| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Inmaculada Cuchillo-Ibáñez, Valeria Balmaceda, Arancha Botella-López, Alberto Rabano, Jesus Avila, Javier Sáez-Valer. Beta-amyloid impairs reelin signaling. PloS one. vol 8. issue 8. 2014-04-15. PMID:23951306. |
reelin is a signaling protein increasingly associated with the pathogenesis of alzheimer's disease that relevantly modulates tau phosphorylation. |
2014-04-15 |
2023-08-12 |
Not clear |
| Yoav Raz, Yifat Mille. Interactions between Aβ and mutated Tau lead to polymorphism and induce aggregation of Aβ-mutated tau oligomeric complexes. PloS one. vol 8. issue 8. 2014-04-15. PMID:23951348. |
experimental studies have shown that in alzheimer's disease aβ peptide forms aggregates both with itself and with wild-type tau. |
2014-04-15 |
2023-08-12 |
Not clear |
| Yongchang Diwu, Jinzhou Tian, Jing Sh. Effect of Xixin decoction on phosphorylation toxicity at specific sites of tau protein in brains of rats with sporadic Alzheimer disease. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 33. issue 6. 2014-04-15. PMID:24660612. |
effect of xixin decoction on phosphorylation toxicity at specific sites of tau protein in brains of rats with sporadic alzheimer disease. |
2014-04-15 |
2023-08-12 |
rat |
| Yongchang Diwu, Jinzhou Tian, Jing Sh. Effect of Xixin decoction on phosphorylation toxicity at specific sites of tau protein in brains of rats with sporadic Alzheimer disease. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 33. issue 6. 2014-04-15. PMID:24660612. |
to explore the mechanism of action of xixin decoction (xxd) for the prevention and treatment of sporadic alzheimer disease (sad) by investigating the effects of xxd on the phosphorylation of thr231 and ser422 sites of tau protein. |
2014-04-15 |
2023-08-12 |
rat |
| Rong-Jie Chen, Wei-Wei Chang, Yu-Chun Lin, Pei-Lin Cheng, Yun-Ru Che. Alzheimer's amyloid-β oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway. ACS chemical neuroscience. vol 4. issue 9. 2014-04-14. PMID:23805846. |
alzheimer's amyloid-β oligomers rescue cellular prion protein induced tau reduction via the fyn pathway. |
2014-04-14 |
2023-08-12 |
human |
| Rong-Jie Chen, Wei-Wei Chang, Yu-Chun Lin, Pei-Lin Cheng, Yun-Ru Che. Alzheimer's amyloid-β oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway. ACS chemical neuroscience. vol 4. issue 9. 2014-04-14. PMID:23805846. |
amyloid-β (aβ) and tau are the pathogenic hallmarks in alzheimer's disease (ad). |
2014-04-14 |
2023-08-12 |
human |
| Johannes Attems, Kurt Jellinge. Neuropathological correlates of cerebral multimorbidity. Current Alzheimer research. vol 10. issue 6. 2014-04-11. PMID:23627751. |
alzheimer's disease (ad), amyloid-β (aβ) hyperphosphorylated tau (tau); lewy body diseases, α- synuclein (α-syn); frontotemporal lobar degeneration, tau, tdp-43, ubiquitin or fus. |
2014-04-11 |
2023-08-12 |
Not clear |
| Virginie Stygelbout, Karelle Leroy, Valérie Pouillon, Kunie Ando, Eva D'Amico, Yonghui Jia, H Robert Luo, Charles Duyckaerts, Christophe Erneux, Stéphane Schurmans, Jean-Pierre Brio. Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology. Brain : a journal of neurology. vol 137. issue Pt 2. 2014-04-11. PMID:24401760. |
however, in the 5x familial alzheimer's disease mouse model, neuronal itpkb overexpression significantly increased extracellular signal-regulated kinases 1/2 activation and β-secretase 1 activity, resulting in exacerbated alzheimer's disease pathology as shown by increased astrogliosis, amyloid-β40 peptide production and tau hyperphosphorylation. |
2014-04-11 |
2023-08-12 |
mouse |
| Virginie Stygelbout, Karelle Leroy, Valérie Pouillon, Kunie Ando, Eva D'Amico, Yonghui Jia, H Robert Luo, Charles Duyckaerts, Christophe Erneux, Stéphane Schurmans, Jean-Pierre Brio. Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology. Brain : a journal of neurology. vol 137. issue Pt 2. 2014-04-11. PMID:24401760. |
together, our results point to the itpkb/inositol 1,3,4,5-tetrakisphosphate/extracellular signal-regulated kinases 1/2 signalling pathway as an important regulator of neuronal cell apoptosis, app processing and tau phosphorylation in alzheimer's disease, and suggest that itpkb could represent a new target for reducing pathology in human patients with alzheimer's disease with itpkb expression. |
2014-04-11 |
2023-08-12 |
mouse |
| Adrian C Lo, Emilia Iscru, David Blum, Ina Tesseur, Zsuzsanna Callaerts-Vegh, Luc Buée, Bart De Strooper, Detlef Balschun, Rudi D'Hoog. Amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 37. issue 1. 2014-04-08. PMID:23788007. |
amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of alzheimer's disease. |
2014-04-08 |
2023-08-12 |
mouse |
| Seameen J Dehdashti, Wei Zheng, Joel R Gever, Robert Wilhelm, Dac-Trung Nguyen, Gurusingham Sittampalam, John C McKew, Christopher P Austin, Stanley B Prusine. A high-throughput screening assay for determining cellular levels of total tau protein. Current Alzheimer research. vol 10. issue 7. 2014-04-08. PMID:23905996. |
in the past decade, the hyperphosphorylated and aggregated states of tau protein have been important targets in the drug discovery field for the potential treatment of alzheimer's disease. |
2014-04-08 |
2023-08-12 |
Not clear |
| Shan Liu, Ariel Breitbart, Yanjie Sun, Pankaj D Mehta, Allal Boutajangout, Henrieta Scholtzova, Thomas Wisniewsk. Blocking the apolipoprotein E/amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology. Journal of neurochemistry. vol 128. issue 4. 2014-04-08. PMID:24117759. |
blocking the apolipoprotein e/amyloid β interaction in triple transgenic mice ameliorates alzheimer's disease related amyloid β and tau pathology. |
2014-04-08 |
2023-08-12 |
mouse |
| Claire H Michel, Satish Kumar, Dorothea Pinotsi, Alan Tunnacliffe, Peter St George-Hyslop, Eckhard Mandelkow, Eva-Maria Mandelkow, Clemens F Kaminski, Gabriele S Kaminski Schierl. Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology. The Journal of biological chemistry. vol 289. issue 2. 2014-04-08. PMID:24235150. |
understanding the formation and propagation of aggregates of the alzheimer disease-associated tau protein in vivo is vital for the development of therapeutics for this devastating disorder. |
2014-04-08 |
2023-08-12 |
Not clear |
| Marisol Herrera-Rivero, Abraham Soto-Cid, María E Hernández, Gonzalo E Aranda-Abre. Tau, APP, NCT and BACE1 in lymphocytes through cognitively normal ageing and neuropathology. Anais da Academia Brasileira de Ciencias. vol 85. issue 4. 2014-04-07. PMID:24346801. |
we analysed the expression of tau, of the amyloid precursor protein, of nicastrin and of the β-site app cleaving enzyme genes by rt-pcr in lymphocytes from a small group of late-onset alzheimer's disease patients, from aged patients suffering from neuropsychological conditions different from alzheimer's and from cognitively healthy subjects divided in four groups by age. |
2014-04-07 |
2023-08-12 |
human |
| Marisol Herrera-Rivero, Abraham Soto-Cid, María E Hernández, Gonzalo E Aranda-Abre. Tau, APP, NCT and BACE1 in lymphocytes through cognitively normal ageing and neuropathology. Anais da Academia Brasileira de Ciencias. vol 85. issue 4. 2014-04-07. PMID:24346801. |
results show no tau expression in lymphocytes, a lack of detection of nicastrin expression in alzheimer's patients and correlations between the medical conditions studied and gene expression in lymphocytes. |
2014-04-07 |
2023-08-12 |
human |
| Hidetoshi Watari, Yutaka Shimada, Chihiro Tohd. New Treatment for Alzheimer's Disease, Kamikihito, Reverses Amyloid-β-Induced Progression of Tau Phosphorylation and Axonal Atrophy. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-04-07. PMID:24707311. |
new treatment for alzheimer's disease, kamikihito, reverses amyloid-β-induced progression of tau phosphorylation and axonal atrophy. |
2014-04-07 |
2023-08-13 |
mouse |
| Valentine Lahmy, Johann Meunier, Susanna Malmström, Gaelle Naert, Laurent Givalois, Seung Hyun Kim, Vanessa Villard, Alexandre Vamvakides, Tangui Mauric. Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 9. 2014-04-04. PMID:23493042. |
blockade of tau hyperphosphorylation and aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative anavex2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of alzheimer's disease. |
2014-04-04 |
2023-08-12 |
mouse |
| Valentine Lahmy, Johann Meunier, Susanna Malmström, Gaelle Naert, Laurent Givalois, Seung Hyun Kim, Vanessa Villard, Alexandre Vamvakides, Tangui Mauric. Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 9. 2014-04-04. PMID:23493042. |
the main objective of the present study was to establish whether the mixed σ₁/muscarinic ligand anavex2-73, shown to be neuroprotective in alzheimer's disease (ad) models in vivo and currently in clinical phase i/iia, could have the ability to reduce the appearance of hyperphosphorylated tau and amyloid-β₁₋₄₂ (aβ₁₋₄₂ in the aβ₂₅₋₃₅ mouse model of ad. |
2014-04-04 |
2023-08-12 |
mouse |
| Anja Soldan, Corinne Pettigrew, Shanshan Li, Mei-Cheng Wang, Abhay Moghekar, Ola A Selnes, Marilyn Albert, Richard O'Brie. Relationship of cognitive reserve and cerebrospinal fluid biomarkers to the emergence of clinical symptoms in preclinical Alzheimer's disease. Neurobiology of aging. vol 34. issue 12. 2014-04-02. PMID:23916061. |
the levels of β-amyloid (aβ) and phosphorylated tau (p-tau), as measured in cerebrospinal fluid, have been associated with the risk of progressing from normal cognition to onset of clinical symptoms during preclinical alzheimer's disease. |
2014-04-02 |
2023-08-12 |
human |
| Koichi It. Frontiers of model animals for neuroscience: two prosperous aging model animals for promoting neuroscience research. Experimental animals. vol 62. issue 4. 2014-04-02. PMID:24172191. |
samp10 also shows age-related impairment of learning and memory, but it does not seem to correspond to alzheimer's disease because senile plaques primarily composed of amyloid β or neurofibrillary tangles primarily composed of phosphorylated tau were not observed. |
2014-04-02 |
2023-08-12 |
mouse |