| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zeba Mueed, Devanshu Mehta, Pankaj K Rai, Mohammad A Kamal, Nitesh K Podda. Cross-Interplay between Osmolytes and mTOR in Alzheimer's Disease Pathogenesis. Current pharmaceutical design. vol 26. issue 37. 2021-03-19. PMID:32418522. |
cross-interplay between osmolytes and mtor in alzheimer's disease pathogenesis. |
2021-03-19 |
2023-08-13 |
Not clear |
| Zeba Mueed, Devanshu Mehta, Pankaj K Rai, Mohammad A Kamal, Nitesh K Podda. Cross-Interplay between Osmolytes and mTOR in Alzheimer's Disease Pathogenesis. Current pharmaceutical design. vol 26. issue 37. 2021-03-19. PMID:32418522. |
alzheimer's disease, categorized by the piling of amyloid-β (aβ), hyperphosphorylated tau, phfs, nfts and mtor hyperactivity, is a neurodegenerative disorder, affecting people across the globe. |
2021-03-19 |
2023-08-13 |
Not clear |
| Yanxin Li, Zhanyun Lv, Jing Zhang, Qianqian Ma, Qiuhua Li, Li Song, Li Gong, Yunliang Zhu, Xiangyuan Li, Yanlei Hao, Yan Yan. Profiling of differentially expressed circular RNAs in peripheral blood mononuclear cells from Alzheimer's disease patients. Metabolic brain disease. vol 35. issue 1. 2021-01-29. PMID:31834549. |
the circrna-mirna-mrna network was most involved in the mapk, mtor, ampk, and wnt signaling pathways in alzheimer's disease. |
2021-01-29 |
2023-08-13 |
Not clear |
| Artem P Gureev, Vasily N Popov, Anatoly A Starko. Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of long-term potentiation. Experimental neurology. vol 328. 2020-12-30. PMID:32165256. |
suppression of mtor activity may impair synaptic plasticity and long-term memory, while mtor activation inhibits autophagy, thereby potentiating amyloidosis and development of alzheimer's disease (ad) accompanied by irreversible memory loss. |
2020-12-30 |
2023-08-13 |
Not clear |
| Xu Wang, Guang-Jian Li, Hai-Xia Hu, Chi Ma, Di-Hui Ma, Xiao-Liang Liu, Xiao-Ming Jian. Cerebral mTOR signal and pro-inflammatory cytokines in Alzheimer's disease rats. Translational neuroscience. vol 7. issue 1. 2020-10-01. PMID:28123835. |
cerebral mtor signal and pro-inflammatory cytokines in alzheimer's disease rats. |
2020-10-01 |
2023-08-13 |
rat |
| Xu Wang, Guang-Jian Li, Hai-Xia Hu, Chi Ma, Di-Hui Ma, Xiao-Liang Liu, Xiao-Ming Jian. Cerebral mTOR signal and pro-inflammatory cytokines in Alzheimer's disease rats. Translational neuroscience. vol 7. issue 1. 2020-10-01. PMID:28123835. |
as a part of alzheimer's disease (ad) development the mammalian target of rapamycin (mtor) has been reported to play a crucial role in regulating cognition and can be used as a neuronal marker. |
2020-10-01 |
2023-08-13 |
rat |
| Jennifer Lee, Lucille M Yanckello, David Ma, Jared D Hoffman, Ishita Parikh, Scott Thalman, Bjoern Bauer, Anika M S Hartz, Fahmeed Hyder, Ai-Ling Li. Neuroimaging Biomarkers of mTOR Inhibition on Vascular and Metabolic Functions in Aging Brain and Alzheimer's Disease. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:30140223. |
neuroimaging biomarkers of mtor inhibition on vascular and metabolic functions in aging brain and alzheimer's disease. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jennifer Lee, Lucille M Yanckello, David Ma, Jared D Hoffman, Ishita Parikh, Scott Thalman, Bjoern Bauer, Anika M S Hartz, Fahmeed Hyder, Ai-Ling Li. Neuroimaging Biomarkers of mTOR Inhibition on Vascular and Metabolic Functions in Aging Brain and Alzheimer's Disease. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:30140223. |
in the central nervous system, mtor inhibition demonstrates neuroprotective patterns in aging and alzheimer's disease (ad) by preserving mitochondrial function and reducing amyloid beta retention. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zeba Mueed, Pallavi Tandon, Sanjeev Kumar Maurya, Ravi Deval, Mohammad A Kamal, Nitesh Kumar Podda. Tau and mTOR: The Hotspots for Multifarious Diseases in Alzheimer's Development. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30686983. |
tau and mtor: the hotspots for multifarious diseases in alzheimer's development. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zeba Mueed, Pallavi Tandon, Sanjeev Kumar Maurya, Ravi Deval, Mohammad A Kamal, Nitesh Kumar Podda. Tau and mTOR: The Hotspots for Multifarious Diseases in Alzheimer's Development. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30686983. |
the hyperphosphorylation of tau protein and the overexpression of mtor are considered to be the driving force behind aβ plaques and neurofibrillay tangles (nft's), hallmarks of alzheimer's disease (ad). |
2020-09-30 |
2023-08-13 |
Not clear |
| Sahar Fanoudi, Mahmoud Hosseini, Mohaddeseh Sadat Alavi, Mohammad Taher Boroushaki, Azar Hosseini, Hamid R Sadeghni. Everolimus, a mammalian target of rapamycin inhibitor, ameliorated streptozotocin-induced learning and memory deficits via neurochemical alterations in male rats. EXCLI journal. vol 17. 2020-09-29. PMID:30564080. |
mtor is a serine/threonine protein kinase and its hyperactivity is involved in the pathophysiology of alzheimer's disease (ad) and associated cognitive deficits. |
2020-09-29 |
2023-08-13 |
rat |
| Arti Tyagi, Mohammad A Kamal, Nitesh Kumar Podda. Integrated Pathways of COX-2 and mTOR: Roles in Cell Sensing and Alzheimer's Disease. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32742252. |
integrated pathways of cox-2 and mtor: roles in cell sensing and alzheimer's disease. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ju-Hyun Lee, Mala V Rao, Dun-Sheng Yang, Philip Stavrides, Eunju Im, Anna Pensalfini, Chunfeng Huo, Pallabi Sarkar, Tamotsu Yoshimori, Ralph A Nixo. Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo. Autophagy. vol 15. issue 3. 2020-05-13. PMID:30269645. |
abbreviations: actb: actin, beta; ad: alzheimer disease; al: autolysosomes; alp: autophagy-lysosome pathway; ap: autophagosome; app: amyloid beta (abeta) precursor protein; atg5: autophagy related 5; atg7: autophagy related 7; av: autophagic vacuoles; cns: central nervous system; ctsd: cathepsin d; cq: chloroquine; dmem: dulbecco's modified eagle's medium; gfp: green fluorescent protein; gabarap: gamma-aminobutyric acid receptor associated protein; gabarapl2/gate16: gamma-aminobutyric acid (gaba) receptor-associated protein-like 2; icc: immunocytochemistry; icv: intra-cerebroventricular; lamp2: lysosomal-associated membrane protein 2; leup: leupeptin; ly: lysosomes; map1lc3/lc3: microtubule-associated protein 1 light chain 3; mtor: mechanistic target of rapamycin kinase; rbfox3/neun: rna binding protein, fox-1 homolog (c. elegans) 3; rfp: red fluorescent protein; rps6kb1: ribosomal protein s6 kinase, polypeptide 1; sds-page: sodium dodecyl sulfate-polyacrylamide gel electrophoresis; sqstm1: sequestosome 1; tflc3: mrfp-egfp-lc3; trgl6: thy1 mrfp egfp lc3-line 6; pcr: polymerase chain reaction; pd: parkinson disease. |
2020-05-13 |
2023-08-13 |
mouse |
| Jun Araya, Kazuya Tsubouchi, Nahoko Sato, Saburo Ito, Shunsuke Minagawa, Hiromichi Hara, Yusuke Hosaka, Akihiro Ichikawa, Nayuta Saito, Tsukasa Kadota, Masahiro Yoshida, Yu Fujita, Hirofumi Utsumi, Kenji Kobayashi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hiroshi Wakui, Takeo Ishikawa, Takanori Numata, Yumi Kaneko, Hisatoshi Asano, Makoto Yamashita, Makoto Odaka, Toshiaki Morikawa, Stephen L Nishimura, Katsutoshi Nakayama, Kazuyoshi Kuwan. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. Autophagy. vol 15. issue 3. 2020-05-13. PMID:30290714. |
abbreviations: ad: alzheimer disease; aec: airway epithelial cells; balf: bronchoalveolar lavage fluid; akt: akt serine/threonine kinase; calcoco2/ndp52: calcium binding and coiled-coil domain 2; cdkn1a: cyclin dependent kinase inhibitor 1a; cdkn2a: cyclin dependent kinase inhibitor 2a; copd: chronic obstructive pulmonary disease; cs: cigarette smoke; cse: cs extract; cxcl1: c-x-c motif chemokine ligand 1; cxcl8: c-x-c motif chemokine ligand 8; hbec: human bronchial epithelial cells; 4-hne: 4-hydroxynonenal; il: interleukin; ko: knockout; lf: lung fibroblasts; lps: lipopolysaccharide; map1lc3/lc3: microtubule associated protein 1 light chain 3; mtor: mechanistic target of rapamycin kinase; 8-ohdg: 8-hydroxy-2'-deoxyguanosine; optn: optineurin; prkn: parkin rbr e3 ubiquitin protein ligase; pcd: programmed cell death; pfd: pirfenidone; pik3c: phosphatidylinositol-4:5-bisphosphate 3-kinase catalytic subunit; pink1: pten induced putative kinase 1; pten: phosphatase and tensin homolog; ra: rheumatoid arthritis; ros: reactive oxygen species; sa-glb1/β-gal: senescence-associated-galactosidase, beta 1; sasp: senescence-associated secretory phenotype; snp: single nucleotide polymorphism; tnf: tumor necrosis factor. |
2020-05-13 |
2023-08-13 |
mouse |
| Zhihua Zhang, Xiaojian Wang, Di Zhang, Yueze Liu, Lin L. Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease. Aging. vol 11. issue 2. 2020-04-03. PMID:30684442. |
geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mtor signaling and enhanced autophagy in a mouse model of alzheimer's disease. |
2020-04-03 |
2023-08-13 |
mouse |
| Zhihua Zhang, Xiaojian Wang, Di Zhang, Yueze Liu, Lin L. Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease. Aging. vol 11. issue 2. 2020-04-03. PMID:30684442. |
modulation of mtor function to increase autophagy and inhibit apoptosis is involved in the protective effects of pharmacologic agents targeting diabetes and alzheimer's disease (ad). |
2020-04-03 |
2023-08-13 |
mouse |
| Matt Kaeberlein, Veronica Galva. Rapamycin and Alzheimer's disease: Time for a clinical trial? Science translational medicine. vol 11. issue 476. 2020-02-21. PMID:30674654. |
despite its compelling preclinical record, no clinical trials have tested rapamycin or other mtor inhibitors in patients with alzheimer's disease. |
2020-02-21 |
2023-08-13 |
mouse |
| Julian M Carosi, Timothy J Sargean. Rapamycin and Alzheimer disease: a double-edged sword? Autophagy. vol 15. issue 8. 2020-02-14. PMID:31066320. |
numerous studies have reported that inhibition of mtor (mechanistic target of rapamycin kinase) clearly reduces alzheimer disease neuropathological hallmarks in mouse models. |
2020-02-14 |
2023-08-13 |
mouse |
| Julian M Carosi, Timothy J Sargean. Rapamycin and Alzheimer disease: a double-edged sword? Autophagy. vol 15. issue 8. 2020-02-14. PMID:31066320. |
we reassess literature described by a recent perspective article calling for the use of mtor inhibition in dementia and conclude that rapamycin could be useful, but only in people who are in the earliest stages of alzheimer disease. |
2020-02-14 |
2023-08-13 |
mouse |
| Ai-Ling Lin, D Allan Butterfield, Arlan Richardso. mTOR: Alzheimer's disease prevention for APOE4 carriers. Oncotarget. vol 7. issue 29. 2019-09-20. PMID:27385004. |
mtor: alzheimer's disease prevention for apoe4 carriers. |
2019-09-20 |
2023-08-13 |
Not clear |