| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela Jimenez-Harrison, Carol J Huseby, Claire N Hoffman, Steven Sher, Dalton Snyder, Brayden Seal, Chunhua Yuan, Hongjun Fu, Vicki Wysocki, Flaviano Giorgini, Jeff Kure. DJ-1 Molecular Chaperone Activity Depresses Tau Aggregation Propensity through Interaction with Monomers. Biochemistry. 2023-02-22. PMID:36813261. |
tau aggregate-bearing lesions are pathological markers and potential mediators of tauopathic neurodegenerative diseases, including alzheimer's disease. |
2023-02-22 |
2023-08-14 |
Not clear |
| Florin Desp. Bloodborne Pancreatic Amylin, A Therapeutic Target for Alzheimer's Disease. Current Alzheimer research. 2023-02-21. PMID:36803745. |
alzheimer disease (ad) pathology has been linked to brain accumulation of β amyloid (aβ) and neurofibrillary tau tangles. |
2023-02-21 |
2023-08-14 |
human |
| Kariem Ezzat, Andrea Sturchio, Alberto J Espa. The shift to a proteinopenia paradigm in neurodegeneration. Handbook of clinical neurology. vol 193. 2023-02-21. PMID:36803814. |
we therefore advocate for a paradigm shift from proteinopathy (gof) to proteinopenia (lof) based on the universal depletion of soluble functional proteins in neurodegenerative diseases (low amyloid-β 42 in alzheimer's disease, low α-synuclein in parkinson's disease, and low tau in progressive supranuclear palsy) and supported by the confluence of biologic, thermodynamic, and evolutionary principles with proteins having evolved to perform a function, not to become toxic, and where protein depletion is consequential. |
2023-02-21 |
2023-08-14 |
Not clear |
| Alberto J Espay, Karl Herrup, Timothy Dal. Finding the falsification threshold of the toxic proteinopathy hypothesis in neurodegeneration. Handbook of clinical neurology. vol 192. 2023-02-16. PMID:36796939. |
the toxic proteinopathy hypothesis posits that neurodegeneration is caused by toxicity of aggregated amyloid in alzheimer's disease (toxic amyloid hypothesis), aggregated α-synuclein in parkinson's disease (toxic synuclein hypothesis), and aggregated tau in progressive supranuclear palsy (toxic tau hypothesis). |
2023-02-16 |
2023-08-14 |
Not clear |
| Clifford R Jack, Heather J Wiste, Alicia Algeciras-Schimnich, Dan J Figdore, Christopher G Schwarz, Val J Lowe, Vijay K Ramanan, Prashanthi Vemuri, Michelle M Mielke, David S Knopman, Jonathan Graff-Radford, Bradley F Boeve, Kejal Kantarci, Petrice M Cogswell, Matthew L Senjem, Jeffrey L Gunter, Terry M Therneau, Ronald C Peterse. Predicting amyloid PET and tau PET stages with plasma biomarkers. Brain : a journal of neurology. 2023-02-15. PMID:36789483. |
participants (n = 1136) were enrolled in either the mayo clinic study of aging or the alzheimer's disease research center, had a concurrent amyloid pet, tau pet, and blood draw, and met clinical criteria for cognitively unimpaired (n = 864), mild cognitive impairment (n = 148), or alzheimer's clinical syndrome with dementia (n = 124). |
2023-02-15 |
2023-08-14 |
human |
| Adriana N Santiago Ruiz, Arian Arab, Siewert Hugelier, Charles Bond, Melike Lakadamyal. In-situ characterization of Alzheimer's disease tau aggregates via super-resolution imaging. Biophysical journal. vol 122. issue 3S1. 2023-02-14. PMID:36782800. |
in-situ characterization of alzheimer's disease tau aggregates via super-resolution imaging. |
2023-02-14 |
2023-08-14 |
Not clear |
| Oleksandr V Savytskyi, Tiffany N H Sirmans, Mathew A Coban, Caleb A Weber, Melissa E Murray, Thomas R Caulfiel. Computational modeling and molecular mapping of serine protease inhibitor family A5 (SERPINA5) structure, associated with tau expression and Alzheimer's disease. Biophysical journal. vol 122. issue 3S1. 2023-02-14. PMID:36784422. |
computational modeling and molecular mapping of serine protease inhibitor family a5 (serpina5) structure, associated with tau expression and alzheimer's disease. |
2023-02-14 |
2023-08-14 |
Not clear |
| Fardin Nabizadeh, Parya Valizadeh, Mohammad Balabandia. Does statin use affect amyloid beta deposition and brain metabolism? CNS neuroscience & therapeutics. 2023-02-14. PMID:36786148. |
there are contradictory findings regarding the effect of statin drugs on amyloid β (aβ) deposition as one of the main hallmarks of alzheimer's disease (ad), along with tau pathology. |
2023-02-14 |
2023-08-14 |
Not clear |
| Viet Hoang Man, Xibing He, Fengyang Han, Lianjin Cai, Luxuan Wang, Taoyu Niu, Jingchen Zhai, Beihong Ji, Jie Gao, Junmei Wan. Phosphorylation at Ser289 Enhances the Oligomerization of Tau Repeat R2. Journal of chemical information and modeling. 2023-02-14. PMID:36786552. |
in tauopathies such as alzheimer's disease (ad), aberrant phosphorylation causes the dissociation of tau proteins from microtubules. |
2023-02-14 |
2023-08-14 |
Not clear |
| Tharick Pascoal, Bruna Bellaver, Guilherme Povala, Pamela Ferreira, João Pedro Ferrari-Souza, Douglas Leffa, Firoza Lussier, Andrea Benedet, Nicholas Ashton, Gallen Triana-Baltzerz, Hartmuth Kolbzh, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Nesrine Rahmouni, Oscar Lopez, Dana Tudorascu, Victor Villemagne, Milos Ikonomovic, Serge Gauthier, Eduardo Zimmer, Henrik Zetterberg, Kaj Blennow, Howard Aizenstein, William Klunk, Beth Snitz, Pauline Maki, Rebecca Thurston, Ann Cohen, Mary Ganguli, Thomas Karikari, Pedro Rosa-Net. Astrocyte reactivity influences the association of amyloid-β and tau biomarkers in preclinical Alzheimer's disease. Research square. 2023-02-13. PMID:36778243. |
astrocyte reactivity influences the association of amyloid-β and tau biomarkers in preclinical alzheimer's disease. |
2023-02-13 |
2023-08-14 |
Not clear |
| Tharick Pascoal, Bruna Bellaver, Guilherme Povala, Pamela Ferreira, João Pedro Ferrari-Souza, Douglas Leffa, Firoza Lussier, Andrea Benedet, Nicholas Ashton, Gallen Triana-Baltzerz, Hartmuth Kolbzh, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Nesrine Rahmouni, Oscar Lopez, Dana Tudorascu, Victor Villemagne, Milos Ikonomovic, Serge Gauthier, Eduardo Zimmer, Henrik Zetterberg, Kaj Blennow, Howard Aizenstein, William Klunk, Beth Snitz, Pauline Maki, Rebecca Thurston, Ann Cohen, Mary Ganguli, Thomas Karikari, Pedro Rosa-Net. Astrocyte reactivity influences the association of amyloid-β and tau biomarkers in preclinical Alzheimer's disease. Research square. 2023-02-13. PMID:36778243. |
an unresolved question for the understanding of alzheimer's disease (ad) pathophysiology is why a significant percentage of amyloid β (aβ)-positive cognitively unimpaired (cu) individuals do not develop detectable downstream tau pathology and, consequently, clinical deterioration. |
2023-02-13 |
2023-08-14 |
Not clear |
| Dominic J Acri, Yanwen You, Mason D Tate, Brianne McCord, A Daniel Sharify, Sutha John, Hande Karahan, Byungwook Kim, Luke C Dabin, Stéphanie Philtjens, H R Sagara Wijeratne, Tyler J McCray, Daniel C Smith, Stephanie J Bissel, Bruce T Lamb, Cristian A Lasagna-Reeves, Jungsu Ki. Network analysis reveals strain-dependent response to misfolded tau aggregates. bioRxiv : the preprint server for biology. 2023-02-13. PMID:36778440. |
however, it is unknown what mechanisms underly these effects of genetic background on modeling alzheimer's disease, specifically tau aggregate-driven pathogenicity. |
2023-02-13 |
2023-08-14 |
mouse |
| Chelsea Marie T Parrocha, James S Nowic. Current Peptide Vaccine and Immunotherapy Approaches Against Alzheimer's Disease. Peptide science (Hoboken, N.J.). vol 115. issue 1. 2023-02-13. PMID:36778914. |
peptide vaccines and immunotherapies against aggregating proteins involved in the pathogenesis and progression of alzheimer's disease (ad) - the β-amyloid peptide (aβ) and tau - are promising therapeutic avenues against ad. |
2023-02-13 |
2023-08-14 |
Not clear |
| Danny Baltissen, Charlotte S Bold, Lena Rehra, Marija Banićević, Justus Fricke, Jennifer Just, Susann Ludewig, Christian J Buchholz, Martin Korte, Ulrike C Mülle. APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice. Frontiers in cellular neuroscience. vol 17. 2023-02-13. PMID:36779015. |
in alzheimer's disease (ad) hyperphosphorylated tau species accumulate as neurofibrillary tangles that constitute a major hallmark of ad. |
2023-02-13 |
2023-08-14 |
mouse |
| Hanseul Park, Byounggook Cho, Hongwon Kim, Takashi Saito, Takaomi C Saido, Kyoung-Jae Won, Jongpil Ki. Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice. Nature communications. vol 14. issue 1. 2023-02-13. PMID:36781874. |
alzheimer's disease (ad) is associated with progressive neuronal degeneration as amyloid-beta (aβ) and tau proteins accumulate in the brain. |
2023-02-13 |
2023-08-14 |
mouse |
| Felicia Liana Andronie-Cioara, Adriana Ioana Ardelean, Carmen Delia Nistor-Cseppento, Anamaria Jurcau, Maria Carolina Jurcau, Nicoleta Pascalau, Florin Marc. Molecular Mechanisms of Neuroinflammation in Aging and Alzheimer's Disease Progression. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768235. |
decades of clinical trials targeting the 2 abnormal proteins in alzheimer's disease, amyloid beta and tau, led to many failures. |
2023-02-11 |
2023-08-14 |
Not clear |
| Tim Altendorf, Ian Gering, Beatrix Santiago-Schübel, Selma Aghabashlou Saisan, Gültekin Tamgüney, Markus Tusche, Dominik Honold, Sarah Schemmert, Wolfgang Hoyer, Jeannine Mohrlüder, Dieter Willbol. Stabilization of Monomeric Tau Protein by All D-Enantiomeric Peptide Ligands as Therapeutic Strategy for Alzheimer's Disease and Other Tauopathies. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768484. |
stabilization of monomeric tau protein by all d-enantiomeric peptide ligands as therapeutic strategy for alzheimer's disease and other tauopathies. |
2023-02-11 |
2023-08-14 |
Not clear |
| Cha-Gyun Jung, Hitoshi Yamashita, Reiko Kato, Chunyu Zhou, Hiroaki Matsushita, Tamaki Takeuchi, Mona Abdelhamid, Yuxin Chen, Makoto Michikaw. Deletion of UCP1 in Tg2576 Mice Increases Body Temperature and Exacerbates Alzheimer's Disease-Related Pathologies. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769062. |
we previously demonstrated that the alzheimer's disease (ad)-like model mice, tg2576, housed at a high ambient temperature of 30 °c for 13 months, exhibited increased body temperature, which increased amyloid-β (aβ) levels and tau stability, leading to tau phosphorylation and ultimately inducing memory impairment. |
2023-02-11 |
2023-08-14 |
mouse |
| Nisha Job, Venkatesan S Thimmakondu, Krishnan Thirumoorth. In Silico Drug Design and Analysis of Dual Amyloid-Beta and Tau Protein-Aggregation Inhibitors for Alzheimer's Disease Treatment. Molecules (Basel, Switzerland). vol 28. issue 3. 2023-02-11. PMID:36771052. |
in silico drug design and analysis of dual amyloid-beta and tau protein-aggregation inhibitors for alzheimer's disease treatment. |
2023-02-11 |
2023-08-14 |
Not clear |
| Courtney J Mycroft-West, Anthony J Devlin, Lynsay C Cooper, Scott E Guimond, Patricia Procter, Gavin J Miller, Marco Guerrini, David G Fernig, Edwin A Yates, Marcelo A Lima, Mark A Skidmor. A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease β-site amyloid precursor protein cleaving enzyme 1 (BACE-1). Carbohydrate research. vol 525. 2023-02-11. PMID:36773398. |
in addition, heparin has been shown to exert favourable bioactivities through a number of pathophysiological pathways involved in the disease processes of alzheimer's disease including inflammation, oxidative stress, tau phosphorylation and amyloid peptide generation. |
2023-02-11 |
2023-08-14 |
cattle |