| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hayk Davtyan, Andrew Bacon, Irina Petrushina, Karen Zagorski, David H Cribbs, Anahit Ghochikyan, Michael G Agadjanya. Immunogenicity of DNA- and recombinant protein-based Alzheimer disease epitope vaccines. Human vaccines & immunotherapeutics. vol 10. issue 5. 2015-06-22. PMID:24525778. |
alzheimer disease (ad) process involves the accumulation of amyloid plaques and tau tangles in the brain, nevertheless the attempts at targeting the main culprits, neurotoxic β-amyloid (aβ) peptides, have thus far proven unsuccessful for improving cognitive function. |
2015-06-22 |
2023-08-12 |
Not clear |
| Allal Boutajangout, Thomas Wisniewsk. Tau-based therapeutic approaches for Alzheimer's disease - a mini-review. Gerontology. vol 60. issue 5. 2015-06-22. PMID:24732638. |
the accumulation of aggregated, hyperphosphorylated tau as neurofibrillary tangles and neuropil threads are cardinal features of alzheimer's disease (ad). |
2015-06-22 |
2023-08-13 |
mouse |
| Sophie Sokolow, Kristen M Henkins, Tina Bilousova, Bianca Gonzalez, Harry V Vinters, Carol A Miller, Lindsey Cornwell, Wayne W Poon, Karen H Gyly. Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease. Journal of neurochemistry. vol 133. issue 3. 2015-06-22. PMID:25393609. |
pre-synaptic c-terminal truncated tau is released from cortical synapses in alzheimer's disease. |
2015-06-22 |
2023-08-13 |
human |
| Sophie Sokolow, Kristen M Henkins, Tina Bilousova, Bianca Gonzalez, Harry V Vinters, Carol A Miller, Lindsey Cornwell, Wayne W Poon, Karen H Gyly. Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease. Journal of neurochemistry. vol 133. issue 3. 2015-06-22. PMID:25393609. |
in our study, we measured synaptic levels of total tau using synaptosomes prepared from cryopreserved human postmortem alzheimer's disease (ad) and control samples. |
2015-06-22 |
2023-08-13 |
human |
| Sophie Sokolow, Kristen M Henkins, Tina Bilousova, Bianca Gonzalez, Harry V Vinters, Carol A Miller, Lindsey Cornwell, Wayne W Poon, Karen H Gyly. Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease. Journal of neurochemistry. vol 133. issue 3. 2015-06-22. PMID:25393609. |
results demonstrate the abundance of tau, mainly c-terminal truncated tau, in synaptic terminals in aged control and in alzheimer's disease (ad) samples. |
2015-06-22 |
2023-08-13 |
human |
| b' S\\xc3\\xa9verine Coutadeur, H\\xc3\\xa9l\\xc3\\xa8ne Benyamine, Laurence Delalonde, Catherine de Oliveira, Bertrand Leblond, Alicia Foucourt, Thierry Besson, Anne-Sophie Casagrande, Thierry Taverne, Ang\\xc3\\xa9lique Girard, Matthew P Pando, Laurent D\\xc3\\xa9sir\\xc3\\xa. A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer\'s disease: effect on Tau and amyloid pathologies in vitro. Journal of neurochemistry. vol 133. issue 3. 2015-06-22. PMID:25556849.' |
a novel dyrk1a (dual specificity tyrosine phosphorylation-regulated kinase 1a) inhibitor for the treatment of alzheimer's disease: effect on tau and amyloid pathologies in vitro. |
2015-06-22 |
2023-08-13 |
Not clear |
| b' S\\xc3\\xa9verine Coutadeur, H\\xc3\\xa9l\\xc3\\xa8ne Benyamine, Laurence Delalonde, Catherine de Oliveira, Bertrand Leblond, Alicia Foucourt, Thierry Besson, Anne-Sophie Casagrande, Thierry Taverne, Ang\\xc3\\xa9lique Girard, Matthew P Pando, Laurent D\\xc3\\xa9sir\\xc3\\xa. A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer\'s disease: effect on Tau and amyloid pathologies in vitro. Journal of neurochemistry. vol 133. issue 3. 2015-06-22. PMID:25556849.' |
the dual-specificity tyrosine phosphorylation-regulated kinase 1a (dyrk1a) gene is located within the down syndrome (ds) critical region on chromosome 21 and is implicated in the generation of tau and amyloid pathologies that are associated with the early onset alzheimer's disease (ad) observed in ds. |
2015-06-22 |
2023-08-13 |
Not clear |
| Adila Elobeid, Katarina Laurell, Kristina Giuliana Cesarini, Irina Alafuzof. Correlations between mini-mental state examination score, cerebrospinal fluid biomarkers, and pathology observed in brain biopsies of patients with normal-pressure hydrocephalus. Journal of neuropathology and experimental neurology. vol 74. issue 5. 2015-06-18. PMID:25868149. |
alzheimer disease hallmark lesions-β-amyloid (aβ) and hyperphosphorylated tau (hptau)-were observed in 47% of subjects, a percentage consistent with that for whole-brain assessment reported postmortem in unselected cohorts. |
2015-06-18 |
2023-08-13 |
human |
| Nimrod Miller, Zhihua Feng, Brittany M Edens, Ben Yang, Han Shi, Christie C Sze, Benjamin Taige Hong, Susan C Su, Jorge A Cantu, Jacek Topczewski, Thomas O Crawford, Chien-Ping Ko, Charlotte J Sumner, Long Ma, Yong-Chao M. Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 15. 2015-06-18. PMID:25878277. |
many studies have established the importance of hyperphosphorylation of the microtubule-associated protein tau in various neurodegenerative disorders, including alzheimer's and parkinson's diseases. |
2015-06-18 |
2023-08-13 |
mouse |
| M D Zwan, N Okamura, M T Fodero-Tavoletti, S Furumoto, C L Masters, C C Rowe, V L Villemagn. Voyage au bout de la nuit: Aβ and tau imaging in dementias. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... vol 58. issue 4. 2015-06-16. PMID:25358680. |
the introduction of these tracers, namely β-amyloid (aβ) and later tau, are providing the tools to change the landscape and refine our understanding of aβ and tau deposition in the brain, allowing to investigate the causes, refine diagnosis and improve treatment of major neurodegenerative conditions such as alzheimer's disease (ad), chronic traumatic encephalopathy (cte) and frontotemporal lobar degeneration (ftld). |
2015-06-16 |
2023-08-13 |
Not clear |
| Mark Yarchoan, Jon B Toledo, Edward B Lee, Zoe Arvanitakis, Hala Kazi, Li-Ying Han, Natalia Louneva, Virginia M-Y Lee, Sangwon F Kim, John Q Trojanowski, Steven E Arnol. Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. Acta neuropathologica. vol 128. issue 5. 2015-06-15. PMID:25107476. |
abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in alzheimer's disease and tauopathies. |
2015-06-15 |
2023-08-13 |
mouse |
| Teresa Lagunes, Marisol Herrera-Rivero, María Elena Hernández-Aguilar, Gonzalo E Aranda-Abre. Abeta(1-42) induces abnormal alternative splicing of tau exons 2/3 in NGF-induced PC12 cells. Anais da Academia Brasileira de Ciencias. vol 86. issue 4. 2015-06-15. PMID:25590729. |
protein tau plays a pivotal role in the pathophysiology of alzheimer's disease, where its hyperphos-phorylation promotes aggregation and microtubule destabilization. |
2015-06-15 |
2023-08-13 |
human |
| Noa Menkes-Caspi, Hagar G Yamin, Vered Kellner, Tara L Spires-Jones, Dana Cohen, Edward A Ster. Pathological tau disrupts ongoing network activity. Neuron. vol 85. issue 5. 2015-06-15. PMID:25704951. |
pathological tau leads to dementia and neurodegeneration in tauopathies, including alzheimer's disease. |
2015-06-15 |
2023-08-13 |
mouse |
| Isidre Ferrer, Andrea Legati, J Carlos García-Monco, Marian Gomez-Beldarrain, Margarita Carmona, Rosa Blanco, William W Seeley, Giovanni Coppol. Familial behavioral variant frontotemporal dementia associated with astrocyte-predominant tauopathy. Journal of neuropathology and experimental neurology. vol 74. issue 4. 2015-06-15. PMID:25756587. |
gel electrophoresis of sarkosyl-insoluble fractions showed 2 bands of 64 and 60 kda and a doublet of 67 to 70 kda (which are different from those seen in alzheimer disease and in typical 4r and 3r tauopathies) together with several bands of lower molecular weight indicative of truncated tau. |
2015-06-15 |
2023-08-13 |
Not clear |
| Sylvia E Perez, Bin He, Muhammad Nadeem, Joanne Wuu, Stephen D Ginsberg, Milos D Ikonomovic, Elliott J Mufso. Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology. Journal of neuropathology and experimental neurology. vol 74. issue 4. 2015-06-15. PMID:25756588. |
endosomal-lysosomal and autophagic dysregulation occurs in the hippocampus in prodromal alzheimer disease (ad), but its relationship with β-amyloid (aβ) and tau pathology remains unclear. |
2015-06-15 |
2023-08-13 |
Not clear |
| Diana L Castillo-Carranza, Marcos J Guerrero-Muñoz, Urmi Sengupta, Caterina Hernandez, Alan D T Barrett, Kelly Dineley, Rakez Kaye. Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an Alzheimer's disease mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 12. 2015-06-15. PMID:25810517. |
tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an alzheimer's disease mouse model. |
2015-06-15 |
2023-08-13 |
mouse |
| Diana L Castillo-Carranza, Marcos J Guerrero-Muñoz, Urmi Sengupta, Caterina Hernandez, Alan D T Barrett, Kelly Dineley, Rakez Kaye. Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an Alzheimer's disease mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 12. 2015-06-15. PMID:25810517. |
in alzheimer's disease (ad), the pathological accumulation of tau appears to be a downstream effect of amyloid β protein (aβ). |
2015-06-15 |
2023-08-13 |
mouse |
| Jack Brelstaff, Bernardino Ossola, Jonas J Neher, Therése Klingstedt, K Peter R Nilsson, Michel Goedert, Maria Grazia Spillantini, Aviva M Tolkovsk. The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice. Frontiers in neuroscience. vol 9. 2015-06-15. PMID:26074756. |
identification of fluorescent dyes that label the filamentous protein aggregates characteristic of neurodegenerative disease, such as β-amyloid and tau in alzheimer's disease, in a live cell culture system has previously been a major hurdle. |
2015-06-15 |
2023-08-13 |
mouse |
| Jack Brelstaff, Bernardino Ossola, Jonas J Neher, Therése Klingstedt, K Peter R Nilsson, Michel Goedert, Maria Grazia Spillantini, Aviva M Tolkovsk. The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice. Frontiers in neuroscience. vol 9. 2015-06-15. PMID:26074756. |
injection of pftaa into 5-month-old p301s tau mice detected cortical and drg neurons immunoreactive for at100, an antibody that identifies solely filamentous tau, or mc1, an antibody that identifies a conformational change in tau that is commensurate with neurofibrillary tangle formation in alzheimer's disease brains. |
2015-06-15 |
2023-08-13 |
mouse |
| Lina Adwan, Gehad M Subaiea, Riyaz Basha, Nasser H Zawi. Tolfenamic acid reduces tau and CDK5 levels: implications for dementia and tauopathies. Journal of neurochemistry. vol 133. issue 2. 2015-06-12. PMID:25279694. |
tau and its aggregates are linked to the pathology of alzheimer's disease (ad) and other tauopathies and, therefore, are explored as therapeutic targets for such disorders. |
2015-06-12 |
2023-08-13 |
mouse |