| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D M Araujo, P A Lapchak, Y Robitaille, S Gauthier, R Quirio. Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease. Journal of neurochemistry. vol 50. issue 6. 1988-06-28. PMID:3373218. |
choline acetyltransferase activity in alzheimer's brains was markedly reduced in various cortical areas, in the hippocampus, and in the nucleus basalis of meynert. |
1988-06-28 |
2023-08-11 |
human |
| D M Araujo, P A Lapchak, Y Robitaille, S Gauthier, R Quirio. Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease. Journal of neurochemistry. vol 50. issue 6. 1988-06-28. PMID:3373218. |
these findings reveal an apparently selective alteration in the densities of putative nicotinic and muscarinic m2, but not m1, receptor sites in cortical areas and in the hippocampus in alzheimer's disease. |
1988-06-28 |
2023-08-11 |
human |
| P Hammond, S Brimijoi. Acetylcholinesterase in Huntington's and Alzheimer's diseases: simultaneous enzyme assay and immunoassay of multiple brain regions. Journal of neurochemistry. vol 50. issue 4. 1988-04-21. PMID:2964509. |
huntington's brain samples showed normal total contents of ache, but alzheimer's brains showed significant decreases of both enzyme activity and immunoreactivity in all seven cortical regions and in two out of the eight subcortical structures examined, hippocampus and nucleus accumbens. |
1988-04-21 |
2023-08-11 |
Not clear |
| W I Rosenblum, A Haide. Negative correlations between parenchymal amyloid and vascular amyloid in hippocampus. The American journal of pathology. vol 130. issue 3. 1988-04-20. PMID:3348357. |
congo red was used to stain amyloid in 29 blocks of hippocampus from 17 unselected cases of alzheimer's disease. |
1988-04-20 |
2023-08-11 |
Not clear |
| T Arendt, G Taubert, V Bigl, A Arend. Amyloid deposition in the nucleus basalis of Meynert complex: a topographic marker for degenerating cell clusters in Alzheimer's disease. Acta neuropathologica. vol 75. issue 3. 1988-04-13. PMID:3348080. |
besides a constant involvement of the cerebral cortex and hippocampus, all cases of alzheimer's disease show a large amount of amyloid in the medial septal nucleus, in the diagonal band nucleus and in the substantia innominata which is correlated with neuronal loss in these areas. |
1988-04-13 |
2023-08-11 |
Not clear |
| D M Mann, C M Tucker, P O Yate. Alzheimer's disease: an olfactory connection? Mechanisms of ageing and development. vol 42. issue 1. 1988-04-11. PMID:2964546. |
the density and distribution of senile plaques and neurofibrillary tangles were examined in the olfactory bulbs and tracts, amygdala and hippocampus of 28 patients with alzheimer's disease, 13 with down's syndrome and 60 non-demented patients of age range 6-84 years. |
1988-04-11 |
2023-08-11 |
Not clear |
| C J Smith, E K Perry, R H Perry, J M Candy, M Johnson, J R Bonham, D J Dick, A Fairbairn, G Blessed, N J Birdsal. Muscarinic cholinergic receptor subtypes in hippocampus in human cognitive disorders. Journal of neurochemistry. vol 50. issue 3. 1988-03-23. PMID:3339358. |
total muscarinic receptor levels, the levels of the subtypes exhibiting high and low affinity for pirenzepine, and the high- and low-affinity agonist states of the receptor were investigated in hippocampal tissue obtained at autopsy from mentally normal individuals and the following pathological groups: alzheimer's disease, parkinson's disease, down's syndrome, alcoholic dementia, huntington's chorea, and motor-neurone disease. |
1988-03-23 |
2023-08-11 |
human |
| G A Higgins, D A Lewis, S Bahmanyar, D Goldgaber, D C Gajdusek, W G Young, J H Morrison, M C Wilso. Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 85. issue 4. 1988-03-21. PMID:3277189. |
differential regulation of amyloid-beta-protein mrna expression within hippocampal neuronal subpopulations in alzheimer disease. |
1988-03-21 |
2023-08-11 |
human |
| G A Higgins, D A Lewis, S Bahmanyar, D Goldgaber, D C Gajdusek, W G Young, J H Morrison, M C Wilso. Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 85. issue 4. 1988-03-21. PMID:3277189. |
in contrast, in the alzheimer disease hippocampal formation, the levels of amyloid-beta-protein mrna in the cornu ammonis field 3 and parasubiculum are equivalent. |
1988-03-21 |
2023-08-11 |
human |
| J Moossy, G S Zubenko, A J Martinez, G R Ra. Bilateral symmetry of morphologic lesions in Alzheimer's disease. Archives of neurology. vol 45. issue 3. 1988-03-17. PMID:3341948. |
the absence of bilateral symmetry for the density of nfts in the hippocampus, where the density of sps was highly symmetrical, suggests that there may be a different pathogenesis for these lesions in alzheimer's disease. |
1988-03-17 |
2023-08-11 |
Not clear |
| J B Gramsbergen, C Q Mountjoy, M N Rossor, G P Reynolds, M Roth, J Kor. A correlative study on hippocampal cation shifts and amino acids and clinico-pathological data in Alzheimer's disease. Neurobiology of aging. vol 8. issue 6. 1988-03-10. PMID:3431623. |
a correlative study on hippocampal cation shifts and amino acids and clinico-pathological data in alzheimer's disease. |
1988-03-10 |
2023-08-11 |
Not clear |
| J B Gramsbergen, C Q Mountjoy, M N Rossor, G P Reynolds, M Roth, J Kor. A correlative study on hippocampal cation shifts and amino acids and clinico-pathological data in Alzheimer's disease. Neurobiology of aging. vol 8. issue 6. 1988-03-10. PMID:3431623. |
amino acid transmitters and cations were assessed in the frontal cortex and hippocampus of 12 alzheimer's disease (ad), 4 multi-infarct dementia (mid) patients, and 12 age-matched controls. |
1988-03-10 |
2023-08-11 |
Not clear |
| M J Bal. Morphometric analyses of neuronal populations and dendritic extent in normal aging and dementia of Alzheimer type: a frank appraisal of the difficulties. Neurobiology of aging. vol 8. issue 6. 1988-03-10. PMID:3431632. |
of special interest are data from flood and coleman's own laboratory in which the unique behaviour of hippocampal nerve cells in autopsy studies suggests that hippocampal pyramidal neurones are a key to the neurobiology of dementia of the alzheimer type. |
1988-03-10 |
2023-08-11 |
human |
| D W Dickson, P Davies, R Mayeux, H Crystal, D S Horoupian, A Thompson, J E Goldma. Diffuse Lewy body disease. Neuropathological and biochemical studies of six patients. Acta neuropathologica. vol 75. issue 1. 1988-03-04. PMID:3434218. |
chat activities were normal in the hippocampus in three patients who also had no significant alzheimer type hippocampal changes. |
1988-03-04 |
2023-08-11 |
Not clear |
| M W Decke. The effects of aging on hippocampal and cortical projections of the forebrain cholinergic system. Brain research. vol 434. issue 4. 1988-02-17. PMID:3319050. |
these observations suggest that unlike alzheimer's disease, normal aging does not reliably produce a degeneration of the cholinergic innervation of the hippocampus and cortex. |
1988-02-17 |
2023-08-11 |
Not clear |
| S Nakamura, T Kawamata, I Akiguchi, M Kameyama, H Kimur. [Reduced nicotinamide adenine dinucleotide phosphate diaphorase histochemistry in neocortex and hippocampus in patients with Alzheimer type dementia and aged controls]. Rinsho shinkeigaku = Clinical neurology. vol 27. issue 8. 1988-02-16. PMID:3690919. |
[reduced nicotinamide adenine dinucleotide phosphate diaphorase histochemistry in neocortex and hippocampus in patients with alzheimer type dementia and aged controls]. |
1988-02-16 |
2023-08-11 |
Not clear |
| D C Chu, J B Penney, A B Youn. Quantitative autoradiography of hippocampal GABAB and GABAA receptor changes in Alzheimer's disease. Neuroscience letters. vol 82. issue 3. 1988-01-28. PMID:2827074. |
quantitative autoradiography of hippocampal gabab and gabaa receptor changes in alzheimer's disease. |
1988-01-28 |
2023-08-11 |
human |
| D C Chu, J B Penney, A B Youn. Quantitative autoradiography of hippocampal GABAB and GABAA receptor changes in Alzheimer's disease. Neuroscience letters. vol 82. issue 3. 1988-01-28. PMID:2827074. |
gabab and gabaa receptors were examined by quantitative [3h]gaba autoradiography in postmortem human hippocampus from 6 histopathologically verified cases of dementia of the alzheimer type (dat) and 6 normal controls. |
1988-01-28 |
2023-08-11 |
human |
| G Perry, P Mulvihill, V Manetto, L Autilio-Gambetti, P Gambett. Immunocytochemical properties of Alzheimer straight filaments. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 7. issue 11. 1988-01-19. PMID:3681409. |
indirect and direct immunogold staining of vibratome sections of alzheimer hippocampus with a monoclonal antibody to nf200 kda (1.1.1.) |
1988-01-19 |
2023-08-11 |
Not clear |
| H K Kulmala, J W Boja, J W Albrecht, J T Hutto. Brain reactive antibodies and the blood-brain barrier: observations in aging rodents and the effects of peripheral kainic acid. Experimental aging research. vol 13. issue 1-2. 1987-12-22. PMID:3678354. |
kainic acid damaged the blood brain barrier and allowed the cns entry of brain-reactive antibodies, especially into the subregions of hippocampus most damaged in alzheimer's. |
1987-12-22 |
2023-08-11 |
mouse |