| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazuyuki Takata, Yoshihisa Kitamur. Molecular approaches to the treatment, prophylaxis, and diagnosis of Alzheimer's disease: tangle formation, amyloid-β, and microglia in Alzheimer's disease. Journal of pharmacological sciences. vol 118. issue 3. 2012-09-10. PMID:22382659. |
molecular approaches to the treatment, prophylaxis, and diagnosis of alzheimer's disease: tangle formation, amyloid-β, and microglia in alzheimer's disease. |
2012-09-10 |
2023-08-12 |
Not clear |
| Helen Crehan, John Hardy, Jennifer Pococ. Microglia, Alzheimer's disease, and complement. International journal of Alzheimer's disease. vol 2012. 2012-09-10. PMID:22957298. |
microglia, alzheimer's disease, and complement. |
2012-09-10 |
2023-08-12 |
Not clear |
| Helen Crehan, John Hardy, Jennifer Pococ. Microglia, Alzheimer's disease, and complement. International journal of Alzheimer's disease. vol 2012. 2012-09-10. PMID:22957298. |
microglia, the immune cell of the brain, are implicated in cascades leading to neuronal loss and cognitive decline in alzheimer's disease (ad). |
2012-09-10 |
2023-08-12 |
Not clear |
| Gaëlle Naert, Serge Rives. Hematopoietic CC-chemokine receptor 2 (CCR2) competent cells are protective for the cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. Molecular medicine (Cambridge, Mass.). vol 18. 2012-09-04. PMID:22160221. |
monocytes emigrate from bone marrow, can infiltrate into brain, differentiate into microglia and clear amyloid β (aβ) from the brain of mouse models of alzheimer's disease (ad). |
2012-09-04 |
2023-08-12 |
mouse |
| Michael J Surace, Michelle L Bloc. Targeting microglia-mediated neurotoxicity: the potential of NOX2 inhibitors. Cellular and molecular life sciences : CMLS. vol 69. issue 14. 2012-09-04. PMID:22581365. |
here, we describe the evidence denoting the role of nox2 in microglia-mediated neurotoxicity with an emphasis on alzheimer's and parkinson's disease, describe available inhibitors that have been tested, and detail evidence of the neuroprotective and therapeutic potential of targeting this enzyme complex to regulate microglia. |
2012-09-04 |
2023-08-12 |
Not clear |
| Kazuyuki Takata, Tetsuya Takada, Aina Ito, Mayo Asai, Manami Tawa, Yuki Saito, Eishi Ashihara, Hidekazu Tomimoto, Yoshihisa Kitamura, Shun Shimoham. Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22645697. |
in alzheimer disease (ad) patient brains, the accumulation of amyloid-β (aβ) peptides is associated with activated microglia. |
2012-08-23 |
2023-08-12 |
rat |
| Robert E Mra. Microglia in Alzheimer brain: a neuropathological perspective. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22655212. |
microglia in alzheimer brain: a neuropathological perspective. |
2012-08-23 |
2023-08-12 |
Not clear |
| Robert E Mra. Microglia in Alzheimer brain: a neuropathological perspective. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22655212. |
microglia have long been noted to be present and activated in alzheimer brain. |
2012-08-23 |
2023-08-12 |
Not clear |
| Robert E Mra. Microglia in Alzheimer brain: a neuropathological perspective. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22655212. |
demonstrations that these microglia are associated with the specific lesions of alzheimer disease-aβ plaques and neurofibrillary tangles-and that these microglia overexpress the potent proinflammatory cytokine interleukin-1 led to the recognition of a potential pathogenic role for these cells in initiation and progression of disease. |
2012-08-23 |
2023-08-12 |
Not clear |
| Robert E Mra. Microglia in Alzheimer brain: a neuropathological perspective. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22655212. |
activated, cytokine-overexpressing microglia are near-universal components of aβ plaques at early (diffuse) and mid (neuritic) stages of progression in alzheimer brain, and only decline in end-stage, dense core plaques. |
2012-08-23 |
2023-08-12 |
Not clear |
| Tetsuya Mizun. The biphasic role of microglia in Alzheimer's disease. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22655214. |
the biphasic role of microglia in alzheimer's disease. |
2012-08-23 |
2023-08-12 |
Not clear |
| Tara M Weitz, Terrence Tow. Microglia in Alzheimer's Disease: It's All About Context. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22779026. |
microglia in alzheimer's disease: it's all about context. |
2012-08-23 |
2023-08-12 |
Not clear |
| Yan Chen Shang, Zhao Zhong Chong, Shaohui Wang, Kenneth Maies. Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL. Aging. vol 4. issue 3. 2012-08-21. PMID:22388478. |
central nervous system microglia promote neuronal regeneration and sequester toxic β-amyloid (aβ) deposition during alzheimer's disease. |
2012-08-21 |
2023-08-12 |
Not clear |
| Sadayuki Hashioka, James G McLarnon, Jae K Ryu, Amal M Youssef, Alaa S Abd-El-Aziz, Edward G Neeland, Andis Klegeri. Pyrazole compound 2-MBAPA as a novel inhibitor of microglial activation and neurotoxicity in vitro and in vivo. Journal of Alzheimer's disease : JAD. vol 27. issue 3. 2012-08-20. PMID:21841251. |
we determined the efficacy of the novel pyrazole compound 2-mbapa (r/s-(±)-2-methylbenzylamino 2-oxo-n-[4-cyano-1-phenyl-1h-pyrazol-5-yl] acetamide) on activated microglia under conditions relevant to inflammation in alzheimer's disease (ad) brain. |
2012-08-20 |
2023-08-12 |
human |
| Sujatha Kannan, Hui Dai, Raghavendra S Navath, Bindu Balakrishnan, Amar Jyoti, James Janisse, Roberto Romero, Rangaramanujam M Kanna. Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model. Science translational medicine. vol 4. issue 130. 2012-08-09. PMID:22517883. |
neuroinflammation, caused by activated microglia and astrocytes, plays a key role in the pathogenesis of cp and disorders such as alzheimer's disease and multiple sclerosis. |
2012-08-09 |
2023-08-12 |
rabbit |
| Marcin Wojtera, Tomasz Sobów, Iwona Kłoszewska, Paweł P Liberski, David R Brown, Beata Sikorsk. Expression of immunohistochemical markers on microglia in Creutzfeldt-Jakob disease and Alzheimer's disease: morphometric study and review of the literature. Folia neuropathologica. vol 50. issue 1. 2012-08-08. PMID:22505366. |
expression of immunohistochemical markers on microglia in creutzfeldt-jakob disease and alzheimer's disease: morphometric study and review of the literature. |
2012-08-08 |
2023-08-12 |
Not clear |
| Stephen Deci, Susan K Lemieux, Carrie A Smith-Bell, D Larry Sparks, Bernard G Schreur. Cholesterol increases ventricular volume in a rabbit model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 29. issue 2. 2012-07-26. PMID:22232012. |
to date we and others have shown that a cholesterol-fed rabbit model of alzheimer's disease displays as many as fourteen different pathological markers of alzheimer's disease including amyloid-β accumulation, thioflavin-s staining, blood brain barrier breach, microglia activation, cerebrovasculature changes, and alterations in learning and memory. |
2012-07-26 |
2023-08-12 |
rabbit |
| Holly F Green, Eimear Treacy, Aoife K Keohane, Aideen M Sullivan, Gerard W O'Keeffe, Yvonne M Nola. A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells. Molecular and cellular neurosciences. vol 49. issue 3. 2012-07-13. PMID:22270046. |
prolonged release of interleukin-1β (il-1β) from activated microglia has a deleterious effect on hippocampal neurons and is implicated in the impaired neurogenesis and cognitive dysfunction associated with aging, alzheimer's disease and depression. |
2012-07-13 |
2023-08-12 |
rat |
| Tyler Bassett, Paxton Bach, Hing Man Cha. Effects of methylmercury on the secretion of pro-inflammatory cytokines from primary microglial cells and astrocytes. Neurotoxicology. vol 33. issue 2. 2012-07-09. PMID:22037494. |
deregulation or changes to cns populations of astrocytes and microglia in particular are expected to play a role in many neurodegenerative diseases, including parkinson's disease, amyotrophic lateral sclerosis (als) and alzheimer's disease (ad). |
2012-07-09 |
2023-08-12 |
mouse |
| Shirong Liu, Yang Liu, Wenlin Hao, Lisa Wolf, Amanda J Kiliaan, Botond Penke, Claudia E Rübe, Jochen Walter, Michael T Heneka, Tobias Hartmann, Michael D Menger, Klaus Fassbende. TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation. Journal of immunology (Baltimore, Md. : 1950). vol 188. issue 3. 2012-06-11. PMID:22198949. |
microglia activated by extracellularly deposited amyloid β peptide (aβ) act as a two-edged sword in alzheimer's disease pathogenesis: on the one hand, they damage neurons by releasing neurotoxic proinflammatory mediators (m1 activation); on the other hand, they protect neurons by triggering anti-inflammatory/neurotrophic m2 activation and by clearing aβ via phagocytosis. |
2012-06-11 |
2023-08-12 |
mouse |