| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miguel Medina, Jesús Avila, Nieves Villanuev. Use of okadaic acid to identify relevant phosphoepitopes in pathology: a focus on neurodegeneration. Marine drugs. vol 11. issue 5. 2014-01-06. PMID:23697949. |
finally, its effect on tau hyperhosphorylation and its relevance in neurodegenerative pathologies such as alzheimer's disease and related dementia will be discussed. |
2014-01-06 |
2023-08-12 |
Not clear |
| Manuela Mellone, Dimitra Kestoras, Melissa R Andrews, Elisa Dassie, R Anthony Crowther, Gorazd B Stokin, Jon Tinsley, Graeme Horne, Michel Goedert, Aviva M Tolkovsky, Maria Grazia Spillantin. Tau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 46. 2014-01-06. PMID:24227726. |
intracellular tau aggregates are the neuropathological hallmark of several neurodegenerative diseases, including alzheimer's disease, progressive supranuclear palsy, and cases of frontotemporal dementia, but the link between these aggregates and neurodegeneration remains unclear. |
2014-01-06 |
2023-08-12 |
mouse |
| Kim Henriksen, Yaguo Wang, Mette G Sørensen, Natasha Barascuk, Joyce Suhy, Jan T Pedersen, Kevin L Duffin, Robert A Dean, Monika Pajak, Claus Christiansen, Qinlong Zheng, Morten A Karsda. An enzyme-generated fragment of tau measured in serum shows an inverse correlation to cognitive function. PloS one. vol 8. issue 5. 2014-01-02. PMID:23717682. |
alzheimer's disease (ad) is a devastating neurological disease characterized by pathological proteolytic cleavage of tau protein, which appears to initiate death of the neurons. |
2014-01-02 |
2023-08-12 |
Not clear |
| Jannic Boeh. A 'danse macabre': tau and Fyn in STEP with amyloid beta to facilitate induction of synaptic depression and excitotoxicity. The European journal of neuroscience. vol 37. issue 12. 2013-12-31. PMID:23773061. |
alzheimer's disease, with its two most prominent pathological factors amyloid beta and tau protein, can be described as a disease of the synapse. |
2013-12-31 |
2023-08-12 |
Not clear |
| Nguyen-Vi Mohamed, Thibaut Herrou, Vanessa Plouffe, Nicolas Piperno, Nicole Lecler. Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission. The European journal of neuroscience. vol 37. issue 12. 2013-12-31. PMID:23773063. |
spreading of tau pathology in alzheimer's disease by cell-to-cell transmission. |
2013-12-31 |
2023-08-12 |
mouse |
| Nguyen-Vi Mohamed, Thibaut Herrou, Vanessa Plouffe, Nicolas Piperno, Nicole Lecler. Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission. The European journal of neuroscience. vol 37. issue 12. 2013-12-31. PMID:23773063. |
it is well documented that neurofibrillary tangles composed of aggregated tau protein propagate in a predictable pattern in alzheimer's disease (ad). |
2013-12-31 |
2023-08-12 |
mouse |
| Kazuhiro Nakamura, Xiao Zhen Zhou, Kun Ping L. Cis phosphorylated tau as the earliest detectable pathogenic conformation in Alzheimer disease, offering novel diagnostic and therapeutic strategies. Prion. vol 7. issue 2. 2013-12-30. PMID:23154634. |
cis phosphorylated tau as the earliest detectable pathogenic conformation in alzheimer disease, offering novel diagnostic and therapeutic strategies. |
2013-12-30 |
2023-08-12 |
Not clear |
| Xia Jiang, Lin-Wei Jia, Xiao-Hong Li, Xiang-Shu Cheng, Jia-Zhao Xie, Zhi-Wei Ma, Wei-Jie Xu, Yue Liu, Yun Yao, Lai-Ling Du, Xin-Wen Zho. Capsaicin ameliorates stress-induced Alzheimer's disease-like pathological and cognitive impairments in rats. Journal of Alzheimer's disease : JAD. vol 35. issue 1. 2013-12-27. PMID:23340038. |
hyperphosphorylated tau aggregated into neurofibrillary tangles is a hallmark lesion of alzheimer's disease (ad) and is linked to synaptic and cognitive impairments. |
2013-12-27 |
2023-08-12 |
rat |
| Jessica M Posimo, Amanda M Titler, Hailey J H Choi, Ajay S Unnithan, Rehana K Lea. Neocortex and allocortex respond differentially to cellular stress in vitro and aging in vivo. PloS one. vol 8. issue 3. 2013-12-27. PMID:23536801. |
in parkinson's and alzheimer's diseases, the allocortex accumulates aggregated proteins such as synuclein and tau well before neocortex. |
2013-12-27 |
2023-08-12 |
rat |
| Min Jae Lee, Jung Hoon Lee, David C Rubinsztei. Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. Progress in neurobiology. vol 105. 2013-12-26. PMID:23528736. |
the two hallmark lesions of alzheimer's disease (ad) are extracellular β-amyloid plaques and intracellular tau tangles. |
2013-12-26 |
2023-08-12 |
Not clear |
| Jhoana Mendoza, Michiko Sekiya, Taizo Taniguchi, Koichi M Iijima, Rong Wang, Kanae And. Global analysis of phosphorylation of tau by the checkpoint kinases Chk1 and Chk2 in vitro. Journal of proteome research. vol 12. issue 6. 2013-12-23. PMID:23550703. |
hyperphosphorylation of microtubule-associated protein tau is thought to contribute to alzheimer's disease (ad) pathogenesis. |
2013-12-23 |
2023-08-12 |
human |
| Irina Lonskaya, Michaeline L Hebron, Nicole M Desforges, Alexander Franjie, Charbel E-H Mouss. Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance. EMBO molecular medicine. vol 5. issue 8. 2013-12-23. PMID:23737459. |
alzheimer is a neurodegenerative disease characterized by accumulation of β-amyloid (plaques) and hyper-phosphorylated tau (tangles). |
2013-12-23 |
2023-08-12 |
mouse |
| Shuk Wai Ho, Yuk Tung Chanel Tsui, Ting Ting Wong, Stanley Kwok-Kuen Cheung, William B Goggins, Lau Ming Yi, Kwok Kin Cheng, Larry Bau. Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer's disease. Translational neurodegeneration. vol 2. issue 1. 2013-12-20. PMID:24344631. |
alzheimer's disease (ad), the most common dementia, is characterized by potentially neurotoxic aggregation of aβ peptide and tau protein, and their deposition as amyloid plaques and neurofibrillary tangles (nfts). |
2013-12-20 |
2023-08-12 |
mouse |
| Richard L Veec. Ketone esters increase brown fat in mice and overcome insulin resistance in other tissues in the rat. Annals of the New York Academy of Sciences. vol 1302. 2013-12-18. PMID:23909803. |
other effects of feeding ketone esters, in addition to their ability to induce brown fat, are discussed such as their ability to overcome certain aspects of insulin resistance and to ameliorate the accumulation of amyloid and phosphorylated tau protein in brain, and improve cognitive function, in a triple transgenic mouse model of alzheimer's disease. |
2013-12-18 |
2023-08-12 |
mouse |
| Artor Niccoli Asabella, Marilena Ruggeri, Domenico Rubini, Lorenzo Polimeno, Cristina Spinelli, Marella Polito, Michele Pennelli, Corinna Altini, Maria Sara De Caro, Giovanni Defazio, Giuseppe Rubin. [Correlation between cognitive impairment and plasma levels of clusterin/ApoJ in Parkinson disease patients not affected by dementia]. Recenti progressi in medicina. vol 104. issue 7-8. 2013-12-17. PMID:24042414. |
recently a contribution of alzheimer's disease for the cognitive dysfunction in pd has been proposed, whereas the presence of tau protein and amyloid was recognized. |
2013-12-17 |
2023-08-12 |
Not clear |
| Robert Siman, Yin-Guo Lin, Gauri Malthankar-Phatak, Yina Don. A rapid gene delivery-based mouse model for early-stage Alzheimer disease-type tauopathy. Journal of neuropathology and experimental neurology. vol 72. issue 11. 2013-12-17. PMID:24128676. |
the perforant pathway projection from the entorhinal cortex (ec) to the hippocampal dentate gyrus is critically important for long-term memory and develops tau and amyloid pathologies and progressive degeneration starting in the early stages of alzheimer disease (ad). |
2013-12-17 |
2023-08-12 |
mouse |
| Dong Liu, Michael Pitta, Haiyang Jiang, Jong-Hwan Lee, Guofeng Zhang, Xinzhi Chen, Elisa M Kawamoto, Mark P Mattso. Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession. Neurobiology of aging. vol 34. issue 6. 2013-12-11. PMID:23273573. |
impaired brain energy metabolism and oxidative stress are implicated in cognitive decline and the pathologic accumulations of amyloid β-peptide (aβ) and hyperphosphorylated tau in alzheimer's disease (ad). |
2013-12-11 |
2023-08-12 |
mouse |
| Yoshihiro Kashiwaya, Christian Bergman, Jong-Hwan Lee, Ruiqian Wan, M Todd King, Mohamed R Mughal, Eitan Okun, Kieran Clarke, Mark P Mattson, Richard L Veec. A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 34. issue 6. 2013-12-11. PMID:23276384. |
a ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of alzheimer's disease. |
2013-12-11 |
2023-08-12 |
mouse |
| Meaghan Morris, Patricia Hamto, Anthony Adame, Nino Devidze, Eliezer Masliah, Lennart Muck. Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice. Neurobiology of aging. vol 34. issue 6. 2013-12-11. PMID:23332171. |
though tau ablation prevented synaptic, network, and cognitive dysfunctions in several models of alzheimer's disease and made mice more resistant to epileptic seizures, a recent study described a parkinsonian phenotype in aging tau knockout mice. |
2013-12-11 |
2023-08-12 |
mouse |
| b' Jin Chu, Domenico Pratic\\xc3\\xb. 5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5. Neurobiology of aging. vol 34. issue 6. 2013-12-11. PMID:23332172.' |
our findings highlight the novel functional role that neuronal 5lo plays in modulating tau phosphorylation, and suggest that pharmacologic inhibition of 5lo could provide a novel therapeutic opportunity also for alzheimer's disease-related tau pathology. |
2013-12-11 |
2023-08-12 |
mouse |