| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinfeng Zhao, Dan Wang, Lingmin Li, Wenhui Zhao, Ce Zhan. Protective effects of humanin on okadaic Acid-induced neurotoxicities in cultured cortical neurons. Neurochemical research. vol 39. issue 11. 2015-07-29. PMID:25142935. |
neurofibrillary tangles are pathological hallmarks of alzheimer's disease (ad), which are mostly composed of hyperphosphorylated tau and directly correlate with dementia in ad patients. |
2015-07-29 |
2023-08-13 |
Not clear |
| Eve Peeraer, Astrid Bottelbergs, Kristof Van Kolen, Ilie-Cosmin Stancu, Bruno Vasconcelos, Michel Mahieu, Hilde Duytschaever, Luc Ver Donck, An Torremans, Ellen Sluydts, Nathalie Van Acker, John A Kemp, Marc Mercken, Kurt R Brunden, John Q Trojanowski, Ilse Dewachter, Virginia M Y Lee, Diederik Moechar. Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice. Neurobiology of disease. vol 73. 2015-07-29. PMID:25220759. |
neurofibrillary tangles composed of hyperphosphorylated fibrillized tau are found in numerous tauopathies including alzheimer's disease. |
2015-07-29 |
2023-08-13 |
mouse |
| Eve Peeraer, Astrid Bottelbergs, Kristof Van Kolen, Ilie-Cosmin Stancu, Bruno Vasconcelos, Michel Mahieu, Hilde Duytschaever, Luc Ver Donck, An Torremans, Ellen Sluydts, Nathalie Van Acker, John A Kemp, Marc Mercken, Kurt R Brunden, John Q Trojanowski, Ilse Dewachter, Virginia M Y Lee, Diederik Moechar. Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice. Neurobiology of disease. vol 73. 2015-07-29. PMID:25220759. |
these results further validate the utility of the tau seeding model in studying disease transmission, and provide a more complete in vivo tauopathy model with associated neurodegeneration which can be used to investigate the mechanisms involved in tau aggregation and spreading, as well as aid in the search for disease modifying treatments for alzheimer's disease and related tauopathies. |
2015-07-29 |
2023-08-13 |
mouse |
| Keith A Vossel, Jordan C Xu, Vira Fomenko, Takashi Miyamoto, Elsa Suberbielle, Joseph A Knox, Kaitlyn Ho, Daniel H Kim, Gui-Qiu Yu, Lennart Muck. Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β. The Journal of cell biology. vol 209. issue 3. 2015-07-29. PMID:25963821. |
axonal transport deficits in alzheimer's disease (ad) are attributed to amyloid β (aβ) peptides and pathological forms of the microtubule-associated protein tau. |
2015-07-29 |
2023-08-13 |
mouse |
| Charles R Harrington, John M D Storey, Scott Clunas, Kathleen A Harrington, David Horsley, Ahtsham Ishaq, Steven J Kemp, Christopher P Larch, Colin Marshall, Sarah L Nicoll, Janet E Rickard, Michael Simpson, James P Sinclair, Lynda J Storey, Claude M Wischi. Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease. The Journal of biological chemistry. vol 290. issue 17. 2015-07-28. PMID:25759392. |
cellular models of aggregation-dependent template-directed proteolysis to characterize tau aggregation inhibitors for treatment of alzheimer disease. |
2015-07-28 |
2023-08-13 |
mouse |
| Charles R Harrington, John M D Storey, Scott Clunas, Kathleen A Harrington, David Horsley, Ahtsham Ishaq, Steven J Kemp, Christopher P Larch, Colin Marshall, Sarah L Nicoll, Janet E Rickard, Michael Simpson, James P Sinclair, Lynda J Storey, Claude M Wischi. Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease. The Journal of biological chemistry. vol 290. issue 17. 2015-07-28. PMID:25759392. |
alzheimer disease (ad) is a degenerative tauopathy characterized by aggregation of tau protein through the repeat domain to form intraneuronal paired helical filaments (phfs). |
2015-07-28 |
2023-08-13 |
mouse |
| Maria João Leitão, Inês Baldeiras, Sanna-Kaisa Herukka, Maria Pikkarainen, Ville Leinonen, Anja Hviid Simonsen, Armand Perret-Liaudet, Anthony Fourier, Isabelle Quadrio, Pedro Mota Veiga, Catarina Resende de Oliveir. Chasing the Effects of Pre-Analytical Confounders - A Multicenter Study on CSF-AD Biomarkers. Frontiers in neurology. vol 6. 2015-07-28. PMID:26217300. |
core cerebrospinal fluid (csf) biomarkers - aβ42, tau, and phosphorylated tau (ptau) - have been recently incorporated in the revised criteria for alzheimer's disease (ad). |
2015-07-28 |
2023-08-13 |
Not clear |
| J Koppel, H Jimenez, M Azose, C D'Abramo, C Acker, J Buthorn, B S Greenwald, J Lewis, M Lesser, Z Liu, P Davie. Pathogenic tau species drive a psychosis-like phenotype in a mouse model of Alzheimer's disease. Behavioural brain research. vol 275. 2015-07-24. PMID:25151619. |
pathogenic tau species drive a psychosis-like phenotype in a mouse model of alzheimer's disease. |
2015-07-24 |
2023-08-13 |
mouse |
| J Koppel, H Jimenez, M Azose, C D'Abramo, C Acker, J Buthorn, B S Greenwald, J Lewis, M Lesser, Z Liu, P Davie. Pathogenic tau species drive a psychosis-like phenotype in a mouse model of Alzheimer's disease. Behavioural brain research. vol 275. 2015-07-24. PMID:25151619. |
psychotic alzheimer's disease (ad+p) is a rapidly progressive variant of ad associated with an increased burden of frontal tau pathology that affects up to 50% of those with ad, and is observed more commonly in females. |
2015-07-24 |
2023-08-13 |
mouse |
| Ethan A Winkler, Abhay P Sagare, Berislav V Zlokovi. The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain pathology (Zurich, Switzerland). vol 24. issue 4. 2015-07-23. PMID:24946075. |
pericytes are cells in the blood-brain barrier (bbb) that degenerate in alzheimer's disease (ad), a neurodegenerative disorder characterized by early neurovascular dysfunction, elevation of amyloid β-peptide (aβ), tau pathology and neuronal loss, leading to progressive cognitive decline and dementia. |
2015-07-23 |
2023-08-13 |
Not clear |
| Tasnim Rahman, Danielle S Davies, Rudi K Tannenberg, Sandra Fok, Claire Shepherd, Peter R Dodd, Karen M Cullen, Claire Goldsbur. Cofilin rods and aggregates concur with tau pathology and the development of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 42. issue 4. 2015-07-23. PMID:25024349. |
cofilin rods and aggregates concur with tau pathology and the development of alzheimer's disease. |
2015-07-23 |
2023-08-13 |
human |
| Arindam Chatterjee, Stephen J Cutler, Robert J Doerksen, Ikhlas A Khan, John S Williamso. Discovery of thienoquinolone derivatives as selective and ATP non-competitive CDK5/p25 inhibitors by structure-based virtual screening. Bioorganic & medicinal chemistry. vol 22. issue 22. 2015-07-23. PMID:25438765. |
thus inhibition of this complex is a viable target for numerous acute and chronic neurodegenerative diseases involving tau protein, including alzheimer's disease. |
2015-07-23 |
2023-08-13 |
Not clear |
| Bonnie J Bolkan, Doris Kretzschma. Loss of Tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila. Developmental neurobiology. vol 74. issue 12. 2015-07-20. PMID:24909306. |
accumulations of tau, a microtubule-associated protein (map), into neurofibrillary tangles is a hallmark of alzheimer's disease and other tauopathies. |
2015-07-20 |
2023-08-13 |
mouse |
| Julia Elisa Sepulveda-Diaz, Seyedeh Maryam Alavi Naini, Minh Bao Huynh, Mohand Ouidir Ouidja, Constantin Yanicostas, Sandrine Chantepie, Joao Villares, Foudil Lamari, Estelle Jospin, Toin H van Kuppevelt, Ayikoe Guy Mensah-Nyagan, Rita Raisman-Vozari, Nadia Soussi-Yanicostas, Dulce Papy-Garci. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology. Brain : a journal of neurology. vol 138. issue Pt 5. 2015-07-17. PMID:25842390. |
hs3st2 expression is critical for the abnormal phosphorylation of tau in alzheimer's disease-related tau pathology. |
2015-07-17 |
2023-08-13 |
human |
| Julia Elisa Sepulveda-Diaz, Seyedeh Maryam Alavi Naini, Minh Bao Huynh, Mohand Ouidir Ouidja, Constantin Yanicostas, Sandrine Chantepie, Joao Villares, Foudil Lamari, Estelle Jospin, Toin H van Kuppevelt, Ayikoe Guy Mensah-Nyagan, Rita Raisman-Vozari, Nadia Soussi-Yanicostas, Dulce Papy-Garci. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology. Brain : a journal of neurology. vol 138. issue Pt 5. 2015-07-17. PMID:25842390. |
however, it is unknown whether hs3st2 and its 3-o-sulphated heparan sulphate products are involved in the mechanisms leading to the abnormal phosphorylation of tau in alzheimer's disease and related tauopathies. |
2015-07-17 |
2023-08-13 |
human |
| Holly C Hunsberger, Carolyn C Rudy, Daniel S Weitzner, Chong Zhang, David E Tosto, Kevin Knowlan, Ying Xu, Miranda N Ree. Effect size of memory deficits in mice with adult-onset P301L tau expression. Behavioural brain research. vol 272. 2015-07-16. PMID:25004446. |
transgenic mice expressing mutations in tau have yielded essential discoveries for alzheimer's disease. |
2015-07-16 |
2023-08-13 |
mouse |
| Holly C Hunsberger, Carolyn C Rudy, Daniel S Weitzner, Chong Zhang, David E Tosto, Kevin Knowlan, Ying Xu, Miranda N Ree. Effect size of memory deficits in mice with adult-onset P301L tau expression. Behavioural brain research. vol 272. 2015-07-16. PMID:25004446. |
our work also suggests the tet-off tg4510 model provides a way to avoid mutant tau expression during the perinatal and early postnatal stages, thereby preventing possible developmental alterations unrelated to alzheimer's disease. |
2015-07-16 |
2023-08-13 |
mouse |
| Claudia Cicognola, Davide Chiasserini, Lucilla Parnett. Preanalytical Confounding Factors in the Analysis of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: The Issue of Diurnal Variation. Frontiers in neurology. vol 6. 2015-07-16. PMID:26175714. |
given the growing use of cerebrospinal fluid (csf) beta-amyloid (aβ) and tau as biomarkers for early diagnosis of alzheimer's disease (ad), it is essential that the diagnostic procedures are standardized and the results comparable across different laboratories. |
2015-07-16 |
2023-08-13 |
human |
| N Satheesh Kumar, N Nish. Phytomedicines as potential inhibitors of β amyloid aggregation: significance to Alzheimer's disease. Chinese journal of natural medicines. vol 12. issue 11. 2015-07-14. PMID:25480511. |
for the treatment of alzheimer's disease the drug discovery focus shifted from cholinesterase inhibitors, to other targets primarily based on two key neuropathological hallmarks, namely the hyperphosphorylation of the tau protein resulting in the formation of neurofibrillary tangles (nfts), and the increased formation and aggregation of amyloid-beta peptide (aβ) derived from amyloid precursor protein (app). |
2015-07-14 |
2023-08-13 |
Not clear |
| Sylvie Slaets, Eugeen Vanmechelen, Nathalie Le Bastard, Hilde Decraemer, Manu Vandijck, Jean-Jacques Martin, Peter Paul De Deyn, Sebastiaan Engelborgh. Increased CSF α-synuclein levels in Alzheimer's disease: correlation with tau levels. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 5 Suppl. 2015-07-13. PMID:24439167. |
increased csf α-synuclein levels in alzheimer's disease: correlation with tau levels. |
2015-07-13 |
2023-08-12 |
Not clear |