| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Denise Visser, Sander C J Verfaillie, Iris Bosch, Iman Brouwer, Hayel Tuncel, Emma M Coomans, Roos M Rikken, Sophie E Mastenbroek, Sandeep S V Golla, Frederik Barkhof, Elsmarieke van de Giessen, Bart N M van Berckel, Wiesje M van der Flier, Rik Ossenkoppel. Tau pathology as determinant of changes in atrophy and cerebral blood flow: a multi-modal longitudinal imaging study. European journal of nuclear medicine and molecular imaging. 2023-03-28. PMID:36976303. |
tau pathology is associated with concurrent atrophy and decreased cerebral blood flow (cbf) in alzheimer's disease (ad), but less is known about their temporal relationships. |
2023-03-28 |
2023-08-14 |
Not clear |
| Maite Solas, Silvia Vela, Cristian Smerdou, Eva Martisova, Iván Martínez-Valbuena, María-Rosario Luquin, María J Ramíre. JNK Activation in Alzheimer's Disease Is Driven by Amyloid β and Is Associated with Tau Pathology. ACS chemical neuroscience. 2023-03-28. PMID:36976903. |
jnk activation in alzheimer's disease is driven by amyloid β and is associated with tau pathology. |
2023-03-28 |
2023-08-14 |
mouse |
| Igor C Fontana, Amit Kumar, Agneta Nordber. The role of astrocytic α7 nicotinic acetylcholine receptors in Alzheimer disease. Nature reviews. Neurology. 2023-03-28. PMID:36977843. |
the ongoing search for therapeutic interventions in alzheimer disease (ad) has highlighted the complexity of this condition and the need for additional biomarkers, beyond amyloid-β (aβ) and tau, to improve clinical assessment. |
2023-03-28 |
2023-08-14 |
Not clear |
| Soraya Meftah, Jian Ga. Alzheimer's disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression. Frontiers in synaptic neuroscience. vol 15. 2023-03-27. PMID:36970154. |
the two main pathological hallmarks of alzheimer's disease, abnormal aggregates of amyloid or tau proteins, have had demonstrable effects on synaptic physiology in animal and cellular models of alzheimer's disease. |
2023-03-27 |
2023-08-14 |
mouse |
| Soraya Meftah, Jian Ga. Alzheimer's disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression. Frontiers in synaptic neuroscience. vol 15. 2023-03-27. PMID:36970154. |
subsequently, animal and cellular models of alzheimer's disease are considered, highlighting mouse models of amyloid and tau pathology and the role these proteins may play in synaptic dysfunction, either in isolation or examining how the two pathologies may interact in dysfunction. |
2023-03-27 |
2023-08-14 |
mouse |
| Soraya Meftah, Jian Ga. Alzheimer's disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression. Frontiers in synaptic neuroscience. vol 15. 2023-03-27. PMID:36970154. |
other important future avenues of note in this field include the role of non-neuronal cell types such as astrocytes and microglia, and mechanisms of dysfunction independent of amyloid and tau in alzheimer's disease. |
2023-03-27 |
2023-08-14 |
mouse |
| Dina Rodrigues Martins, Marc Vandermeeren, Kristof Van Kolen, Eddy Brepoels, Marianne Borgers, Cindy Wintmolders, Charlotte Delay, Astrid Bottelbergs, Marc Mercken, Clara Theuni. Development and Characterization of Mouse-Specific Anti-Tau Monoclonal Antibodies: Relevance for Analysis of Murine Tau in Cerebrospinal Fluid. Journal of Alzheimer's disease : JAD. 2023-03-27. PMID:36970909. |
clearance of tau seeds by immunization with tau antibodies is currently evaluated as therapeutic strategy to block the spreading of tau pathology in alzheimer's disease and other tauopathies. |
2023-03-27 |
2023-08-14 |
mouse |
| Christopher A Ayoub, Connor S Wagner, Jeff Kure. Identification of gene networks mediating regional resistance to tauopathy in late-onset Alzheimer's disease. PLoS genetics. vol 19. issue 3. 2023-03-27. PMID:36972319. |
neurofibrillary lesions composed of tau protein aggregates are defining hallmarks of alzheimer's disease. |
2023-03-27 |
2023-08-14 |
Not clear |
| Haruaki Sato, Kensaku Kasuga, Noriko Isoo, Toshihiro Hayashi, Takeshi Ikeuchi, Yukiko Hori, Taisuke Tomit. Soluble form of the APP fragment, sAPPβ, positively regulates tau secretion. Neuroscience research. 2023-03-26. PMID:36967088. |
extracellular tau has been highlighted in the pathogenesis of alzheimer disease (ad), which is the most common neurodegenerative disease. |
2023-03-26 |
2023-08-14 |
mouse |
| Diana I Bocancea, Anna L Svenningsson, Anna C van Loenhoud, Colin Groot, Frederik Barkhof, Olof Strandberg, Ruben Smith, Renaud La Joie, Howard J Rosen, Michael J Pontecorvo, Gil D Rabinovici, Wiesje M van der Flier, Oskar Hansson, Rik Ossenkoppel. Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis. Brain : a journal of neurology. 2023-03-26. PMID:36967222. |
mechanisms of resilience against tau pathology in individuals across the alzheimer's disease spectrum are insufficiently understood. |
2023-03-26 |
2023-08-14 |
Not clear |
| Diana I Bocancea, Anna L Svenningsson, Anna C van Loenhoud, Colin Groot, Frederik Barkhof, Olof Strandberg, Ruben Smith, Renaud La Joie, Howard J Rosen, Michael J Pontecorvo, Gil D Rabinovici, Wiesje M van der Flier, Oskar Hansson, Rik Ossenkoppel. Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis. Brain : a journal of neurology. 2023-03-26. PMID:36967222. |
in this longitudinal study of clinically impaired individuals with underlying alzheimer's disease neuropathological changes, we identified education as the most robust determinant of both cognitive and brain resilience against tau pathology. |
2023-03-26 |
2023-08-14 |
Not clear |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
trem2 gene expression of the dorsolateral prefrontal cortex, posterior cingulate cortex, and caudate nucleus was assessed with respect to core pathology of alzheimer's disease (amyloid-β, and tau), cerebrovascular pathology (cerebral infarcts, arteriolosclerosis, atherosclerosis, and cerebral amyloid angiopathy), microglial activation (proportion of activated microglia), and cognitive performance. |
2023-03-25 |
2023-08-14 |
Not clear |
| Devin Wahl, Meghan E Smith, Cali M McEntee, Alyssa N Cavalier, Shelby C Osburn, Samuel D Burke, Randy A Grant, David Nerguizian, Daniel S Lark, Christopher D Link, Thomas J LaRocc. The reverse transcriptase inhibitor 3TC protects against age-related cognitive dysfunction. Aging cell. 2023-03-23. PMID:36949552. |
age-related increases in transposable element (te) transcripts might contribute to reduced cognitive function with brain aging, as the reverse transcriptase inhibitor 3tc reduces inflammation in peripheral tissues and te transcripts have been linked with tau pathology in alzheimer's disease. |
2023-03-23 |
2023-08-14 |
mouse |
| Xinhua Zhou, Kaipeng Huang, Yuqiang Wang, Zaijun Zhang, Yingying Liu, Qinghua Hou, Xifei Yang, Maggie Pui Man Ho. Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer's disease mouse model and proteomics analysis. Frontiers in pharmacology. vol 14. 2023-03-23. PMID:36950017. |
the pathophysiology of alzheimer's disease (ad) is multifactorial with characteristic extracellular accumulation of amyloid-beta (aβ) and intraneuronal aggregation of hyperphosphorylated tau in the brain. |
2023-03-23 |
2023-08-14 |
mouse |
| Christina B Young, Elizabeth C Mormino, Kathleen L Poston, Keith A Johnson, Dorene M Rentz, Reisa A Sperling, Kathryn V Pap. Computerized cognitive practice effects in relation to amyloid and tau in preclinical Alzheimer's disease: Results from a multi-site cohort. Alzheimer's & dementia (Amsterdam, Netherlands). vol 15. issue 1. 2023-03-23. PMID:36950699. |
computerized cognitive practice effects in relation to amyloid and tau in preclinical alzheimer's disease: results from a multi-site cohort. |
2023-03-23 |
2023-08-14 |
Not clear |
| Richard A Hartz, Vijay T Ahuja, Prasanna Sivaprakasam, Hong Xiao, Carol M Krause, Wendy J Clarke, Kevin Kish, Hal Lewis, Nicolas Szapiel, Ramu Ravirala, Sayali Mutalik, Deepa Nakmode, Devang Shah, Catherine R Burton, John E Macor, Gene M Dubowchi. Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2- Journal of medicinal chemistry. vol 66. issue 6. 2023-03-23. PMID:36950863. |
gsk-3β has been linked to the formation of the neurofibrillary tangles associated with alzheimer's disease that arise from the hyperphosphorylation of tau protein. |
2023-03-23 |
2023-08-14 |
Not clear |
| Violina Kakoty, Sarathlal Kc, Shobha Kumari, Chih-Hao Yang, Sunil Kumar Dubey, Amirhossein Sahebkar, Prashant Kesharwani, Rajeev Taliya. Brain insulin resistance linked Alzheimer's and Parkinson's disease pathology: An undying implication of epigenetic and autophagy modulation. Inflammopharmacology. 2023-03-23. PMID:36952096. |
bir causes an upsurge in the activity of glycogen synthase kinase-3 beta, increased amyloid beta (aβ) accumulation, hyperphosphorylation of tau, aggravated formation of aβ oligomers and simultaneously neurofibrillary tangle formation, all of which are believed to be direct contributors in alzheimer's disease (ad) pathology. |
2023-03-23 |
2023-08-14 |
Not clear |
| Carlo Condello, Jacob I Ayers, Clifton L Dalgard, M Madhy Garcia Garcia, Brianna M Rivera, William W Seeley, Daniel P Perl, Stanley B Prusine. Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 13. 2023-03-23. PMID:36952379. |
building on prior work describing the detection of tau and aβ prions in alzheimer's disease (ad) and down syndrome brains, we investigated als-pdc brain samples for the presence of prions. |
2023-03-23 |
2023-08-14 |
Not clear |
| Collyn M Kellogg, Kevin Pham, Adeline H Machalinski, Hunter L Porter, Harris E Blankenship, Michael B Stout, Heather C Rice, Amanda L Sharpe, Michael J Beckstead, Ana J Chucair-Elliott, Sarah R Ocañas, Willard M Freema. Microglial MHC-I induction with aging and Alzheimer's is conserved in mouse models and humans. bioRxiv : the preprint server for biology. 2023-03-22. PMID:36945372. |
neuronal mhc-i expression has been proposed to regulate developmental synapse elimination and tau pathology in alzheimer's disease (ad). |
2023-03-22 |
2023-08-14 |
mouse |
| Aaron T Balana, Anne-Laure Mahul-Mellier, Binh A Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Prat. O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology. bioRxiv : the preprint server for biology. 2023-03-22. PMID:36945566. |
amyloid-forming proteins such α-synuclein and tau, which are implicated in the pathogenesis of alzheimer's and parkinson's disease, can form different types of fibril structure, or strains, that exhibit distinct structures, toxic properties, seeding activities, and pathology spreading patterns in the brain. |
2023-03-22 |
2023-08-14 |
Not clear |