| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Geidy E Serrano, Jessica Walker, Courtney Nelson, Michael Glass, Richard Arce, Anthony Intorcia, Madison P Cline, Natalie Nabaty, Amanda Acuña, Ashton Huppert Steed, Lucia I Sue, Christine Belden, Parichita Choudhury, Eric Reiman, Alireza Atri, Thomas G Beac. Correlation of Presynaptic and Postsynaptic Proteins with Pathology in Alzheimer's Disease. International journal of molecular sciences. vol 25. issue 6. 2024-03-28. PMID:38542104. |
alzheimer's disease dementia (add) is characterized by synaptic loss in the mesial temporal lobe and cerebral neocortex, both of which are brain areas associated with memory and cognition. |
2024-03-28 |
2024-03-30 |
human |
| Mingzhu Xu, Run Lin, Huaneng Wen, Yixiao Wang, John Wong, Zhihua Peng, Lu Liu, Binbin Nie, Jing Luo, Xiaoyu Tang, Shaoyang Cu. Electroacupuncture Enhances the Functional Connectivity of Limbic System to Neocortex in the 5xFAD Mouse Model of Alzheimer's Disease. Neuroscience. 2024-02-29. PMID:38423162. |
electroacupuncture enhances the functional connectivity of limbic system to neocortex in the 5xfad mouse model of alzheimer's disease. |
2024-02-29 |
2024-03-03 |
mouse |
| Meixiang Huang, Carolyn Tallon, Xiaolei Zhu, Kaitlyn D J Huizar, Silvia Picciolini, Ajit G Thomas, Lukas Tenora, Wathsala Liyanage, Francesca Rodà, Alice Gualerzi, Rangaramanujam M Kannan, Marzia Bedoni, Rana Rais, Barbara S Slushe. Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice. Pharmaceutics. vol 15. issue 9. 2023-09-28. PMID:37765332. |
the progression of alzheimer's disease (ad) correlates with the propagation of hyperphosphorylated tau (ptau) from the entorhinal cortex to the hippocampus and neocortex. |
2023-09-28 |
2023-10-07 |
mouse |
| Joyce R Chong, Yuek Ling Chai, Huayang Xing, Deron R Herr, Markus R Wenk, Paul T Francis, Clive Ballard, Dag Aarsland, David L Silver, Christopher P Chen, Amaury Cazenave-Gassiot, Mitchell K P La. Decreased DHA-containing phospholipids in the neocortex of dementia with Lewy bodies are associated with soluble Aβ Brain pathology (Zurich, Switzerland). 2023-07-18. PMID:37463072. |
while alterations of specific dha-containing phospholipids have been described in the neocortex of patients with alzheimer's disease (ad), the status of these lipids in dementia with lewy bodies (dlb), known to manifest aggregated α-synuclein-containing lewy bodies together with variable amyloid pathology, is unclear. |
2023-07-18 |
2023-08-14 |
Not clear |
| Leon M Aksman, Neil P Oxtoby, Marzia A Scelsi, Peter A Wijeratne, Alexandra L Young, Isadora Lopes Alves, Lyduine E Collij, Jacob W Vogel, Frederik Barkhof, Daniel C Alexander, Andre Altman. A data-driven study of Alzheimer's disease related amyloid and tau pathology progression. Brain : a journal of neurology. 2023-07-11. PMID:37433038. |
amyloid-beta is thought to facilitate the spread of tau throughout the neocortex in alzheimer's disease, though how this occurs is not well understood. |
2023-07-11 |
2023-08-14 |
Not clear |
| Eugen Semikasev, Barbara Ahlemeyer, Till Acker, Anne Schänzer, Eveline Baumgart-Vog. Rise and fall of peroxisomes during Alzheimer´s disease: a pilot study in human brains. Acta neuropathologica communications. vol 11. issue 1. 2023-05-11. PMID:37170361. |
except for one study analysing abcd3-positive peroxisomes in neurons of the frontal neocortex of alzheimer disease (ad) patients, no data on other brain regions or peroxisomal proteins are available. |
2023-05-11 |
2023-08-14 |
human |
| Yuek Ling Chai, Jasinda H Lee, Joyce R Chong, Clive Ballard, Paul T Francis, Brian K Kennedy, Thiruma V Arumugam, Christopher P Chen, Dag Aarsland, Mitchell K P La. Inflammatory panel cytokines are elevated in the neocortex of late-stage Alzheimer's disease but not Lewy body dementias. Journal of neuroinflammation. vol 20. issue 1. 2023-05-09. PMID:37158957. |
inflammatory panel cytokines are elevated in the neocortex of late-stage alzheimer's disease but not lewy body dementias. |
2023-05-09 |
2023-08-14 |
Not clear |
| Teresa Juárez-Cedillo, Nancy Martínez-Rodríguez, José Manuel Fragoso, Valentin Islas-Pérez, Amara López-Martínez, Antonio Valle-Medin. Multifactor Dimensionality Reduction Analysis to Evaluate the Association of Dopamine Beta-Hydroxylase (DΒH) Polymorphisms with Susceptibility to Dementia (SADEM Study). Molecular neurobiology. 2023-05-06. PMID:37148523. |
since the activity of dopamine b hydroxylase (dβh) is reduced in the hippocampus and neocortex in the brain, changes in the physiological status of dopamine have been reported in alzheimer's disease (ad) induced by this enzyme. |
2023-05-06 |
2023-08-14 |
Not clear |
| Gemma Shireby, Emma L Dempster, Stefania Policicchio, Rebecca G Smith, Ehsan Pishva, Barry Chioza, Jonathan P Davies, Joe Burrage, Katie Lunnon, Dorothea Seiler Vellame, Seth Love, Alan Thomas, Keeley Brookes, Kevin Morgan, Paul Francis, Eilis Hannon, Jonathan Mil. DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types. Nature communications. vol 13. issue 1. 2022-09-24. PMID:36153390. |
alzheimer's disease (ad) is a chronic neurodegenerative disease characterized by the progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex. |
2022-09-24 |
2023-08-14 |
Not clear |
| Michael Rullmann, Matthias Brendel, Matthias L Schroeter, Dorothee Saur, Johannes Levin, Robert G Perneczky, Solveig Tiepolt, Marianne Patt, Andre Mueller, Victor L Villemagne, Joseph Classen, Andrew W Stephens, Osama Sabri, Henryk Barthel, On Behalf Of The German Imaging Initiative For Tauopathies Gii . Multicenter Biomolecules. vol 12. issue 3. 2022-03-25. PMID:35327650. |
multicenter tau aggregates accumulate in the alzheimer's disease (ad) brain according to the established braak staging scheme and spread from transentorhinal over limbic regions to the neocortex. |
2022-03-25 |
2023-08-13 |
Not clear |
| Alexander Joseph McDonald, Alvaro Duqu. Specific neuronal subpopulations in the amygdala of macaque monkeys express high levels of nonphosphorylated neurofilaments. Brain research. 2021-12-27. PMID:34958755. |
pyramidal neurons in the neocortex that express nonphosphorylated neurofilaments (npnfs) are especially vulnerable to degeneration in alzheimer's disease. |
2021-12-27 |
2023-08-13 |
rat |
| Eric E Abrahamson, Julia K Kofler, Carl R Becker, Julie C Price, Kathy L Newell, Bernardino Ghetti, Jill R Murrell, Catriona A McLean, Oscar L Lopez, Chester A Mathis, William E Klunk, Victor L Villemagne, Milos D Ikonomovi. 11C-PiB PET can underestimate brain amyloid-β burden when cotton wool plaques are numerous. Brain : a journal of neurology. 2021-12-17. PMID:34918018. |
cotton wool plaques were present in the neocortex of all familial alzheimer's disease cases and one sporadic alzheimer's disease case, in the caudate nucleus from four familial alzheimer's disease cases, but not in the cerebellum. |
2021-12-17 |
2023-08-13 |
human |
| Eric E Abrahamson, Julia K Kofler, Carl R Becker, Julie C Price, Kathy L Newell, Bernardino Ghetti, Jill R Murrell, Catriona A McLean, Oscar L Lopez, Chester A Mathis, William E Klunk, Victor L Villemagne, Milos D Ikonomovi. 11C-PiB PET can underestimate brain amyloid-β burden when cotton wool plaques are numerous. Brain : a journal of neurology. 2021-12-17. PMID:34918018. |
relative to amyloid-β plaque load, cyano-pittsburgh compound-b plaque load was similar in sporadic alzheimer's disease while in familial alzheimer's disease it was lower in the neocortex and the caudate nucleus. |
2021-12-17 |
2023-08-13 |
human |
| Xin Ying Chua, Joyce R Chong, Ai Ling Cheng, Jasinda H Lee, Clive Ballard, Dag Aarsland, Paul T Francis, Mitchell K P La. Elevation of inactive cleaved annexin A1 in the neocortex is associated with amyloid, inflammatory and apoptotic markers in neurodegenerative dementias. Neurochemistry international. vol 152. 2021-12-11. PMID:34861326. |
in this study, we measured anxa1 immunoreactivities in postmortem neocortex (brodmann areas ba9 and ba40) of well characterized alzheimer's disease (ad), parkinson disease dementia (pdd) and dementia with lewy bodies (dlb) patients as well as aged controls. |
2021-12-11 |
2023-08-13 |
Not clear |
| He Liu, Chae Kim, Tracy Haldiman, Christina J Sigurdson, Sofie Nyström, K Peter R Nilsson, Mark L Cohen, Thomas Wisniewski, Per Hammarström, Jiri G Safa. Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer's disease. The Journal of biological chemistry. vol 297. issue 5. 2021-12-08. PMID:34599965. |
distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive alzheimer's disease. |
2021-12-08 |
2023-08-13 |
Not clear |
| He Liu, Chae Kim, Tracy Haldiman, Christina J Sigurdson, Sofie Nyström, K Peter R Nilsson, Mark L Cohen, Thomas Wisniewski, Per Hammarström, Jiri G Safa. Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer's disease. The Journal of biological chemistry. vol 297. issue 5. 2021-12-08. PMID:34599965. |
amyloid beta (aβ) deposition in the neocortex is a major hallmark of alzheimer's disease (ad), but the extent of deposition does not readily explain phenotypic diversity and rate of disease progression. |
2021-12-08 |
2023-08-13 |
Not clear |
| Christine W Fung, Jia Guo, Hongjun Fu, Helen Y Figueroa, Elisa E Konofagou, Karen E Duf. Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy. Science advances. vol 6. issue 42. 2021-11-17. PMID:33067235. |
tau pathology in alzheimer's disease (ad) first develops in the entorhinal cortex (ec), then spreads to the hippocampus, followed by the neocortex. |
2021-11-17 |
2023-08-13 |
mouse |
| Balbir Singh, Hasandeep Singh, Brahmjot Singh, Navkaran Kumar, Ankita Rajput, Disha Sidhu, Amandeep Kaur, Saroj Arora, Sarabjit Kau. A comprehensive review on medicinal herbs and novel formulations for the prevention of Alzheimer's disease. Current drug delivery. 2021-11-15. PMID:34779370. |
alzheimer's disease (ad) is thought to occur due to the accumulation of β-amyloid (aβ) in the neocortex portion of the brain, nitric oxide mediated dysfunctioning of blood-brain barrier, reduced activity of serine racemase enzyme, cell cycle disturbances, damage of n-methyl-d-aspartate (nmda) receptors and glutamatergic neurotransmission. |
2021-11-15 |
2023-08-13 |
Not clear |
| D Yu Zhdanova, R A Poltavtseva, E V Svirshchevskaya, N V Bobkov. Effect of Intranasal Administration of Multipotent Mesenchymal Stromal Cell Exosomes on Memory of Mice in Alzheimer's Disease Model. Bulletin of experimental biology and medicine. vol 170. issue 4. 2021-11-04. PMID:33725248. |
after administration, labeled exosomes were found in the hippocampus and neocortex, the structures playing an important role in learning and memory processes and affected by alzheimer's disease. |
2021-11-04 |
2023-08-13 |
mouse |
| Natalia V Bobkova, Daria Y Zhdanova, Natalia V Belosludtseva, Nikita V Penkov, Galina D Mironov. Intranasal administration of mitochondria improves spatial memory in olfactory bulbectomized mice. Experimental biology and medicine (Maywood, N.J.). 2021-11-03. PMID:34727745. |
the injected mitochondria labeled with the mitotracker red localized in different brain regions, including the neocortex and hippocampus, which are responsible for memory and affected by degeneration in patients with alzheimer's disease. |
2021-11-03 |
2023-08-13 |
mouse |