| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sussy Bastías-Candia, Nady Braidy, Juan M Zolezzi, Nibaldo C Inestros. Teneurins and Alzheimer's disease: a suggestive role for a unique family of proteins. Medical hypotheses. vol 84. issue 4. 2015-12-03. PMID:25665860. |
during the last few years, several cellular signaling pathways have been associated with the pathogenesis of alzheimer's disease, such as notch, mtor and wnt. |
2015-12-03 |
2023-08-13 |
Not clear |
| Shan Wang, Shan-lei Zhou, Fang-yuan Min, Jin-ju Ma, Xia-jie Shi, Erika Bereczki, Jing W. mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice. Metabolic brain disease. vol 29. issue 3. 2015-10-16. PMID:24682776. |
abnormal levels of mammalian target of rapamycin (mtor) signaling have been recently implicated in the pathophysiology of neurodegenerative diseases, such as alzheimer's disease (ad). |
2015-10-16 |
2023-08-12 |
mouse |
| Zhi Tang, Eniko Ioja, Erika Bereczki, Kjell Hultenby, Chunxia Li, Zhizhong Guan, Bengt Winblad, Jin-Jing Pe. mTor mediates tau localization and secretion: Implication for Alzheimer's disease. Biochimica et biophysica acta. vol 1853. issue 7. 2015-08-25. PMID:25791428. |
mtor mediates tau localization and secretion: implication for alzheimer's disease. |
2015-08-25 |
2023-08-13 |
human |
| David Heras-Sandoval, Jazmin M Pérez-Rojas, Jacqueline Hernández-Damián, José Pedraza-Chaverr. The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration. Cellular signalling. vol 26. issue 12. 2015-08-06. PMID:25173700. |
upstream of mtor the survival pi3k/akt pathway modulates mtor activity that is also altered in neurodegenerative diseases of alzheimer and parkinson. |
2015-08-06 |
2023-08-13 |
Not clear |
| Antonella Tramutola, Judy C Triplett, Fabio Di Domenico, Dana M Niedowicz, Michael P Murphy, Raffaella Coccia, Marzia Perluigi, D Allan Butterfiel. Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD. Journal of neurochemistry. vol 133. issue 5. 2015-06-24. PMID:25645581. |
alteration of mtor signaling occurs early in the progression of alzheimer disease (ad): analysis of brain from subjects with pre-clinical ad, amnestic mild cognitive impairment and late-stage ad. |
2015-06-24 |
2023-08-13 |
human |
| Julie Davies, Elena Zachariades, Karly-Rai Rogers-Broadway, Emmanouil Karteri. Elucidating the role of DEPTOR in Alzheimer's disease. International journal of molecular medicine. vol 34. issue 5. 2015-06-17. PMID:25119265. |
it has also been implicated in alzheimer's disease (ad) with neuronal cells and hippocampal slices of ad transgenic mice experiencing dysregulated mtor and synaptic plasticity in response to treatment with the toxic amyloid β (aβ(1-42)) peptide, which has been implicated in ad. |
2015-06-17 |
2023-08-13 |
mouse |
| Zhiyou Cai, Guanghui Chen, Wenbo He, Ming Xiao, Liang-Jun Ya. Activation of mTOR: a culprit of Alzheimer's disease? Neuropsychiatric disease and treatment. vol 11. 2015-04-28. PMID:25914534. |
activation of mtor: a culprit of alzheimer's disease? |
2015-04-28 |
2023-08-13 |
Not clear |
| Zhi Tang, Ahmet Tarik Baykal, Hui Gao, Hernan Concha Quezada, Haiyan Zhang, Erika Bereczki, Muge Serhatli, Betul Baykal, Cigdem Acioglu, Shan Wang, Eniko Ioja, Xinying Ji, Yan Zhang, Zhizhong Guan, Bengt Winblad, Jin-Jing Pe. mTor is a signaling hub in cell survival: a mass-spectrometry-based proteomics investigation. Journal of proteome research. vol 13. issue 5. 2015-04-20. PMID:24694195. |
recently, we have demonstrated that perturbations of mtor signaling are implicated in alzheimer's disease (ad) and that mtor complex 1 (mtorc1) is involved in the formation of toxic phospho-tau. |
2015-04-20 |
2023-08-13 |
human |
| Sharon C Yates, Amen Zafar, Paul Hubbard, Sheila Nagy, Sarah Durant, Roy Bicknell, Gordon Wilcock, Sharon Christie, Margaret M Esiri, A David Smith, Zsuzsanna Nag. Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease. Acta neuropathologica communications. vol 1. 2015-03-31. PMID:24252508. |
dysfunction of the mtor pathway is a risk factor for alzheimer's disease. |
2015-03-31 |
2023-08-12 |
Not clear |
| Sharon C Yates, Amen Zafar, Paul Hubbard, Sheila Nagy, Sarah Durant, Roy Bicknell, Gordon Wilcock, Sharon Christie, Margaret M Esiri, A David Smith, Zsuzsanna Nag. Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease. Acta neuropathologica communications. vol 1. 2015-03-31. PMID:24252508. |
the development of disease-modifying therapies for alzheimer's disease is hampered by our lack of understanding of the early pathogenic mechanisms and the lack of early biomarkers and risk factors.we have documented the expression pattern of mtor regulated genes in the frontal cortex of alzheimer's disease patients. |
2015-03-31 |
2023-08-12 |
Not clear |
| Sharon C Yates, Amen Zafar, Paul Hubbard, Sheila Nagy, Sarah Durant, Roy Bicknell, Gordon Wilcock, Sharon Christie, Margaret M Esiri, A David Smith, Zsuzsanna Nag. Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease. Acta neuropathologica communications. vol 1. 2015-03-31. PMID:24252508. |
we have also examined the functional integrity of mtor signaling in peripheral lymphocytes in alzheimer's disease patients relative to healthy controls. |
2015-03-31 |
2023-08-12 |
Not clear |
| Chong Wang, Jin-Tai Yu, Dan Miao, Zhong-Chen Wu, Meng-Shan Tan, Lan Ta. Targeting the mTOR signaling network for Alzheimer's disease therapy. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23853042. |
targeting the mtor signaling network for alzheimer's disease therapy. |
2014-10-27 |
2023-08-12 |
human |
| Chong Wang, Jin-Tai Yu, Dan Miao, Zhong-Chen Wu, Meng-Shan Tan, Lan Ta. Targeting the mTOR signaling network for Alzheimer's disease therapy. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23853042. |
encouraging data from experiments have provided sufficient evidence for the relationship between the mtor signaling pathway and alzheimer's disease (ad). |
2014-10-27 |
2023-08-12 |
human |
| Kenneth Maies. Driving neural regeneration through the mammalian target of rapamycin. Neural regeneration research. vol 9. issue 15. 2014-10-15. PMID:25317149. |
targeting by mtor of specific pathways that drive long-term potentiation, synaptic plasticity, and β-amyloid toxicity may offer new strategies for disorders such as stroke and alzheimer's disease. |
2014-10-15 |
2023-08-13 |
Not clear |
| Anand M Iyer, Jackelien van Scheppingen, Ivan Milenkovic, Jasper J Anink, Homa Adle-Biassette, Gabor G Kovacs, Eleonora Aronic. mTOR Hyperactivation in down syndrome hippocampus appears early during development. Journal of neuropathology and experimental neurology. vol 73. issue 7. 2014-08-06. PMID:24918639. |
the expression patterns and cellular distribution of components of mtor signaling (phosphorylated s6, phosphorylated s6 kinase, phosphorylated eukaryotic initiation factor 4e binding protein 1, and phosphorylated mtor) were investigated in developing hippocampi from controls and patients with ds and from adults with ds and alzheimer disease-associated pathology using immunocytochemistry. |
2014-08-06 |
2023-08-13 |
human |
| Anand M Iyer, Jackelien van Scheppingen, Ivan Milenkovic, Jasper J Anink, Homa Adle-Biassette, Gabor G Kovacs, Eleonora Aronic. mTOR Hyperactivation in down syndrome hippocampus appears early during development. Journal of neuropathology and experimental neurology. vol 73. issue 7. 2014-08-06. PMID:24918639. |
prominent expression of mtor components was observed in pyramidal neurons with granulovacuolar degeneration and in neurons containing neurofibrillary tangles in the hippocampi of ds subjects with alzheimer disease pathology. |
2014-08-06 |
2023-08-13 |
human |
| Anand M Iyer, Jackelien van Scheppingen, Ivan Milenkovic, Jasper J Anink, Homa Adle-Biassette, Gabor G Kovacs, Eleonora Aronic. mTOR Hyperactivation in down syndrome hippocampus appears early during development. Journal of neuropathology and experimental neurology. vol 73. issue 7. 2014-08-06. PMID:24918639. |
moreover, the expression patterns of mtor components in adult ds hippocampus support its association with alzheimer disease-related histopathologic changes. |
2014-08-06 |
2023-08-13 |
human |
| Antonella Caccamo, Vito De Pinto, Angela Messina, Caterina Branca, Salvatore Odd. Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 23. 2014-07-25. PMID:24899720. |
elevated mammalian target of rapamycin (mtor) signaling has been found in alzheimer's disease (ad) patients and is linked to diabetes and aging, two known risk factors for ad. |
2014-07-25 |
2023-08-13 |
mouse |
| Shan Wang, Jing Wu, Sheng-Dan Nie, Erika Bereczki, Jin-Jing Pe. Dysregulated mTOR-dependent signaling in neurodegeneration or carcinogenesis: implication for Alzheimer's disease and brain tumors. Journal of Alzheimer's disease : JAD. vol 37. issue 3. 2014-06-27. PMID:23948902. |
recent evidence implicated aberrant mammalian target of rapamycin (mtor)-dependent signaling in both alzheimer's disease (ad) and brain tumors. |
2014-06-27 |
2023-08-12 |
Not clear |
| Yong-Xin Sun, Xunming Ji, Xiaoou Mao, Lin Xie, Jianping Jia, Veronica Galvan, David A Greenberg, Kunlin Ji. Differential activation of mTOR complex 1 signaling in human brain with mild to severe Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 38. issue 2. 2014-06-27. PMID:23979023. |
differential activation of mtor complex 1 signaling in human brain with mild to severe alzheimer's disease. |
2014-06-27 |
2023-08-12 |
human |