| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andreas Fellgiebel, Thomas Siessmeier, Armin Scheurich, Georg Winterer, Peter Bartenstein, Lutz G Schmidt, Matthias J Mülle. Association of elevated phospho-tau levels with Alzheimer-typical 18F-fluoro-2-deoxy-D-glucose positron emission tomography findings in patients with mild cognitive impairment. Biological psychiatry. vol 56. issue 4. 2004-09-30. PMID:15312816. |
phosphorylated tau protein in cerebrospinal fluid and even more decrements of cerebral glucose metabolism in parietal, temporal, or cingulate regions have shown favorable specificity for the diagnosis of alzheimer dementia and could be useful supplementary tools to determine alzheimer pathology in early stages. |
2004-09-30 |
2023-08-12 |
Not clear |
| Chihiro Yoshizaki, Mariko Tsukane, Takashi Yamauch. Overexpression of tau leads to the stimulation of neurite outgrowth, the activation of caspase 3 activity, and accumulation and phosphorylation of tau in neuroblastoma cells on cAMP treatment. Neuroscience research. vol 49. issue 4. 2004-09-27. PMID:15236861. |
to explore changes to the tau molecule in alzheimer's disease, we studied the effect of tau expression in stably transfected neuroblastoma x glioma hybrid ng108-15 cells (tau cells). |
2004-09-27 |
2023-08-12 |
Not clear |
| Chihiro Yoshizaki, Mariko Tsukane, Takashi Yamauch. Overexpression of tau leads to the stimulation of neurite outgrowth, the activation of caspase 3 activity, and accumulation and phosphorylation of tau in neuroblastoma cells on cAMP treatment. Neuroscience research. vol 49. issue 4. 2004-09-27. PMID:15236861. |
these observations have implications for the cellular causes of alzheimer's disease where the accumulation and mislocation of tau occur concomitant with neuronal degeneration. |
2004-09-27 |
2023-08-12 |
Not clear |
| Magnus Sjögren, Elisabet Englun. Negative neurofilament light and tau immunostaining in frontotemporal dementia. Dementia and geriatric cognitive disorders. vol 17. issue 4. 2004-09-24. PMID:15178951. |
we investigated the immunohistochemical stainability of phosphorylated tau and the light (nfl), intermediate (nfm), and heavy (nfh) neurofilament proteins in postmortem brain tissue from 8 patients with frontotemporal dementia (ftd), for comparison with 6 patients with alzheimer's disease (ad), and 6 normal controls. |
2004-09-24 |
2023-08-12 |
Not clear |
| Christopher L Hunter, Heather A Bimonte-Nelson, Mathew Nelson, Christopher B Eckman, Ann-Charlotte Granhol. Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen. Neurobiology of aging. vol 25. issue 7. 2004-09-21. PMID:15212841. |
individuals with down's syndrome (ds) develop neuropathological features similar to alzheimer's disease (ad) early in life, including dementia, accumulation of beta-amyloid, and irregular phosphorylation of tau proteins. |
2004-09-21 |
2023-08-12 |
mouse |
| François Devred, Pascale Barbier, Soazig Douillard, Octavio Monasterio, José Manuel Andreu, Vincent Peyro. Tau induces ring and microtubule formation from alphabeta-tubulin dimers under nonassembly conditions. Biochemistry. vol 43. issue 32. 2004-09-14. PMID:15301550. |
tau is a neuronal microtubule-associated protein that plays a central role in many cellular processes, both physiological and pathological, such as axons stabilization and alzheimer's disease. |
2004-09-14 |
2023-08-12 |
Not clear |
| Manuela Neumann, Veronika Müller, Karin Görner, Hans A Kretzschmar, Christian Haass, Philipp J Kahl. Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease. Acta neuropathologica. vol 107. issue 6. 2004-09-13. PMID:14991385. |
neuronal tau inclusions were dj-1 immunopositive in pick's disease (pid), corticobasal degeneration (cbd), progressive supranuclear palsy (psp), and alzheimer's disease. |
2004-09-13 |
2023-08-12 |
mouse |
| N S M Schoonenboom, Y A L Pijnenburg, C Mulder, S M Rosso, E-J Van Elk, G J Van Kamp, J C Van Swieten, Ph Schelten. Amyloid beta(1-42) and phosphorylated tau in CSF as markers for early-onset Alzheimer disease. Neurology. vol 62. issue 9. 2004-09-03. PMID:15136685. |
amyloid beta(1-42) and phosphorylated tau in csf as markers for early-onset alzheimer disease. |
2004-09-03 |
2023-08-12 |
Not clear |
| N S M Schoonenboom, Y A L Pijnenburg, C Mulder, S M Rosso, E-J Van Elk, G J Van Kamp, J C Van Swieten, Ph Schelten. Amyloid beta(1-42) and phosphorylated tau in CSF as markers for early-onset Alzheimer disease. Neurology. vol 62. issue 9. 2004-09-03. PMID:15136685. |
to determine the diagnostic value of csf amyloid beta(1-42) (abeta42), csf total tau, and csf tau phosphorylated at threonine-181 (ptau-181) in early-onset alzheimer disease (ead) vs frontotemporal lobar degeneration (ftld). |
2004-09-03 |
2023-08-12 |
Not clear |
| Hirotaka Yoshida, C James Hastie, Hilary McLauchlan, Philip Cohen, Michel Goeder. Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK). Journal of neurochemistry. vol 90. issue 2. 2004-09-03. PMID:15228592. |
these findings extend the number of candidate protein kinases for the hyperphosphorylation of tau in alzheimer's disease and other neurodegenerative disorders. |
2004-09-03 |
2023-08-12 |
Not clear |
| Piotr Lewczuk, Hermann Esselmann, Mirko Bibl, Georg Beck, Juan Manuel Maler, Markus Otto, Johannes Kornhuber, Jens Wiltfan. Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer's disease: original data and review of the literature. Journal of molecular neuroscience : MN. vol 23. issue 1-2. 2004-09-01. PMID:15126697. |
tau protein phosphorylated at threonine 181 in csf as a neurochemical biomarker in alzheimer's disease: original data and review of the literature. |
2004-09-01 |
2023-08-12 |
Not clear |
| Piotr Lewczuk, Hermann Esselmann, Mirko Bibl, Georg Beck, Juan Manuel Maler, Markus Otto, Johannes Kornhuber, Jens Wiltfan. Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer's disease: original data and review of the literature. Journal of molecular neuroscience : MN. vol 23. issue 1-2. 2004-09-01. PMID:15126697. |
cerebrospinal fluid (csf) concentrations of total tau and tau phosphorylated at threonine (position 181 [ptau181]) were studied with elisa in a group of carefully selected patients with a neurochemically supported diagnosis of alzheimer's disease (ad, n = 9; age range, 51-89 yr) and in a group of sex- and age-matched nondemented controls (n = 9; age range, 52-81 yr). |
2004-09-01 |
2023-08-12 |
Not clear |
| Fei Liu, Khalid Iqbal, Inge Grundke-Iqbal, Gerald W Hart, Cheng-Xin Gon. O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 29. 2004-08-26. PMID:15249677. |
o-glcnacylation regulates phosphorylation of tau: a mechanism involved in alzheimer's disease. |
2004-08-26 |
2023-08-12 |
mouse |
| Fei Liu, Khalid Iqbal, Inge Grundke-Iqbal, Gerald W Hart, Cheng-Xin Gon. O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 29. 2004-08-26. PMID:15249677. |
microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles in brains of individuals with alzheimer's disease (ad) and other tauopathies. |
2004-08-26 |
2023-08-12 |
mouse |
| Q Tian, Z-Q Lin, X-C Wang, J Chen, Q Wang, C-X Gong, J-Z Wan. Injection of okadaic acid into the meynert nucleus basalis of rat brain induces decreased acetylcholine level and spatial memory deficit. Neuroscience. vol 126. issue 2. 2004-08-24. PMID:15207345. |
abnormal hyperphosphorylation of tau and cholinergic deficit occur in the early stage of alzheimer's disease (ad) and relate to the dementia symptom. |
2004-08-24 |
2023-08-12 |
rat |
| Huishan Guo, Steffen Albrecht, Martine Bourdeau, Tracy Petzke, Catherine Bergeron, Andrea C LeBlan. Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease. The American journal of pathology. vol 165. issue 2. 2004-08-24. PMID:15277226. |
active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of alzheimer's disease. |
2004-08-24 |
2023-08-12 |
human |
| Cristian A Zambrano, José T Egaña, Marco T Núñez, Ricardo B Maccioni, Christian González-Billaul. Oxidative stress promotes tau dephosphorylation in neuronal cells: the roles of cdk5 and PP1. Free radical biology & medicine. vol 36. issue 11. 2004-08-19. PMID:15135175. |
abnormal phosphorylation of tau has been implicated in the etiopathogenesis of alzheimer's disease. |
2004-08-19 |
2023-08-12 |
human |
| Chun-I Sze, Meng Su, Subbiah Pugazhenthi, Purevsuren Jambal, Li-Jin Hsu, John Heath, Lori Schultz, Nan-Shan Chan. Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease. The Journal of biological chemistry. vol 279. issue 29. 2004-08-17. PMID:15126504. |
numerous enzymes hyperphosphorylate tau in vivo, leading to the formation of neurofibrillary tangles (nfts) in the neurons of alzheimer's disease (ad). |
2004-08-17 |
2023-08-12 |
Not clear |
| Gary W Arendash, Jada Lewis, Ralph E Leighty, Eileen McGowan, Jennifer R Cracchiolo, Mike Hutton, Marcos F Garci. Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. Brain research. vol 1012. issue 1-2. 2004-08-17. PMID:15158158. |
multi-metric behavioral comparison of appsw and p301l models for alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. |
2004-08-17 |
2023-08-12 |
mouse |
| Fumitaka Oyama, Svetlana Kotliarova, Akihiro Harada, Mamoru Ito, Haruko Miyazaki, Yoshito Ueyama, Nobutaka Hirokawa, Nobuyuki Nukina, Yasuo Ihar. Gem GTPase and tau: morphological changes induced by gem GTPase in cho cells are antagonized by tau. The Journal of biological chemistry. vol 279. issue 26. 2004-08-13. PMID:15087445. |
tau is also the major component of paired helical filaments found in brains affected by alzheimer's disease. |
2004-08-13 |
2023-08-12 |
mouse |