| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mak Adam Daulatza. Death by a thousand cuts in Alzheimer's disease: hypoxia--the prodrome. Neurotoxicity research. vol 24. issue 2. 2014-03-03. PMID:23400634. |
strong evidence underscores that cerebral amyloidogenesis and tau phosphorylation--two cardinal features of alzheimer's disease (ad), are triggered by hypoxia. |
2014-03-03 |
2023-08-12 |
mouse |
| Teikichi Ikura, Nobutoshi It. Peptidyl-prolyl isomerase activity of FK506 binding protein 12 prevents tau peptide from aggregating. Protein engineering, design & selection : PEDS. vol 26. issue 9. 2014-03-03. PMID:23832849. |
the alzheimer's disease-related protein, tau, aggregates into neurofibrillary tangles when it is hyperphosphorylated. |
2014-03-03 |
2023-08-12 |
Not clear |
| Martin Schwalbe, Jacek Biernat, Stefan Bibow, Valéry Ozenne, Malene R Jensen, Harindranath Kadavath, Martin Blackledge, Eckhard Mandelkow, Markus Zweckstette. Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2. Biochemistry. vol 52. issue 50. 2014-03-03. PMID:24251416. |
tau protein plays an important role in neuronal physiology and alzheimer's neurodegeneration. |
2014-03-03 |
2023-08-12 |
human |
| Hadas Erez, Or A Shemesh, Micha E Spir. Rescue of tau-induced synaptic transmission pathology by paclitaxel. Frontiers in cellular neuroscience. vol 8. 2014-02-27. PMID:24574970. |
behavioral and electrophysiological studies of alzheimer's disease (ad) and other tauopathies have revealed that the onset of cognitive decline correlates better with synaptic dysfunctions than with hallmark pathologies such as extracellular amyloid-β plaques, intracellular hyperphosphorylated tau or neuronal loss. |
2014-02-27 |
2023-08-12 |
aplysia |
| Pedro Rosa-Neto, Ging-Yuek Hsiung, Mario Maselli. Fluid biomarkers for diagnosing dementia: rationale and the Canadian Consensus on Diagnosis and Treatment of Dementia recommendations for Canadian physicians. Alzheimer's research & therapy. vol 5. issue Suppl 1. 2014-02-25. PMID:24565514. |
evidence for csf aβ1-42, total tau and phosphorylated tau in the diagnosis of alzheimer pathology is much stronger, and can be considered at the tertiary care level for selected cases to improve diagnostic certainty, particularly in those cases presenting atypical clinical features. |
2014-02-25 |
2023-08-12 |
Not clear |
| K Nakamura, X Z Zhou, K P L. Distinct functions of cis and trans phosphorylated tau in Alzheimer's disease and their therapeutic implications. Current molecular medicine. vol 13. issue 7. 2014-02-24. PMID:23157676. |
distinct functions of cis and trans phosphorylated tau in alzheimer's disease and their therapeutic implications. |
2014-02-24 |
2023-08-12 |
human |
| J Cummings, K Zhon. Biomarker-driven therapeutic management of Alzheimer's disease: establishing the foundations. Clinical pharmacology and therapeutics. vol 95. issue 1. 2014-02-24. PMID:24105258. |
amyloid measures become abnormal early in the alzheimer's disease process and have only weak correlations with disease progression and cognitive decline; cerebrospinal fluid tau, brain atrophy, and reduced cortical metabolism correlate with cognitive measures and disease progression. |
2014-02-24 |
2023-08-12 |
Not clear |
| Micaela Johanna Glat, Daniel Offe. Cell and gene therapy in Alzheimer's disease. Stem cells and development. vol 22. issue 10. 2014-02-20. PMID:23320452. |
alzheimer's disease (ad) is a progressive neurological disorder characterized by the aggregation of two proteins, amyloid-β and hyperphosphorylated tau, and by neuronal and synaptic loss. |
2014-02-20 |
2023-08-12 |
Not clear |
| Maria Manczak, P Hemachandra Redd. RNA silencing of genes involved in Alzheimer's disease enhances mitochondrial function and synaptic activity. Biochimica et biophysica acta. vol 1832. issue 12. 2014-02-20. PMID:24063855. |
an age-dependent increase in mrna levels of the amyloid precursor protein (app), the microtubule-associated protein tau, and voltage-dependent anion channel 1 (vdac1) genes are reported to be toxic to neurons affected by alzheimer's disease (ad). |
2014-02-20 |
2023-08-12 |
human |
| Elisabet Barbero-Camps, Anna Fernández, Laura Martínez, Jose C Fernández-Checa, Anna Colel. APP/PS1 mice overexpressing SREBP-2 exhibit combined Aβ accumulation and tau pathology underlying Alzheimer's disease. Human molecular genetics. vol 22. issue 17. 2014-02-19. PMID:23648430. |
app/ps1 mice overexpressing srebp-2 exhibit combined aβ accumulation and tau pathology underlying alzheimer's disease. |
2014-02-19 |
2023-08-12 |
mouse |
| Pranay Bharadwaj, Christine McInnis, Amanda M K Madden, Paul J Bonthuis, Susan Zup, Emilie F Rissman, Jin Ho Par. Increased dendritic spine density and tau expression are associated with individual differences in steroidal regulation of male sexual behavior. PloS one. vol 8. issue 7. 2014-02-19. PMID:23874981. |
interestingly, best known for their association with alzheimer's disease, amyloid precursor protein (app) and the microtubule-associated protein tau (mapt) were elevated in maters. |
2014-02-19 |
2023-08-12 |
mouse |
| Siddhartha Mondragón-Rodríguez, George Perry, Xiongwei Zhu, Paula I Moreira, Mariana C Acevedo-Aquino, Sylvain William. Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: implications for Alzheimer's disease. Oxidative medicine and cellular longevity. vol 2013. 2014-02-19. PMID:23936615. |
phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: implications for alzheimer's disease. |
2014-02-19 |
2023-08-12 |
Not clear |
| Siddhartha Mondragón-Rodríguez, George Perry, Xiongwei Zhu, Paula I Moreira, Mariana C Acevedo-Aquino, Sylvain William. Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: implications for Alzheimer's disease. Oxidative medicine and cellular longevity. vol 2013. 2014-02-19. PMID:23936615. |
alzheimer's disease (ad) is defined by the concurrence of abnormal aggregates composed of phosphorylated tau protein and of abnormal cellular changes including neurite degeneration, loss of neurons, and loss of cognitive functions. |
2014-02-19 |
2023-08-12 |
Not clear |
| Maria Carmela Tartaglia, Lili-Naz Hazrati, Karen D Davis, Robin E A Green, Richard Wennberg, David Mikulis, Leo J Ezerins, Michelle Keightley, Charles Tato. Chronic traumatic encephalopathy and other neurodegenerative proteinopathies. Frontiers in human neuroscience. vol 8. 2014-02-19. PMID:24550810. |
much remains unknown about the development of cte but its pathological substrate is usually tau, similar to that seen in alzheimer's disease (ad) and frontotemporal lobar degeneration (ftld). |
2014-02-19 |
2023-08-12 |
Not clear |
| b' Jin Chu, Jian-Guo Li, Carolina Ceballos-Diaz, Todd Golde, Domenico Pratic\\xc3\\xb. The influence of 5-lipoxygenase on Alzheimer\'s disease-related tau pathology: in vivo and in vitro evidence. Biological psychiatry. vol 74. issue 5. 2014-02-18. PMID:23352590.' |
the influence of 5-lipoxygenase on alzheimer's disease-related tau pathology: in vivo and in vitro evidence. |
2014-02-18 |
2023-08-12 |
Not clear |
| b' Jin Chu, Jian-Guo Li, Carolina Ceballos-Diaz, Todd Golde, Domenico Pratic\\xc3\\xb. The influence of 5-lipoxygenase on Alzheimer\'s disease-related tau pathology: in vivo and in vitro evidence. Biological psychiatry. vol 74. issue 5. 2014-02-18. PMID:23352590.' |
intracellular deposition of tau protein is a hallmark lesion of alzheimer's disease. |
2014-02-18 |
2023-08-12 |
Not clear |
| Jose Abisambra, Umesh K Jinwal, Yoshinari Miyata, Justin Rogers, Laura Blair, Xiaokai Li, Sandlin P Seguin, Li Wang, Ying Jin, Justin Bacon, Sarah Brady, Matthew Cockman, Chantal Guidi, Juan Zhang, John Koren, Zapporah T Young, Christopher A Atkins, Bo Zhang, Lisa Y Lawson, Edwin J Weeber, Jeffrey L Brodsky, Jason E Gestwicki, Chad A Dicke. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biological psychiatry. vol 74. issue 5. 2014-02-18. PMID:23607970. |
the microtubule-associated protein tau accumulates in neurodegenerative diseases known as tauopathies, the most common being alzheimer's disease. |
2014-02-18 |
2023-08-12 |
Not clear |
| John R Dickson, Carla Kruse, Daniel R Montagna, Bente Finsen, Michael S Wolf. Alternative polyadenylation and miR-34 family members regulate tau expression. Journal of neurochemistry. vol 127. issue 6. 2014-02-18. PMID:24032460. |
tau pathologically aggregates in alzheimer's disease, and evidence suggests that reducing tau expression may be safe and beneficial for the prevention or treatment of this disease. |
2014-02-18 |
2023-08-12 |
human |
| John R Dickson, Carla Kruse, Daniel R Montagna, Bente Finsen, Michael S Wolf. Alternative polyadenylation and miR-34 family members regulate tau expression. Journal of neurochemistry. vol 127. issue 6. 2014-02-18. PMID:24032460. |
improved understanding of the regulation of tau expression by its 3'-utr may ultimately lead to the development of novel therapeutic strategies for the treatment of alzheimer's disease and other tauopathies. |
2014-02-18 |
2023-08-12 |
human |
| John R Dickson, Carla Kruse, Daniel R Montagna, Bente Finsen, Michael S Wolf. Alternative polyadenylation and miR-34 family members regulate tau expression. Journal of neurochemistry. vol 127. issue 6. 2014-02-18. PMID:24032460. |
despite the centrality of the tau protein in alzheimer's and other neurodegenerative diseases, the human tau 3'-utr has been little studied. |
2014-02-18 |
2023-08-12 |
human |