| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Wallace, B Winbla. Towards a molecular genetic approach to Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 10. issue 3-5. 1987-02-06. PMID:3797689. |
in characterizing the gene expression in demented tissue, we have found that rna from alzheimer frontal cortex and hippocampus was partially degraded compared to rna isolated from control. |
1987-02-06 |
2023-08-11 |
Not clear |
| A Delacourte, A Defosse. Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments. Journal of the neurological sciences. vol 76. issue 2-3. 1987-02-05. PMID:3098926. |
this antiserum stains specifically neurofibrillary tangles (nft) at the light-microscopic level and phf at the electron-microscopic level in sections of alzheimer neocortex and hippocampus. |
1987-02-05 |
2023-08-11 |
rabbit |
| A Defossez, P Persuy, G Tramu, A Delacourt. [Immunohistochemical study of the basic lesions of Alzheimer's disease]. L'Encephale. vol 12. issue 4. 1987-02-02. PMID:3539580. |
the anti-phf antibodies detected specifically nft and sp on nervous tissue sections of alzheimer brains, and also nft in the hippocampus of normal aged brains. |
1987-02-02 |
2023-08-11 |
Not clear |
| B T Hyman, G W Van Hoesen, L J Kromer, A R Damasi. Perforant pathway changes and the memory impairment of Alzheimer's disease. Annals of neurology. vol 20. issue 4. 1986-12-29. PMID:3789663. |
because of the central role of the hippocampus and parahippocampal gyrus in learning, it is likely that pathological changes in the perforant pathway, by precluding normal hippocampal operation, account for some aspects of the memory impairment in alzheimer's disease. |
1986-12-29 |
2023-08-11 |
human |
| G S Zubenk. Hippocampal membrane alteration in Alzheimer's disease. Brain research. vol 385. issue 1. 1986-12-18. PMID:3768709. |
hippocampal membrane alteration in alzheimer's disease. |
1986-12-18 |
2023-08-11 |
Not clear |
| G S Zubenk. Hippocampal membrane alteration in Alzheimer's disease. Brain research. vol 385. issue 1. 1986-12-18. PMID:3768709. |
the biophysical properties of hippocampal membrane preparations from patients with alzheimer's disease were examined by fluorescence spectroscopy using the membrane lipid probe 1,6-diphenyl-1,3,5-hexatriene (dph) and its cationic derivative 1-[4-(trimethylamino)-phenyl]-6-phenyl-1,3,5-hexatriene (tma-dph). |
1986-12-18 |
2023-08-11 |
Not clear |
| A Nordberg, I Alafuzoff, B Winbla. Muscarinic receptor subtypes in hippocampus in Alzheimer's disease and mixed dementia type. Neuroscience letters. vol 70. issue 1. 1986-12-17. PMID:3774212. |
muscarinic receptor subtypes in hippocampus in alzheimer's disease and mixed dementia type. |
1986-12-17 |
2023-08-11 |
Not clear |
| A Nordberg, I Alafuzoff, B Winbla. Muscarinic receptor subtypes in hippocampus in Alzheimer's disease and mixed dementia type. Neuroscience letters. vol 70. issue 1. 1986-12-17. PMID:3774212. |
the relative proportion of super-high, high and low affinity agonist binding sites was measured in the hippocampus from individuals with dementia of the alzheimer type (ad/sdat), mixed (ad-mid) type and controls, using labelled quinuclidinyl benzilate ([3h]qnb) competing with unlabelled carbachol. |
1986-12-17 |
2023-08-11 |
Not clear |
| D W Dickson, S H Yen, D S Horoupia. Pick body-like inclusions in the dentate fascia of the hippocampus in Alzheimer's disease. Acta neuropathologica. vol 71. issue 1-2. 1986-12-04. PMID:3022536. |
pick body-like inclusions in the dentate fascia of the hippocampus in alzheimer's disease. |
1986-12-04 |
2023-08-11 |
Not clear |
| J W Geddes, C W Cotma. Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease. Neuroscience research. vol 3. issue 6. 1986-11-26. PMID:2877425. |
plasticity in hippocampal excitatory amino acid receptors in alzheimer's disease. |
1986-11-26 |
2023-08-11 |
human |
| J W Geddes, C W Cotma. Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease. Neuroscience research. vol 3. issue 6. 1986-11-26. PMID:2877425. |
quantitative autoradiography was used to examine the density and distribution of n-methyl-d-aspartate (nmda) and kainic acid (ka) receptors in human hippocampus obtained post-mortem from alzheimer's disease patients and from age-matched controls. |
1986-11-26 |
2023-08-11 |
human |
| H Arai, T Moroji, K Kosaka, R Iizuk. Extrahypophyseal distribution of alpha-melanocyte stimulating hormone (alpha-MSH)-like immunoreactivity in postmortem brains from normal subjects and Alzheimer-type dementia patients. Brain research. vol 377. issue 2. 1986-09-17. PMID:3524751. |
in the alzheimer brains, although the temporal cortex and hippocampus had normal concentrations of alpha-msh-li, the cingulate cortex, caudate and substantia nigra showed significantly lower concentrations of alpha-msh-li than those of the control brains. |
1986-09-17 |
2023-08-11 |
human |
| D P Perl, W W Pendlebur. Neuropathology of dementia. Neurologic clinics. vol 4. issue 2. 1986-06-30. PMID:2940454. |
the most important, alzheimer's disease, is characterized by the widespread development of neurofibrillary tangles and senile or neuritic plaques in the hippocampus and neocortex. |
1986-06-30 |
2023-08-11 |
Not clear |
| D M Mann, P O Yates, B Marcyniu. A comparison of nerve cell loss in cortical and subcortical structures in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 49. issue 3. 1986-05-22. PMID:3958743. |
loss of nerve cells from temporal cortex, hippocampus, nucleus basalis of meynert and locus caeruleus was measured in 32 patients with alzheimer's disease ranging from 48 to 92 years of age. |
1986-05-22 |
2023-08-11 |
Not clear |
| L S Wolfe, N M Ng Ying Kin, J Palo, C Bergeron, M Kotila, S Varone. Dolichols are elevated in brain tissue from Alzheimer's disease, but not in urinary sediment from Alzheimer's disease and Down's syndrome. Neurochemical pathology. vol 3. issue 4. 1986-05-06. PMID:2938031. |
out of the individual dolichol molecular species, the one with the most isoprene units (c105) was significantly increased in the temporal cortex, hippocampus, and basal forebrain of alzheimer patients, compared with the controls. |
1986-05-06 |
2023-08-11 |
Not clear |
| M J Bal. Herpesvirus in the hippocampus as a cause of Alzheimer's disease. Archives of neurology. vol 43. issue 4. 1986-04-21. PMID:3006646. |
herpesvirus in the hippocampus as a cause of alzheimer's disease. |
1986-04-21 |
2023-08-11 |
Not clear |
| E B De Souza, P J Whitehouse, M J Kuhar, D L Price, W W Val. Reciprocal changes in corticotropin-releasing factor (CRF)-like immunoreactivity and CRF receptors in cerebral cortex of Alzheimer's disease. Nature. vol 319. issue 6054. 1986-03-20. PMID:3003585. |
alzheimer's disease is a progressive degenerative disease of the nervous system characterized neuropathologically by the presence of senile plaques and neurofibrillary tangles in amygdala, hippocampus and neocortex. |
1986-03-20 |
2023-08-11 |
Not clear |
| H K Kulmala, J T Hutto. Role of the senile plaque in neuropeptide deficits of Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 9. issue 5-6. 1986-03-18. PMID:2868494. |
the senile plaque may precipitate much of the hippocampal denervation seen in alzheimer's disease. |
1986-03-18 |
2023-08-11 |
Not clear |
| F Koukolí. [Criticism of the hippocampal hypothesis of dementia in Alzheimer's disease]. Casopis lekaru ceskych. vol 124. issue 48. 1986-01-22. PMID:4064101. |
[criticism of the hippocampal hypothesis of dementia in alzheimer's disease]. |
1986-01-22 |
2023-08-11 |
Not clear |
| J W Geddes, D T Monaghan, C W Cotman, I T Lott, R C Kim, H C Chu. Plasticity of hippocampal circuitry in Alzheimer's disease. Science (New York, N.Y.). vol 230. issue 4730. 1985-12-27. PMID:4071042. |
plasticity of hippocampal circuitry in alzheimer's disease. |
1985-12-27 |
2023-08-11 |
human |