| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David J Irwin, Todd J Cohen, Murray Grossman, Steven E Arnold, Sharon X Xie, Virginia M-Y Lee, John Q Trojanowsk. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain : a journal of neurology. vol 135. issue Pt 3. 2012-04-09. PMID:22366796. |
acetylated-tau pathology was compared with the sequential emergence of other tau modifications in the alzheimer's disease hippocampus using monoclonal antibodies to multiple well-characterized tau epitopes. |
2012-04-09 |
2023-08-12 |
Not clear |
| David J Irwin, Todd J Cohen, Murray Grossman, Steven E Arnold, Sharon X Xie, Virginia M-Y Lee, John Q Trojanowsk. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain : a journal of neurology. vol 135. issue Pt 3. 2012-04-09. PMID:22366796. |
acetylated-tau pathology was largely in intracellular, thioflavin-s-positive tau inclusions in alzheimer's disease, and also thioflavin-s-negative pathology in corticobasal degeneration and progressive supranuclear palsy. |
2012-04-09 |
2023-08-12 |
Not clear |
| David J Irwin, Todd J Cohen, Murray Grossman, Steven E Arnold, Sharon X Xie, Virginia M-Y Lee, John Q Trojanowsk. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain : a journal of neurology. vol 135. issue Pt 3. 2012-04-09. PMID:22366796. |
acetylated-tau was present throughout all stages of alzheimer's disease pathology, but was more prominently associated with pathological tau epitopes in moderate to severe-stage cases. |
2012-04-09 |
2023-08-12 |
Not clear |
| David J Irwin, Todd J Cohen, Murray Grossman, Steven E Arnold, Sharon X Xie, Virginia M-Y Lee, John Q Trojanowsk. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain : a journal of neurology. vol 135. issue Pt 3. 2012-04-09. PMID:22366796. |
these temporal and morphological immunohistochemical features suggest acetylation of tau at this epitope is preceded by early modifications, including phosphorylation, and followed by later truncation events and cell death in alzheimer's disease. |
2012-04-09 |
2023-08-12 |
Not clear |
| Gurdeep Marwarha, Bhanu Dasari, Othman Ghrib. Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol. Cellular signalling. vol 24. issue 2. 2012-04-06. PMID:21983012. |
epidemiological studies have suggested an inverse relationship between the adipocytokine leptin and the onset of alzheimer's disease (ad), and leptin supplementation decreases amyloid-β (aβ) production and tau phosphorylation (p-tau), two major biochemical events that play a key role in the pathogenesis of ad. |
2012-04-06 |
2023-08-12 |
human |
| Michael R Sierks, Gaurav Chatterjee, Claire McGraw, Srinath Kasturirangan, Philip Schulz, Shalini Prasa. CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease. Integrative biology : quantitative biosciences from nano to macro. vol 3. issue 12. 2012-04-04. PMID:22076255. |
csf levels of tau and aβ have been shown to have great promise as biomarkers for alzheimer's disease. |
2012-04-04 |
2023-08-12 |
human |
| Byong-kyu Shin, Sunil Saxen. Insight into potential Cu(II)-binding motifs in the four pseudorepeats of tau protein. The journal of physical chemistry. B. vol 115. issue 50. 2012-04-04. PMID:22085212. |
tau protein and cu(ii) are believed to be associated with the pathogenesis of alzheimer's disease. |
2012-04-04 |
2023-08-12 |
Not clear |
| N Mattsson, E Rosén, O Hansson, N Andreasen, L Parnetti, M Jonsson, S-K Herukka, W M van der Flier, M A Blankenstein, M Ewers, K Rich, E Kaiser, M M Verbeek, M Olde Rikkert, M Tsolaki, E Mulugeta, D Aarsland, P J Visser, J Schröder, J Marcusson, M de Leon, H Hampel, P Scheltens, A Wallin, M Eriksdotter-Jönhagen, L Minthon, B Winblad, K Blennow, H Zetterber. Age and diagnostic performance of Alzheimer disease CSF biomarkers. Neurology. vol 78. issue 7. 2012-04-04. PMID:22302554. |
core csf changes in alzheimer disease (ad) are decreased amyloid β(1-42), increased total tau, and increased phospho-tau, probably indicating amyloid plaque accumulation, axonal degeneration, and tangle pathology, respectively. |
2012-04-04 |
2023-08-12 |
Not clear |
| Eva Alonso, Carmen Vale, Mercedes R Vieytes, Frank M Laferla, Lydia Giménez-Llort, Luis M Botan. 13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro. Neurochemistry international. vol 59. issue 7. 2012-04-03. PMID:21907746. |
in this study we examined the effect of 13-desmethyl spirolide-c (spx) on amyloid-beta (aβ) accumulation and tau hyperphosphorylation in a neuronal model from triple transgenic mice (3xtg) for alzheimer disease (ad). |
2012-04-03 |
2023-08-12 |
mouse |
| Peng Lei, Scott Ayton, David I Finkelstein, Loredana Spoerri, Giuseppe D Ciccotosto, David K Wright, Bruce X W Wong, Paul A Adlard, Robert A Cherny, Linh Q Lam, Blaine R Roberts, Irene Volitakis, Gary F Egan, Catriona A McLean, Roberto Cappai, James A Duce, Ashley I Bus. Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nature medicine. vol 18. issue 2. 2012-03-29. PMID:22286308. |
the microtubule-associated protein tau has risk alleles for both alzheimer's disease and parkinson's disease and mutations that cause brain degenerative diseases termed tauopathies. |
2012-03-29 |
2023-08-12 |
mouse |
| Peng Lei, Scott Ayton, David I Finkelstein, Loredana Spoerri, Giuseppe D Ciccotosto, David K Wright, Bruce X W Wong, Paul A Adlard, Robert A Cherny, Linh Q Lam, Blaine R Roberts, Irene Volitakis, Gary F Egan, Catriona A McLean, Roberto Cappai, James A Duce, Ashley I Bus. Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nature medicine. vol 18. issue 2. 2012-03-29. PMID:22286308. |
soluble tau levels fall in affected brain regions in alzheimer's disease and tauopathies, and we found a similar decrease of soluble tau in the sn in both parkinson's disease and the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) mouse model. |
2012-03-29 |
2023-08-12 |
mouse |
| Peng Lei, Scott Ayton, David I Finkelstein, Loredana Spoerri, Giuseppe D Ciccotosto, David K Wright, Bruce X W Wong, Paul A Adlard, Robert A Cherny, Linh Q Lam, Blaine R Roberts, Irene Volitakis, Gary F Egan, Catriona A McLean, Roberto Cappai, James A Duce, Ashley I Bus. Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nature medicine. vol 18. issue 2. 2012-03-29. PMID:22286308. |
these data suggest that the loss of soluble tau could contribute to toxic neuronal iron accumulation in alzheimer's disease, parkinson's disease and tauopathies, and that it can be rescued pharmacologically. |
2012-03-29 |
2023-08-12 |
mouse |
| Ayoub Dakson, Osamu Yokota, Margaret Esiri, Eileen H Bigio, Michael Horan, Neil Pendleton, Anna Richardson, David Neary, Julie S Snowden, Andrew Robinson, Yvonne S Davidson, David M A Man. Granular expression of prolyl-peptidyl isomerase PIN1 is a constant and specific feature of Alzheimer's disease pathology and is independent of tau, Aβ and TDP-43 pathology. Acta neuropathologica. vol 121. issue 5. 2012-03-26. PMID:21243369. |
granular expression of prolyl-peptidyl isomerase pin1 is a constant and specific feature of alzheimer's disease pathology and is independent of tau, aβ and tdp-43 pathology. |
2012-03-26 |
2023-08-12 |
Not clear |
| Leslie M Shaw, Hugo Vanderstichele, Malgorzata Knapik-Czajka, Michal Figurski, Els Coart, Kaj Blennow, Holly Soares, Adam J Simon, Piotr Lewczuk, Robert A Dean, Eric Siemers, William Potter, Virginia M-Y Lee, John Q Trojanowsk. Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI. Acta neuropathologica. vol 121. issue 5. 2012-03-26. PMID:21311900. |
to address this challenge, we conducted a seven-center inter-laboratory standardization study for csf total tau (t-tau), phospho-tau (p-tau(181)) and aβ(1-42) as part of the alzheimer's disease neuroimaging initiative (adni). |
2012-03-26 |
2023-08-12 |
Not clear |
| Heiko Braak, Kelly Del Tredic. Alzheimer's pathogenesis: is there neuron-to-neuron propagation? Acta neuropathologica. vol 121. issue 5. 2012-03-26. PMID:21516512. |
in this review, we discuss the idea of possible disease progression from the locus coeruleus to the transentorhinal region of the cerebral cortex via neuron-to-neuron transmission and transsynaptic transport of tau protein aggregates, and we speculate that such a mechanism together with the very long prodromal period that characterizes alzheimer's disease may be indicative of a prion-like pathogenesis for this tauopathy. |
2012-03-26 |
2023-08-12 |
Not clear |
| Heiko Braak, Kelly Del Tredic. Alzheimer's pathogenesis: is there neuron-to-neuron propagation? Acta neuropathologica. vol 121. issue 5. 2012-03-26. PMID:21516512. |
the fact that at8-immunoreactive abnormal tau aggregates (pretangles) develop within proximal axons of noradrenergic coeruleus projection neurons in the absence of both tau lesions (pretangles, nfts/nts) in the transentorhinal region as well as cortical amyloid-β pathology means that currently used neuropathological stages for alzheimer's disease will have to be reclassified. |
2012-03-26 |
2023-08-12 |
Not clear |
| Robert D Dayton, David B Wang, Cooper D Cain, Lisa M Schrott, Julio J Ramirez, Michael A King, Ronald L Klei. Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Experimental neurology. vol 233. issue 2. 2012-03-26. PMID:22177996. |
the models could be of value for studying mechanisms of ftld and other diseases with tau and tdp-43 pathology in the hippocampus including alzheimer's disease, with relevance to early stage mild impairment. |
2012-03-26 |
2023-08-12 |
human |
| Sudad Saman, WonHee Kim, Mario Raya, Yvonne Visnick, Suhad Miro, Sarmad Saman, Bruce Jackson, Ann C McKee, Victor E Alvarez, Norman C Y Lee, Garth F Hal. Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. The Journal of biological chemistry. vol 287. issue 6. 2012-03-25. PMID:22057275. |
exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early alzheimer disease. |
2012-03-25 |
2023-08-12 |
human |
| Sudad Saman, WonHee Kim, Mario Raya, Yvonne Visnick, Suhad Miro, Sarmad Saman, Bruce Jackson, Ann C McKee, Victor E Alvarez, Norman C Y Lee, Garth F Hal. Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. The Journal of biological chemistry. vol 287. issue 6. 2012-03-25. PMID:22057275. |
exosome-associated tau is also present in human csf samples and is phosphorylated at thr-181 (at270), an established phosphotau biomarker for alzheimer disease (ad), in both m1c cells and in csf samples from patients with mild (braak stage 3) ad. |
2012-03-25 |
2023-08-12 |
human |
| Sylvia E Perez, Damianka P Getova, Bin He, Scott E Counts, Changiz Geula, Laurent Desire, Severine Coutadeur, Helene Peillon, Stephen D Ginsberg, Elliott J Mufso. Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease. The American journal of pathology. vol 180. issue 2. 2012-03-25. PMID:22142809. |
rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in alzheimer's disease. |
2012-03-25 |
2023-08-12 |
Not clear |