neuropsychological testing. |
2017-05-08 |
2023-08-13 |
human |
| Rik Ossenkoppele, Daniel R Schonhaut, Michael Schöll, Samuel N Lockhart, Nagehan Ayakta, Suzanne L Baker, James P O'Neil, Mustafa Janabi, Andreas Lazaris, Averill Cantwell, Jacob Vogel, Miguel Santos, Zachary A Miller, Brianne M Bettcher, Keith A Vossel, Joel H Kramer, Maria L Gorno-Tempini, Bruce L Miller, William J Jagust, Gil D Rabinovic. Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 5. 2017-05-08. PMID:26962052. |
in conclusion, tau imaging-contrary to amyloid-β imaging-shows a strong regional association with clinical and anatomical heterogeneity in alzheimer's disease. |
2017-05-08 |
2023-08-13 |
human |
| Rik Ossenkoppele, Daniel R Schonhaut, Michael Schöll, Samuel N Lockhart, Nagehan Ayakta, Suzanne L Baker, James P O'Neil, Mustafa Janabi, Andreas Lazaris, Averill Cantwell, Jacob Vogel, Miguel Santos, Zachary A Miller, Brianne M Bettcher, Keith A Vossel, Joel H Kramer, Maria L Gorno-Tempini, Bruce L Miller, William J Jagust, Gil D Rabinovic. Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 5. 2017-05-08. PMID:26962052. |
although preliminary, these results are consistent with and expand upon findings from post-mortem, animal and cerebrospinal fluid studies, and suggest that the pathological aggregation of tau is closely linked to patterns of neurodegeneration and clinical manifestations of alzheimer's disease. |
2017-05-08 |
2023-08-13 |
human |
| Tomohiro Umeda, Kenjiro Ono, Ayumi Sakai, Minato Yamashita, Mineyuki Mizuguchi, William L Klein, Masahito Yamada, Hiroshi Mori, Takami Tomiyam. Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers. Brain : a journal of neurology. vol 139. issue Pt 5. 2017-05-08. PMID:27020329. |
amyloid-β, tau, and α-synuclein, or more specifically their soluble oligomers, are the aetiologic molecules in alzheimer's disease, tauopathies, and α-synucleinopathies, respectively. |
2017-05-08 |
2023-08-13 |
mouse |
| Tomohiro Umeda, Kenjiro Ono, Ayumi Sakai, Minato Yamashita, Mineyuki Mizuguchi, William L Klein, Masahito Yamada, Hiroshi Mori, Takami Tomiyam. Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers. Brain : a journal of neurology. vol 139. issue Pt 5. 2017-05-08. PMID:27020329. |
the inhibitory effects of rifampicin against amyloid-β and tau oligomers were evaluated in apposk mice (amyloid-β oligomer model), tg2576 mice (alzheimer's disease model), and tau609 mice (tauopathy model). |
2017-05-08 |
2023-08-13 |
mouse |
| Chelsea T Tiernan, Benjamin Combs, Kristine Cox, Gerardo Morfini, Scott T Brady, Scott E Counts, Nicholas M Kanaa. Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. Experimental neurology. vol 283. issue Pt A. 2017-05-05. PMID:27373205. |
in alzheimer's disease (ad), tau undergoes numerous modifications, including increased phosphorylation at serine-422 (ps422). |
2017-05-05 |
2023-08-13 |
human |