| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuei Sugama, Takato Takenouchi, Byung P Cho, Tong H Joh, Makoto Hashimoto, Hiroshi Kitan. Possible roles of microglial cells for neurotoxicity in clinical neurodegenerative diseases and experimental animal models. Inflammation & allergy drug targets. vol 8. issue 4. 2010-05-13. PMID:19754411. |
microglia has been demonstrated to play critical roles in various neurodegenerative disorders, such as parkinson's disease (pd), alzheimer's disease (ad), huntington's disease (hd) as well as neuroinflammatory disorders including aids encephalitis, multiple sclerosis. |
2010-05-13 |
2023-08-12 |
human |
| Mark F McCarty, Jorge Barroso-Aranda, Francisco Contrera. Oral phycocyanobilin may diminish the pathogenicity of activated brain microglia in neurodegenerative disorders. Medical hypotheses. vol 74. issue 3. 2010-05-07. PMID:19576698. |
there is considerable evidence that activated microglia play a central role in the pathogenesis of many prominent neurodegenerative disorders, including parkinson's and alzheimer's diseases. |
2010-05-07 |
2023-08-12 |
mouse |
| Fang Fang, Lih-Fen Lue, Shiqiang Yan, Hongwei Xu, John S Luddy, Doris Chen, Douglas G Walker, David M Stern, Shifang Yan, Ann Marie Schmidt, John X Chen, Shirley ShiDu Ya. RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 4. 2010-04-28. PMID:19906677. |
rage-dependent signaling in microglia contributes to neuroinflammation, abeta accumulation, and impaired learning/memory in a mouse model of alzheimer's disease. |
2010-04-28 |
2023-08-12 |
mouse |
| Fang Fang, Lih-Fen Lue, Shiqiang Yan, Hongwei Xu, John S Luddy, Doris Chen, Douglas G Walker, David M Stern, Shifang Yan, Ann Marie Schmidt, John X Chen, Shirley ShiDu Ya. RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 4. 2010-04-28. PMID:19906677. |
microglia are critical for amyloid-beta peptide (abeta)-mediated neuronal perturbation relevant to alzheimer's disease (ad) pathogenesis. |
2010-04-28 |
2023-08-12 |
mouse |
| Fang Fang, Lih-Fen Lue, Shiqiang Yan, Hongwei Xu, John S Luddy, Doris Chen, Douglas G Walker, David M Stern, Shifang Yan, Ann Marie Schmidt, John X Chen, Shirley ShiDu Ya. RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 4. 2010-04-28. PMID:19906677. |
we conclude that blockade of microglial rage may have a beneficial effect on abeta-mediated neuronal perturbation relevant to ad pathogenesis.-fang, f., lue, l.-f., yan, s., xu, h., luddy, j. s., chen, d., walker, d. g., stern, d. m., yan, s., schmidt, a. m., chen, j. x., yan, s. s. rage-dependent signaling in microglia contributes to neuroinflammation, abeta accumulation, and impaired learning/memory in a mouse model of alzheimer's disease. |
2010-04-28 |
2023-08-12 |
mouse |
| Sadayuki Hashioka, Patrick L McGeer, Akira Monji, Shigenobu Kanb. Anti-inflammatory effects of antidepressants: possibilities for preventives against Alzheimer's disease. Central nervous system agents in medicinal chemistry. vol 9. issue 1. 2010-04-27. PMID:20021334. |
because of the anti-inflammatory effects of antidepressants, they might also act as preventives for neurodegenerative dementias including alzheimer's disease, where the pathogenesis involves chronic inflammation associated with activated microglia. |
2010-04-27 |
2023-08-12 |
Not clear |
| b' Gerd Schmitz, Kerstin Leuth\\xc3\\xa4user-Jaschinski, Evelyn Ors\\xc3\\xb. Are circulating monocytes as microglia orthologues appropriate biomarker targets for neuronal diseases? Central nervous system agents in medicinal chemistry. vol 9. issue 4. 2010-04-27. PMID:20021364.' |
this review summarizes the current knowledge about the role of microglia in neurodegenerative diseases with a focus on alzheimer s disease. |
2010-04-27 |
2023-08-12 |
Not clear |
| Martin Fuhrmann, Tobias Bittner, Christian K E Jung, Steffen Burgold, Richard M Page, Gerda Mitteregger, Christian Haass, Frank M LaFerla, Hans Kretzschmar, Jochen Herm. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nature neuroscience. vol 13. issue 4. 2010-04-22. PMID:20305648. |
microglia, the immune cells of the brain, can have a beneficial effect in alzheimer's disease by phagocytosing amyloid-beta. |
2010-04-22 |
2023-08-12 |
mouse |
| Martin Fuhrmann, Tobias Bittner, Christian K E Jung, Steffen Burgold, Richard M Page, Gerda Mitteregger, Christian Haass, Frank M LaFerla, Hans Kretzschmar, Jochen Herm. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nature neuroscience. vol 13. issue 4. 2010-04-22. PMID:20305648. |
two-photon in vivo imaging of neuron loss in the intact brain of living alzheimer's disease mice revealed an involvement of microglia in neuron elimination, indicated by locally increased number and migration velocity of microglia around lost neurons. |
2010-04-22 |
2023-08-12 |
mouse |
| Manuel B Graeber, Wolfgang J Strei. Microglia: biology and pathology. Acta neuropathologica. vol 119. issue 1. 2010-03-15. PMID:20012873. |
premature commercial interests may be responsible for some of the confusion that currently surrounds microglia in both the alzheimer and parkinson's disease research fields. |
2010-03-15 |
2023-08-12 |
Not clear |
| Elisa Braghin, Daniela Galimberti, Elio Scarpini, Nereo Bresolin, Pierluigi Baro. Alpha1-antichymotrypsin induces TNF-alpha production and NF-kappaB activation in the murine N9 microglial cell line. Neuroscience letters. vol 467. issue 1. 2010-02-25. PMID:19800391. |
microglia are known to accumulate in senile plaques of alzheimer's disease (ad) together with a set of proteins including alpha(1)-antichymotrypsin (act). |
2010-02-25 |
2023-08-12 |
Not clear |
| Sadanand Gaikwad, Sergey Larionov, Yiner Wang, Holger Dannenberg, Takashi Matozaki, Alon Monsonego, Dietmar R Thal, Harald Neuman. Signal regulatory protein-beta1: a microglial modulator of phagocytosis in Alzheimer's disease. The American journal of pathology. vol 175. issue 6. 2010-02-25. PMID:19893026. |
here, we found that sirpbeta1 was up-regulated and acted as a phagocytic receptor on microglia in amyloid precursor protein j20 (app/j20) transgenic mice and in alzheimer's disease (ad) patients. |
2010-02-25 |
2023-08-12 |
mouse |
| Christopher M Davenport, Ioanna G Sevastou, Claudie Hooper, Jennifer M Pococ. Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides. Journal of neurochemistry. vol 112. issue 2. 2010-02-05. PMID:19895660. |
inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to alzheimer peptides. |
2010-02-05 |
2023-08-12 |
Not clear |
| Christopher M Davenport, Ioanna G Sevastou, Claudie Hooper, Jennifer M Pococ. Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides. Journal of neurochemistry. vol 112. issue 2. 2010-02-05. PMID:19895660. |
inhibiting p53 mediated microglial apoptosis prevented microglial neurotoxicity suggesting targeting of p53-mediated pathways in microglia may have therapeutic benefit in alzheimer's disease. |
2010-02-05 |
2023-08-12 |
Not clear |
| Stefan A Grathwohl, Roland E Kälin, Tristan Bolmont, Stefan Prokop, Georg Winkelmann, Stephan A Kaeser, Jörg Odenthal, Rebecca Radde, Therese Eldh, Sam Gandy, Adriano Aguzzi, Matthias Staufenbiel, Paul M Mathews, Hartwig Wolburg, Frank L Heppner, Mathias Jucke. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nature neuroscience. vol 12. issue 11. 2010-01-22. PMID:19838177. |
formation and maintenance of alzheimer's disease beta-amyloid plaques in the absence of microglia. |
2010-01-22 |
2023-08-12 |
mouse |
| Stefan A Grathwohl, Roland E Kälin, Tristan Bolmont, Stefan Prokop, Georg Winkelmann, Stephan A Kaeser, Jörg Odenthal, Rebecca Radde, Therese Eldh, Sam Gandy, Adriano Aguzzi, Matthias Staufenbiel, Paul M Mathews, Hartwig Wolburg, Frank L Heppner, Mathias Jucke. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nature neuroscience. vol 12. issue 11. 2010-01-22. PMID:19838177. |
in alzheimer's disease, microglia cluster around beta-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. |
2010-01-22 |
2023-08-12 |
mouse |
| Ilaria Bulgarelli, Laura Tamiazzo, Elena Bresciani, Daniela Rapetti, Simona Caporali, Donatella Lattuada, Vittorio Locatelli, Antonio Torsell. Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by beta-amyloid fibrils. Journal of neuroscience research. vol 87. issue 12. 2010-01-12. PMID:19382238. |
data from alzheimer's disease (ad) patients and ad animal models demonstrate the accumulation of inflammatory microglia at sites of insoluble fibrillar beta-amyloid protein (fabeta) deposition. |
2010-01-12 |
2023-08-12 |
mouse |
| Yukiko Doi, Tetsuya Mizuno, Yuki Maki, Shijie Jin, Hiroyuki Mizoguchi, Masayoshi Ikeyama, Minoru Doi, Makoto Michikawa, Hideyuki Takeuchi, Akio Suzumur. Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of Alzheimer's disease. The American journal of pathology. vol 175. issue 5. 2010-01-11. PMID:19834064. |
microglia activated with the toll-like receptor 9 ligand cpg attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of alzheimer's disease. |
2010-01-11 |
2023-08-12 |
mouse |
| Marina A Lync. The multifaceted profile of activated microglia. Molecular neurobiology. vol 40. issue 2. 2009-12-15. PMID:19629762. |
particular emphasis has been placed on increasing our understanding of the function of microglia because a change from the ramified "resting" state of these cells has been associated with the pathogenesis of several neurodegenerative diseases, notably alzheimer's disease. |
2009-12-15 |
2023-08-12 |
Not clear |
| Hsiao-Wen Lin, Steven W Leviso. Context-dependent IL-6 potentiation of interferon- gamma-induced IL-12 secretion and CD40 expression in murine microglia. Journal of neurochemistry. vol 111. issue 3. 2009-11-06. PMID:19712053. |
interleukin-6 (il-6) is produced by neurons, astrocytes, and microglia, and elevated levels of il-6 within the cns have been documented in multiple neurological disorders including alzheimer's disease, stroke, epilepsy, attention deficit disorder, cerebral palsy, and multiple sclerosis. |
2009-11-06 |
2023-08-12 |
Not clear |