Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Siddhartha Mondragón-Rodríguez, George Perry, Xiongwei Zhu, Jannic Boeh. Amyloid Beta and tau proteins as therapeutic targets for Alzheimer's disease treatment: rethinking the current strategy. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22482074. |
alzheimer's disease (ad) is defined by the concurrence of accumulation of abnormal aggregates composed of two proteins: amyloid beta (aβ) and tau, and of cellular changes including neurite degeneration and loss of neurons and cognitive functions. |
2012-08-23 |
2023-08-12 |
Not clear |
Carlos Carrasco-Gallardo, Leonardo Guzmán, Ricardo B Maccion. Shilajit: a natural phytocomplex with potential procognitive activity. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22482077. |
thus, fulvic acid, the main active principle, blocks tau self-aggregation, opening an avenue toward the study of alzheimer's therapy. |
2012-08-23 |
2023-08-12 |
human |
Carole J Proctor, Douglas A Gra. A unifying hypothesis for familial and sporadic Alzheimer's disease. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22482080. |
alzheimer's disease (ad) is characterised by the aggregation of two quite different proteins, namely, amyloid-beta (aβ), which forms extracellular plaques, and tau, the main component of cytoplasmic neurofibrillary tangles. |
2012-08-23 |
2023-08-12 |
Not clear |
Mario Nizzari, Stefano Thellung, Alessandro Corsaro, Valentina Villa, Aldo Pagano, Carola Porcile, Claudio Russo, Tullio Flori. Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling. Journal of toxicology. vol 2012. 2012-08-23. PMID:22496686. |
alzheimer disease (ad) is a heterogeneous neurodegenerative disorder characterized by (1) progressive loss of synapses and neurons, (2) intracellular neurofibrillary tangles, composed of hyperphosphorylated tau protein, and (3) amyloid plaques. |
2012-08-23 |
2023-08-12 |
Not clear |
Nicole Gallo-Payet, Marie-Odile Guimond, Lyne Bilodeau, Charlotta Wallinder, Mathias Alterman, Anders Hallber. Angiotensin II, a Neuropeptide at the Frontier between Endocrinology and Neuroscience: Is There a Link between the Angiotensin II Type 2 Receptor and Alzheimer's Disease? Frontiers in endocrinology. vol 2. 2012-08-23. PMID:22649365. |
amyloid-β peptide deposition, abnormal hyperphosphorylation of tau, as well as inflammation and vascular damage, are associated with the development of alzheimer's disease (ad). |
2012-08-23 |
2023-08-12 |
Not clear |
Jose F Abisambra, Umesh K Jinwal, Jeffrey R Jones, Laura J Blair, John Koren, Chad A Dicke. Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics. Current neuropharmacology. vol 9. issue 4. 2012-08-23. PMID:22654720. |
in alzheimer's disease, extracellular accumulation of the amyloid β peptide (aβ) and intracellular aggregation of the microtubule associated protein tau may result from mechanisms involving chaperone proteins like the hsps. |
2012-08-23 |
2023-08-12 |
Not clear |
Sergio A Rosales-Corral, Gabriela Lopez-Armas, Jose Cruz-Ramos, Valery G Melnikov, Dun-Xian Tan, Lucien C Manchester, Ruben Munoz, Russel J Reite. Alterations in Lipid Levels of Mitochondrial Membranes Induced by Amyloid-β: A Protective Role of Melatonin. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22666620. |
alzheimer pathogenesis involves mitochondrial dysfunction, which is closely related to amyloid-β (aβ) generation, abnormal tau phosphorylation, oxidative stress, and apoptosis. |
2012-08-23 |
2023-08-12 |
rat |
Michala Kolarova, Francisco García-Sierra, Ales Bartos, Jan Ricny, Daniela Ripov. Structure and pathology of tau protein in Alzheimer disease. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22690349. |
structure and pathology of tau protein in alzheimer disease. |
2012-08-23 |
2023-08-12 |
human |
Marc Gistelinck, Jean-Charles Lambert, Patrick Callaerts, Bart Dermaut, Pierre Dourle. Drosophila models of tauopathies: what have we learned? International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22701808. |
aggregates of the microtubule-associated protein tau are neuropathological hallmark lesions in alzheimer's disease (ad) and related primary tauopathies. |
2012-08-23 |
2023-08-12 |
mouse |
Natalia Crespo-Biel, Clara Theunis, Fred Van Leuve. Protein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22720188. |
protein tau: prime cause of synaptic and neuronal degeneration in alzheimer's disease. |
2012-08-23 |
2023-08-12 |
human |
Sébastien S Hébert, Nicolas Sergeant, Luc Bué. MicroRNAs and the Regulation of Tau Metabolism. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22720189. |
abnormal regulation of tau phosphorylation and/or alternative splicing is associated with the development of a large (>20) group of neurodegenerative disorders collectively known as tauopathies, the most common being alzheimer's disease. |
2012-08-23 |
2023-08-12 |
mouse |
Yazi D Ke, Alexandra K Suchowerska, Julia van der Hoven, Dineeka M De Silva, Christopher W Wu, Janet van Eersel, Arne Ittner, Lars M Ittne. Lessons from tau-deficient mice. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22720190. |
both alzheimer's disease (ad) and frontotemporal dementia (ftd) are characterized by the deposition of hyperphosphorylated forms of the microtubule-associated protein tau in neurons and/or glia. |
2012-08-23 |
2023-08-12 |
mouse |
Nadia Canu, Ilaria Filesi, Andrea Pristerà, Maria Teresa Ciotti, Silvia Biocc. Altered intracellular distribution of PrPC and impairment of proteasome activity in tau overexpressing cortical neurons. Journal of Alzheimer's disease : JAD. vol 27. issue 3. 2012-08-20. PMID:21841253. |
the microtubule associated protein tau plays a crucial role in alzheimer's disease and in many neurodegenerative disorders collectively known as tauopathies. |
2012-08-20 |
2023-08-12 |
Not clear |
Nikolai N Sluchanko, Nikolai B Guse. Probable participation of 14-3-3 in tau protein oligomerization and aggregation. Journal of Alzheimer's disease : JAD. vol 27. issue 3. 2012-08-20. PMID:21876254. |
aggregation of tau proteins followed by formation of paired helical filaments and neurofibrillary tangles is considered as a hallmark of certain neurodegenerative disorders such as different tauopathies and alzheimer's disease (ad). |
2012-08-20 |
2023-08-12 |
human |
Najla Kfoury, Brandon B Holmes, Hong Jiang, David M Holtzman, Marc I Diamon. Trans-cellular propagation of Tau aggregation by fibrillar species. The Journal of biological chemistry. vol 287. issue 23. 2012-08-20. PMID:22461630. |
aggregation of the microtubule associated protein tau is associated with several neurodegenerative disorders, including alzheimer disease and frontotemporal dementia. |
2012-08-20 |
2023-08-12 |
Not clear |
Najla Kfoury, Brandon B Holmes, Hong Jiang, David M Holtzman, Marc I Diamon. Trans-cellular propagation of Tau aggregation by fibrillar species. The Journal of biological chemistry. vol 287. issue 23. 2012-08-20. PMID:22461630. |
in alzheimer disease, tau pathology spreads progressively throughout the brain, possibly along existing neural networks. |
2012-08-20 |
2023-08-12 |
Not clear |
José L Molinuevo, Juan D Gispert, Jesús Pujol, Santiago Rojas, Albert Lladó, Mircea Balasa, Anna Antonell, Raquel Sánchez-Valle, Lorena Ram. [A new approach to the Alzheimer's disease diagnosis with biomarkers: description of the AD-CSF-Index]. Revista de neurologia. vol 54. issue 9. 2012-08-20. PMID:22532214. |
studies with cerebrospinal fluid (csf) biomarkers in patients with confirmed alzheimer's disease (ad) pathology have shown that decreased levels of abeta(1-42) and increased levels of tau and p-tau, are a specific feature of the ad type pathology. |
2012-08-20 |
2023-08-12 |
Not clear |
Julia Miralbell, Gabriela Spulber, Babak Hooshmand, Ariadna Besga, Maria Mataró, Angel Cedazo-Minguez, Miia Kivipelto, Lars-Olof Wahlun. Grey matter and cognitive patterns in cognitive impaired subjects using CSF biomarker cut-offs. Journal of Alzheimer's disease : JAD. vol 29. issue 4. 2012-08-17. PMID:22330819. |
patients with abnormal levels of csf tau (but not aβ1-42) showed an alzheimer's disease-like pattern for both gm distribution and cognitive profile, compared to those with normal levels. |
2012-08-17 |
2023-08-12 |
human |
María Llorens-Martin, Cátia M Teixeira, Almudena Fuster-Matanzo, Jerónimo Jurado-Arjona, Víctor Borrell, Eduardo Soriano, Jesús Avila, Félix Hernánde. Tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: implications for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 29. issue 4. 2012-08-17. PMID:22337826. |
tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: implications for alzheimer's disease. |
2012-08-17 |
2023-08-12 |
mouse |
Nancy Beyer, David T R Coulson, Shirley Heggarty, Rivka Ravid, Jan Hellemans, G Brent Irvine, Janet A Johnsto. Zinc transporter mRNA levels in Alzheimer's disease postmortem brain. Journal of Alzheimer's disease : JAD. vol 29. issue 4. 2012-08-17. PMID:22349685. |
zn2+ can accelerate assembly of the amyloid-β peptides (aβ) and tau protein central to the neuropathological changes found in alzheimer's disease (ad). |
2012-08-17 |
2023-08-12 |
human |