| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dexin Sui, Mengyu Liu, Min-Hao Ku. In vitro aggregation assays using hyperphosphorylated tau protein. Journal of visualized experiments : JoVE. issue 95. 2015-03-06. PMID:25590418. |
novel therapeutics for alzheimer's disease and other tauopathies can potentially be discovered using hyperphosphorylated tau isoforms. |
2015-03-06 |
2023-08-13 |
human |
| Daniel Paris, Ghania Ait-Ghezala, Corbin Bachmeier, Gary Laco, David Beaulieu-Abdelahad, Yong Lin, Chao Jin, Fiona Crawford, Michael Mulla. The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation. The Journal of biological chemistry. vol 289. issue 49. 2015-03-03. PMID:25331948. |
the spleen tyrosine kinase (syk) regulates alzheimer amyloid-β production and tau hyperphosphorylation. |
2015-03-03 |
2023-08-13 |
mouse |
| Daniel Paris, Ghania Ait-Ghezala, Corbin Bachmeier, Gary Laco, David Beaulieu-Abdelahad, Yong Lin, Chao Jin, Fiona Crawford, Michael Mulla. The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation. The Journal of biological chemistry. vol 289. issue 49. 2015-03-03. PMID:25331948. |
in addition, treatment of p301s mutant human tau transgenic mice (transgenic tau p301s) with (-)-nilvadipine reduces tau hyperphosphorylation at several alzheimer disease (ad) pertinent epitopes. |
2015-03-03 |
2023-08-13 |
mouse |
| Katharina Tepper, Jacek Biernat, Satish Kumar, Susanne Wegmann, Thomas Timm, Sabrina Hübschmann, Lars Redecke, Eva-Maria Mandelkow, Daniel J Müller, Eckhard Mandelko. Oligomer formation of tau protein hyperphosphorylated in cells. The Journal of biological chemistry. vol 289. issue 49. 2015-03-03. PMID:25339173. |
abnormal phosphorylation ("hyperphosphorylation") and aggregation of tau protein are hallmarks of alzheimer disease and other tauopathies, but their causative connection is still a matter of debate. |
2015-03-03 |
2023-08-13 |
Not clear |
| Paola Flores-Rodríguez, Miguel A Ontiveros-Torres, María C Cárdenas-Aguayo, Juan P Luna-Arias, Marco A Meraz-Ríos, Amparo Viramontes-Pintos, Charles R Harrington, Claude M Wischik, Raúl Mena, Benjamin Florán-Garduño, José Luna-Muño. The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease. Frontiers in neuroscience. vol 9. 2015-02-26. PMID:25717290. |
the relationship between truncation and phosphorylation at the c-terminus of tau protein in the paired helical filaments of alzheimer's disease. |
2015-02-26 |
2023-08-13 |
Not clear |
| Paola Flores-Rodríguez, Miguel A Ontiveros-Torres, María C Cárdenas-Aguayo, Juan P Luna-Arias, Marco A Meraz-Ríos, Amparo Viramontes-Pintos, Charles R Harrington, Claude M Wischik, Raúl Mena, Benjamin Florán-Garduño, José Luna-Muño. The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease. Frontiers in neuroscience. vol 9. 2015-02-26. PMID:25717290. |
we previously demonstrated that, in the early stages of tau processing in alzheimer's disease, the n-terminal part of the molecule undergoes a characteristic cascade of phosphorylation and progressive misfolding of the proteins resulting in a structural conformation detected by alz-50. |
2015-02-26 |
2023-08-13 |
Not clear |
| Paola Flores-Rodríguez, Miguel A Ontiveros-Torres, María C Cárdenas-Aguayo, Juan P Luna-Arias, Marco A Meraz-Ríos, Amparo Viramontes-Pintos, Charles R Harrington, Claude M Wischik, Raúl Mena, Benjamin Florán-Garduño, José Luna-Muño. The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease. Frontiers in neuroscience. vol 9. 2015-02-26. PMID:25717290. |
a model is presented here in which truncated tau protein represents an early neurotoxic species while phosphorylated tau species may provide a neuroprotective role in alzheimer's disease. |
2015-02-26 |
2023-08-13 |
Not clear |
| Claudia Balducci, Gianluigi Forlon. In vivo application of beta amyloid oligomers: a simple tool to evaluate mechanisms of action and new therapeutic approaches. Current pharmaceutical design. vol 20. issue 15. 2015-02-24. PMID:23859553. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by cerebral accumulation of extracellular amyloid β (aβ) and neurofibrillary tangles made of hyperphosphorylated tau protein, two main lesions which appear sequentially during the disease progression. |
2015-02-24 |
2023-08-12 |
mouse |
| Yat Fung Shea, Leung-Wing Chu, Ming-yee Maggie Mok, Man-Fai La. Amyloid beta 1-42 and tau in the cerebrospinal fluid of renal failure patients for the diagnosis of Alzheimer's disease. Journal of nephrology. vol 27. issue 2. 2015-02-23. PMID:24473733. |
amyloid beta 1-42 and tau in the cerebrospinal fluid of renal failure patients for the diagnosis of alzheimer's disease. |
2015-02-23 |
2023-08-12 |
Not clear |
| Yat Fung Shea, Leung-Wing Chu, Ming-yee Maggie Mok, Man-Fai La. Amyloid beta 1-42 and tau in the cerebrospinal fluid of renal failure patients for the diagnosis of Alzheimer's disease. Journal of nephrology. vol 27. issue 2. 2015-02-23. PMID:24473733. |
cerebrospinal fluid (csf) aβ42, total tau and phosphorylated tau (p-tau) are well-defined diagnostic markers for alzheimer's disease (ad). |
2015-02-23 |
2023-08-12 |
Not clear |
| Elena V Wisely, Yang K Xiang, Salvatore Odd. Genetic suppression of β2-adrenergic receptors ameliorates tau pathology in a mouse model of tauopathies. Human molecular genetics. vol 23. issue 15. 2015-02-20. PMID:24626633. |
accumulation of the microtubule-binding protein tau is a key event in several neurodegenerative disorders referred to as tauopathies, which include alzheimer's disease, frontotemporal lobar degeneration, pick's disease, progressive supranuclear palsy and corticobasal degeneration. |
2015-02-20 |
2023-08-12 |
mouse |
| Hervé Maurin, Benoit Lechat, Peter Borghgraef, Herman Devijver, Tomasz Jaworski, Fred Van Leuve. Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β. The European journal of neuroscience. vol 40. issue 2. 2015-02-20. PMID:24754737. |
the microtubule-associated protein tau is responsible for a large group of neurodegenerative disorders, known as tauopathies, including alzheimer's disease. |
2015-02-20 |
2023-08-13 |
mouse |
| Elka R Georgieva, Shifeng Xiao, Peter P Borbat, Jack H Freed, David Elieze. Tau binds to lipid membrane surfaces via short amphipathic helices located in its microtubule-binding repeats. Biophysical journal. vol 107. issue 6. 2015-02-20. PMID:25229151. |
tau is a microtubule-associated protein that is genetically linked to dementia and linked to alzheimer's disease via its presence in intraneuronal neurofibrillary tangle deposits, where it takes the form of aggregated paired helical and straight filaments. |
2015-02-20 |
2023-08-13 |
Not clear |
| Abigail Herrmann, Tara Spires-Jone. Clearing the way for tau immunotherapy in Alzheimer's disease. Journal of neurochemistry. vol 132. issue 1. 2015-02-19. PMID:25156069. |
clearing the way for tau immunotherapy in alzheimer's disease. |
2015-02-19 |
2023-08-13 |
Not clear |
| Jeffrey J Iliff, Michael J Chen, Benjamin A Plog, Douglas M Zeppenfeld, Melissa Soltero, Lijun Yang, Itender Singh, Rashid Deane, Maiken Nedergaar. Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 49. 2015-02-19. PMID:25471560. |
traumatic brain injury (tbi) is an established risk factor for the early development of dementia, including alzheimer's disease, and the post-traumatic brain frequently exhibits neurofibrillary tangles comprised of aggregates of the protein tau. |
2015-02-19 |
2023-08-13 |
mouse |
| Heike J Wobst, Apurwa Sharma, Marc I Diamond, Erich E Wanker, Jan Bieschk. The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios. FEBS letters. vol 589. issue 1. 2015-02-17. PMID:25436420. |
the accumulation of amyloid-beta (aβ) and tau aggregates is a pathological hallmark of alzheimer's disease. |
2015-02-17 |
2023-08-13 |
Not clear |
| Hong Zhao, Wenjuan Zhao, Kenghoe Lok, Zejian Wang, Ming Yi. A synergic role of caspase-6 and caspase-3 in Tau truncation at D421 induced by H2O 2. Cellular and molecular neurobiology. vol 34. issue 3. 2015-02-12. PMID:24363090. |
tau truncation is widely detected in alzheimer's disease brain. |
2015-02-12 |
2023-08-12 |
human |
| Jeremy Koppel, Chris Acker, Peter Davies, Oscar L Lopez, Heidy Jimenez, Miriam Azose, Blaine S Greenwald, Patrick S Murray, Caitlin M Kirkwood, Julia Kofler, Robert A Swee. Psychotic Alzheimer's disease is associated with gender-specific tau phosphorylation abnormalities. Neurobiology of aging. vol 35. issue 9. 2015-02-12. PMID:24731519. |
psychotic alzheimer's disease is associated with gender-specific tau phosphorylation abnormalities. |
2015-02-12 |
2023-08-13 |
human |
| Jeremy Koppel, Chris Acker, Peter Davies, Oscar L Lopez, Heidy Jimenez, Miriam Azose, Blaine S Greenwald, Patrick S Murray, Caitlin M Kirkwood, Julia Kofler, Robert A Swee. Psychotic Alzheimer's disease is associated with gender-specific tau phosphorylation abnormalities. Neurobiology of aging. vol 35. issue 9. 2015-02-12. PMID:24731519. |
converging evidence suggests that psychotic alzheimer's disease (ad + p) is associated with an acceleration of frontal degeneration, with tau pathology playing a primary role. |
2015-02-12 |
2023-08-13 |
human |
| Cyril Laurent, Sabiha Eddarkaoui, Maxime Derisbourg, Antoine Leboucher, Dominique Demeyer, Sébastien Carrier, Marion Schneider, Malika Hamdane, Christa E Müller, Luc Buée, David Blu. Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology. Neurobiology of aging. vol 35. issue 9. 2015-02-12. PMID:24780254. |
beneficial effects of caffeine in a transgenic model of alzheimer's disease-like tau pathology. |
2015-02-12 |
2023-08-13 |
mouse |