| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hanyu Liang, Jia Nie, Candice E Van Skike, Joseph M Valentine, Miranda E Or. Mammalian Target of Rapamycin at the Crossroad Between Alzheimer's Disease and Diabetes. Advances in experimental medicine and biology. vol 1128. 2019-08-07. PMID:31062331. |
aberrant regulation of mtor occurs in the brains of patients with alzheimer's disease and in numerous tissues of individuals with type 2 diabetes (mannaa et al, j mol med (berl) 91(10):1167-1175, 2013). |
2019-08-07 |
2023-08-13 |
Not clear |
| Hanyu Liang, Jia Nie, Candice E Van Skike, Joseph M Valentine, Miranda E Or. Mammalian Target of Rapamycin at the Crossroad Between Alzheimer's Disease and Diabetes. Advances in experimental medicine and biology. vol 1128. 2019-08-07. PMID:31062331. |
in this chapter, we discuss the physiological role of mtor signaling and the consequences of mtor dysregulation in the brain and peripheral tissues, with emphasis on its relevance to the development of alzheimer's disease and link to type 2 diabetes. |
2019-08-07 |
2023-08-13 |
Not clear |
| Xianjuan Kou, Dandan Chen, Ning Che. Physical Activity Alleviates Cognitive Dysfunction of Alzheimer's Disease through Regulating the mTOR Signaling Pathway. International journal of molecular sciences. vol 20. issue 7. 2019-07-22. PMID:30934958. |
physical activity alleviates cognitive dysfunction of alzheimer's disease through regulating the mtor signaling pathway. |
2019-07-22 |
2023-08-13 |
Not clear |
| Shohreh Majd, John H T Powe. Oxidative Stress and Decreased Mitochondrial Superoxide Dismutase 2 and Peroxiredoxins 1 and 4 Based Mechanism of Concurrent Activation of AMPK and mTOR in Alzheimer's Disease. Current Alzheimer research. vol 15. issue 8. 2019-07-12. PMID:29473507. |
oxidative stress and decreased mitochondrial superoxide dismutase 2 and peroxiredoxins 1 and 4 based mechanism of concurrent activation of ampk and mtor in alzheimer's disease. |
2019-07-12 |
2023-08-13 |
Not clear |
| Huajie Li, Dan Ye, Wei Xie, Fei Hua, Yilin Yang, Jian Wu, Aifang Gu, Yi Ren, Keshi Ma. Defect of branched-chain amino acid metabolism promotes the development of Alzheimer's disease by targeting the mTOR signaling. Bioscience reports. vol 38. issue 4. 2019-04-15. PMID:29802157. |
defect of branched-chain amino acid metabolism promotes the development of alzheimer's disease by targeting the mtor signaling. |
2019-04-15 |
2023-08-13 |
mouse |
| Tommaso Cassano, Alessandro Magini, Stefano Giovagnoli, Alice Polchi, Silvio Calcagnini, Lorenzo Pace, Michele Angelo Lavecchia, Caterina Scuderi, Maria Rosanna Bronzuoli, Loredana Ruggeri, Maria Pia Gentileschi, Adele Romano, Silvana Gaetani, Federico De Marco, Carla Emiliani, Diego Dolcett. Early intrathecal infusion of everolimus restores cognitive function and mood in a murine model of Alzheimer's disease. Experimental neurology. vol 311. 2019-04-10. PMID:30243986. |
the discovery that mammalian target of rapamycin (mtor) inhibition increases lifespan in mice and restores/delays many aging phenotypes has led to the identification of a novel potential therapeutic target for the treatment of alzheimer's disease (ad). |
2019-04-10 |
2023-08-13 |
mouse |
| Fabio Di Domenico, Antonella Tramutola, Cesira Foppoli, Elizabeth Head, Marzia Perluigi, D Allan Butterfiel. mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia. Free radical biology & medicine. vol 114. 2019-03-13. PMID:28807816. |
mtor in down syndrome: role in aß and tau neuropathology and transition to alzheimer disease-like dementia. |
2019-03-13 |
2023-08-13 |
human |
| Fabio Di Domenico, Antonella Tramutola, Cesira Foppoli, Elizabeth Head, Marzia Perluigi, D Allan Butterfiel. mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia. Free radical biology & medicine. vol 114. 2019-03-13. PMID:28807816. |
numerous studies linked the alterations of mtor pathway to age-dependent cognitive decline, pathogenesis of alzheimer disease (ad) and ad-like dementia in down syndrome (ds). |
2019-03-13 |
2023-08-13 |
human |
| Candice E Van Skike, Jordan B Jahrling, Angela B Olson, Naomi L Sayre, Stacy A Hussong, Zoltan Ungvari, James D Lechleiter, Veronica Galva. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. American journal of physiology. Heart and circulatory physiology. vol 314. issue 4. 2019-01-07. PMID:29351469. |
inhibition of mtor protects the blood-brain barrier in models of alzheimer's disease and vascular cognitive impairment. |
2019-01-07 |
2023-08-13 |
mouse |
| Jordan B Jahrling, Ai-Ling Lin, Nicholas DeRosa, Stacy A Hussong, Candice E Van Skike, Milena Girotti, Martin Javors, Qingwei Zhao, Leigh Ann Maslin, Reto Asmis, Veronica Galva. mTOR drives cerebral blood flow and memory deficits in LDLR Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 38. issue 1. 2018-12-24. PMID:28511572. |
mtor drives cerebral blood flow and memory deficits in ldlr we recently showed that mtor attenuation blocks progression and abrogates established cognitive deficits in alzheimer's disease (ad) mouse models. |
2018-12-24 |
2023-08-13 |
mouse |
| Candice E Van Skike, Veronica Galva. A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review. Gerontology. vol 64. issue 3. 2018-11-26. PMID:29320772. |
a perfect storm: the role of the mammalian target of rapamycin (mtor) in cerebrovascular dysfunction of alzheimer's disease: a mini-review. |
2018-11-26 |
2023-08-13 |
Not clear |
| Antonella Caccamo, Ramona Belfiore, Salvatore Odd. Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 68. 2018-10-16. PMID:29729422. |
genetically reducing mtor signaling rescues central insulin dysregulation in a mouse model of alzheimer's disease. |
2018-10-16 |
2023-08-13 |
mouse |
| Ying-Chun Liu, Xiao-Xiao Gao, Zhi-Guang Zhang, Zhao-Hua Lin, Qi-Lian Zo. PPAR Gamma Coactivator 1 Beta (PGC-1β) Reduces Mammalian Target of Rapamycin (mTOR) Expression via a SIRT1-Dependent Mechanism in Neurons. Cellular and molecular neurobiology. vol 37. issue 5. 2018-02-23. PMID:27631411. |
since decreased mtor activity has been found to slow aging in many species, the aim of this study was to examine the activity of mtor and its phosphorylated form in in vitro and in vivo models mimicking alzheimer's disease (ad), and investigate the potential pathway of pgc-1β in regulating mtor expression. |
2018-02-23 |
2023-08-13 |
Not clear |
| Kenneth Maies. Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders. British journal of clinical pharmacology. vol 82. issue 5. 2017-12-29. PMID:26469771. |
the mechanistic target of rapamycin (mtor), also known as the mammalian target of rapamycin, is a 289 kda serine/threonine protein kinase that offers exciting possibilities for novel treatment strategies for a host of neurodegenerative diseases that include alzheimer's disease, parkinson's disease, huntington's disease, epilepsy, stroke and trauma. |
2017-12-29 |
2023-08-13 |
Not clear |
| Andrés Norambuena, Horst Wallrabe, Lloyd McMahon, Antonia Silva, Eric Swanson, Shahzad S Khan, Daniel Baerthlein, Erin Kodis, Salvatore Oddo, James W Mandell, George S Bloo. mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 13. issue 2. 2017-12-04. PMID:27693185. |
mtor and neuronal cell cycle reentry: how impaired brain insulin signaling promotes alzheimer's disease. |
2017-12-04 |
2023-08-13 |
Not clear |
| Katarzyna Switon, Katarzyna Kotulska, Aleksandra Janusz-Kaminska, Justyna Zmorzynska, Jacek Jaworsk. Molecular neurobiology of mTOR. Neuroscience. vol 341. 2017-07-03. PMID:27889578. |
changes in mtor activity are often observed in nervous system diseases, including genetic diseases (e.g., tuberous sclerosis complex, pten-related syndromes, neurofibromatosis, and fragile x syndrome), epilepsy, brain tumors, and neurodegenerative disorders (alzheimer's disease, parkinson's disease, and huntington's disease). |
2017-07-03 |
2023-08-13 |
Not clear |
| Rafael Franco, Eva Martínez-Pinilla, Gemma Navarro, Marta Zamarbid. Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease. Progress in neurobiology. vol 149-150. 2017-06-08. PMID:28189739. |
potential of gpcrs to modulate mapk and mtor pathways in alzheimer's disease. |
2017-06-08 |
2023-08-13 |
Not clear |
| Yongzhe Liu, Li Ma, Linbo Jiao, Minglong Gao, Wenzhi Guo, Lin Chen, Ningling Pan, Yaqun M. Mammalian target of rapamycin/p70 ribosomal S6 protein kinase signaling is altered by sevoflurane and/or surgery in aged rats. Molecular medicine reports. vol 12. issue 6. 2016-09-22. PMID:26497858. |
the memory impairment in patients with alzheimer's disease (ad) has been suggested to be contributed to by abnormal mtor signaling. |
2016-09-22 |
2023-08-13 |
rat |
| Mohammad A Khanfar, Sanaa K Bardaweel, Mohamed R Akl, Khalid A El Saye. Olive Oil-derived Oleocanthal as Potent Inhibitor of Mammalian Target of Rapamycin: Biological Evaluation and Molecular Modeling Studies. Phytotherapy research : PTR. vol 29. issue 11. 2016-03-29. PMID:26248874. |
the established anticancer and neuroprotective properties of oleocanthal combined with the reported role of mammalian target of rapamycin (mtor) in cancer and alzheimer's disease development encouraged us to examine the possibility that oleocanthal inhibits mtor. |
2016-03-29 |
2023-08-13 |
Not clear |
| Shanshan Gao, Chunli Duan, Ge Gao, Xiaoming Wang, Hui Yan. Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling. The international journal of biochemistry & cell biology. vol 64. 2016-03-11. PMID:25813876. |
insulin receptor substrate (irs)-1 is a docking protein linking irs to downstream signaling pathways such as phosphatidylinositol 3-kinase/akt and mammalian target of rapamycin (mtor)/ribosomal protein s6 kinase (s6k)1; the latter exerts negative feedback control on insulin signaling, which is impaired in alzheimer's disease. |
2016-03-11 |
2023-08-13 |
mouse |